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Molecular and Cellular Biology Volume 20, 2000 - Issue 17
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Mammalian Genetic Models with Minimal or Complex Phenotypes

Ras-Guanine Nucleotide Exchange Factor Sos2 Is Dispensable for Mouse Growth and Development

Luis M. Esteban1 Centro de Investigación del Cáncer, IBMCC, CSIC-USAL, University of Salamanca, 37007Salamanca, Spain;2 Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland20892
,
Alberto Fernández-Medarde1 Centro de Investigación del Cáncer, IBMCC, CSIC-USAL, University of Salamanca, 37007Salamanca, Spain;2 Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland20892
,
Eva López2 Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland20892
,
Kate Yienger2 Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland20892
,
Carmen Guerrero1 Centro de Investigación del Cáncer, IBMCC, CSIC-USAL, University of Salamanca, 37007Salamanca, Spain;2 Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland20892
,
Jerrold M. Ward3 Veterinary and Tumor Pathology Section
,
Lino Tessarollo4 Mammalian Genetics Laboratory, National Cancer Institute, Frederick, Maryland21702
&
Eugenio Santos1 Centro de Investigación del Cáncer, IBMCC, CSIC-USAL, University of Salamanca, 37007Salamanca, Spain;2 Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland20892Correspondence[email protected]
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Pages 6410-6413 | Received 21 Apr 2000, Accepted 22 May 2000, Published online: 28 Mar 2023

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Pilar Liceras-Boillos, David Jimeno, Rósula García-Navas, L. Francisco Lorenzo-Martín, Mauricio Menacho-Marquez, Carmen Segrelles, Carmela Gómez, Nuria Calzada, Rocío Fuentes-Mateos, Jesús M. Paramio, Xosé R. Bustelo, Fernando C. Baltanás & Eugenio Santos. (2018) Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis. Molecular and Cellular Biology 38:16.
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Fernando C. Baltanás, Martín Pérez-Andrés, Alicia Ginel-Picardo, David Diaz, David Jimeno, Pilar Liceras-Boillos, Robert L. Kortum, Lawrence E. Samelson, Alberto Orfao & Eugenio Santos. (2013) Functional Redundancy of Sos1 and Sos2 for Lymphopoiesis and Organismal Homeostasis and Survival. Molecular and Cellular Biology 33:22, pages 4562-4578.
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Robert L. Kortum, Connie L. Sommers, John M. Pinski, Clayton P. Alexander, Robert K. Merrill, Wenmei Li, Paul E. Love & Lawrence E. Samelson. (2012) Deconstructing Ras Signaling in the Thymus. Molecular and Cellular Biology 32:14, pages 2748-2759.
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Alberto Fernández-Medarde, Luis M. Esteban, Alejandro Núñez, Ángel Porteros, Lino Tessarollo & Eugenio Santos. (2002) Targeted Disruption of Ras-Grf2 Shows Its Dispensability for Mouse Growth and Development. Molecular and Cellular Biology 22:8, pages 2498-2504.
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Articles from other publishers (44)

Guangmei Luo, Bingrui Wang, Qiangqiang Hou & Xiaoxing Wu. (2023) Development of Son of Sevenless Homologue 1 (SOS1) Modulators To Treat Cancers by Regulating RAS Signaling. Journal of Medicinal Chemistry 66:7, pages 4324-4341.
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Carmela Gómez, Rósula Garcia-Navas, Fernando C. Baltanás, Rocío Fuentes-Mateos, Alberto Fernández-Medarde, Nuria Calzada & Eugenio Santos. (2022) Critical Requirement of SOS1 for Development of BCR/ABL-Driven Chronic Myelogenous Leukemia. Cancers 14:16, pages 3893.
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Katie E. Hebron, Edjay Ralph Hernandez & Marielle E. Yohe. (2022) The RASopathies: from pathogenetics to therapeutics. Disease Models & Mechanisms 15:2.
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Rósula García-Navas, Pilar Liceras-Boillos, Carmela Gómez, Fernando C. Baltanás, Nuria Calzada, Cristina Nuevo-Tapioles, José M. Cuezva & Eugenio Santos. (2021) Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis. Oncogene 40:27, pages 4538-4551.
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Fernando C. Baltanás, Rósula García-Navas & Eugenio Santos. (2021) SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology. International Journal of Molecular Sciences 22:12, pages 6613.
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Arathi Nair, Katharina F. Kubatzky & Bhaskar Saha. (2021) Ras Isoforms from Lab Benches to Lives—What Are We Missing and How Far Are We?. International Journal of Molecular Sciences 22:12, pages 6508.
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Fernando C. Baltanás, Cynthia Mucientes-Valdivieso, L. Francisco Lorenzo-Martín, Natalia Fernández-Parejo, Rósula García-Navas, Carmen Segrelles, Nuria Calzada, Rocío Fuentes-Mateos, Jesús M. Paramio, Xosé R. Bustelo & Eugenio Santos. (2021) Functional Specificity of the Members of the Sos Family of Ras-GEF Activators: Novel Role of Sos2 in Control of Epidermal Stem Cell Homeostasis. Cancers 13:9, pages 2152.
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Marco H. Hofmann, Michael Gmachl, Juergen Ramharter, Fabio Savarese, Daniel Gerlach, Joseph R. Marszalek, Michael P. Sanderson, Dirk Kessler, Francesca Trapani, Heribert Arnhof, Klaus Rumpel, Dana-Adriana Botesteanu, Peter Ettmayer, Thomas Gerstberger, Christiane Kofink, Tobias Wunberg, Andreas Zoephel, Szu-Chin Fu, Jessica L. Teh, Jark Böttcher, Nikolai Pototschnig, Franziska Schachinger, Katharina Schipany, Simone Lieb, Christopher P. Vellano, Jonathan C. O'Connell, Rachel L. Mendes, Jurgen Moll, Mark Petronczki, Timothy P. Heffernan, Mark Pearson, Darryl B. McConnell & Norbert Kraut. (2021) BI-3406, a Potent and Selective SOS1–KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition. Cancer Discovery 11:1, pages 142-157.
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Juhyun Shin, Jun-Ha Choi, Seunghwa Jung, Somi Jeong, Jeongheon Oh, Do-Young Yoon, Man Hee Rhee, Jaehong Ahn, Se-Hyuk Kim & Jae-Wook Oh. (2019) MUDENG Expression Profiling in Cohorts and Brain Tumor Biospecimens to Evaluate Its Role in Cancer. Frontiers in Genetics 10.
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