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Cell Growth and Development

The Cytoplasmic Tyrosines of Integrin Subunit β1 Are Involved in Focal Adhesion Kinase Activation

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Pages 5758-5765 | Received 04 Jan 2000, Accepted 01 May 2000, Published online: 28 Mar 2023

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Hicham Lahlou & William J Muller. (2011) β1-integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer. Breast Cancer Research 13:6.
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Kathrin S. Zeller, Olof Idevall-Hagren, Anne Stefansson, Teet Velling, Shaun P. Jackson, Julian Downward, Anders Tengholm & Staffan Johansson. (2010) PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading. Cellular Signalling 22:12, pages 1838-1848.
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Nicholas J. Anthis, Jacob R. Haling, Camilla L. Oxley, Massimiliano Memo, Kate L. Wegener, Chinten J. Lim, Mark H. Ginsberg & Iain D. Campbell. (2009) β Integrin Tyrosine Phosphorylation Is a Conserved Mechanism for Regulating Talin-induced Integrin Activation. Journal of Biological Chemistry 284:52, pages 36700-36710.
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Lulu Cao, Kebing Yu, Cindy Banh, Vinh Nguyen, Anna Ritz, Benjamin J. Raphael, Yuko Kawakami, Toshiaki Kawakami & Arthur R. Salomon. (2007) Quantitative Time-Resolved Phosphoproteomic Analysis of Mast Cell Signaling. The Journal of Immunology 179:9, pages 5864-5876.
Crossref
A. A. Terentiev & N. T. Moldogazieva. (2007) Cell adhesion proteins and α-fetoprotein. Similar structural motifs as prerequisites for common functions. Biochemistry (Moscow) 72:9, pages 920-935.
Crossref
Danelle S Eto, Tiffani A Jones, Jamie L Sundsbak & Matthew A Mulvey. (2007) Integrin-Mediated Host Cell Invasion by Type 1–Piliated Uropathogenic Escherichia coli. PLoS Pathogens 3:7, pages e100.
Crossref
Yasuhiro Kumai, Hiroaki Ooboshi, Setsuro Ibayashi, Eiichi Ishikawa, Hiroshi Sugimori, Masahiro Kamouchi, Takanari Kitazono, Kensuke Egashira & Mitsuo Iida. (2006) Postischemic Gene Transfer of Soluble Flt-1 Protects against Brain Ischemia with Marked Attenuation of Blood—Brain Barrier Permeability. Journal of Cerebral Blood Flow & Metabolism 27:6, pages 1152-1160.
Crossref
Wendy L. Connors, Johanna Jokinen, Daniel J. White, J. Santeri Puranen, Pasi Kankaanpaöaö, Paula Upla, Mira Tulla, Mark S. Johnson & Jyrki Heino. (2007) Two Synergistic Activation Mechanisms of α2β1 Integrin-mediated Collagen Binding. Journal of Biological Chemistry 282:19, pages 14675-14683.
Crossref
Savita V. Dandapani, Hikaru Sugimoto, Benjamin D. Matthews, Robert J. Kolb, Sumita Sinha, Robert E. Gerszten, Jing Zhou, Donald E. Ingber, Raghu Kalluri & Martin R. Pollak. (2007) α-Actinin-4 Is Required for Normal Podocyte Adhesion. Journal of Biological Chemistry 282:1, pages 467-477.
Crossref
Han-Qin Wang, Ling Bai, Bao-Rong Shen, Zhi-Qiang Yan & Zong-Lai Jiang. (2007) Coculture with endothelial cells enhances vascular smooth muscle cell adhesion and spreading via activation of β1-integrin and phosphatidylinositol 3-kinase/Akt. European Journal of Cell Biology 86:1, pages 51-62.
Crossref
Aleksandra Czuchra, Hannelore Meyer, Kyle R. Legate, Cord Brakebusch & Reinhard Fässler. (2006) Genetic analysis of β1 integrin “activation motifs” in mice. Journal of Cell Biology 174:6, pages 889-899.
Crossref
Mike R. Douglas & Christopher D. Buckley. 2006. Wiley Encyclopedia of Biomedical Engineering. Wiley Encyclopedia of Biomedical Engineering.
Stina Nilsson, Dorota Kaniowska, Cord Brakebusch, Reinhard Fässler & Staffan Johansson. (2006) Threonine 788 in integrin subunit β1 regulates integrin activation. Experimental Cell Research 312:6, pages 844-853.
Crossref
N Cordes, J Seidler, R Durzok, H Geinitz & C Brakebusch. (2005) β1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury. Oncogene 25:9, pages 1378-1390.
Crossref
B.I. RATNIKOV, A.W. PARTRIDGE & M.H. GINSBERG. (2005) Integrin activation by talin. Journal of Thrombosis and Haemostasis 3:8, pages 1783-1790.
Crossref
Julia Seidler, Rita Durzok, Cord Brakebusch & Nils Cordes. (2005) Interactions of the integrin subunit β1A with protein kinase B/Akt, p130Cas and paxillin contribute to regulation of radiation survival. Radiotherapy and Oncology 76:2, pages 129-134.
Crossref
G. Caron-Lormier & H. Berry. (2005) Amplification and oscillations in the FAK/Src kinase system during integrin signaling. Journal of Theoretical Biology 232:2, pages 235-248.
Crossref
Wara A.K.M. Khyrul, David P. LaLonde, Michael C. Brown, Howard Levinson & Christopher E. Turner. (2004) The Integrin-linked Kinase Regulates Cell Morphology and Motility in a Rho-associated Kinase-dependent Manner. Journal of Biological Chemistry 279:52, pages 54131-54139.
Crossref
Neil C. Henderson, Elizabeth A. Collis, Alison C. Mackinnon, Kenneth J. Simpson, Christopher Haslett, Roy Zent, Mark Ginsberg & Tariq Sethi. (2004) CD98hc (SLC3A2) Interaction with β1 Integrins Is Required for Transformation. Journal of Biological Chemistry 279:52, pages 54731-54741.
Crossref
Teet Velling, Stina Nilsson, Anne Stefansson & Staffan Johansson. (2004) β1‐Integrins induce phosphorylation of Akt on serine 473 independently of focal adhesion kinase and Src family kinases. EMBO reports 5:9, pages 901-905.
Crossref
David D Schlaepfer, Satyajit K Mitra & Dusko Ilic. (2004) Control of motile and invasive cell phenotypes by focal adhesion kinase. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1692:2-3, pages 77-102.
Crossref
Michele A Wozniak, Katarzyna Modzelewska, Lina Kwong & Patricia J Keely. (2004) Focal adhesion regulation of cell behavior. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1692:2-3, pages 103-119.
Crossref
Annika Armulik, Teet Velling & Staffan Johansson. (2004) The Integrin β1 Subunit Transmembrane Domain Regulates Phosphatidylinositol 3-Kinase-dependent Tyrosine Phosphorylation of Crk-associated Substrate. Molecular Biology of the Cell 15:6, pages 2558-2567.
Crossref
Vinicio Carloni, Antonio Mazzocca & Kodimangalam S Ravichandran. (2003) Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells. Oncogene 23:8, pages 1566-1574.
Crossref
Seon-Myung Kim, Min Seong Kwon, Chun Shik Park, Kyeong-Rock Choi, Jang-Soo Chun, Joohong Ahn & Woo Keun Song. (2004) Modulation of Thr Phosphorylation of Integrin β1 during Muscle Differentiation. Journal of Biological Chemistry 279:8, pages 7082-7090.
Crossref
Y. Miyamoto, P. Reddig & R. L. Juliano. 2004. Cell Adhesion. Cell Adhesion 197 216 .
Katsuo Suzuki & Kazuhide Takahashi. (2003) Reduced cell adhesion during mitosis by threonine phosphorylation of ?1 integrin. Journal of Cellular Physiology 197:2, pages 297-305.
Crossref
Dong-Wan Seo, Hongmei Li, Liliana Guedez, Paul T. Wingfield, Tere Diaz, Rita Salloum, Bei-yang Wei & William G. Stetler-Stevenson. (2003) TIMP-2 Mediated Inhibition of Angiogenesis. Cell 114:2, pages 171-180.
Crossref
Trent Fowler, Staffan Johansson, Kishore K. Wary & Magnus Hook. (2003) Src kinase has a central role in in vitro cellular internalization of Staphylococcus aureus. Cellular Microbiology 5:6, pages 417-426.
Crossref
Roumen Pankov, Edna Cukierman, Katherine Clark, Kazue Matsumoto, Cornelia Hahn, Benoit Poulin & Kenneth M. Yamada. (2003) Specific β1 Integrin Site Selectively Regulates Akt/Protein Kinase B Signaling via Local Activation of Protein Phosphatase 2A. Journal of Biological Chemistry 278:20, pages 18671-18681.
Crossref
Allison L. Berrier, Robert Martinez, Gary M. Bokoch & Susan E. LaFlamme. (2002) The integrin β tail is required and sufficient to regulate adhesion signaling to Rac1. Journal of Cell Science 115:22, pages 4285-4291.
Crossref
John K.G. Crean, Darren Finlay, Madeline Murphy, Catherine Moss, Catherine Godson, Finian Martin & Hugh R. Brady. (2002) The Role of p42/44 MAPK and Protein Kinase B in Connective Tissue Growth Factor Induced Extracellular Matrix Protein Production, Cell Migration, and Actin Cytoskeletal Rearrangement in Human Mesangial Cells. Journal of Biological Chemistry 277:46, pages 44187-44194.
Crossref
Robert C. Rintoul, Robert C. Buttery, Alison C Mackinnon, Weng Sie Wong, Deane Mosher, Christopher Haslett & Tariq Sethi. (2002) Cross-Linking CD98 Promotes Integrin-like Signaling and Anchorage-independent Growth. Molecular Biology of the Cell 13:8, pages 2841-2852.
Crossref
Anna Gustavsson, Annika Armulik, Cord Brakebusch, Reinhard Fässler, Staffan Johansson & Maria Fällman. (2002) Role of the β1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia . Journal of Cell Science 115:13, pages 2669-2678.
Crossref
R. L. Juliano. (2002) Signal Transduction by Cell Adhesion Receptors and the Cytoskeleton: Functions of Integrins, Cadherins, Selectins, and Immunoglobulin-Superfamily Members. Annual Review of Pharmacology and Toxicology 42:1, pages 283-323.
Crossref
Alison L. Jannuzi, Thomas A. Bunch, Marc C. Brabant, Steven W. Miller, Leona Mukai, Michael Zavortink & Danny L. Brower. (2002) Disruption of C-Terminal Cytoplasmic Domain of βPS Integrin Subunit Has Dominant Negative Properties in Developing Drosophila . Molecular Biology of the Cell 13:4, pages 1352-1365.
Crossref
Brian P. Eliceiri, Xose S. Puente, John D. Hood, Dwayne G. Stupack, David D. Schlaepfer, Xiaozhu Z. Huang, Dean Sheppard & David A. Cheresh. (2002) Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling. Journal of Cell Biology 157:1, pages 149-160.
Crossref
David D. Chang, Bao Q. Hoang, Jenny Liu & Timothy A. Springer. (2002) Molecular Basis for Interaction between Icap1α PTB Domain and β1 Integrin. Journal of Biological Chemistry 277:10, pages 8140-8145.
Crossref
Jordan A. Kreidberg. 2002. 309 324 .
Amy L. Bodeau, Allison L. Berrier, Anthony M. Mastrangelo, Robert Martinez & Susan E. LaFlamme. (2001) A functional comparison of mutations in integrin β cytoplasmic domains. Journal of Cell Science 114:15, pages 2795-2807.
Crossref
Takao Sakai, Richard Jove, Reinhard Fässler & Deane F. Mosher. (2001) Role of the cytoplasmic tyrosines of β1A integrins in transformation by v-src. Proceedings of the National Academy of Sciences 98:7, pages 3808-3813.
Crossref

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