Molecular and Cellular Biology, Volume 20, Issue 17 (2000)

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Molecular and Cellular Biology, Volume 20, Issue 17 (2000)

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Minireviews

Article
Class II Transactivator: Mastering the Art of Major Histocompatibility Complex Expression
Jonathan A. Harton & Jenny P.-Y. Ting
Pages: 6185-6194
Published online: 28 Mar 2023
First Page PreviewforClass II Transactivator: Mastering the Art of Major Histocompatibility Complex Expression | Full Text | References | PDF (535.8 KB)
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Mammalian Genetic Models With Minimal Or Complex Phenotypes

Article
Immunocytochemical Analyses and Targeted Gene Disruption of GTPBP1
Satoru Senju, Ken-ichi Iyama, Hironori Kudo, Shinichi Aizawa & Yasuharu Nishimura
Pages: 6195-6200
Published online: 28 Mar 2023
AbstractforImmunocytochemical Analyses and Targeted Gene Disruption of GTPBP1 | Full Text | References | PDF (734.8 KB)
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Article
Targeted Disruption of the mPer3 Gene: Subtle Effects on Circadian Clock Function
Lauren P. Shearman, Xiaowei Jin, Choogon Lee, Steven M. Reppert & David R. Weaver
Pages: 6269-6275
Published online: 28 Mar 2023
AbstractforTargeted Disruption of the mPer3 Gene: Subtle Effects on Circadian Clock Function | Full Text | References | PDF (2.4 MB)
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Article
Ras-Guanine Nucleotide Exchange Factor Sos2 Is Dispensable for Mouse Growth and Development
Luis M. Esteban, Alberto Fernández-Medarde, Eva López, Kate Yienger, Carmen Guerrero, Jerrold M. Ward, Lino Tessarollo & Eugenio Santos
Pages: 6410-6413
Published online: 28 Mar 2023
AbstractforRas-Guanine Nucleotide Exchange Factor Sos2 Is Dispensable for Mouse Growth and Development | Full Text | References | PDF (426.9 KB)
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Article
Targeted Deletion of Minpp1 Provides New Insight into the Activity of Multiple Inositol Polyphosphate Phosphatase In Vivo
Hongbo Chi, Xiaonian Yang, Paul D. Kingsley, Regis J. O'Keefe, J. Edward Puzas, Randy N. Rosier, Stephen B. Shears & Paul R. Reynolds
Pages: 6496-6507
Published online: 28 Mar 2023
AbstractforTargeted Deletion of Minpp1 Provides New Insight into the Activity of Multiple Inositol Polyphosphate Phosphatase In Vivo | Full Text | References | PDF (2.9 MB)
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Article
Phosphoenolpyruvate Carboxykinase Is Necessary for the Integration of Hepatic Energy Metabolism
Pengxiang She, Masakazu Shiota, Kathy D. Shelton, Roger Chalkley, Catherine Postic & Mark A. Magnuson
Pages: 6508-6517
Published online: 28 Mar 2023
AbstractforPhosphoenolpyruvate Carboxykinase Is Necessary for the Integration of Hepatic Energy Metabolism | Full Text | References | PDF (1.9 MB)
  • 136 Views
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Cell Growth and Development

Article
BF-1 Interferes with Transforming Growth Factor β Signaling by Associating with Smad Partners
Changlin Dou, Jun Lee, Bo Liu, Fang Liu, Joan Massague, Shouhong Xuan & Eseng Lai
Pages: 6201-6211
Published online: 28 Mar 2023
AbstractforBF-1 Interferes with Transforming Growth Factor β Signaling by Associating with Smad Partners | Full Text | References | PDF (1.6 MB)
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Article
Gic2p May Link Activated Cdc42p to Components Involved in Actin Polarization, Including Bni1p and Bud6p (Aip3p)
Malika Jaquenoud & Matthias Peter
Pages: 6244-6258
Published online: 28 Mar 2023
AbstractforGic2p May Link Activated Cdc42p to Components Involved in Actin Polarization, Including Bni1p and Bud6p (Aip3p) | Full Text | References | PDF (2.7 MB)
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Article
p12DOC-1 Is a Novel Cyclin-Dependent Kinase 2-Associated Protein
Satoru Shintani, Hiroe Ohyama, Xue Zhang, Jim McBride, Kou Matsuo, Takanori Tsuji, Miaofen G. Hu, Guofu Hu, Yohko Kohno, Michael Lerman, Randy Todd & David T. W. Wong
Pages: 6300-6307
Published online: 28 Mar 2023
Abstractforp12DOC-1 Is a Novel Cyclin-Dependent Kinase 2-Associated Protein | Full Text | References | PDF (1.4 MB)
  • 24 Views
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Article
Insulin-Activated Protein Kinase Cβ Bypasses Ras and Stimulates Mitogen-Activated Protein Kinase Activity and Cell Proliferation in Muscle Cells
Pietro Formisano, Francesco Oriente, Francesca Fiory, Matilde Caruso, Claudia Miele, Maria Alessandra Maitan, Francesco Andreozzi, Giovanni Vigliotta, Gerolama Condorelli & Francesco Beguinot
Pages: 6323-6333
Published online: 28 Mar 2023
AbstractforInsulin-Activated Protein Kinase Cβ Bypasses Ras and Stimulates Mitogen-Activated Protein Kinase Activity and Cell Proliferation in Muscle Cells | Full Text | References | PDF (1.5 MB)
  • 9 Views
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Article
Coupling of PAK-Interacting Exchange Factor PIX to GIT1 Promotes Focal Complex Disassembly
Zhou-shen Zhao, Edward Manser, Tsui-Han Loo & Louis Lim
Pages: 6354-6363
Published online: 28 Mar 2023
AbstractforCoupling of PAK-Interacting Exchange Factor PIX to GIT1 Promotes Focal Complex Disassembly | Full Text | References | PDF (11.4 MB)
  • 53 Views
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Article
Vav Family Proteins Couple to Diverse Cell Surface Receptors
Sheri L. Moores, Laura M. Selfors, Jessica Fredericks, Timo Breit, Keiko Fujikawa, Frederick W. Alt, Joan S. Brugge & Wojciech Swat
Pages: 6364-6373
Published online: 28 Mar 2023
AbstractforVav Family Proteins Couple to Diverse Cell Surface Receptors | Full Text | References | PDF (928.1 KB)
  • 37 Views
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Article
Human Papillomavirus Type 16 E7 Oncoprotein Binds and Inactivates Growth-Inhibitory Insulin-Like Growth Factor Binding Protein 3
Boris Mannhardt, Stuart A. Weinzimer, Mechthild Wagner, Marc Fiedler, Pinchas Cohen, Pidder Jansen-Dürr & Werner Zwerschke
Pages: 6483-6495
Published online: 28 Mar 2023
AbstractforHuman Papillomavirus Type 16 E7 Oncoprotein Binds and Inactivates Growth-Inhibitory Insulin-Like Growth Factor Binding Protein 3 | Full Text | References | PDF (4 MB)
  • 5 Views
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Article
The SH3 Domain Directs Acto-Myosin-Dependent Targeting of v-Src to Focal Adhesions via Phosphatidylinositol 3-Kinase
Valerie J. Fincham, Valerie G. Brunton & Margaret C. Frame
Pages: 6518-6536
Published online: 28 Mar 2023
AbstractforThe SH3 Domain Directs Acto-Myosin-Dependent Targeting of v-Src to Focal Adhesions via Phosphatidylinositol 3-Kinase | Full Text | References | PDF (4.4 MB)
  • 9 Views
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Article
Retinoic Acid Regulation of Cdx1: an Indirect Mechanism for Retinoids and Vertebral Specification
Martin Houle, Panagiotis Prinos, Angelo Iulianella, Nathalie Bouchard & David Lohnes
Pages: 6579-6586
Published online: 28 Mar 2023
AbstractforRetinoic Acid Regulation of Cdx1: an Indirect Mechanism for Retinoids and Vertebral Specification | Full Text | References | PDF (1.3 MB)
  • 35 Views
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Article
A Calcineurin-NFATc3-Dependent Pathway Regulates Skeletal Muscle Differentiation and Slow Myosin Heavy-Chain Expression
Ulrike Delling, Jolana Tureckova, Hae W. Lim, Leon J. De Windt, Peter Rotwein & Jeffery D. Molkentin
Pages: 6600-6611
Published online: 28 Mar 2023
AbstractforA Calcineurin-NFATc3-Dependent Pathway Regulates Skeletal Muscle Differentiation and Slow Myosin Heavy-Chain Expression | Full Text | References | PDF (5.2 MB)
  • 65 Views
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Article
The SMRT Corepressor Is Regulated by a MEK-1 Kinase Pathway: Inhibition of Corepressor Function Is Associated with SMRT Phosphorylation and Nuclear Export
Suk-Hyun Hong & Martin L. Privalsky
Pages: 6612-6625
Published online: 28 Mar 2023
AbstractforThe SMRT Corepressor Is Regulated by a MEK-1 Kinase Pathway: Inhibition of Corepressor Function Is Associated with SMRT Phosphorylation and Nuclear Export | Full Text | References | PDF (1.6 MB)
  • 11 Views
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Gene Expression

Article
Termination and Peptide Release at the Upstream Open Reading Frame Are Required for Downstream Translation on Synthetic Shunt-Competent mRNA Leaders
Maja Hemmings-Mieszczak, Thomas Hohn & Thomas Preiss
Pages: 6212-6223
Published online: 28 Mar 2023
AbstractforTermination and Peptide Release at the Upstream Open Reading Frame Are Required for Downstream Translation on Synthetic Shunt-Competent mRNA Leaders | Full Text | References | PDF (1.1 MB)
  • 9 Views
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Article
Eukaryotic Translation Initiation Factor 4GI Is a Cellular Target for NS1 Protein, a Translational Activator of Influenza Virus
Tomás Aragón, Susana de la Luna, Isabel Novoa, Luis Carrasco, Juan Ortín & Amelia Nieto
Pages: 6259-6268
Published online: 28 Mar 2023
AbstractforEukaryotic Translation Initiation Factor 4GI Is a Cellular Target for NS1 Protein, a Translational Activator of Influenza Virus | Full Text | References | PDF (1.8 MB)
  • 36 Views
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Article
The RNA-Binding Protein TIA-1 Is a Novel Mammalian Splicing Regulator Acting through Intron Sequences Adjacent to a 5′ Splice Site
Fabienne Del Gatto-Konczak, Cyril F. Bourgeois, Caroline Le Guiner, Liliane Kister, Marie-Claude Gesnel, James Stévenin & Richard Breathnach
Pages: 6287-6299
Published online: 28 Mar 2023
AbstractforThe RNA-Binding Protein TIA-1 Is a Novel Mammalian Splicing Regulator Acting through Intron Sequences Adjacent to a 5′ Splice Site | Full Text | References | PDF (2.2 MB)
  • 54 Views
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Article
The Poly(A)-Binding Protein and an mRNA Stability Protein Jointly Regulate an Endoribonuclease Activity
Zuoren Wang & Megerditch Kiledjian
Pages: 6334-6341
Published online: 28 Mar 2023
AbstractforThe Poly(A)-Binding Protein and an mRNA Stability Protein Jointly Regulate an Endoribonuclease Activity | Full Text | References | PDF (1 MB)
  • 63 Views
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Article
mRNA Stability and Polysome Loss in Hibernating Arctic Ground Squirrels (Spermophilus parryii)
Jason E. Knight, Erin Nicol Narus, Sandra L. Martin, Allan Jacobson, Brian M. Barnes & Bert B. Boyer
Pages: 6374-6379
Published online: 28 Mar 2023
AbstractformRNA Stability and Polysome Loss in Hibernating Arctic Ground Squirrels (Spermophilus parryii) | Full Text | References | PDF (536.2 KB)
  • 17 Views
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Article
Multiple Splicing Defects in an Intronic False Exon
Hanzhen Sun & Lawrence A. Chasin
Pages: 6414-6425
Published online: 28 Mar 2023
AbstractforMultiple Splicing Defects in an Intronic False Exon | Full Text | References | PDF (1.1 MB)
  • 29 Views
  • 143 CrossRef citations
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Article
Protein Kinase A and Mitogen-Activated Protein Kinase Pathways Antagonistically Regulate Fission Yeast fbp1 Transcription by Employing Different Modes of Action at Two Upstream Activation Sites
Lori A. Neely & Charles S. Hoffman
Pages: 6426-6434
Published online: 28 Mar 2023
AbstractforProtein Kinase A and Mitogen-Activated Protein Kinase Pathways Antagonistically Regulate Fission Yeast fbp1 Transcription by Employing Different Modes of Action at Two Upstream Activation Sites | Full Text | References | PDF (926.4 KB)
  • 18 Views
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Transcriptional Regulation

Article
Prothymosin Alpha Selectively Enhances Estrogen Receptor Transcriptional Activity by Interacting with a Repressor of Estrogen Receptor Activity
Paolo G. V. Martini, Regis Delage-Mourroux, Dennis M. Kraichely & Benita S. Katzenellenbogen
Pages: 6224-6232
Published online: 28 Mar 2023
AbstractforProthymosin Alpha Selectively Enhances Estrogen Receptor Transcriptional Activity by Interacting with a Repressor of Estrogen Receptor Activity | Full Text | References | PDF (913.5 KB)
  • 24 Views
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Article
The Molecular Chaperone Activity of Simian Virus 40 Large T Antigen Is Required To Disrupt Rb-E2F Family Complexes by an ATP-Dependent Mechanism
Christopher S. Sullivan, Paul Cantalupo & James M. Pipas
Pages: 6233-6243
Published online: 28 Mar 2023
AbstractforThe Molecular Chaperone Activity of Simian Virus 40 Large T Antigen Is Required To Disrupt Rb-E2F Family Complexes by an ATP-Dependent Mechanism | Full Text | References | PDF (1.7 MB)
  • 7 Views
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Article
Potentiation of GATA-2 Activity through Interactions with the Promyelocytic Leukemia Protein (PML) and the t(15;17)-Generated PML-Retinoic Acid Receptor α Oncoprotein
Shinobu Tsuzuki, Masayuki Towatari, Hidehiko Saito & Tariq Enver
Pages: 6276-6286
Published online: 28 Mar 2023
AbstractforPotentiation of GATA-2 Activity through Interactions with the Promyelocytic Leukemia Protein (PML) and the t(15;17)-Generated PML-Retinoic Acid Receptor α Oncoprotein | Full Text | References | PDF (2.1 MB)
  • 6 Views
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Article
Selective DNA Binding and Association with the CREB Binding Protein Coactivator Contribute to Differential Activation of Alpha/Beta Interferon Genes by Interferon Regulatory Factors 3 and 7
Rongtuan Lin, Pierre Génin, Yaël Mamane & John Hiscott
Pages: 6342-6353
Published online: 28 Mar 2023
AbstractforSelective DNA Binding and Association with the CREB Binding Protein Coactivator Contribute to Differential Activation of Alpha/Beta Interferon Genes by Interferon Regulatory Factors 3 and 7 | Full Text | References | PDF (2.7 MB)
  • 84 Views
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Article
Octamer Transfer and Creation of Stably Remodeled Nucleosomes by Human SWI-SNF and Its Isolated ATPases
Michael L. Phelan, Gavin R. Schnitzler & Robert E. Kingston
Pages: 6380-6389
Published online: 28 Mar 2023
AbstractforOctamer Transfer and Creation of Stably Remodeled Nucleosomes by Human SWI-SNF and Its Isolated ATPases | Full Text | References | PDF (2.2 MB)
  • 26 Views
  • 86 CrossRef citations
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Article
Cell Cycle-Dependent Binding of Yeast Heat Shock Factor to Nucleosomes
Christina Bourgeois Venturi, Alexander M. Erkine & David S. Gross
Pages: 6435-6448
Published online: 28 Mar 2023
AbstractforCell Cycle-Dependent Binding of Yeast Heat Shock Factor to Nucleosomes | Full Text | References | PDF (2 MB)
  • 19 Views
  • 23 CrossRef citations
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Article
Molecular Determinants for Targeting Heterochromatin Protein 1-Mediated Gene Silencing: Direct Chromoshadow Domain–KAP-1 Corepressor Interaction Is Essential
Mark S. Lechner, Gillian E. Begg, David W. Speicher & Frank J. Rauscher III
Pages: 6449-6465
Published online: 28 Mar 2023
AbstractforMolecular Determinants for Targeting Heterochromatin Protein 1-Mediated Gene Silencing: Direct Chromoshadow Domain–KAP-1 Corepressor Interaction Is Essential | Full Text | References | PDF (1.7 MB)
  • 64 Views
  • 157 CrossRef citations
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Article
Structure and Dynamic Properties of a Glucocorticoid Receptor-Induced Chromatin Transition
Terace M. Fletcher, Byung-Woo Ryu, Christopher T. Baumann, Barbour S. Warren, Gilberto Fragoso, Sam John & Gordon L. Hager
Pages: 6466-6475
Published online: 28 Mar 2023
AbstractforStructure and Dynamic Properties of a Glucocorticoid Receptor-Induced Chromatin Transition | Full Text | References | PDF (2 MB)
  • 10 Views
  • 72 CrossRef citations
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Article
In-Depth Mutational Analysis of the Promyelocytic Leukemia Zinc Finger BTB/POZ Domain Reveals Motifs and Residues Required for Biological and Transcriptional Functions
Ari Melnick, K. Farid Ahmad, Sally Arai, Adam Polinger, Helen Ball, Katherine L. Borden, Graeme W. Carlile, Gilbert G. Prive & Jonathan D. Licht
Pages: 6550-6567
Published online: 28 Mar 2023
AbstractforIn-Depth Mutational Analysis of the Promyelocytic Leukemia Zinc Finger BTB/POZ Domain Reveals Motifs and Residues Required for Biological and Transcriptional Functions | Full Text | References | PDF (3.2 MB)
  • 54 Views
  • 143 CrossRef citations
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Article
Associations and Interactions between Bare Lymphocyte Syndrome Factors
Angela M. DeSandro, Uma M. Nagarajan & Jeremy M. Boss
Pages: 6587-6599
Published online: 28 Mar 2023
AbstractforAssociations and Interactions between Bare Lymphocyte Syndrome Factors | Full Text | References | PDF (2.6 MB)
  • 23 Views
  • 74 CrossRef citations
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Dna Dynamics and Chromosome Structure

Article
Replication of Heterochromatin and Structure of Polytene Chromosomes
Thomas J. Leach, Heather L. Chotkowski, Michael G. Wotring, Robert L. Dilwith & Robert L. Glaser
Pages: 6308-6316
Published online: 28 Mar 2023
AbstractforReplication of Heterochromatin and Structure of Polytene Chromosomes | Full Text | References | PDF (1.1 MB)
  • 24 Views
  • 52 CrossRef citations
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Article
Plant Enzymes but Not Agrobacterium VirD2 Mediate T-DNA Ligation In Vitro
Alicja Ziemienowicz, Bruno Tinland, John Bryant, Veronique Gloeckler & Barbara Hohn
Pages: 6317-6322
Published online: 28 Mar 2023
AbstractforPlant Enzymes but Not Agrobacterium VirD2 Mediate T-DNA Ligation In Vitro | Full Text | References | PDF (166.4 KB)
  • 17 Views
  • 47 CrossRef citations
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Article
Functional Studies on the Candidate ATPase Domains of Saccharomyces cerevisiae MutLα
Phuoc T. Tran & R. Michael Liskay
Pages: 6390-6398
Published online: 28 Mar 2023
AbstractforFunctional Studies on the Candidate ATPase Domains of Saccharomyces cerevisiae MutLα | Full Text | References | PDF (647.5 KB)
  • 27 Views
  • 70 CrossRef citations
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Article
Sgs1 Helicase Activity Is Required for Mitotic but Apparently Not for Meiotic Functions
Atsuko Miyajima, Masayuki Seki, Fumitoshi Onoda, Miwa Shiratori, Nao Odagiri, Kunihiro Ohta, Yoshiko Kikuchi, Yasuo Ohno & Takemi Enomoto
Pages: 6399-6409
Published online: 28 Mar 2023
AbstractforSgs1 Helicase Activity Is Required for Mitotic but Apparently Not for Meiotic Functions | Full Text | References | PDF (962.7 KB)
  • 7 Views
  • 39 CrossRef citations
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Article
The Rad51 Paralog Rad51B Promotes Homologous Recombinational Repair
Minoru Takata, Masao S. Sasaki, Eiichiro Sonoda, Toru Fukushima, Ciaran Morrison, Joanna S. Albala, Sigrid M. A. Swagemakers, Roland Kanaar, Larry H. Thompson & Shunichi Takeda
Pages: 6476-6482
Published online: 28 Mar 2023
AbstractforThe Rad51 Paralog Rad51B Promotes Homologous Recombinational Repair | Full Text | References | PDF (1.1 MB)
  • 68 Views
  • 186 CrossRef citations
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Article
A Bromodomain Protein, MCAP, Associates with Mitotic Chromosomes and Affects G2-to-M Transition
Anup Dey, Jan Ellenberg, Andrea Farina, Allen E. Coleman, Tetsuo Maruyama, Selvaggia Sciortino, Jennifer Lippincott-Schwartz & Keiko Ozato
Pages: 6537-6549
Published online: 28 Mar 2023
AbstractforA Bromodomain Protein, MCAP, Associates with Mitotic Chromosomes and Affects G2-to-M Transition | Full Text | References | PDF (11.6 MB)
  • 118 Views
  • 223 CrossRef citations
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Cell and Organelle Structure and Assembly

Article
Divergent N-Terminal Sequences Target an Inducible Testis Deubiquitinating Enzyme to Distinct Subcellular Structures
Haijiang Lin, Anne Keriel, Carlos R. Morales, Nathalie Bedard, Qing Zhao, Pascal Hingamp, Stephane Lefrançois, Lydie Combaret & Simon S. Wing
Pages: 6568-6578
Published online: 28 Mar 2023
AbstractforDivergent N-Terminal Sequences Target an Inducible Testis Deubiquitinating Enzyme to Distinct Subcellular Structures | Full Text | References | PDF (2 MB)
  • 11 Views
  • 57 CrossRef citations
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