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Cell Growth and Development

Class II Phosphoinositide 3-Kinases Are Downstream Targets of Activated Polypeptide Growth Factor Receptors

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Pages 3817-3830 | Received 07 Sep 1999, Accepted 15 Feb 2000, Published online: 28 Mar 2023

REFERENCES

  • Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., and Cohen, P.. 1997. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr. Biol. 7:261–269
  • Arcaro, A., Volinia, S., Zvelebil, M. J., Stein, R., Watton, S. J., Layton, M. J., Gout, I., Ahmadi, K., Downward, J., and Waterfield, M. D.. 1998. Human PI3-kinase C2β—the role of calcium and the C2 domain in enzyme activity. J. Biol. Chem. 273:33082–33091
  • Arcaro, A., and Wymann, M. P.. 1993. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem. J. 296:297–301
  • Bondeva, T., Pirola, L., Bulgarelli-Leva, G., Rubio, I., Wetzker, R., and Wymann, M.. 1998. Bifurcation of lipid and protein kinase signals of PI3Kγ to the protein kinases PBK and MAPK. Science 282:293–296
  • Brown, R. A., Domin, J., Arcaro, A., Waterfield, M. D., and Shepherd, P. R.. 1999. Insulin activates the alpha isoform of class II phosphoinositide 3-kinase. J. Biol. Chem. 274:14529–14532
  • Brown, R. A., Ho, L. K., Weber-Hall, S. J., Shipley, J. M., and Fry, M. J.. 1997. Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K. Biochem. Biophys. Res. Commun. 233:537–544
  • Bunday, L., and Downward, J.. 1993. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein and Sos nucleotide exchange factor. Cell 73:611–620
  • Carter, A. N., and Downes, C. P.. 1992. Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells. J. Biol. Chem. 267:14563–14567
  • Chung, J., Grammer, T. C., Lemon, K. P., Kazlauskas, A., and Blenis, J.. 1994. PDGF- and insulin-dependent pp70 S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature 370:71–75
  • Cohen, G., Ren, B. R., and Baltimore, D.. 1995. Modular binding domains in signal transduction proteins. Cell 80:237–248
  • De Camilli, P., Emr, S. D., McPherson, P. S., and Novick, P.. 1996. Phosphoinositides as regulators in membrane traffic. Science 271:1533–1539
  • Dhand, R., Hiles, I., Panayotou, G., Roche, S., Fry, M. J., Gout, I., Totty, N. F., Truong, O., Vicendo, P., Yonezawa, K., Kasuga, M., Courtneidge, S. A., and Waterfield, M. D.. 1994. PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity. EMBO J. 13:522–533
  • Domin, J., Dhand, R., and Waterfield, M. D.. 1996. Binding to the platelet derived growth factor receptor transiently activates the p85α-p110α phosphoinositide 3-kinase complex in vivo. J. Biol. Chem. 271:21614–21621
  • Domin, J., Pages, F., Volinia, S., Rittenhouse, S. E., Zvelebil, M. J., Stein, R. C., and Waterfield, M. D.. 1997. Cloning of a human phosphatidylinositol 3-kinase with a C2 domain which displays reduced sensitivity to the inhibitor wortmannin. Biochem. J. 326:139–147
  • Domin, J., and Waterfield, M. D.. 1997. Using structure to define the function of phosphoinositide 3-kinase family members. FEBS Lett. 410:91–95
  • Downing, G. L., Kim, S., Nakanishi, S., Catt, J., and Balla, T.. 1996. Characterization of a soluble adrenal phosphatidylinositol 4-kinase reveals wortmannin sensitivity of type III phosphatidylinositol kinases. Biochemistry 35:3587–3594
  • Emlet, D. R., Moscatello, D. K., Ludlow, L. B., and Wong, A. J.. 1997. Subsets of epidermal growth factor receptors during activation and endocytosis. J. Biol. Chem. 272:4079–4086
  • Franke, T. F., Yang, S.-I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R., and Tsichlis, P. N.. 1995. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81:727–736
  • Fruman, D. A., Meyers, R. E., and Cantley, L. C.. 1998. Phosphoinositide kinases. Annu. Rev. Biochem. 67:481–507
  • Gullick, W. J.. 1991. Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers. Br. Med. Bull. 47:87–98
  • Hawkins, P. T., Jackson, T. R., and Stephens, L. R.. 1992. Platelet-derived growth factor stimulates synthesis of PtdIns(3,4,5)P3 by activating a PtdIns(4,5)P2 3-OH kinase. Nature 358:157–159
  • Herman, P. K., and Emr, S. D.. 1990. Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Mol. Cell. Biol. 10:6742–6754
  • Hiles, I. D., Otsu, M., Volinia, S., Fry, M. J., Gout, I., Dhand, R., Panayotou, G., Ruiz-Larrea, F., Thompson, A., Totty, N. F., Justin Hsuan, J., Courtneidge, S. A., Parker, P. J., and Waterfield, M. D.. 1992. Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit. Cell 70:419–429
  • Hu, P., Margolis, B., Skolnik, E. Y., Lammers, R., Ullrich, A., and Schlessinger, J.. 1992. Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors. Mol. Cell. Biol. 12:981–990
  • Kapeller, R., and Cantley, L. C.. 1994. Phosphatidylinositol 3-kinase. BioEssays 16:565–576
  • Karunagraran, D., Tzahar, E., Beerli, R. R., Chen, X., Graus-Porta, D., Ratzkin, B. J., Segar, R., Hynes, N. E., and Yarden, Y.. 1996. ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J. 15:254–264
  • Kraus, M. H., Fedi, P., Starks, V., Muraro, R., and Aaronson, S. A.. 1993. Demonstration of ligand dependent signalling by the erbB-3 tyrosine kinase and its constitutive activation in human breast tumor cells. Proc. Natl. Acad. Sci. USA 90:2900–2904
  • Layton, M. J., Harpur, A. G., Panayotou, G., Bastiaens, P. I., and Waterfield, M. D.. 1998. Binding of a diphosphotyrosine-containing peptide that mimics activated platelet-derived growth factor receptor beta induces oligomerization of phosphatidylinositol 3-kinase. J. Biol. Chem. 273:33379–33385
  • Lenferink, A. E. G., Pinkas-Kramarski, R., van de Poll, M. L. M., van Vugt, M. J. H., Klapper, L. N., Tzahar, E., Waterman, H., Sela, M., van Zoelen, E. J. J., and Yarden, Y.. 1998. Differential endocytic routing of homo- and heterodimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. EMBO J. 17:3385–3397
  • Luttrell, D. K., Lee, A., Lansing, T. J., Crosby, R. M., Jung, K. D., Willard, D., Luther, M., Rodriguez, M., Berman, J., and Gilmer, T. M.. 1994. Involvement of pp60c-src with two major signalling pathways in human breast cancer. Proc. Natl. Acad. USA 91:83–87
  • MacDougall, L. K., Domin, J., and Waterfield, M. D.. 1995. A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction. Curr. Biol. 5:1404–1415
  • Margolis, B., Li, N., Koch, A., Mohammadi, M., Hurwitz, D. R., Zilberstein, A., Ullrich, A., Pawson, T., and Schlessinger, J.. 1990. The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma. EMBO J. 9:4375–4380
  • Miller, E. S., and Ascoli, M.. 1990. Anti-phosphotyrosine immunoprecipitation of phosphoinositol 3 ′kinase activity in different cell types after exposure to epidermal growth factor. Biochem. Biophys. Res. Commun. 173:289–295
  • Misawa, H., Ohtsubo, M., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., and Yoshimura, A.. 1998. Cloning and characterisation of a novel class II phosphoinositide 3-kinase containing C2 domain. Biochem. Biophys. Res. Commun. 244:531–539
  • Molz, L., Chen, Y. W., Hirano, M., and Williams, L. T.. 1996. Cpk is a novel class of drosophila PtdIns 3-kinase containing a C2 domain. J. Biol. Chem. 271:13892–13899
  • Mori, S. L., Ronnstrand, L., Yokote, K., Engstrom, A., Courtneidge, S. A., Claesson-Welsh, L., and Heldin, C. H.. 1993. Identification of two juxtamembrane autophosphorylation sites in the PDGF beta receptor: involvement in the interaction with Src family tyrosine kinases. EMBO J. 12:2257–2264
  • Moscatello, D. K., Holgado-Madruga, M., Emlet, D. R., Montgomery, B., and Wong, A. J.. 1998. Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor. J. Biol. Chem. 273:200–206
  • Nakanishi, H., Brewer, K. A., and Exton, J. H.. 1993. Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 268:13–16
  • Ono, F., Nakagawa, T., Saito, S., Owada, Y., Sakagami, H., Goto, K., Suzuki, M., Matsuno, S., and Kondo, H.. 1998. A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration. J. Biol. Chem. 273:7731–7736
  • Panayotou, G., Gish, G., End, P., Truong, O., Gout, I., Dhand, R., Fry, M. J., Hiles, I., Pawson, T., and Waterfield, M. D.. 1993. Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach. Mol. Cell. Biol. 13:3567–3576
  • Pear, W. S., Nolan, G. P., Scott, M. L., and Baltimore, D.. 1993. Production of high-titre helper free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90:8392–8396
  • Pelicci, G., Lanfrancone, L., Grignani, F., McGlade, J., Cavallo, F., Forni, G., Nicoletti, I., Pawson, T., and Pelicci, P. G.. 1992. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70:93–104
  • Porfiri, E., Evans, T., Chardin, P., and Hancock, J. F.. 1994. Prenylation of Ras proteins is required for efficient hSOS1-promoted guanine nucleotide exchange. J. Biol. Chem. 269:22672–22677
  • Prigent, S. A., and Gullick, W. J.. 1994. Identification of c-erbB-3 binding sites for phosphatidylinositol 3′-kinase and SHC using an EGF receptor/c-erbB-3 chimera. EMBO J. 13:2831–2841
  • Raffioni, S., and Bradshaw, R. A.. 1992. Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor and nerve growth factor in PC12 pheochromocytoma cells. Proc. Natl. Acad. Sci. USA 89:9121–9125
  • Riese, D. J.II, and Stern, D. F.. 1998. Specificity within the EGF family/ErbB receptor family signalling network. Bioessays 20:41–48
  • Rizo, J., and Sudhof, T. C.. 1998. C2-domains, structure and function of a universal Ca2+-binding domain. J. Biol. Chem. 273:15879–15882
  • Schu, P. V., Takegawa, K., Fry, M. J., Stack, J. H., Waterfield, M. D., and Emr, S. D.. 1993. Phosphatidylinositol 3-kinase encoded by the yeast VPS34 gene essential for protein sorting. Science 260:88–92
  • Skolnik, E. Y., Margolis, B., Mohammadi, M., Lowenstein, E., Fisher, R., Drepps, A., Ullrich, A., and Schlessinger, J.. 1991. Cloning of PI3-kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell 65:83–90
  • Soltoff, S. P., and Cantley, L. C.. 1996. p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells. J. Biol. Chem. 271:563–567
  • Soltoff, S. P., Carraway, S. A., Prigent, S. A., Gullick, W. G., and Cantley, L. C.. 1994. ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor. Mol. Cell. Biol. 14:3550–3558
  • Stephens, L. R., Eguinoa, A., Erdjument-Bromage, H., Lui, M., Cooke, F., Coadwell, J., Smrcka, A. S., Thelen, M., Cadwallader, K., Tempst, P., and Hawkins, P. T.. 1997. The Gβγ sensitivity of a PI3K is dependent upon a tightly associated adapter, p101. Cell 89:105–114
  • Stephens, L. R., Hughes, K. T., and Irvine, R. F.. 1991. Pathways of phosphatidylinositol (3,4,5)-trisphosphate synthesis in activated neutrophils. Nature 351:33–39
  • Stephens, L. R., Jackson, T. R., and Hawkins, P. T.. 1993. Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system? Biochim. Biophys. Acta 1179:27–75
  • Toker, A., and Cantley, L. C.. 1997. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387:673–676
  • Turner, S. J., Domin, J., Waterfield, M. D., Ward, S. G., and Westwick, J.. 1998. The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2α. J. Biol. Chem. 273:25987–25995
  • Ullrich, A., and Schlessinger, J.. 1990. Signal transduction by receptors with tyrosine kinase activity. Cell 61:203–211
  • Vanhaesebroeck, B., Leevers, S., Panayotou, G., and Waterfield, M. D.. 1997. Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem. Sci. 22:267–272
  • Virbasius, J. V., Guilherme, A., and Czech, M. P.. 1996. Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain. J. Biol. Chem. 271:13304–13307
  • Volinia, S., Dhand, R., Vanhaesebroeck, B., MacDougall, L. K., Stein, R., Zvelebil, M. J., Domin, J., Panaretou, C., and Waterfield, M. D.. 1995. A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. EMBO J. 14:3339–3348
  • Walsh, J. P., Caldwell, K. K., and Majerus, P. W.. 1991. Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate. Proc. Natl. Acad. Sci. USA 88:9184–9187
  • Weng, Q. P., Andrabi, K., Klippel, A., Kozlowski, M. T., Williams, L. T., and Avruch, J.. 1995. Phosphatidylinositol 3-kinase signals activation of p70S6 kinase in situ through site-specific p70 phosphorylation. Proc. Natl. Acad. Sci. USA 92:5744–5748
  • Wymann, M. P., Bulgarelli-Leva, G., Zvelebil, M. J., Pirola, L., Vanhaesebroeck, B., Waterfield, M. D., and Panayotou, G.. 1996. Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Mol. Cell. Biol. 16:1722–1733
  • Yu, J., Zhang, Y., McIlroy, J., Rordorf-Nikolic, T., Orr, G. A., and Backer, J. M.. 1998. Regulation of the p85-p110 phosphatidylinositol 3′-kinase: stabilization and inhibition of the p110α catalytic subunit by the p85 regulatory subunit. Mol. Cell. Biol. 18:1379–1387
  • Zhang, J., Banfic, H., Straforini, F., Tosi, L., Volinia, S., and Rittenhouse, S.. 1998. A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate. J. Biol. Chem. 273:14081–14084
  • Zhou, S. Y., Shoelson, S. E., Chaudhuri, M., Gish, G., Pawson, T., Haser, W. G., King, F., Roberts, T., Ratnofsky, S., Lechleider, R. J. et al. 1993. SH2 domains recognize specific phosphopeptide sequences. Cell 72:767–778

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