Molecular and Cellular Biology, Volume 20, Issue 15 (2000)

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Molecular and Cellular Biology, Volume 20, Issue 15 (2000)

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Cell Growth and Development

Article
Targeted Inactivation of the Tetraspanin CD37 Impairs T-Cell-Dependent B-Cell Response under Suboptimal Costimulatory Conditions
Klaus-Peter Knobeloch, Mark D. Wright, Adrian F. Ochsenbein, Oliver Liesenfeld, Jürgen Löhler, Rolf M. Zinkernagel, Ivan Horak & Zane Orinska
Pages: 5363-5369
Published online: 28 Mar 2023
AbstractforTargeted Inactivation of the Tetraspanin CD37 Impairs T-Cell-Dependent B-Cell Response under Suboptimal Costimulatory Conditions | Full Text | References | PDF (217 KB)
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Article
Role for Lyn Tyrosine Kinase as a Regulator of Stress-Activated Protein Kinase Activity in Response to DNA Damage
Kiyotsugu Yoshida, Ralph Weichselbaum, Surender Kharbanda & Donald Kufe
Pages: 5370-5380
Published online: 28 Mar 2023
AbstractforRole for Lyn Tyrosine Kinase as a Regulator of Stress-Activated Protein Kinase Activity in Response to DNA Damage | Full Text | References | PDF (3 MB)
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Article
Role of the IκB Kinase Complex in Oncogenic Ras- and Raf-Mediated Transformation of Rat Liver Epithelial Cells
Marcello Arsura, Frank Mercurio, Aundrea L. Oliver, Snorri S. Thorgeirsson & Gail E. Sonenshein
Pages: 5381-5391
Published online: 28 Mar 2023
AbstractforRole of the IκB Kinase Complex in Oncogenic Ras- and Raf-Mediated Transformation of Rat Liver Epithelial Cells | Full Text | References | PDF (1.2 MB)
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Article
Different Protein Kinase C Isoforms Determine Growth Factor Specificity in Neuronal Cells
Kevin C. Corbit, Jae-Won Soh, Keiko Yoshida, Eva M. Eves, I. Bernard Weinstein & Marsha Rich Rosner
Pages: 5392-5403
Published online: 28 Mar 2023
AbstractforDifferent Protein Kinase C Isoforms Determine Growth Factor Specificity in Neuronal Cells | Full Text | References | PDF (6 MB)
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Article
Shared Roles of Yeast Glycogen Synthase Kinase 3 Family Members in Nitrogen-Responsive Phosphorylation of Meiotic Regulator Ume6p
Yang Xiao & Aaron P. Mitchell
Pages: 5447-5453
Published online: 28 Mar 2023
AbstractforShared Roles of Yeast Glycogen Synthase Kinase 3 Family Members in Nitrogen-Responsive Phosphorylation of Meiotic Regulator Ume6p | Full Text | References | PDF (564.6 KB)
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Article
BNIP3 and Genetic Control of Necrosis-Like Cell Death through the Mitochondrial Permeability Transition Pore
C. Vande Velde, J. Cizeau, D. Dubik, J. Alimonti, T. Brown, S. Israels, R. Hakem & A. H. Greenberg
Pages: 5454-5468
Published online: 28 Mar 2023
AbstractforBNIP3 and Genetic Control of Necrosis-Like Cell Death through the Mitochondrial Permeability Transition Pore | Full Text | References | PDF (2.4 MB)
  • 82 Views
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Article
The T-Cell Receptor Regulates Akt (Protein Kinase B) via a Pathway Involving Rac1 and Phosphatidylinositide 3-Kinase
Elisabeth M. Genot, Cecile Arrieumerlou, Gregory Ku, Boudewijn M. T. Burgering, Arthur Weiss & Ijsbrand M. Kramer
Pages: 5469-5478
Published online: 28 Mar 2023
AbstractforThe T-Cell Receptor Regulates Akt (Protein Kinase B) via a Pathway Involving Rac1 and Phosphatidylinositide 3-Kinase | Full Text | References | PDF (2 MB)
  • 26 Views
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Article
Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice
Lori D. Klaman, Olivier Boss, Odile D. Peroni, Jason K. Kim, Jennifer L. Martino, Janice M. Zabolotny, Nadeem Moghal, Margaret Lubkin, Young-Bum Kim, Arlene H. Sharpe, Alain Stricker-Krongrad, Gerald I. Shulman, Benjamin G. Neel & Barbara B. Kahn
Pages: 5479-5489
Published online: 28 Mar 2023
AbstractforIncreased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice | Full Text | References | PDF (618.4 KB)
  • 144 Views
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Article
HMG-I/Y, a New c-Myc Target Gene and Potential Oncogene
Lisa J. Wood, Mita Mukherjee, Christine E. Dolde, Yi Xu, Joseph F. Maher, Tracie E. Bunton, John B. Williams & Linda M. S. Resar
Pages: 5490-5502
Published online: 28 Mar 2023
AbstractforHMG-I/Y, a New c-Myc Target Gene and Potential Oncogene | Full Text | References | PDF (2.3 MB)
  • 21 Views
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Article
CD40 Induces Apoptosis in Carcinoma Cells through Activation of Cytotoxic Ligands of the Tumor Necrosis Factor Superfamily
Aristides G. Eliopoulos, Clare Davies, Pauline G. Knox, Neil J. Gallagher, Simon C. Afford, David H. Adams & Lawrence S. Young
Pages: 5503-5515
Published online: 28 Mar 2023
AbstractforCD40 Induces Apoptosis in Carcinoma Cells through Activation of Cytotoxic Ligands of the Tumor Necrosis Factor Superfamily | Full Text | References | PDF (1.3 MB)
  • 70 Views
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Article
Identification of B-KSR1, a Novel Brain-Specific Isoform of KSR1 That Functions in Neuronal Signaling
Jürgen Müller, Angela M. Cacace, W. Ernest Lyons, Carolyn B. McGill & Deborah K. Morrison
Pages: 5529-5539
Published online: 28 Mar 2023
AbstractforIdentification of B-KSR1, a Novel Brain-Specific Isoform of KSR1 That Functions in Neuronal Signaling | Full Text | References | PDF (8.9 MB)
  • 31 Views
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Article
Defect in the p53-Mdm2 Autoregulatory Loop Resulting from Inactivation of TAFII250 in Cell Cycle Mutant tsBN462 Cells
Christine Wasylyk & Bohdan Wasylyk
Pages: 5554-5570
Published online: 28 Mar 2023
AbstractforDefect in the p53-Mdm2 Autoregulatory Loop Resulting from Inactivation of TAFII250 in Cell Cycle Mutant tsBN462 Cells | Full Text | References | PDF (2.8 MB)
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Article
Establishment of Irreversible Growth Arrest in Myogenic Differentiation Requires the RB LXCXE-Binding Function
Tung-Ti Chen & Jean Y. J. Wang
Pages: 5571-5580
Published online: 28 Mar 2023
AbstractforEstablishment of Irreversible Growth Arrest in Myogenic Differentiation Requires the RB LXCXE-Binding Function | Full Text | References | PDF (2.1 MB)
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Article
MCG10, a Novel p53 Target Gene That Encodes a KH Domain RNA-Binding Protein, Is Capable of Inducing Apoptosis and Cell Cycle Arrest in G2-M
Jianhui Zhu & Xinbin Chen
Pages: 5602-5618
Published online: 28 Mar 2023
AbstractforMCG10, a Novel p53 Target Gene That Encodes a KH Domain RNA-Binding Protein, Is Capable of Inducing Apoptosis and Cell Cycle Arrest in G2-M | Full Text | References | PDF (3 MB)
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Article
Identification of the Cytolinker Plectin as a Major Early In Vivo Substrate for Caspase 8 during CD95- and Tumor Necrosis Factor Receptor-Mediated Apoptosis
Alexander H. Stegh, Harald Herrmann, Stefan Lampel, Dieter Weisenberger, Kerstin Andrä, Martin Seper, Gerhard Wiche, Peter H. Krammer & Marcus E. Peter
Pages: 5665-5679
Published online: 28 Mar 2023
AbstractforIdentification of the Cytolinker Plectin as a Major Early In Vivo Substrate for Caspase 8 during CD95- and Tumor Necrosis Factor Receptor-Mediated Apoptosis | Full Text | References | PDF (3.1 MB)
  • 19 Views
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Article
Bcl-xL Prevents the Initial Decrease in Mitochondrial Membrane Potential and Subsequent Reactive Oxygen Species Production during Tumor Necrosis Factor Alpha-Induced Apoptosis
Eyal Gottlieb, Matthew G. Vander Heiden & Craig B. Thompson
Pages: 5680-5689
Published online: 28 Mar 2023
AbstractforBcl-xL Prevents the Initial Decrease in Mitochondrial Membrane Potential and Subsequent Reactive Oxygen Species Production during Tumor Necrosis Factor Alpha-Induced Apoptosis | Full Text | References | PDF (1.7 MB)
  • 64 Views
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Article
Evidence for a Telomere-Independent “Clock” Limiting RAS Oncogene-Driven Proliferation of Human Thyroid Epithelial Cells
C. J. Jones, D. Kipling, M. Morris, P. Hepburn, J. Skinner, A. Bounacer, F. S. Wyllie, M. Ivan, J. Bartek, D. Wynford-Thomas & J. A. Bond
Pages: 5690-5699
Published online: 28 Mar 2023
AbstractforEvidence for a Telomere-Independent “Clock” Limiting RAS Oncogene-Driven Proliferation of Human Thyroid Epithelial Cells | Full Text | References | PDF (1.4 MB)
  • 10 Views
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Article
Effect of Phosphoinositide-Dependent Kinase 1 on Protein Kinase B Translocation and Its Subsequent Activation
Nathalie Filippa, Carol L. Sable, Brian A. Hemmings & Emmanuel Van Obberghen
Pages: 5712-5721
Published online: 28 Mar 2023
AbstractforEffect of Phosphoinositide-Dependent Kinase 1 on Protein Kinase B Translocation and Its Subsequent Activation | Full Text | References | PDF (1.5 MB)
  • 17 Views
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Article
Species-Specific Elements in the Large T-Antigen J Domain Are Required for Cellular Transformation and DNA Replication by Simian Virus 40
Christopher S. Sullivan, James D. Tremblay, Sheara W. Fewell, John A. Lewis, Jeffrey L. Brodsky & James M. Pipas
Pages: 5749-5757
Published online: 28 Mar 2023
AbstractforSpecies-Specific Elements in the Large T-Antigen J Domain Are Required for Cellular Transformation and DNA Replication by Simian Virus 40 | Full Text | References | PDF (2.3 MB)
  • 12 Views
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Article
The Cytoplasmic Tyrosines of Integrin Subunit β1 Are Involved in Focal Adhesion Kinase Activation
Krister Wennerberg, Annika Armulik, Takao Sakai, Marjam Karlsson, Reinhard Fässler, Erik M. Schaefer, Deane F. Mosher & Staffan Johansson
Pages: 5758-5765
Published online: 28 Mar 2023
AbstractforThe Cytoplasmic Tyrosines of Integrin Subunit β1 Are Involved in Focal Adhesion Kinase Activation | Full Text | References | PDF (2 MB)
  • 14 Views
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Dna Dynamics and Chromosome Structure

Article
Stimulation of Mitotic Recombination Events by High Levels of RNA Polymerase II Transcription in Yeast
Dean Saxe, Abhijit Datta & Sue Jinks-Robertson
Pages: 5404-5414
Published online: 28 Mar 2023
AbstractforStimulation of Mitotic Recombination Events by High Levels of RNA Polymerase II Transcription in Yeast | Full Text | References | PDF (132.8 KB)
  • 13 Views
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Article
In Vitro Properties of the Conserved Mammalian Protein hnRNP D Suggest a Role in Telomere Maintenance
Ashley Eversole & Nancy Maizels
Pages: 5425-5432
Published online: 28 Mar 2023
AbstractforIn Vitro Properties of the Conserved Mammalian Protein hnRNP D Suggest a Role in Telomere Maintenance | Full Text | References | PDF (1.4 MB)
  • 17 Views
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Article
Long-Distance Control of Origin Choice and Replication Timing in the Human β-Globin Locus Are Independent of the Locus Control Region
Daniel M. Cimbora, Dirk Schübeler, Andreas Reik, Joan Hamilton, Claire Francastel, Elliot M. Epner & Mark Groudine
Pages: 5581-5591
Published online: 28 Mar 2023
AbstractforLong-Distance Control of Origin Choice and Replication Timing in the Human β-Globin Locus Are Independent of the Locus Control Region | Full Text | References | PDF (1.3 MB)
  • 24 Views
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Article
Mutations in Conserved Regions of the Predicted RAG2 Kelch Repeats Block Initiation of V(D)J Recombination and Result in Primary Immunodeficiencies
Carlos A. Gomez, Leon M. Ptaszek, Anna Villa, Fabio Bozzi, Cristina Sobacchi, Edward G. Brooks, Luigi D. Notarangelo, Eugenia Spanopoulou, Z. Q. Pan, Paolo Vezzoni, Patricia Cortes & Sandro Santagata
Pages: 5653-5664
Published online: 28 Mar 2023
AbstractforMutations in Conserved Regions of the Predicted RAG2 Kelch Repeats Block Initiation of V(D)J Recombination and Result in Primary Immunodeficiencies | Full Text | References | PDF (2.4 MB)
  • 14 Views
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Article
Histone-Histone Interactions and Centromere Function
Lynn Glowczewski, Peirong Yang, Tatyana Kalashnikova, Maria Soledad Santisteban & M. Mitchell Smith
Pages: 5700-5711
Published online: 28 Mar 2023
AbstractforHistone-Histone Interactions and Centromere Function | Full Text | References | PDF (4 MB)
  • 19 Views
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Article
Activation of the Kss1 Invasive-Filamentous Growth Pathway Induces Ty1 Transcription and Retrotransposition in Saccharomyces cerevisiae
Antonin Morillon, Mathias Springer & Pascale Lesage
Pages: 5766-5776
Published online: 28 Mar 2023
AbstractforActivation of the Kss1 Invasive-Filamentous Growth Pathway Induces Ty1 Transcription and Retrotransposition in Saccharomyces cerevisiae | Full Text | References | PDF (1 MB)
  • 29 Views
  • 60 CrossRef citations
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Article
Architecture of the Replication Fork Stalled at the 3′ End of Yeast Ribosomal Genes
Markus Gruber, Ralf Erik Wellinger & José M. Sogo
Pages: 5777-5787
Published online: 28 Mar 2023
AbstractforArchitecture of the Replication Fork Stalled at the 3′ End of Yeast Ribosomal Genes | Full Text | References | PDF (1.6 MB)
  • 15 Views
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Gene Expression

Article
Precursors to the U3 Small Nucleolar RNA Lack Small Nucleolar RNP Proteins but Are Stabilized by La Binding
Joanna Kufel, Christine Allmang, Guillaume Chanfreau, Elisabeth Petfalski, Denis L. J. Lafontaine & David Tollervey
Pages: 5415-5424
Published online: 28 Mar 2023
AbstractforPrecursors to the U3 Small Nucleolar RNA Lack Small Nucleolar RNP Proteins but Are Stabilized by La Binding | Full Text | References | PDF (1.9 MB)
  • 54 Views
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Article
Bop1 Is a Mouse WD40 Repeat Nucleolar Protein Involved in 28S and 5.8S rRNA Processing and 60S Ribosome Biogenesis
Žaklina Strezoska, Dimitri G. Pestov & Lester F. Lau
Pages: 5516-5528
Published online: 28 Mar 2023
AbstractforBop1 Is a Mouse WD40 Repeat Nucleolar Protein Involved in 28S and 5.8S rRNA Processing and 60S Ribosome Biogenesis | Full Text | References | PDF (4.6 MB)
  • 68 Views
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Article
A Novel Murine Staufen Isoform Modulates the RNA Content of Staufen Complexes
Thomas Duchaîne, Hui-Jun Wang, Ming Luo, Sergey V. Steinberg, Ivan R. Nabi & Luc DesGroseillers
Pages: 5592-5601
Published online: 28 Mar 2023
AbstractforA Novel Murine Staufen Isoform Modulates the RNA Content of Staufen Complexes | Full Text | References | PDF (2.7 MB)
  • 12 Views
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Transcriptional Regulation

Article
Specific Structural Motifs Determine TRAP220 Interactions with Nuclear Hormone Receptors
Yunsheng Ren, Evan Behre, Zhaojun Ren, Jiachang Zhang, Qianben Wang & Joseph D. Fondell
Pages: 5433-5446
Published online: 28 Mar 2023
AbstractforSpecific Structural Motifs Determine TRAP220 Interactions with Nuclear Hormone Receptors | Full Text | References | PDF (1.2 MB)
  • 36 Views
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Article
Adenovirus E1B 55-Kilodalton Oncoprotein Inhibits p53 Acetylation by PCAF
Yue Liu, April L. Colosimo, Xiang-Jiao Yang & Daiqing Liao
Pages: 5540-5553
Published online: 28 Mar 2023
AbstractforAdenovirus E1B 55-Kilodalton Oncoprotein Inhibits p53 Acetylation by PCAF | Full Text | References | PDF (2.7 MB)
  • 23 Views
  • 74 CrossRef citations
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Article
Modulation of Histone Acetyltransferase Activity through Interaction of Epstein-Barr Nuclear Antigen 3C with Prothymosin Alpha
Murray A. Cotter II & Erle S. Robertson
Pages: 5722-5735
Published online: 28 Mar 2023
AbstractforModulation of Histone Acetyltransferase Activity through Interaction of Epstein-Barr Nuclear Antigen 3C with Prothymosin Alpha | Full Text | References | PDF (2.8 MB)
  • 27 Views
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Nucleocytoplasmic Communication

Article
Nup50, a Nucleoplasmically Oriented Nucleoporin with a Role in Nuclear Protein Export
Tinglu Guan, Ralph H. Kehlenbach, Eric C. Schirmer, Angelika Kehlenbach, Fan Fan, Bruce E. Clurman, Norman Arnheim & Larry Gerace
Pages: 5619-5630
Published online: 28 Mar 2023
AbstractforNup50, a Nucleoplasmically Oriented Nucleoporin with a Role in Nuclear Protein Export | Full Text | References | PDF (3.8 MB)
  • 99 Views
  • 101 CrossRef citations
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Article
Characterization and Targeted Disruption of Murine Nup50, a p27Kip1-Interacting Component of the Nuclear Pore Complex
Matthew Smitherman, Keesook Lee, Jherek Swanger, Raj Kapur & Bruce E. Clurman
Pages: 5631-5642
Published online: 28 Mar 2023
AbstractforCharacterization and Targeted Disruption of Murine Nup50, a p27Kip1-Interacting Component of the Nuclear Pore Complex | Full Text | References | PDF (2.4 MB)
  • 47 Views
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Article
Assembly and Preferential Localization of Nup116p on the Cytoplasmic Face of the Nuclear Pore Complex by Interaction with Nup82p
Albert K. Ho, Tian Xiang Shen, Kathryn J. Ryan, Elena Kiseleva, Marilyn Aach Levy, Terence D. Allen & Susan R. Wente
Pages: 5736-5748
Published online: 28 Mar 2023
AbstractforAssembly and Preferential Localization of Nup116p on the Cytoplasmic Face of the Nuclear Pore Complex by Interaction with Nup82p | Full Text | References | PDF (4.7 MB)
  • 7 Views
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Mammalian Genetic Models With Minimal Or Complex Phenotypes

Article
Hemorrhage, Impaired Hematopoiesis, and Lethality in Mouse Embryos Carrying a Targeted Disruption of the Fli1Transcription Factor
Demetri D. Spyropoulos, Pamela N. Pharr, Kim R. Lavenburg, Pascale Jackers, Takis S. Papas, Makio Ogawa & Dennis K. Watson
Pages: 5643-5652
Published online: 28 Mar 2023
AbstractforHemorrhage, Impaired Hematopoiesis, and Lethality in Mouse Embryos Carrying a Targeted Disruption of the Fli1Transcription Factor | Full Text | References | PDF (2.1 MB)
  • 53 Views
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