Advanced search
Publication Cover
Molecular and Cellular Biology Volume 20, 2000 - Issue 15
Submit an article Journal homepage
9
Views
56
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Establishment of Irreversible Growth Arrest in Myogenic Differentiation Requires the RB LXCXE-Binding Function

Tung-Ti ChenDepartment of Biology and the Cancer Center, University of California, San Diego, La Jolla, California92093-0322
&
Jean Y. J. WangDepartment of Biology and the Cancer Center, University of California, San Diego, La Jolla, California92093-0322Correspondence[email protected]
Pages 5571-5580 | Received 20 Dec 1999, Accepted 25 Apr 2000, Published online: 28 Mar 2023

Citations (56)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (8)

Martin Fischer & Gerd A. Müller. (2017) Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes. Critical Reviews in Biochemistry and Molecular Biology 52:6, pages 638-662.
Read now
Jon Sin, Allen M. Andres, David J. R. Taylor, Thomas Weston, Yoshimi Hiraumi, Aleksandr Stotland, Brandon J. Kim, Chengqun Huang, Kelly S. Doran & Roberta A. Gottlieb. (2016) Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts. Autophagy 12:2, pages 369-380.
Read now
Sarah M. Francis, Jacqueline Bergsied, Christian E. Isaac, Courtney H. Coschi, Alison L. Martens, Carlo V. Hojilla, Subrata Chakrabarti, Gabriel E. DiMattia, Rama Khoka, Jean Y. J. Wang & Frederick A. Dick. (2009) A Functional Connection between pRB and Transforming Growth Factor β in Growth Inhibition and Mammary Gland Development. Molecular and Cellular Biology 29:16, pages 4455-4466.
Read now
Heather A. Hirsch, Gauri W. Jawdekar, Kang-Ae Lee, Liping Gu & R. William Henry. (2004) Distinct Mechanisms for Repression of RNA Polymerase III Transcription by the Retinoblastoma Tumor Suppressor Protein. Molecular and Cellular Biology 24:13, pages 5989-5999.
Read now
Hasan Siddiqui, David A. Solomon, Ranjaka W. Gunawardena, Ying Wang & Erik S. Knudsen. (2003) Histone Deacetylation of RB-Responsive Promoters: Requisite for Specific Gene Repression but Dispensable for Cell Cycle Inhibition. Molecular and Cellular Biology 23:21, pages 7719-7731.
Read now
Anton Chestukhin, Larisa Litovchick, Katherine Rudich & James A. DeCaprio. (2002) Nucleocytoplasmic Shuttling of p130/RBL2: Novel Regulatory Mechanism. Molecular and Cellular Biology 22:2, pages 453-468.
Read now
Laurence Vandel, Estelle Nicolas, Olivier Vaute, Roger Ferreira, Slimane Ait-Si-Ali & Didier Trouche. (2001) Transcriptional Repression by the Retinoblastoma Protein through the Recruitment of a Histone Methyltransferase. Molecular and Cellular Biology 21:19, pages 6484-6494.
Read now
Albert Lai, Brian K. Kennedy, David A. Barbie, Nicholas R. Bertos, Xiang Jiao Yang, Marie-Christine Theberge, Shih-Chang Tsai, Edward Seto, Yi Zhang, Andrei Kuzmichev, William S. Lane, Danny Reinberg, Ed Harlow & Philip E. Branton. (2001) RBP1 Recruits the mSIN3-Histone Deacetylase Complex to the Pocket of Retinoblastoma Tumor Suppressor Family Proteins Found in Limited Discrete Regions of the Nucleus at Growth Arrest. Molecular and Cellular Biology 21:8, pages 2918-2932.
Read now

Articles from other publishers (48)

Satoko Iwahori, Angie C. Umaña, Halena R. VanDeusen & Robert F. Kalejta. (2017) Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins. Journal of Biological Chemistry 292:16, pages 6583-6599.
Crossref
Manzar Hossain & Bruce Stillman. (2016) Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription. eLife 5.
Crossref
Chiharu Uchida. (2016) Roles of pRB in the Regulation of Nucleosome and Chromatin Structures. BioMed Research International 2016, pages 1-11.
Crossref
Satoko Iwahori, Morgan Hakki, Sunwen Chou & Robert F. Kalejta. (2015) Molecular Determinants for the Inactivation of the Retinoblastoma Tumor Suppressor by the Viral Cyclin-dependent Kinase UL97. Journal of Biological Chemistry 290:32, pages 19666-19680.
Crossref
Tinke L. Vormer, Kamila Wojciechowicz, Marleen Dekker, Sandra de Vries, Anja van der Wal, Elly Delzenne-Goette, Sjalin H. Naik, Ji-Ying Song, Jan-Hermen Dannenberg, Jacob B. Hansen & Hein te Riele. (2014) RB Family Tumor Suppressor Activity May Not Relate to Active Silencing of E2F Target Genes. Cancer Research 74:18, pages 5266-5276.
Crossref
Hasan N. Rajabi, Chiaki Takahashi & Mark E. Ewen. (2014) Retinoblastoma Protein and MyoD Function Together to Effect the Repression of Fra-1 and in Turn Cyclin D1 during Terminal Cell Cycle Arrest Associated with Myogenesis. Journal of Biological Chemistry 289:34, pages 23417-23427.
Crossref
Anil M Narasimha, Manuel Kaulich, Gary S Shapiro, Yoon J Choi, Piotr Sicinski & Steven F Dowdy. (2014) Cyclin D activates the Rb tumor suppressor by mono-phosphorylation. eLife 3.
Crossref
Renze Heidstra & Sabrina Sabatini. (2014) Plant and animal stem cells: similar yet different. Nature Reviews Molecular Cell Biology 15:5, pages 301-312.
Crossref
Alfredo Cruz-Ramírez, Sara Díaz-Triviño, Guy Wachsman, Yujuan Du, Mario Arteága-Vázquez, Hongtao Zhang, Rene Benjamins, Ikram Blilou, Anne B. Neef, Vicki Chandler & Ben Scheres. (2013) A SCARECROW-RETINOBLASTOMA Protein Network Controls Protective Quiescence in the Arabidopsis Root Stem Cell Organizer. PLoS Biology 11:11, pages e1001724.
Crossref
YUJUAN ZHU, DAMING DENG, CHONGDE LONG, GUORONG JIN, QINGJIONG ZHANG & HUANGXUAN SHEN. (2013) Abnormal expression of seven myogenesis-related genes in extraocular muscles of patients with concomitant strabismus. Molecular Medicine Reports 7:1, pages 217-222.
Crossref
Patima Sdek, Peng Zhao, Yaping Wang, Chang-jiang Huang, Christopher Y. Ko, Peter C. Butler, James N. Weiss & W. Robb MacLellan. (2011) Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes. Journal of Cell Biology 194:3, pages 407-423.
Crossref
Ryan J. Bourgo, Chellappagounder Thangavel, Adam Ertel, Jacqueline Bergseid, A. Kathleen McClendon, Ludwig Wilkens, Agnieszka K. Witkiewicz, Jean Y.J. Wang & Erik S. Knudsen. (2011) RB Restricts DNA Damage-Initiated Tumorigenesis through an LXCXE-Dependent Mechanism of Transcriptional Control. Molecular Cell 43:4, pages 663-672.
Crossref
Giovanni Ciavarra, Andrew T. Ho, David Cobrinik & Eldad Zacksenhaus. (2011) Critical Role of the Rb Family in Myoblast Survival and Fusion. PLoS ONE 6:3, pages e17682.
Crossref
Giovanni Ciavarra & Eldad Zacksenhaus. (2010) Rescue of myogenic defects in Rb-deficient cells by inhibition of autophagy or by hypoxia-induced glycolytic shift. Journal of Cell Biology 191:2, pages 291-301.
Crossref
S Munro, N Khaire, A Inche, S Carr & N B La Thangue. (2010) Lysine methylation regulates the pRb tumour suppressor protein. Oncogene 29:16, pages 2357-2367.
Crossref
M P Markey, J Bergseid, E E Bosco, K Stengel, H Xu, C N Mayhew, S J Schwemberger, W A Braden, Y Jiang, G F Babcock, A G Jegga, B J Aronow, M F Reed, J Y J Wang & E S Knudsen. (2007) Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function. Oncogene 26:43, pages 6307-6318.
Crossref
Mark W. Landis, Nelson E. Brown, Gregory L. Baker, Anna Shifrin, Manjusri Das, Yan Geng, Piotr Sicinski & Philip W. Hinds. (2007) The LxCxE pRb Interaction Domain of Cyclin D1 Is Dispensable for Murine Development. Cancer Research 67:16, pages 7613-7620.
Crossref
B. Nelson Chau, Chris W. Pan & Jean Y.J. Wang. (2006) Separation of Anti-Proliferation and Anti-Apoptotic Functions of Retinoblastoma Protein through Targeted Mutations of Its A/B Domain. PLoS ONE 1:1, pages e82.
Crossref
Erik S. Knudsen & Karen E. Knudsen. (2016) Retinoblastoma Tumor Suppressor: Where Cancer Meets the Cell Cycle. Experimental Biology and Medicine 231:7, pages 1271-1281.
Crossref
Lucia Latella & Pier Lorenzo Puri. 2006. Rb and Tumorigenesis. Rb and Tumorigenesis 106 117 .
Jacqueline L. Vanderluit, Kerry L. Ferguson & Ruth S. Slack. 2006. Rb and Tumorigenesis. Rb and Tumorigenesis 81 105 .
Mahavir Singh, Marcin Krajewski, Aleksandra Mikolajka & Tad A. Holak. (2005) Molecular Determinants for the Complex Formation between the Retinoblastoma Protein and LXCXE Sequences. Journal of Biological Chemistry 280:45, pages 37868-37876.
Crossref
Alison R. Meloni, Chun-Hsiang Lai, Tso-Pang Yao & Joseph R. Nevins. (2005) A Mechanism of COOH–Terminal Binding Protein–Mediated Repression. Molecular Cancer Research 3:10, pages 575-583.
Crossref
Jooyoung Jung, Tae-gyun Kim, Gary E. Lyons, Hyeong-Reh C. Kim & Youngsook Lee. (2005) Jumonji Regulates Cardiomyocyte Proliferation via Interaction with Retinoblastoma Protein. Journal of Biological Chemistry 280:35, pages 30916-30923.
Crossref
Soheil Naderi, Jean Y.J. Wang, Tung-Ti Chen, Kristine B. Gutzkow & Heidi K. Blomhoff. (2005) cAMP-mediated Inhibition of DNA Replication and S Phase Progression: Involvement of Rb, p21 Cip1 , and PCNA . Molecular Biology of the Cell 16:3, pages 1527-1542.
Crossref
Fei Chen & Val Vallyathan. 2004. Phytopharmaceuticals in Cancer Chemoprevention. Phytopharmaceuticals in Cancer Chemoprevention.
Vincent Pennaneach, Valerie Barbier, Karine Regazzoni, Rati Fotedar & Arun Fotedar. (2004) Rb Inhibits E2F-1-induced Cell Death in a LXCXE-dependent Manner by Active Repression. Journal of Biological Chemistry 279:22, pages 23376-23383.
Crossref
Hong Xin, Rocky Pramanik & Divaker Choubey. (2003) Retinoblastoma (Rb) protein upregulates expression of the Ifi202 gene encoding an interferon-inducible negative regulator of cell growth. Oncogene 22:31, pages 4775-4785.
Crossref
Marie Classon & Ed Harlow. (2002) The retinoblastoma tumour suppressor in development and cancer. Nature Reviews Cancer 2:12, pages 910-917.
Crossref
Cai Bowen, Michael Birrer & Edward P. Gelmann. (2002) Retinoblastoma Protein-mediated Apoptosis After γ-Irradiation. Journal of Biological Chemistry 277:47, pages 44969-44979.
Crossref
Thomas Farkas, Klaus Hansen, Karin Holm, Jiri Lukas & Jiri Bartek. (2002) Distinct Phosphorylation Events Regulate p130- and p107-mediated Repression of E2F-4. Journal of Biological Chemistry 277:30, pages 26741-26752.
Crossref
Frederick A. Dick & Nicholas J. Dyson. (2002) Three Regions of the pRB Pocket Domain Affect Its Inactivation by Human Papillomavirus E7 Proteins. Journal of Virology 76:12, pages 6224-6234.
Crossref
Steven M. Frisch & Joe S. Mymryk. (2002) Adenovirus-5 E1A: paradox and paradigm. Nature Reviews Molecular Cell Biology 3:6, pages 441-452.
Crossref
Zhong Huang, Xue-Ming Tang & Franca Cambi. (2002) Down-Regulation of the Retinoblastoma Protein (Rb) Is Associated with Rat Oligodendrocyte Differentiation. Molecular and Cellular Neuroscience 19:2, pages 250-262.
Crossref
Jeffrey M. Trimarchi & Jacqueline A. Lees. (2002) Sibling rivalry in the E2F family. Nature Reviews Molecular Cell Biology 3:1, pages 11-20.
Crossref
Brian K. Kennedy. (2002) Mammalian transcription factors in yeast: strangers in a familiar land. Nature Reviews Molecular Cell Biology 3:1, pages 41-49.
Crossref
Pier Lorenzo Puri, Simona Iezzi, Peter Stiegler, Tung-Ti Chen, R.Louis Schiltz, George E.O Muscat, Antonio Giordano, Larry Kedes, Jean Y.J Wang & Vittorio Sartorelli. (2001) Class I Histone Deacetylases Sequentially Interact with MyoD and pRb during Skeletal Myogenesis. Molecular Cell 8:4, pages 885-897.
Crossref
Donato Tedesco & Cesare Vesco. (2001) MyoD Activity Upregulates E2F1 and Enhances Transcription from the Cyclin E Promoter in Differentiating Myoblasts Lacking a Functional Retinoblastoma Protein. Experimental Cell Research 269:2, pages 301-311.
Crossref
Ho Man Chan, Linda Smith & Nicholas B La Thangue. (2001) Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein. Oncogene 20:43, pages 6152-6163.
Crossref
Brian K. Kennedy, Oliver W. Liu, Fred A. Dick, Nick Dyson, Ed Harlow & Marc Vidal. (2001) Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft. Proceedings of the National Academy of Sciences 98:15, pages 8720-8725.
Crossref
H Steven Zhang & Douglas C Dean. (2001) Rb-mediated chromatin structure regulation and transcriptional repression. Oncogene 20:24, pages 3134-3138.
Crossref
V Pennaneach, I Salles-Passador, A Munshi, H Brickner, K Regazzoni, F Dick, N Dyson, T.-T Chen, J.Y.J Wang, R Fotedar & A Fotedar. (2001) The Large Subunit of Replication Factor C Promotes Cell Survival after DNA Damage in an LxCxE Motif– and Rb-Dependent Manner. Molecular Cell 7:4, pages 715-727.
Crossref
Peter D. Adams. (2001) Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1471:3, pages M123-M133.
Crossref
Lei Zheng & Wen-Hwa Lee. (2001) The Retinoblastoma Gene: A Prototypic and Multifunctional Tumor Suppressor. Experimental Cell Research 264:1, pages 2-18.
Crossref
John F. Ross, Anders Näär, Hieu Cam, Richard Gregory & Brian David Dynlacht. (2001) Active repression and E2F inhibition by pRB are biochemically distinguishable. Genes & Development 15:4, pages 392-397.
Crossref
Erick J. Morris & Nicholas J. Dyson. 2001. 1 54 .
J William Harbour & Douglas C Dean. (2000) Chromatin remodeling and Rb activity. Current Opinion in Cell Biology 12:6, pages 685-689.
Crossref
J. William Harbour & Douglas C. Dean. (2000) The Rb/E2F pathway: expanding roles and emerging paradigms. Genes & Development 14:19, pages 2393-2409.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.