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Molecular and Cellular Biology Volume 20, 2000 - Issue 11
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Cell Growth and Development

Class II Phosphoinositide 3-Kinases Are Downstream Targets of Activated Polypeptide Growth Factor Receptors

Alexandre Arcaro1 Ludwig Institute for Cancer Research, University College, LondonW1P 8BT
,
Marketa J. Zvelebil1 Ludwig Institute for Cancer Research, University College, LondonW1P 8BT
,
Christian Wallasch2 Max-Planck-Institut fur Biochemie, 82152Martinsried, Federal Republic of Germany
,
Axel Ullrich2 Max-Planck-Institut fur Biochemie, 82152Martinsried, Federal Republic of Germany
,
Michael D. Waterfield1 Ludwig Institute for Cancer Research, University College, LondonW1P 8BT;3 Department of Biochemistry and Molecular Biology, University College, LondonWC1E 6BT, United Kingdom
&
Jan Domin1 Ludwig Institute for Cancer Research, University College, LondonW1P 8BTCorrespondence[email protected]
Pages 3817-3830 | Received 07 Sep 1999, Accepted 15 Feb 2000, Published online: 28 Mar 2023

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Zhuo Liu, Xiao Li, Jie Ma, Dechuan Li, Haixing Ju, Yong Liu, Yinbo Chen, Xujun He & Yuping Zhu. (2020) Integrative Analysis of the IQ Motif-Containing GTPase-Activating Protein Family Indicates That the IQGAP3-PIK3C2B Axis Promotes Invasion in Colon Cancer. OncoTargets and Therapy 13, pages 8299-8311.
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Xinlei Yu, Yun Chau Long & Han-Ming Shen. (2015) Differential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagy. Autophagy 11:10, pages 1711-1728.
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David P. Harris, Peter Vogel, Marie Wims, Karen Moberg, Juliane Humphries, Kanchan G. Jhaver, Christopher M. DaCosta, Melanie K. Shadoan, Nianhua Xu, Gwenn M. Hansen, Sanjeevi Balakrishnan, Jan Domin, David R. Powell & Tamas Oravecz. (2011) Requirement for Class II Phosphoinositide 3-Kinase C2α in Maintenance of Glomerular Structure and Function. Molecular and Cellular Biology 31:1, pages 63-80.
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Weidong Yu, Xiaolin Sun, Hongxing Tang, Yunxia Tao & Zonghan Dai. (2010) Inhibition of class II phosphoinositide 3-kinase γ expression by p185Bcr–Abl contributes to impaired chemotaxis and aberrant homing of leukemic cells. Leukemia & Lymphoma 51:6, pages 1098-1107.
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Laura Braccini, Elisa Ciraolo, Fulvio Morello, Xiaoyun Lu & Emilio Hirsch. (2009) PI3K signaling: a crossroads of metabolic regulation. Expert Review of Endocrinology & Metabolism 4:4, pages 349-357.
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Sauveur-Michel Maira, Charles Voliva & Carlos Garcia-Echeverria. (2008) Class IA phosphatidylinositol 3-kinase: from their biologic implication in human cancers to drug discovery. Expert Opinion on Therapeutic Targets 12:2, pages 223-238.
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Margaret Das, Erica Scappini, Negin P. Martin, Katy A. Wong, Sara Dunn, Yun-Ju Chen, Stephanie L. H. Miller, Jan Domin & John P. O'Bryan. (2007) Regulation of Neuron Survival through an Intersectin-Phosphoinositide 3′-Kinase C2β-AKT Pathway. Molecular and Cellular Biology 27:22, pages 7906-7917.
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Marco Falasca & Tania Maffucci. (2006) Emerging roles of phosphatidylinositol 3-monophosphate as a dynamic lipid second messenger. Archives of Physiology and Biochemistry 112:4-5, pages 274-284.
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Kazutoshi Harada, Amy B. Truong, Ti Cai & Paul A. Khavari. (2005) The Class II Phosphoinositide 3-Kinase C2β Is Not Essential for Epidermal Differentiation. Molecular and Cellular Biology 25:24, pages 11122-11130.
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Lindsay K. MacDougall, Mary Elizabeth Gagou, Sally J. Leevers, Ernst Hafen & Michael D. Waterfield. (2004) Targeted Expression of the Class II Phosphoinositide 3-Kinase in Drosophila melanogaster Reveals Lipid Kinase-Dependent Effects on Patterning and Interactions with Receptor Signaling Pathways. Molecular and Cellular Biology 24:2, pages 796-808.
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Matthew Wheeler & Jan Domin. (2001) Recruitment of the Class II Phosphoinositide 3-Kinase C2β to the Epidermal Growth Factor Receptor: Role of Grb2. Molecular and Cellular Biology 21:19, pages 6660-6667.
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Christopher P Berrie. (2001) Phosphoinositide 3-kinase inhibition in cancer treatment. Expert Opinion on Investigational Drugs 10:6, pages 1085-1098.
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Zhimin Lu, Guoqiang Jiang, Peter Blume-Jensen & Tony Hunter. (2001) Epidermal Growth Factor-Induced Tumor Cell Invasion and Metastasis Initiated by Dephosphorylation and Downregulation of Focal Adhesion Kinase. Molecular and Cellular Biology 21:12, pages 4016-4031.
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