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Molecular and Cellular Biology Volume 20, 2000 - Issue 15
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Cell Growth and Development

The T-Cell Receptor Regulates Akt (Protein Kinase B) via a Pathway Involving Rac1 and Phosphatidylinositide 3-Kinase

Elisabeth M. Genot1 Department of Immunology, Imperial College, LondonW12 0NN, United Kingdom;2 Growth Factors and Differentiation Laboratory, University of Bordeaux I, 33 405Talence CedexCorrespondence[email protected]
,
Cecile Arrieumerlou3 Laboratoire d'Immunologie Cellulaire, CERVI, UMR 7627 CNRS, 75013Paris, France
,
Gregory Ku4 Department of Medicine, Microbiology and Immunology, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California94143-0795
,
Boudewijn M. T. Burgering5 Laboratory for Physiological Chemistry, Utrecht University, 3584 CGUtrecht, The Netherlands
,
Arthur Weiss4 Department of Medicine, Microbiology and Immunology, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California94143-0795
&
Ijsbrand M. Kramer2 Growth Factors and Differentiation Laboratory, University of Bordeaux I, 33 405Talence Cedex
Pages 5469-5478 | Received 03 Feb 2000, Accepted 08 May 2000, Published online: 28 Mar 2023

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Xue Chen. (2020) Rac1 regulates platelet microparticles formation and rheumatoid arthritis deterioration. Platelets 31:1, pages 112-119.
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Alexander F. Rowland, Mark Larance, William E. Hughes & David E. James. (2011) Identification of RhoGAP22 as an Akt-Dependent Regulator of Cell Motility in Response to Insulin. Molecular and Cellular Biology 31:23, pages 4789-4800.
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Guilin Qiao, Zhenping Li, Luciana Molinero, Maria-Luisa Alegre, Haiyan Ying, Zuoming Sun, Josef M. Penninger & Jian Zhang. (2008) T-Cell Receptor-Induced NF-κB Activation Is Negatively Regulated by E3 Ubiquitin Ligase Cbl-b. Molecular and Cellular Biology 28:7, pages 2470-2480.
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Tanja Bosse, Julia Ehinger, Aleksandra Czuchra, Stefanie Benesch, Anika Steffen, Xunwei Wu, Kathrin Schloen, Hartmut H. Niemann, Giorgio Scita, Theresia E. B. Stradal, Cord Brakebusch & Klemens Rottner. (2007) Cdc42 and Phosphoinositide 3-Kinase Drive Rac-Mediated Actin Polymerization Downstream of c-Met in Distinct and Common Pathways. Molecular and Cellular Biology 27:19, pages 6615-6628.
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Ingrid Remy & Stephen W. Michnick. (2004) Regulation of Apoptosis by the Ft1 Protein, a New Modulator of Protein Kinase B/Akt. Molecular and Cellular Biology 24:4, pages 1493-1504.
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Olivier Zugasti, Wilfrid Rul, Pierre Roux, Carole Peyssonnaux, Alain Eychene, Thomas F. Franke, Philippe Fort & Urszula Hibner. (2001) Raf-MEK-Erk Cascade in Anoikis Is Controlled by Rac1 and Cdc42 via Akt. Molecular and Cellular Biology 21:19, pages 6706-6717.
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Partha S. Biswas, Govind Bhagat & Alessandra B. Pernis. (2010) IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?. Immunological Reviews 233:1, pages 79-96.
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Yoshinori Sato, Hiroyo Oda, Michael S. Patrick, Yukari Baba, Ahmed A. Rus’d, Yoshinao Azuma, Takaya Abe, Mutsunori Shirai & Harumi Suzuki. (2009) Rac GTPases are involved in development, survival and homeostasis of T cells. Immunology Letters 124:1, pages 27-34.
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Alessandra B. Pernis. (2009) Rho GTPase-mediated pathways in mature CD4+ T cells. Autoimmunity Reviews 8:3, pages 199-203.
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S. Morley, J. Wagner, K. Kauppinen, M. Sherman & D. Manor. (2007) Requirement for Akt-mediated survival in cell transformation by the dbl oncogene. Cellular Signalling 19:1, pages 211-218.
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Virgínia O. Crema, Dânia E. Hamassaki & Marinilce F. Santos. (2006) Small Rho GTPases are important for acinus formation in a human salivary gland cell line. Cell and Tissue Research 325:3, pages 493-500.
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Qian Chen, Alan Coffey, Sylvain G. Bourgoin & Massimo Gadina. (2006) Cytohesin Binder and Regulator Augments T Cell Receptor-induced Nuclear Factor of Activated T Cells·AP-1 Activation through Regulation of the JNK Pathway. Journal of Biological Chemistry 281:29, pages 19985-19994.
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Paul A. Saunders, Vana R. Hendrycks, William A. Lidinsky & Melody L. Woods. (2005) PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion. European Journal of Immunology 35:12, pages 3561-3569.
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Marie-Liesse Asselin-LabatArmelle Biola-VidammentStéphane KerbratMarc Lombès, Jacques BertoglioMarc Pallardy. (2005) FoxO3 Mediates Antagonistic Effects of Glucocorticoids and Interleukin-2 on Glucocorticoid-Induced Leucine Zipper Expression. Molecular Endocrinology 19:7, pages 1752-1764.
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Kimberley F. Tolias, Jay B. Bikoff, Alain Burette, Suzanne Paradis, Dana Harrar, Sohail Tavazoie, Richard J. Weinberg & Michael E. Greenberg. (2005) The Rac1-GEF Tiam1 Couples the NMDA Receptor to the Activity-Dependent Development of Dendritic Arbors and Spines. Neuron 45:4, pages 525-538.
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Ruchika Nijhara, Paula B. van Hennik, Michelle L Gignac, Michael J. Kruhlak, Peter L. Hordijk, Jerome Delon & Stephen Shaw. (2004) Rac1 Mediates Collapse of Microvilli on Chemokine-Activated T Lymphocytes. The Journal of Immunology 173:8, pages 4985-4993.
Crossref
Tzu-Ling Cheng, Marc Symons & Tzuu-Shuh Jou. (2004) Regulation of anoikis by Cdc42 and Rac1. Experimental Cell Research 295:2, pages 497-511.
Crossref
Paul M Campbell & Channing J Der. (2004) Oncogenic Ras and its role in tumor cell invasion and metastasis. Seminars in Cancer Biology 14:2, pages 105-114.
Crossref
Curzio Rüegg, Olivier Dormond & Agnese Mariotti. (2004) Endothelial cell integrins and COX-2: mediators and therapeutic targets of tumor angiogenesis. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1654:1, pages 51-67.
Crossref
Kaili Wu, Maria Elena Bottazzi, Cynthia de la Fuente, Longwen Deng, Scott D. Gitlin, Anil Maddukuri, Shabnam Dadgar, Hong Li, Akos Vertes, Anne Pumfery & Fatah Kashanchi. (2004) Protein Profile of Tax-associated Complexes. Journal of Biological Chemistry 279:1, pages 495-508.
Crossref
Myrto Raftopoulou & Alan Hall. (2004) Cell migration: Rho GTPases lead the way. Developmental Biology 265:1, pages 23-32.
Crossref
Yves Gorin, Jill M. Ricono, Nam-Ho Kim, Basant Bhandari, Goutam Ghosh Choudhury & Hanna E. Abboud. (2003) Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells. American Journal of Physiology-Renal Physiology 285:2, pages F219-F229.
Crossref
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Crossref
Jan Czyzyk, Jennifer L. Brogdon, Abdallah Badou, Octavian Henegariu, Paula Preston Hurlburt, Richard Flavell & Kim Bottomly. (2003) Activation of CD4 T cells by Raf-independent effectors of Ras. Proceedings of the National Academy of Sciences 100:10, pages 6003-6008.
Crossref
Birgit Bauer, Marcel Jenny, Fiedrich Fresser, Florian Überall & Gottfried Baier. (2003) AKT1/PKBα is recruited to lipid rafts and activated downstream of PKC isotypes in CD3-induced T cell signaling. FEBS Letters 541:1-3, pages 155-162.
Crossref
Klaus Okkenhaug & Bart Vanhaesebroeck. (2003) PI3K in lymphocyte development, differentiation and activation. Nature Reviews Immunology 3:4, pages 317-330.
Crossref
Oreste Acuto, Setsuko Mise-Omata, Giorgio Mangino & Frédérique Michel. (2003) Molecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 costimulatory receptor. Immunological Reviews 192:1, pages 21-31.
Crossref
Maria-Cristina Seminario & Ronald L. Wange. (2003) Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial. Immunological Reviews 192:1, pages 80-97.
Crossref
Lawrence P. Kane & Arthur Weiss. (2003) The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP 3 . Immunological Reviews 192:1, pages 7-20.
Crossref
Dianne Khurana & Paul J Leibson. (2003) Regulation of lymphocyte-mediated killing by GTP-binding proteins. Journal of Leukocyte Biology 73:3, pages 333-338.
Crossref
Toshifumi Sugatani, Ulises Alvarez & Keith A. Hruska. (2003) PTEN Regulates RANKL- and Osteopontin-stimulated Signal Transduction during Osteoclast Differentiation and Cell Motility. Journal of Biological Chemistry 278:7, pages 5001-5008.
Crossref
Yuri Pekarsky, Cora Hallas & Carlo M. Croce. (2003) Targeting Mature T Cell Leukemia. American Journal of PharmacoGenomics 3:1, pages 31-36.
Crossref
Kun JiangBin ZhongConnie RitcheyDanielle L. GilvaryElizabeth Hong-GellerSheng WeiJulie Y. Djeu. (2003) Regulation of Akt-dependent cell survival by Syk and Rac. Blood 101:1, pages 236-244.
Crossref
Katrina K. Hoyer, Samuel W. French, Devin E. Turner, Mai T. N. Nguyen, Mathilde Renard, Cindy S. Malone, Sonja Knoetig, Chen-Feng Qi, Thomas T. Su, Hilde Cheroutre, Randolph Wall, David J. Rawlings, Herbert C. MorseIIIIII & Michael A. Teitell. (2002) Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma . Proceedings of the National Academy of Sciences 99:22, pages 14392-14397.
Crossref
Frédérique MichelOreste Acuto. (2002) CD28 Costimulation: A Source of Vav-1 for TCR Signaling with the Help of SLP-76?. Science's STKE 2002:144.
Crossref
Orion D. Weiner, Paul O. Neilsen, Glenn D. Prestwich, Marc W. Kirschner, Lewis C. Cantley & Henry R. Bourne. (2002) A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nature Cell Biology 4:7, pages 509-513.
Crossref
Ichiro ShiojimaKenneth Walsh. (2002) Role of Akt Signaling in Vascular Homeostasis and Angiogenesis. Circulation Research 90:12, pages 1243-1250.
Crossref
Birgit Bauer & Gottfried Baier. (2002) Protein kinase C and AKT/protein kinase B in CD4+ T-lymphocytes: new partners in TCR/CD28 signal integration. Molecular Immunology 38:15, pages 1087-1099.
Crossref
Lucinda F. Reynolds, Lesley A. Smyth, Trisha Norton, Norman Freshney, Julian Downward, Dimitris Kioussis & Victor L.J. Tybulewicz. (2002) Vav1 Transduces T Cell Receptor Signals to the Activation of Phospholipase C-γ1 via Phosphoinositide 3-Kinase-dependent and -independent Pathways. Journal of Experimental Medicine 195:9, pages 1103-1114.
Crossref
Orion D Weiner. (2002) Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. Current Opinion in Cell Biology 14:2, pages 196-202.
Crossref
Tung O. Chan, Ulrich Rodeck, Andrew M. Chan, Alec C. Kimmelman, Susan E. Rittenhouse, George Panayotou & Philip N. Tsichlis. (2002) Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit. Cancer Cell 1:2, pages 181-191.
Crossref
Maria-Cristina Seminario & Ronald L Wange. (2002) Signaling pathways of D3-phosphoinositide-binding kinases in T cells and their regulation by PTEN. Seminars in Immunology 14:1, pages 27-36.
Crossref
Doreen Cantrell. (2002) Protein kinase B (Akt) regulation and function in T lymphocytes. Seminars in Immunology 14:1, pages 19-26.
Crossref
Kazunori Inabe, Masamichi Ishiai, Andrew M. Scharenberg, Norman Freshney, Julian Downward & Tomohiro Kurosaki. (2002) Vav3 Modulates B Cell Receptor Responses by Regulating Phosphoinositide 3-Kinase Activation. Journal of Experimental Medicine 195:2, pages 189-200.
Crossref
Cristina Murga, Muriel Zohar, Hidemi Teramoto & J Silvio Gutkind. (2002) Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-κB. Oncogene 21:2, pages 207-216.
Crossref
Hyun Kang, Helga Schneider & Christopher E. Rudd. (2002) Phosphatidylinositol 3-Kinase p85 Adaptor Function in T-cells. Journal of Biological Chemistry 277:2, pages 912-921.
Crossref
Mercedes Zubiaur, Olga Fernández, Enza Ferrero, Javier Salmerón, Bernard Malissen, Fabio Malavasi & Jaime Sancho. (2002) CD38 Is Associated with Lipid Rafts and upon Receptor Stimulation Leads to Akt/Protein Kinase B and Erk Activation in the Absence of the CD3-ζ Immune Receptor Tyrosine-based Activation Motifs. Journal of Biological Chemistry 277:1, pages 13-22.
Crossref
Michael L. Dustin. 2002. Lymphocyte Activation and Immune Regulation IX. Lymphocyte Activation and Immune Regulation IX 191 201 .
Yona Zaffran, Olivier Destaing, Agnès Roux, Stéphane Ory, Thao Nheu, Pierre Jurdic, Chantal Rabourdin-Combe & Anne L. Astier. (2001) CD46/CD3 Costimulation Induces Morphological Changes of Human T Cells and Activation of Vav, Rac, and Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase. The Journal of Immunology 167:12, pages 6780-6785.
Crossref
Maiko Higuchi, Norihisa Masuyama, Yasuhisa Fukui, Akira Suzuki & Yukiko Gotoh. (2001) Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells. Current Biology 11:24, pages 1958-1962.
Crossref
Michael L. DustinShannon K. BromleyMark M. DavisCheng Zhu. (2001) Identification of Self Through Two-Dimensional Chemistry and Synapses. Annual Review of Cell and Developmental Biology 17:1, pages 133-157.
Crossref
Menq-Jer Lee, Shobha Thangada, Ji-Hye Paik, Gopal P. Sapkota, Nicolas Ancellin, Sung-Suk Chae, Mingtao Wu, Manuel Morales-Ruiz, William C. Sessa, Dario R. Alessi & Timothy Hla. (2001) Akt-Mediated Phosphorylation of the G Protein-Coupled Receptor EDG-1 Is Required for Endothelial Cell Chemotaxis. Molecular Cell 8:3, pages 693-704.
Crossref
Birgit Bauer, Nina Krumböck, Friedrich Fresser, Franz Hochholdinger, Martin Spitaler, Andreas Simm, Florian Überall, Burkhart Schraven & Gottfried Baier. (2001) Complex Formation and Cooperation of Protein Kinase Cθ and Akt1/Protein Kinase Bα in the NF-κB Transactivation Cascade in Jurkat T Cells. Journal of Biological Chemistry 276:34, pages 31627-31634.
Crossref
Salvatore J. Coniglio, Tzuu-Shuh Jou & Marc Symons. (2001) Rac1 Protects Epithelial Cells against Anoikis. Journal of Biological Chemistry 276:30, pages 28113-28120.
Crossref
Bart Vanhaesebroeck, Sally J. Leevers, Khatereh Ahmadi, John Timms, Roy Katso, Paul C. Driscoll, Rudiger Woscholski, Peter J. Parker & Michael D. Waterfield. (2001) Synthesis and Function of 3-Phosphorylated Inositol Lipids. Annual Review of Biochemistry 70:1, pages 535-602.
Crossref
Virginie Lafont, Emmanuelle Astoul, Arian Laurence, Janny Liautard & Doreen Cantrell. (2000) The T cell antigen receptor activates phosphatidylinositol 3-kinase-regulated serine kinases protein kinase B and ribosomal S6 kinase 1. FEBS Letters 486:1, pages 38-42.
Crossref
Bice Perussia. (2000) Signaling for cytotoxicity. Nature Immunology 1:5, pages 372-374.
Crossref
Ok-Sun Bang, Byung-Guen Ha, Eui Kyun Park & Shin-Sung Kang. (2000) Activation of Akt Is Induced by Heat Shock and Involved in Suppression of Heat-Shock-Induced Apoptosis of NIH3T3 Cells. Biochemical and Biophysical Research Communications 278:2, pages 306-311.
Crossref
Manuel Gomez, Victor Tybulewicz & Doreen A. Cantrell. (2000) Control of pre-T cell proliferation and differentiation by the GTPase Rac-1. Nature Immunology 1:4, pages 348-352.
Crossref

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