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Molecular and Cellular Biology Volume 20, 2000 - Issue 11
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Cell Growth and Development

Granzyme B Short-Circuits the Need for Caspase 8 Activity during Granule-Mediated Cytotoxic T-Lymphocyte Killing by Directly Cleaving Bid

Michele Barry1 Department of Biochemistry, University of Alberta, Edmonton, AlbertaT6G 2H7
,
Jeffrey A. Heibein1 Department of Biochemistry, University of Alberta, Edmonton, AlbertaT6G 2H7
,
Michael J. Pinkoski2 La Jolla Institute for Allergy and Immunology, San Diego, California92122
,
Siow-Fong Lee3 Department of Laboratory Medicine and Pathology, University of Alberta Hospital, Edmonton, AlbertaT6G 2B7, Canada
,
Richard W. Moyer4 Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida32610-0266
,
Douglas R. Green2 La Jolla Institute for Allergy and Immunology, San Diego, California92122
&
R. Chris Bleackley1 Department of Biochemistry, University of Alberta, Edmonton, AlbertaT6G 2H7Correspondence[email protected]
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Pages 3781-3794 | Received 07 Jul 1999, Accepted 22 Feb 2000, Published online: 28 Mar 2023

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Aleš Tichý, Darina Záškodová, Jaroslav Pejchal, Martina ŘezáČová, Jan Österreicher, Jiřina Vávrová & Jaroslav Cerman. (2008) Gamma irradiation of human leukaemic cells HL-60 and MOLT-4 induces decrease in Mcl-1 and Bid, release of cytochrome c, and activation of caspase-8 and caspase-9. International Journal of Radiation Biology 84:6, pages 523-530.
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Pierre-François Cartron, Philippe Juin, Lisa Oliver, Stéphane Martin, Khaled Meflah & François M. Vallette. (2003) Nonredundant Role of Bax and Bak in Bid-Mediated Apoptosis. Molecular and Cellular Biology 23:13, pages 4701-4712.
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Aleksandra Mandic, Kristina Viktorsson, Linda Strandberg, Thomas Heiden, Johan Hansson, Stig Linder & Maria C. Shoshan. (2002) Calpain-Mediated Bid Cleavage and Calpain-Independent Bak Modulation: Two Separate Pathways in Cisplatin-Induced Apoptosis. Molecular and Cellular Biology 22:9, pages 3003-3013.
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Zusen Fan, Paul J. Beresford, Dong Zhang & Judy Lieberman. (2002) HMG2 Interacts with the Nucleosome Assembly Protein SET and Is a Target of the Cytotoxic T-Lymphocyte Protease Granzyme A. Molecular and Cellular Biology 22:8, pages 2810-2820.
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Fabrizio Condorelli, Paolo Salomoni, Sophie Cotteret, Vincenzo Cesi, Srinivasa M. Srinivasula, Emad S. Alnemri & Bruno Calabretta. (2001) Caspase Cleavage Enhances the Apoptosis-Inducing Effects of BAD. Molecular and Cellular Biology 21:9, pages 3025-3036.
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Sarah Greene, Priya Patel & Clint T. Allen. (2019) How patients with an intact immune system develop head and neck cancer. Oral Oncology 92, pages 26-32.
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Johan Spetz, Adam G. Presser & Kristopher A. Sarosiek. 2019. Biology of T Cells - Part B. Biology of T Cells - Part B 27 71 .
Paula Jaime-Sánchez, Elena Catalán, Iratxe Uranga-Murillo, Nacho Aguiló, Llipsy Santiago, Pilar M Lanuza, Diego de Miguel, Maykel A Arias & Julián Pardo. (2018) Antigen-specific primed cytotoxic T cells eliminate tumour cells in vivo and prevent tumour development, regardless of the presence of anti-apoptotic mutations conferring drug resistance. Cell Death & Differentiation 25:9, pages 1536-1548.
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Alex M. Abel, Chao Yang, Monica S. Thakar & Subramaniam Malarkannan. (2018) Natural Killer Cells: Development, Maturation, and Clinical Utilization. Frontiers in Immunology 9.
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Clarissa Liesche, Patricia Sauer, Isabel Prager, Doris Urlaub, Maren Claus, Roland Eils, Joël Beaudouin & Carsten Watzl. (2018) Single-Fluorescent Protein Reporters Allow Parallel Quantification of Natural Killer Cell-Mediated Granzyme and Caspase Activities in Single Target Cells. Frontiers in Immunology 9.
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Lanfei Feng, Snezana Vujicic, Michael E. Dietrich, Natalia Litbarg, Suman Setty, Angelika Antoni, Joyce Rauch & Jerrold S. Levine. (2018) Repeated exposure of epithelial cells to apoptotic cells induces the specific selection of an adaptive phenotype: Implications for tumorigenesis. Journal of Biological Chemistry 293:26, pages 10245-10263.
Crossref
Mikhail Y. Drokov, Julia O. Davydova, Larisa A. Kuzmina, Irina V. Galtseva, Nikolay M. Kapranov, Vera A. Vasilyeva, Darya S. Dubnyak, Olga M. Koroleva, Ekaterina D. Mikhalcova, Natalia N. Popova, Elena N. Parovichnikova & Valery G. Savchenko. (2017) Level of Granzyme B-positive T-regulatory cells is a strong predictor biomarker of acute Graft-versus-host disease after day +30 after allo-HSCT. Leukemia Research 54, pages 25-29.
Crossref
Joseph A Trapani. 2001. eLS. eLS 1 7 .
Helen M. Beere & Douglas R. Green. 2017. Kelley and Firestein's Textbook of Rheumatology. Kelley and Firestein's Textbook of Rheumatology 418 448.e6 .
Guojun Zhang, Mingkai Xu, Huiwen Zhang, Yubo Song, Jian Wang & Chenggang Zhang. (2016) Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1–6 cells. Toxicology and Applied Pharmacology 313, pages 1-9.
Crossref
Lorna Flanagan, Federico Lucantoni & J. H. M. Prehn. 2016. Mitochondria and Cell Death. Mitochondria and Cell Death 45 67 .
Simon Neumann, Souhayla El Maadidi, Laura Faletti, Florian Haun, Shirin Labib, Andrea Schejtman, Ulrich Maurer & Christoph Borner. (2015) How do viruses control mitochondria-mediated apoptosis?. Virus Research 209, pages 45-55.
Crossref
RHUN YIAN KOH, YI CHI SIM, HWEE JIN TOH, LIANG KUAN LIAM, RACHAEL SZE LYNN ONG, MEI YENG YEW, YEE LIAN TIONG, ANNA PICK KIONG LING, SOI MOI CHYE & KHUEN YEN NG. (2015) Cytotoxic and apoptogenic effects of Strobilanthes crispa Blume extracts on nasopharyngeal cancer cells. Molecular Medicine Reports 12:4, pages 6293-6299.
Crossref
Marie-Josee Hébert & Anthony M. Jevnikar. (2015) The Impact of Regulated Cell Death Pathways on Alloimmune Responses and Graft Injury. Current Transplantation Reports 2:3, pages 242-258.
Crossref
Sabina SperandioCorinne BaratMiguel A. CabritaAna GargaunMaxim V. BerezovskiMichel J. TremblayIan de Belle. (2015) TOE1 is an inhibitor of HIV-1 replication with cell-penetrating capability. Proceedings of the National Academy of Sciences 112:26.
Crossref
Ning Yang, Paul Gilman, Razmik Mirzayans, Xuejun Sun, Nicolas Touret, Michael Weinfeld & Ing Swie Goping. (2015) Characterization of the Apoptotic Response Induced by the Cyanine Dye D112: A Potentially Selective Anti-Cancer Compound. PLOS ONE 10:4, pages e0125381.
Crossref
Elena Catalán, Paula Jaime-Sánchez, Nacho Aguiló, Markus M. Simon, Christopher J. Froelich & Julián Pardo. (2015) Mouse Cytotoxic T Cell-derived Granzyme B Activates the Mitochondrial Cell Death Pathway in a Bim-dependent Fashion. Journal of Biological Chemistry 290:11, pages 6868-6877.
Crossref
M. Marcet-Palacios, C. Ewen, E. Pittman, B. Duggan, K. Carmine-Simmen, R. P. Fahlman & R. C. Bleackley. (2014) Design and characterization of a novel human Granzyme B inhibitor. Protein Engineering Design and Selection 28:1, pages 9-17.
Crossref
Andrew H. Moraco & Hardy Kornfeld. (2014) Cell death and autophagy in tuberculosis. Seminars in Immunology 26:6, pages 497-511.
Crossref
Rong Hua, Yongmei Zhang, Fuxing Chen, Zhonghai Zhou, Xi Li, Boming Shao, Shangjing Wang, Yujing Zhang & Xiaoting Lv. (2014) Decreased levels of perforin-positive lymphocytes are associated with posttraumatic complications in patients with major trauma. Injury 45:12, pages 2089-2095.
Crossref
Gregory J. Baker, Peter Chockley, Viveka Nand Yadav, Robert Doherty, Michael Ritt, Sivaraj Sivaramakrishnan, Maria G. Castro & Pedro R. Lowenstein. (2014) Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity. Cancer Research 74:18, pages 5079-5090.
Crossref
Sonja Schiffer, Reinhard Rosinke, Edgar Jost, Grit Hehmann-Titt, Michael Huhn, Georg Melmer, Stefan Barth & Theo Thepen. (2014) Targeted ex vivo reduction of CD64-positive monocytes in chronic myelomonocytic leukemia and acute myelomonocytic leukemia using human granzyme B-based cytolytic fusion proteins . International Journal of Cancer 135:6, pages 1497-1508.
Crossref
A Prakasam, S Ghose, N V Oleinik, J R Bethard, Y K Peterson, N I Krupenko & S A Krupenko. (2014) JNK1/2 regulate Bid by direct phosphorylation at Thr59 in response to ALDH1L1. Cell Death & Disease 5:7, pages e1358-e1358.
Crossref
D Brasacchio, T Noori, C House, A J Brennan, K J Simpson, O Susanto, P I Bird, R W Johnstone & J A Trapani. (2014) A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage. Cell Death & Differentiation 21:5, pages 748-760.
Crossref
Si-Zhen Tan, Delicia Shu-Qin Ooi, Han-Ming Shen & Chew-Kiat Heng. (2014) The Atherogenic Effects of Serum Amyloid A are Potentially Mediated via Inflammation and Apoptosis. Journal of Atherosclerosis and Thrombosis 21:8, pages 854-867.
Crossref
Catherine L. Ewen, Kevin P. Kane & R. Chris Bleackley. (2013) Granzyme H induces cell death primarily via a Bcl-2-sensitive mitochondrial cell death pathway that does not require direct Bid activation. Molecular Immunology 54:3-4, pages 309-318.
Crossref
María Laura Gabelloni, Analía Silvina Trevani, Juan Sabatté & Jorge Geffner. (2013) Mechanisms regulating neutrophil survival and cell death. Seminars in Immunopathology 35:4, pages 423-437.
Crossref
Pranav Oberoi, Robert Jabulowsky & Winfried Wels. (2013) Selective Induction of Cancer Cell Death by Targeted Granzyme B. Antibodies 2:4, pages 130-151.
Crossref
Yuki Fujiwara, Hiroaki Shiba, Ryota Iwase, Koichiro Haruki, Kenei Furukawa, Tadashi Uwagawa, Takeyuki Misawa, Toya Ohashi & Katsuhiko Yanaga. (2013) Inhibition of Nuclear Factor Kappa-B Enhances the Antitumor Effect of Combination Treatment with Tumor Necrosis Factor-Alpha Gene Therapy and Gemcitabine for Pancreatic Cancer in Mice. Journal of the American College of Surgeons 216:2, pages 320-332e3.
Crossref
Sonja Schiffer, Dmitrij Hristodorov, Radoslav Mladenov, Eric Aslanian, Michael Huhn, Rainer Fischer, Stefan Barth & Theo Thepen. (2013) Species-Dependent Functionality of the Human Cytolytic Fusion Proteins Granzyme B-H22(scFv) and H22(scFv)-Angiogenin in Macrophages. Antibodies 2:4, pages 9-18.
Crossref
Clinton Jones. (2013) Bovine Herpes Virus 1 (BHV-1) and Herpes Simplex Virus Type 1 (HSV-1) Promote Survival of Latently Infected Sensory Neurons, in Part by Inhibiting Apoptosis. Journal of Cell Death 6, pages JCD.S10803.
Crossref
YAN-YAN YAN, JIAN-PING BAI, YONG XIE, JIE-ZHONG YU & CUN-GEN MA. (2013) The triterpenoid pristimerin induces U87 glioma cell apoptosis through reactive oxygen species-mediated mitochondrial dysfunction. Oncology Letters 5:1, pages 242-248.
Crossref
Fabio Ghiotto, Claudya Tenca, Franco Fais & Silvia Bruno. 2013. Trends in Stem Cell Proliferation and Cancer Research. Trends in Stem Cell Proliferation and Cancer Research 205 249 .
Toru Okamoto, Stephanie Campbell, Ninad Mehta, John Thibault, Peter M. Colman, Michele Barry, David C. S. Huang & Marc Kvansakul. (2012) Sheeppox Virus SPPV14 Encodes a Bcl-2-Like Cell Death Inhibitor That Counters a Distinct Set of Mammalian Proapoptotic Proteins. Journal of Virology 86:21, pages 11501-11511.
Crossref
V R Sutton, K Sedelies, G Dewson, M E Christensen, P I Bird, R W Johnstone, R M Kluck, J A Trapani & N J Waterhouse. (2012) Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737. Cell Death & Disease 3:7, pages e344-e344.
Crossref
C L Ewen, K P Kane & R C Bleackley. (2011) A quarter century of granzymes. Cell Death & Differentiation 19:1, pages 28-35.
Crossref
Sarah Elizabeth Stewart, Matthew Stephen James Mangan, Phillip Ian Bird & Dion Kaiserman. 2012. Leucocytes. Leucocytes 251 260 .
Marcelo Marcet-Palacios, Brenda Lee Duggan, Irene Shostak, Michele Barry, Tracy Geskes, John A. Wilkins, Akiko Yanagiya, Nahum Sonenberg & R. Chris Bleackley. (2011) Granzyme B Inhibits Vaccinia Virus Production through Proteolytic Cleavage of Eukaryotic Initiation Factor 4 Gamma 3. PLoS Pathogens 7:12, pages e1002447.
Crossref
Steven D. Mason & Johanna A. Joyce. 2012. Cancer Metastasis. Cancer Metastasis 167 182 .
Aintzane Apraiz, Maria Dolores Boyano & Aintzane Asumendi. (2011) Cell-Centric View of Apoptosis and Apoptotic Cell Death-Inducing Antitumoral Strategies. Cancers 3:1, pages 1042-1080.
Crossref
DRAGAN V. JOVANOVIC, LAURENCE BOUMSELL, ARMAND BENSUSSAN, XAVIER CHEVALIER, ARTURO MANCINI & JOHN A. DI BATTISTA. (2011) CD101 Expression and Function in Normal and Rheumatoid Arthritis-affected Human T Cells and Monocytes/Macrophages. The Journal of Rheumatology 38:3, pages 419-428.
Crossref
Logan Banadyga, Sing-Chi Lam, Toru Okamoto, Marc Kvansakul, David C. Huang & Michele Barry. (2011) Deerpox Virus Encodes an Inhibitor of Apoptosis That Regulates Bak and Bax. Journal of Virology 85:5, pages 1922-1934.
Crossref
Kim Plasman, Petra Van Damme, Dion Kaiserman, Francis Impens, Kimberly Demeyer, Kenny Helsens, Marc Goethals, Phillip I. Bird, Joël Vandekerckhove & Kris Gevaert. (2011) Probing the Efficiency of Proteolytic Events by Positional Proteomics. Molecular & Cellular Proteomics 10:2, pages S1-S10.
Crossref
Ganta Vijay Chaitanya, Prabhakar Eeka, Reinhold Munker, Jonathan Steven Alexander & Phanithi Prakash Babu. (2011) Role of Cytotoxic Protease Granzyme-b in Neuronal Degeneration During Human Stroke. Brain Pathology 21:1, pages 16-30.
Crossref
Gina B. ScottPaul A. BowlesErica B. WilsonJosephine L. MeadeBoon Chuan Low, Adam DavisonG. Eric BlairGraham P. Cook. (2010) Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing. Biochemical Journal 431:3, pages 423-431.
Crossref
Juan I Aguiló, Alberto Anel, Elena Catalán, Alvaro Sebastián, Rebeca Acín‐Pérez, Javier Naval, Reinhard Wallich, Markus M Simon & Julián Pardo. (2010) Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase‐dependent NADPH oxidase activation. Immunology & Cell Biology 88:5, pages 545-554.
Crossref
Inna S. Afonina, Sean P. Cullen & Seamus J. Martin. (2010) Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B. Immunological Reviews 235:1, pages 105-116.
Crossref
Desiree A. Anthony, Daniel M. Andrews, Sally V. Watt, Joseph A. Trapani & Mark J. Smyth. (2010) Functional dissection of the granzyme family: cell death and inflammation. Immunological Reviews 235:1, pages 73-92.
Crossref
Judy Lieberman. (2010) Granzyme A activates another way to die. Immunological Reviews 235:1, pages 93-104.
Crossref
Karen Schrader, Jisen Huai, Lars Jöckel, Carolin Oberle & Christoph Borner. (2010) Non-caspase proteases: triggers or amplifiers of apoptosis?. Cellular and Molecular Life Sciences 67:10, pages 1607-1618.
Crossref
S P Cullen, M Brunet & S J Martin. (2010) Granzymes in cancer and immunity. Cell Death & Differentiation 17:4, pages 616-623.
Crossref
J C Choy. (2009) Granzymes and perforin in solid organ transplant rejection. Cell Death & Differentiation 17:4, pages 567-576.
Crossref
Stephanie Campbell, Bart Hazes, Marc Kvansakul, Peter Colman & Michele Barry. (2010) Vaccinia Virus F1L Interacts with Bak Using Highly Divergent Bcl-2 Homology Domains and Replaces the Function of Mcl-1. Journal of Biological Chemistry 285:7, pages 4695-4708.
Crossref
Thanh-Trang Vo & Anthony Letai. 2010. BCL-2 Protein Family. BCL-2 Protein Family 49 63 .
Nigel J Waterhouse, Olivia Susanto, Karin A Sedelies & Joseph A Trapani. 2001. eLS. eLS.
Phillip I. Bird, Joseph A. Trapani & José A. Villadangos. (2009) Endolysosomal proteases and their inhibitors in immunity. Nature Reviews Immunology 9:12, pages 871-882.
Crossref
L Shi, L Wu, S Wang & Z Fan. (2009) Granzyme F induces a novel death pathway characterized by Bid-independent cytochrome c release without caspase activation. Cell Death & Differentiation 16:12, pages 1694-1706.
Crossref
Tomokazu Ikemoto, Yukihiro Hojo, Hideyuki Kondo, Nozomu Takahashi, Masahiro Hirose, Yoshioki Nishimura, Takaaki Katsuki & Kazuyuki Shimada. (2009) Plasma granzyme B as a predicting factor of coronary artery disease—Clinical significance in patients with chronic renal failure. Journal of Cardiology 54:3, pages 409-415.
Crossref
Patrice X. Petit, Pauline Dupaigne, Fabrizio Pariselli, François Gonzalvez, François Etienne, Carole Rameau & Sophie Bernard. (2009) Interaction of the alpha-helical H6 peptide from the pro-apoptotic protein tBid with cardiolipin. FEBS Journal 276:21, pages 6338-6354.
Crossref
Logan Banadyga, Kirstin Veugelers, Stephanie Campbell & Michele Barry. (2009) The Fowlpox Virus BCL-2 Homologue, FPV039, Interacts with Activated Bax and a Discrete Subset of BH3-Only Proteins To Inhibit Apoptosis. Journal of Virology 83:14, pages 7085-7098.
Crossref
David A. Ngan, Shawna V. Vickerman, David J. Granville, S. F. Paul Man & Don D. Sin. (2009) The possible role of granzyme B in the pathogenesis of chronic obstructive pulmonary disease. Therapeutic Advances in Respiratory Disease 3:3, pages 113-129.
Crossref
Sheng F. Cai, Todd A. Fehniger, Xuefang Cao, Joshua C. Mayer, Joel D. Brune, Anthony R. French & Timothy J. Ley. (2009) Differential Expression of Granzyme B and C in Murine Cytotoxic Lymphocytes. The Journal of Immunology 182:10, pages 6287-6297.
Crossref
George Makedonas, Pinaki P. Banerjee, Rahul Pandey, Adam R. Hersperger, Keri B. Sanborn, Gareth A. D. Hardy, Jordan S. Orange & Michael R. Betts. (2009) Rapid Up-Regulation and Granule-Independent Transport of Perforin to the Immunological Synapse Define a Novel Mechanism of Antigen-Specific CD8+ T Cell Cytotoxic Activity. The Journal of Immunology 182:9, pages 5560-5569.
Crossref
Jamie S. Mader, Neeloffer Mookherjee, Robert E.W. Hancock & R. Chris Bleackley. (2009) The Human Host Defense Peptide LL-37 Induces Apoptosis in a Calpain- and Apoptosis-Inducing Factor–Dependent Manner Involving Bax Activity. Molecular Cancer Research 7:5, pages 689-702.
Crossref
Guoqiang Hua, Shuo Wang, Chao Zhong, Peng Xue & Zusen Fan. (2009) Ignition of p53 Bomb Sensitizes Tumor Cells to Granzyme K-Mediated Cytolysis. The Journal of Immunology 182:4, pages 2152-2159.
Crossref
T C M Th Van Maarsseveen, W Vos & P J Van Diest. (2009) Giant cell formation in sarcoidosis: cell fusion or proliferation with non-division?. Clinical and Experimental Immunology 155:3, pages 476-486.
Crossref
Christopher P. Dillon & Douglas R. Green. 2009. Essentials of Apoptosis. Essentials of Apoptosis 423 442 .
Stefan J. Riedl & Fiona L. Scott. 2009. Essentials of Apoptosis. Essentials of Apoptosis 3 24 .
Wenwen Shen & Clinton Jones. (2008) Open Reading Frame 2, Encoded by the Latency-Related Gene of Bovine Herpesvirus 1, Has Antiapoptotic Activity in Transiently Transfected Neuroblastoma Cells. Journal of Virology 82:21, pages 10940-10945.
Crossref
R Schickel, B Boyerinas, S-M Park & M E Peter. (2008) MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death. Oncogene 27:45, pages 5959-5974.
Crossref
Sonja M. Best. (2008) Viral Subversion of Apoptotic Enzymes: Escape from Death Row. Annual Review of Microbiology 62:1, pages 171-192.
Crossref
Indrajit Chowdhury, Binu Tharakan & Ganapathy K. Bhat. (2008) Caspases — An update. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 151:1, pages 10-27.
Crossref
Yanyan Yan, Xiaodong Su, Yongju Liang, Jianye Zhang, Chengjun Shi, Yu Lu, Lianquan Gu & Liwu Fu. (2008) Emodin azide methyl anthraquinone derivative triggers mitochondrial-dependent cell apoptosis involving in caspase-8-mediated Bid cleavage. Molecular Cancer Therapeutics 7:6, pages 1688-1697.
Crossref
Dipanjan Chowdhury & Judy Lieberman. (2008) Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death. Annual Review of Immunology 26:1, pages 389-420.
Crossref
K A Sedelies, A Ciccone, C J P Clarke, J Oliaro, V R Sutton, F L Scott, J Silke, O Susanto, D R Green, R W Johnstone, P I Bird, J A Trapani & N J Waterhouse. (2008) Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity. Cell Death & Differentiation 15:4, pages 708-717.
Crossref
Sean P. Cullen, Alexander U. Lüthi & Seamus J. Martin. (2008) Analysis of apoptosis in cell-free systems. Methods 44:3, pages 273-279.
Crossref
Ing Swie Goping, Tracy Sawchuk, Aja Rieger, Irene Shostak & R. Chris Bleackley. (2008) Cytotoxic T lymphocytes overcome Bcl-2 inhibition: target cells contribute to their own demise. Blood 111:4, pages 2142-2151.
Crossref
Susan E. Logue & Seamus J. Martin. (2008) Caspase activation cascades in apoptosis. Biochemical Society Transactions 36:1, pages 1-9.
Crossref
S P Cullen & S J Martin. (2007) Mechanisms of granule-dependent killing. Cell Death & Differentiation 15:2, pages 251-262.
Crossref
Clinton Jones & Shafiqul Chowdhury. (2008) A review of the biology of bovine herpesvirus type 1 (BHV-1), its role as a cofactor in the bovine respiratory disease complex and development of improved vaccines. Animal Health Research Reviews 8:2, pages 187-205.
Crossref
Boaz Nachmias, Sa'ar Mizrahi, Meital Elmalech, Itay Lazar, Yaqoub Ashhab, Roi Gazit, Gal Markel, Dina Ben-Yehuda & Ofer Mandelboim. (2007) Manipulation of NK cytotoxicity by the IAP family member Livin. European Journal of Immunology 37:12, pages 3467-3476.
Crossref
Franck Meslin, Jerome Thiery, Catherine Richon, Abdelali Jalil & Salem Chouaib. (2007) Granzyme B-induced Cell Death Involves Induction of p53 Tumor Suppressor Gene and Its Activation in Tumor Target Cells. Journal of Biological Chemistry 282:45, pages 32991-32999.
Crossref
Logan Banadyga, Jenna Gerig, Tara Stewart & Michele Barry. (2007) Fowlpox Virus Encodes a Bcl-2 Homologue That Protects Cells from Apoptotic Death through Interaction with the Proapoptotic Protein Bak. Journal of Virology 81:20, pages 11032-11045.
Crossref
K. Tabuchi, K. Pak, E. Chavez & A.F. Ryan. (2007) Role of inhibitor of apoptosis protein in gentamicin-induced cochlear hair cell damage. Neuroscience 149:1, pages 213-222.
Crossref
A.R. O'Connell & C. Stenson-Cox. (2007) A more serine way to die: Defining the characteristics of serine protease-mediated cell death cascades. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773:10, pages 1491-1499.
Crossref
Beverly Z. Packard, William G. Telford, Akira Komoriya & Pierre A. Henkart. (2007) Granzyme B Activity in Target Cells Detects Attack by Cytotoxic Lymphocytes. The Journal of Immunology 179:6, pages 3812-3820.
Crossref
Johnson Agniswamy, Bin Fang & Irene T. Weber. (2007) Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis. FEBS Journal 274:18, pages 4752-4765.
Crossref
Guoqiang Hua, Qixiang Zhang & Zusen Fan. (2007) Heat Shock Protein 75 (TRAP1) Antagonizes Reactive Oxygen Species Generation and Protects Cells from Granzyme M-mediated Apoptosis. Journal of Biological Chemistry 282:28, pages 20553-20560.
Crossref
Vito Racanelli & Tobias Manigold. (2007) Presentation of HCV antigens to naive CD8+T cells: Why the where, when, what and how are important for virus control and infection outcome. Clinical Immunology 124:1, pages 5-12.
Crossref
Veronika Stoka, Vito Turk & Boris Turk. (2007) Lysosomal cysteine cathepsins: signaling pathways in apoptosis. bchm 388:6, pages 555-560.
Crossref
Tongbiao Zhao, Honglian Zhang, Yuming Guo & Zusen Fan. (2007) Granzyme K Directly Processes Bid to Release Cytochrome c and Endonuclease G Leading to Mitochondria-dependent Cell Death. Journal of Biological Chemistry 282:16, pages 12104-12111.
Crossref
Sean P. Cullen, Colin Adrain, Alexander U. Lüthi, Patrick J. Duriez & Seamus J. Martin. (2007) Human and murine granzyme B exhibit divergent substrate preferences. Journal of Cell Biology 176:4, pages 435-444.
Crossref
Yutaro Azuma, Yoshikazu Kurusu, Hirotaka Sato, Koji Higai & Kojiro Matsumoto. (2007) Increased Expression of Lewis X and Y Antigens on the Cell Surface and FUT 4 mRNA during Granzyme B-Induced Jurkat Cell Apoptosis. Biological and Pharmaceutical Bulletin 30:4, pages 655-660.
Crossref
Ciara M. ChamberlainDavid J. Granville. (2007) The role of Granzyme B in atheromatous diseasesThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigators' Forum.. Canadian Journal of Physiology and Pharmacology 85:1, pages 89-95.
Crossref
Florencia Meyer, Sandra Perez, Vicki Geiser, Mark Sintek, Melissa Inman & Clinton Jones. (2007) A Protein Encoded by the Bovine Herpesvirus 1 Latency-Related Gene Interacts with Specific Cellular Regulatory Proteins, Including CCAAT Enhancer Binding Protein Alpha. Journal of Virology 81:1, pages 59-67.
Crossref
Stefan W. RyterHong Pyo KimAlexander HoetzelJeong W. ParkKiichi NakahiraXue WangAugustine M. K. Choi. (2007) Mechanisms of Cell Death in Oxidative Stress. Antioxidants & Redox Signaling 9:1, pages 49-89.
Crossref
J C Timmer & G S Salvesen. (2006) Caspase substrates. Cell Death & Differentiation 14:1, pages 66-72.
Crossref
Marcus Lettau, Hendrik Schmidt, Dieter Kabelitz & Ottmar Janssen. (2007) Secretory lysosomes and their cargo in T and NK cells. Immunology Letters 108:1, pages 10-19.
Crossref
Ruben A. Mesa & Scott H. Kaufmann. 2007. Acute Myelogenous Leukemia. Acute Myelogenous Leukemia 133 161 .
Scott H. Kaufmann. 2007. Apoptosis, Senescence, and Cancer. Apoptosis, Senescence, and Cancer 3 30 .
Elizabeth L. Williams & Steven Jacobson. 2007. Immune Regulation and Immunotherapy in Autoimmune Disease. Immune Regulation and Immunotherapy in Autoimmune Disease 188 213 .
M. L. McEwen & J. E. Springer. 2007. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology 515 550 .
D. Du Pasquier, A. Chesneau, Q. Ymlahi-Ouazzani, R. Boistel, N. Pollet, C. Ballagny, L.M. Sachs, B. Demeneix & A. Mazabraud. (2007) TBid mediated activation of the mitochondrial death pathway leads to genetic ablation of the lens inXenopus laevis. genesis 45:1, pages 1-10.
Crossref
Andrew J. Bredemeyer, Patricia E. Carrigan, Todd A. Fehniger, David F. Smith & Timothy J. Ley. (2006) Hop Cleavage and Function in Granzyme B-induced Apoptosis. Journal of Biological Chemistry 281:48, pages 37130-37141.
Crossref
John M. Taylor, Douglas Quilty, Logan Banadyga & Michele Barry. (2006) The Vaccinia Virus Protein F1L Interacts with Bim and Inhibits Activation of the Pro-apoptotic Protein Bax. Journal of Biological Chemistry 281:51, pages 39728-39739.
Crossref
Ilia Voskoboinik, Mark J. Smyth & Joseph A. Trapani. (2006) Perforin-mediated target-cell death and immune homeostasis. Nature Reviews Immunology 6:12, pages 940-952.
Crossref
Aaron D. Schimmer. (2006) Induction of apoptosis in lymphoid and myeloid leukemia. Current Oncology Reports 8:6, pages 430-436.
Crossref
David L. Vaux & Andreas Strasser. 2006. Encyclopedia of Molecular Cell Biology and Molecular Medicine. Encyclopedia of Molecular Cell Biology and Molecular Medicine.
Carly R.K. Loeb, Jennifer L. Harris & Charles S. Craik. (2006) Granzyme B Proteolyzes Receptors Important to Proliferation and Survival, Tipping the Balance toward Apoptosis. Journal of Biological Chemistry 281:38, pages 28326-28335.
Crossref
Eugene Estella, Mark D. McKenzie, Tara Catterall, Vivien R. Sutton, Phillip I. Bird, Joseph A. Trapani, Thomas W. Kay & Helen E. Thomas. (2006) Granzyme B–Mediated Death of Pancreatic β-Cells Requires the Proapoptotic BH3-Only Molecule Bid. Diabetes 55:8, pages 2212-2219.
Crossref
L D Walensky. (2006) BCL-2 in the crosshairs: tipping the balance of life and death. Cell Death & Differentiation 13:8, pages 1339-1350.
Crossref
J E Chipuk, L Bouchier-Hayes & D R Green. (2006) Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death & Differentiation 13:8, pages 1396-1402.
Crossref
Satish Devadas, Jyoti Das, Catherine Liu, Liying Zhang, Arthur I. Roberts, Zui Pan, Paul A. Moore, Gobardhan Das & Yufang Shi. (2006) Granzyme B Is Critical for T Cell Receptor-Induced Cell Death of Type 2 Helper T Cells. Immunity 25:2, pages 237-247.
Crossref
Pritha Majumder, Biswanath Chattopadhyay, Arindam Mazumder, Pradeep Das & Nitai P. Bhattacharyya. (2006) Induction of apoptosis in cells expressing exogenous Hippi, a molecular partner of huntingtin-interacting protein Hip1. Neurobiology of Disease 22:2, pages 242-256.
Crossref
Mireille Laforge, Nicolas Bidère, Sylvie Carmona, Aurore Devocelle, Bernard Charpentier & Anna Senik. (2006) Apoptotic Death Concurrent with CD3 Stimulation in Primary Human CD8+ T Lymphocytes: A Role for Endogenous Granzyme B. The Journal of Immunology 176:7, pages 3966-3977.
Crossref
B Dälken, U Giesübel, S K Knauer & W S Wels. (2005) Targeted induction of apoptosis by chimeric granzyme B fusion proteins carrying antibody and growth factor domains for cell recognition. Cell Death & Differentiation 13:4, pages 576-585.
Crossref
N J Waterhouse, K A Sedelies, V R Sutton, M J Pinkoski, K Y Thia, R Johnstone, P I Bird, D R Green & J A Trapani. (2005) Functional dissociation of ΔΨm and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis. Cell Death & Differentiation 13:4, pages 607-618.
Crossref
Ulrike Giesübel, Benjamin Dälken, Hayat Mahmud & Winfried S. Wels. (2006) Cell binding, internalization and cytotoxic activity of human granzyme B expressed in the yeast Pichia pastoris . Biochemical Journal 394:3, pages 563-573.
Crossref
Ing Swie Goping, Tracy Sawchuk, D. Alan Underhill & R. Chris Bleackley. (2006) Identification of α-tubulin as a granzyme B substrate during CTL-mediated apoptosis. Journal of Cell Science 119:5, pages 858-865.
Crossref
Hugo Caldas, Florinda O. Jaynes, Michael W. Boyer, Sue Hammond & Rachel A. Altura. (2006) Survivin and Granzyme B–induced apoptosis, a novel anticancer therapy . Molecular Cancer Therapeutics 5:3, pages 693-703.
Crossref
Xiao-Ming Yin. (2006) Bid, a BH3-only multi-functional molecule, is at the cross road of life and death. Gene 369, pages 7-19.
Crossref
U Fischer, C Stroh & K Schulze-Osthoff. (2005) Unique and overlapping substrate specificities of caspase-8 and caspase-10. Oncogene 25:1, pages 152-159.
Crossref
Qingqing Wei, Xiao-Ming Yin, Mong-Heng Wang & Zheng Dong. (2006) Bid deficiency ameliorates ischemic renal failure and delays animal death in C57BL/6 mice. American Journal of Physiology-Renal Physiology 290:1, pages F35-F42.
Crossref
John M. Taylor & Michele Barry. (2006) Near death experiences: Poxvirus regulation of apoptotic death. Virology 344:1, pages 139-150.
Crossref
Catherine L. Ewen, Jianhui Rong, Andy I. Kokaji, R. Chris Bleackley & Kevin P. Kane. (2006) Evaluating antigen-specific cytotoxic T lymphocyte responses by a novel mouse granzyme B ELISPOT assay. Journal of Immunological Methods 308:1-2, pages 156-166.
Crossref
R Chris Bleackley. (2005) A molecular view of cytotoxic T lymphocyte induced killing. Biochemistry and Cell Biology 83:6, pages 747-751.
Crossref
B. FADEEL & S. ORRENIUS. (2005) Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. Journal of Internal Medicine 258:6, pages 479-517.
Crossref
E. Grosicka, B. Sadurska, M. Szumiło, T. Grzela, P. Łazarczyk, J. Niderla-Bielińska & I. Rahden-Staroń. (2005) Effect of glutathione depletion on apoptosis induced by thiram in Chinese hamster fibroblasts. International Immunopharmacology 5:13-14, pages 1945-1956.
Crossref
M. Gronda, J. Brandwein, M. D. Minden, G. R. Pond, A. C. Schuh, R. A. Wells, H. Messner, K. Chun & A. D. Schimmer. (2005) Assessment of the downstream portion of the mitochondrial pathway of caspase activation in patients with acute myeloid leukemia. Apoptosis 10:6, pages 1285-1294.
Crossref
C. G. Bien & C. E. Elger. (2005) Neue Erkenntnis zur Rasmussen-EnzephalitisRecent insights into Rasmussen encephalitis. Der Nervenarzt 76:12, pages 1470-1487.
Crossref
Michael Pinkoski. 2005. Cell Death During HIV Infection. Cell Death During HIV Infection 77 89 .
Hui-Chen Hsu, Donald K. Scott & John D. Mountz. (2005) Impaired apoptosis and immune senescence - cause or effect?. Immunological Reviews 205:1, pages 130-146.
Crossref
F Gonzalvez, J-J Bessoule, F Rocchiccioli, S Manon & P X Petit. (2005) Role of cardiolipin on tBid and tBid/Bax synergistic effects on yeast mitochondria. Cell Death & Differentiation 12:6, pages 659-667.
Crossref
Ludivine Walter & György Hajnóczky. (2005) Mitochondria and Endoplasmic Reticulum: The Lethal Interorganelle Cross-Talk. Journal of Bioenergetics and Biomembranes 37:3, pages 191-206.
Crossref
Harutaka Katano & Jeffrey I. Cohen. (2005) Perforin and lymphohistiocytic proliferative disorders. British Journal of Haematology 128:6, pages 739-750.
Crossref
Andreas Wenzel, Christian Grimm, Marijana Samardzija & Charlotte E. Remé. (2005) Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Progress in Retinal and Eye Research 24:2, pages 275-306.
Crossref
Denis Martinvalet, Pengcheng Zhu & Judy Lieberman. (2005) Granzyme A Induces Caspase-Independent Mitochondrial Damage, a Required First Step for Apoptosis. Immunity 22:3, pages 355-370.
Crossref
Pere Santamaria & R. Chris Bleackly. 2010. Apoptosis in Health and Disease. Apoptosis in Health and Disease 188 218 .
Michael Sebbagh, Jocelyne Hamelin, Jacques Bertoglio, Eric Solary & Jacqueline Bréard. (2005) Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner. Journal of Experimental Medicine 201:3, pages 465-471.
Crossref
Nigel J. Waterhouse, Karin A. Sedelies, Kylie A. Browne, Michelle E. Wowk, Andrea Newbold, Vivien R. Sutton, Chris J. P Clarke, Jane Oliaro, Ralph K. Lindemann, Phillip I. Bird, Ricky W. Johnstone & Joseph A. Trapani. (2005) A Central Role for Bid in Granzyme B-induced Apoptosis. Journal of Biological Chemistry 280:6, pages 4476-4482.
Crossref
Colin Adrain, Brona M. Murphy & Seamus J. Martin. (2005) Molecular Ordering of the Caspase Activation Cascade Initiated by the Cytotoxic T Lymphocyte/Natural Killer (CTL/NK) Protease Granzyme B. Journal of Biological Chemistry 280:6, pages 4663-4673.
Crossref
M M L Green, G J Hutchison, H R Valentine, R J Fitzmaurice, S E Davidson, R D Hunter, C Dive, C M L West & I J Stratford. (2005) Expression of the proapoptotic protein Bid is an adverse prognostic factor for radiotherapy outcome in carcinoma of the cervix. British Journal of Cancer 92:3, pages 449-458.
Crossref
Deborah Braun & Matthew L. Albert. 2005. Measuring Immunity. Measuring Immunity 369 379 .
Mohammed S. RazzaqueWesam Ahmed, Mohammed S. Razzaque & Takashi Taguchi. 2005. Fibrogenesis: Cellular and Molecular Basis. Fibrogenesis: Cellular and Molecular Basis 160 177 .
Marwan S. Abougergi, Sarah J. Gidner, David K. Spady, Bonnie C. Miller & Dwain L. Thiele. (2005) Fas and TNFR1, but not cytolytic granule-dependent mechanisms, mediate clearance of murine liver adenoviral infection. Hepatology 41:1, pages 97-105.
Crossref
Pablo FUENTES-PRIOR & Guy S. SALVESEN. (2004) The protein structures that shape caspase activity, specificity, activation and inhibition. Biochemical Journal 384:2, pages 201-232.
Crossref
Michael T. CrowKartik ManiYoung-Jae NamRichard N. Kitsis. (2004) The Mitochondrial Death Pathway and Cardiac Myocyte Apoptosis. Circulation Research 95:10, pages 957-970.
Crossref
Julián Pardo, Alberto Bosque, Reina Brehm, Reinhard Wallich, Javier Naval, Arno Müllbacher, Alberto Anel & Markus M. Simon. (2004) Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis. Journal of Cell Biology 167:3, pages 457-468.
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Arnon P. Kater, Ludo M. Evers, Ester B. M. Remmerswaal, Annelieke Jaspers, Michiel F. Oosterwijk, René A. W. van Lier, Marinus H. J. van Oers & Eric Eldering. (2004) CD40 stimulation of B-cell chronic lymphocytic leukaemia cells enhances the anti-apoptotic profile, but also Bid expression and cells remain susceptible to autologous cytotoxic T-lymphocyte attack. British Journal of Haematology 127:4, pages 404-415.
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Soizic DanielMaria B. ArveloVirendra I. PatelChristopher R. LongoGautam ShrikhandeTala ShukriJerome MahiouDavid W. SunChristina MottleyShane T. GreyChristiane Ferran. (2004) A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation. Blood 104:8, pages 2376-2384.
Crossref
Aaron D. Schimmer. (2004) Inhibitor of Apoptosis Proteins: Translating Basic Knowledge into Clinical Practice. Cancer Research 64:20, pages 7183-7190.
Crossref
John A. Rutigliano & Barney S. Graham. (2004) Prolonged Production of TNF-α Exacerbates Illness during Respiratory Syncytial Virus Infection. The Journal of Immunology 173:5, pages 3408-3417.
Crossref
Hirohito Yamaguchi, Jiandong Chen, Kapil Bhalla & Hong-Gang Wang. (2004) Regulation of Bax Activation and Apoptotic Response to Microtubule-damaging Agents by p53 Transcription-dependent and -independent Pathways. Journal of Biological Chemistry 279:38, pages 39431-39437.
Crossref
Nigel J. Waterhouse, Chris J.P. Clarke, Karin A. Sedelies, Michele W. Teng & Joseph A. Trapani. (2004) Cytotoxic lymphocytes; instigators of dramatic target cell death. Biochemical Pharmacology 68:6, pages 1033-1040.
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Andrew J. Bredemeyer, Renate M. Lewis, James P. Malone, Alan E. Davis, Julia Gross, R. Reid Townsend & Timothy J. Ley. (2004) A proteomic approach for the discovery of protease substrates. Proceedings of the National Academy of Sciences 101:32, pages 11785-11790.
Crossref
Jianhui Rong, Xiaolin Xu, Catherine Ewen, R. Chris Bleackley & Kevin P. Kane. (2004) Isolation and Characterization of Novel Single-Chain Fv Specific for Human Granzyme B. Hybridoma and Hybridomics 23:4, pages 219-231.
Crossref
Hongxiang Hui, Francesco Dotta, Umberto Di Mario & Riccardo Perfetti. (2004) Role of caspases in the regulation of apoptotic pancreatic islet beta-cells death. Journal of Cellular Physiology 200:2, pages 177-200.
Crossref
Tae-Hyoung Kim, Yongge Zhao, Wen-Xing Ding, Jin Na Shin, Xi He, Young-Woo Seo, Jun Chen, Hannah Rabinowich, Andrew A. Amoscato & Xiao-Ming Yin. (2004) Bid-Cardiolipin Interaction at Mitochondrial Contact Site Contributes to Mitochondrial Cristae Reorganization and Cytochrome c Release . Molecular Biology of the Cell 15:7, pages 3061-3072.
Crossref
Xuejun JiangXiaodong Wang. (2004) Cytochrome C -Mediated Apoptosis . Annual Review of Biochemistry 73:1, pages 87-106.
Crossref
Kirstin VeugelersBruce MotykaChristine FrantzIrene ShostakTracy SawchukR. Chris Bleackley. (2004) The granzyme B–serglycin complex from cytotoxic granules requires dynamin for endocytosis. Blood 103:10, pages 3845-3853.
Crossref
German G. Gomez, Susana B. Read, Lazaro E. Gerschenson, Daniela Santoli, Adam Zweifach & Carol A. Kruse. (2004) Interactions of the allogeneic effector leukemic T cell line, TALL-104, with human malignant brain tumors. Neuro-Oncology 6:2, pages 83-95.
Crossref
Matthias Regner & Arno Müllbacher. (2004) Granzymes in cytolytic lymphocytes − to kill a killer?. Immunology & Cell Biology 82:2, pages 161-169.
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Rui Li, Dominik Rüttinger, Walter Urba, Bernard A. Fox & Hong-Ming Hu. (2004) Targeting and amplification of immune killing of tumor cells by pro-Smac. International Journal of Cancer 109:1, pages 85-94.
Crossref
Amere Subbarao Sreedhar & Peter Csermely. (2004) Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy. Pharmacology & Therapeutics 101:3, pages 227-257.
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Maryanne Donovan & Thomas G. Cotter. (2004) Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1644:2-3, pages 133-147.
Crossref
Felipe Andrade, Livia A. Casciola-Rosen & Antony Rosen. (2004) Granzyme B-Induced Cell Death. Acta Haematologica 111:1-2, pages 28-41.
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William F. PendergraftIIIIII, Earl H. Rudolph, Ronald J. Falk, Jennifer E. Jahn, Matthias Grimmler, Ludger Hengst, J. Charles Jennette & Gloria A. Preston. (2004) Proteinase 3 sidesteps caspases and cleaves p21Waf1/Cip1/Sdi1 to induce endothelial cell apoptosis. Kidney International 65:1, pages 75-84.
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Jian-Hua Li, Wei Shi, Marie Chia, Otto Sanchez-Sweatman, Christopher Siatskas, Dolly Huang, Pierre Busson, Henry Klamut, Wen-Chen Yeh, Chris Richardson, Brian O'Sullivan, Pat Gullane, Peter Neligan, Jeff Medin & Fei-Fei Liu. (2003) Efficacy of targeted FasL in nasopharyngeal carcinoma. Molecular Therapy 8:6, pages 964-973.
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Shawn T. Wasilenko, Tara L. Stewart, Adrienne F. A. Meyers & Michele Barry. (2003) Vaccinia virus encodes a previously uncharacterized mitochondrial-associated inhibitor of apoptosis. Proceedings of the National Academy of Sciences 100:24, pages 14345-14350.
Crossref
Shigang Lin, Makoto Fujii & De-Xing Hou. (2003) Rhein induces apoptosis in HL-60 cells via reactive oxygen species-independent mitochondrial death pathway. Archives of Biochemistry and Biophysics 418:2, pages 99-107.
Crossref
Joseph A Trapani & Vivien R Sutton. (2003) Granzyme B: pro-apoptotic, antiviral and antitumor functions. Current Opinion in Immunology 15:5, pages 533-543.
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Chantal Éthier, Valérie-Ann Raymond, Lina Musallam, Robert Houle & Marc Bilodeau. (2003) Antiapoptotic effect of EGF on mouse hepatocytes associated with downregulation of proapoptotic Bid protein. American Journal of Physiology-Gastrointestinal and Liver Physiology 285:2, pages G298-G308.
Crossref
Alexandrina Burlacu. (2003) Regulation of apoptosis by Bcl-2 family proteins. Journal of Cellular and Molecular Medicine 7:3, pages 249-257.
Crossref

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