Advanced search
Publication Cover
Molecular and Cellular Biology Volume 20, 2000 - Issue 2
Submit an article Journal homepage
7
Views
43
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Role of the Distal Half of the c-Mpl Intracellular Domain in Control of Platelet Production by Thrombopoietin In Vivo

Shiuh-Ming Luoh1 Departments of Molecular Oncology
,
Eric Stefanich2 Metabolism, Genentech, Inc., South San Francisco, California94080
,
Gregg Solar3 Cardiovascular, and Pharmacokinetics
,
Hope Steinmetz3 Cardiovascular, and Pharmacokinetics
,
Terry Lipari3 Cardiovascular, and Pharmacokinetics
,
Tamara I. Pestina4 Division of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee38105-2794
,
Carl W. Jackson4 Division of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee38105-2794
&
Frederic J. de Sauvage1 Departments of Molecular OncologyCorrespondence[email protected]
 show all
Pages 507-515 | Received 17 Aug 1999, Accepted 21 Oct 1999, Published online: 28 Mar 2023

Citations (43)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Carolyn A. de Graaf & Donald Metcalf. (2011) Thrombopoietin and hematopoietic stem cells. Cell Cycle 10:10, pages 1582-1589.
Read now

Articles from other publishers (42)

Marcel G.E. Rommel, Keven Hoerster, Christian Milde, Franziska Schenk, Luise Roser, Saskia Kohlscheen, Niels Heinz & Ute Modlich. (2020) Signaling properties of murine MPL and MPL mutants after stimulation with thrombopoietin and romiplostim. Experimental Hematology 85, pages 33-46.e6.
Crossref
Thomas Balligand, Younes Achouri, Christian Pecquet, Gilles Gaudray, Didier Colau, Eva Hug, Yacine Rahmani, Vincent Stroobant, Isabelle Plo, William Vainchenker, Robert Kralovics, Benoît J. Van den Eynde, Jean-Philippe Defour & Stefan N. Constantinescu. (2019) Knock-in of murine Calr del52 induces essential thrombocythemia with slow-rising dominance in mice and reveals key role of Calr exon 9 in cardiac development. Leukemia 34:2, pages 510-521.
Crossref
James Bussel, Austin Kulasekararaj, Nichola Cooper, Amit Verma, Ulrich Steidl, John W. Semple & Britta Will. (2019) Mechanisms and therapeutic prospects of thrombopoietin receptor agonists. Seminars in Hematology 56:4, pages 262-278.
Crossref
Ian S. Hitchcock & Kenneth Kaushansky. (2014) Thrombopoietin from beginning to end. British Journal of Haematology 165:2, pages 259-268.
Crossref
Alexis Kaushansky & Kenneth Kaushansky. 2014. A Systems Biology Approach to Blood. A Systems Biology Approach to Blood 59 84 .
Qiong Wang, Rui Sun, Leyan Wu, Junfeng Huang, Ping Wang, Hailong Yuan, Feifei Qiu, Xiaohong Xu, Di Wu, Ying Yu, Xin Liu & Qing Zhang. (2013) Identification and characterization of an alternative splice variant of Mpl with a high affinity for TPO and its activation of ERK1/2 signaling. The International Journal of Biochemistry & Cell Biology 45:12, pages 2852-2863.
Crossref
Stefan N. ConstantinescuWilliam Vainchenker. (2012) Small-molecule inhibitors in myeloproliferative neoplasms: are we aiming for the right targets?. Hematology 2012:1, pages 553-560.
Crossref
Wilko ThieleJaya KrishnanMelanie RothleyDebra Weih, Diana PlaumannVanessa KuchLuca QuagliataHerbert A. Weich & Jonathan P. Sleeman. (2012) VEGFR-3 is expressed on megakaryocyte precursors in the murine bone marrow and plays a regulatory role in megakaryopoiesis. Blood 120:9, pages 1899-1907.
Crossref
Pani A. Apostolidis, Donna S. Woulfe, Massiel Chavez, William M. Miller & Eleftherios T. Papoutsakis. (2012) Role of tumor suppressor p53 in megakaryopoiesis and platelet function. Experimental Hematology 40:2, pages 131-142.e4.
Crossref
Wei-Min Chen, Bo Yu, Qing Zhang & Peilin Xu. (2010) Identification of the Residues in the Extracellular Domain of Thrombopoietin Receptor Involved in the Binding of Thrombopoietin and a Nuclear Distribution Protein (Human NUDC). Journal of Biological Chemistry 285:34, pages 26697-26709.
Crossref
Amy E. Geddis. (2010) Megakaryopoiesis. Seminars in Hematology 47:3, pages 212-219.
Crossref
Christina AbbottGuo HuangAaron R. EllisonChing ChenTaruna AroraStephen J. SzilvassyPing Wei. (2010) Mouse Monoclonal Antibodies Against Human c-Mpl and Characterization for Flow Cytometry Applications. Hybridoma 29:2, pages 103-113.
Crossref
Shayne Cox GadZvia Agur, Moran Elishmereni, Yuri Kogan, Yuri Kheifetz, Irit Ziv, Meir Shoham & Vladimir Vainstein. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Christian PecquetJudith StaerkRonan ChalignéValerie GossKimberly A. LeeXiaowu ZhangJohn RushJoanne Van HeesHélène A. Poirel, Jean-Marie Scheiff, William VainchenkerStéphane GiraudierRoberto D. PolakiewiczStefan N. Constantinescu. (2010) Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor. Blood 115:5, pages 1037-1048.
Crossref
Ping Wei. 2011. Hematopoietic Growth Factors in Oncology. Hematopoietic Growth Factors in Oncology 75 93 .
Hyun O. Lee, Jean M. Davidson & Robert J. Duronio. (2009) Endoreplication: polyploidy with purpose. Genes & Development 23:21, pages 2461-2477.
Crossref
K. KAUSHANSKY. (2009) Molecular mechanisms of thrombopoietin signaling. Journal of Thrombosis and Haemostasis 7, pages 235-238.
Crossref
Stefan N. Constantinescu. (2009) Mpl and thrombocytosis: levels matter. Blood 113:8, pages 1617-1618.
Crossref
Ralph TiedtJörn CoersSandra ZieglerAdrian WiestnerHui Hao-ShenCaroline BornmannJohannes SchenkelSvetlana KarakhanovaFrederic J. de Sauvage, Carl W. Jackson & Radek C. Skoda. (2009) Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes. Blood 113:8, pages 1768-1777.
Crossref
E. Ricky Chan, Heather Lavender, Geqiang Li, Peter Haviernik, Kevin D. Bunting & Mark D. Adams. (2009) An ENU-induced recessive mutation in Mpl leads to thrombocytopenia with overdominance. Experimental Hematology 37:2, pages 276-284.
Crossref
Ralph TiedtHui Hao-ShenMarta A. SobasRenate LooserStephan Dirnhofer, Jürg Schwaller & Radek C. Skoda. (2008) Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice. Blood 111:8, pages 3931-3940.
Crossref
Wei Tong, Yessenia M. Ibarra & Harvey F. Lodish. (2007) Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal. Experimental Hematology 35:9, pages 1447-1455.
Crossref
Wei Tong, Rita Sulahian, Alec W. Gross, Natalie Hendon, Harvey F. Lodish & Lily Jun-shen Huang. (2006) The Membrane-proximal Region of the Thrombopoietin Receptor Confers Its High Surface Expression by JAK2-dependent and -independent Mechanisms. Journal of Biological Chemistry 281:50, pages 38930-38940.
Crossref
Keita Kirito & Kenneth Kaushansky. (2006) Transcriptional regulation of megakaryopoiesis: thrombopoietin signaling and nuclear factors. Current Opinion in Hematology 13:3, pages 151-156.
Crossref
Tamara I Pestina & Carl W Jackson. (2003) Differential role of Stat5 isoforms in effecting hematopoietic recovery induced by Mpl-ligand in lethally myelosuppressed mice. Experimental Hematology 31:12, pages 1198-1205.
Crossref
Kirill Skomorovski, Hila Harpak, Anton Ianovski, Moshe Vardi, Trudi P Visser, Simone CC Hartong, Huub HDM van Vliet, Gerard Wagemaker & Zvia Agur. (2003) New TPO treatment schedules of increased safety and efficacy: pre-clinical validation of a thrombopoiesis simulation model. British Journal of Haematology 123:4, pages 683-691.
Crossref
K. Kaushansky. (2003) Thrombopoietin: a tool for understanding thrombopoiesis. Journal of Thrombosis and Haemostasis 1:7, pages 1587-1592.
Crossref
M Abe, K Suzuki, O Inagaki, S Sassa & H Shikama. (2002) A novel MPL point mutation resulting in thrombopoietin-independent activation. Leukemia 16:8, pages 1500-1506.
Crossref
Jonathan G. Drachman, Yoshitaka Miyakawa, Jennifer N. Luthi, Debra D. Dahlen, Alexa Raney, Amy E. Geddis & Kenneth Kaushansky. (2002) Studies with Chimeric Mpl/JAK2 Receptors Indicate That Both JAK2 and the Membrane-proximal Domain of Mpl Are Required for Cellular Proliferation. Journal of Biological Chemistry 277:26, pages 23544-23553.
Crossref
Itaru Matsumura & Yuzuru Kanakura. (2002) Molecular Control of Megakaryopoiesis and Thrombopoiesis. International Journal of Hematology 75:5, pages 473-483.
Crossref
Fabrice Piu, Michael Magnani & Max E Ader. (2002) Dissection of the cytoplasmic domains of cytokine receptors involved in STAT and Ras dependent proliferation. Oncogene 21:22, pages 3579-3591.
Crossref
Kenneth Kaushansky & Jonathan G Drachman. (2002) The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production. Oncogene 21:21, pages 3359-3367.
Crossref
Keita KiritoMasatake OsawaHaruhiko MoritaRitsuko ShimizuMasayuki YamamotoAtsushi OdaHiroyoshi FujitaMasaru TanakaKoichi NakajimaYasusada MiuraKeiya OzawaNorio Komatsu. (2002) A functional role of Stat3 in in vivo megakaryopoiesis. Blood 99:9, pages 3220-3227.
Crossref
Caroline Meunier, Didier Bordereaux, Françoise Porteu, Sylvie Gisselbrecht, Stany Chrétien & Geneviève Courtois. (2002) Cloning and Characterization of a Family of Proteins Associated with Mpl. Journal of Biological Chemistry 277:11, pages 9139-9147.
Crossref
Marie-Dominique FilippiFrançoise PorteuFrançoise Le PesteurValérie SchiavonGaël A. MillotWilliam VainchenkerFrédéric J. de SauvageAnne Dubart KupperschmittFrancoise Sainteny. (2002) Requirement for mitogen-activated protein kinase activation in the response of embryonic stem cell–derived hematopoietic cells to thrombopoietin in vitro. Blood 99:4, pages 1174-1182.
Crossref
Gaël A Millot, Fréderic Feger, Loic Garçon, William Vainchenker, Dominique Dumenil & Fédor Svinarchuk. (2002) MplK, a natural variant of the thrombopoietin receptor with a truncated cytoplasmic domain, binds thrombopoietin but does not interfere with thrombopoietin-mediated cell growth. Experimental Hematology 30:2, pages 166-175.
Crossref
Fabrice Gouilleux. 2002. Hormone Signaling. Hormone Signaling 145 178 .
Ponlapat Rojnuckarin, Yoshitaka Miyakawa, Norma E. Fox, Jessie Deou, Guenter Daum & Kenneth Kaushansky. (2001) The Roles of Phosphatidylinositol 3-Kinase and Protein Kinase Cζ for Thrombopoietin-induced Mitogen-activated Protein Kinase Activation in Primary Murine Megakaryocytes. Journal of Biological Chemistry 276:44, pages 41014-41022.
Crossref
Meenakshi GaurGeorge J. MurphyFrederic J. deSauvageAndrew D. Leavitt. (2001) Characterization of Mpl mutants using primary megakaryocyte-lineage cells from mpl−/−mice: a new system for Mpl structure–function studies. Blood 97:6, pages 1653-1661.
Crossref
Yoshitaka Miyakawa, Ponlapat Rojnuckarin, Tania Habib & Kenneth Kaushansky. (2001) Thrombopoietin Induces Phosphoinositol 3-Kinase Activation through SHP2, Gab, and Insulin Receptor Substrate Proteins in BAF3 Cells and Primary Murine Megakaryocytes. Journal of Biological Chemistry 276:4, pages 2494-2502.
Crossref
Marie-Dominique Filippi, Françoise Porteu, Françoise Le Pesteur, Philippe Rameau, Maria Manuela Nogueira, Najet Debili, William Vainchenker, Frederic J de Sauvage, Anne Dubart Kupperschmitt & Françoise Sainteny. (2000) Embryonic stem cell differentiation to hematopoietic cells. Experimental Hematology 28:12, pages 1363-1372.
Crossref
Yoshitaka Miyakawa, Jonathan G. Drachman, Byron Gallis, Alexis Kaushansky & Kenneth Kaushansky. (2000) A Structure-Function Analysis of Serine/Threonine Phosphorylation of the Thrombopoietin Receptor, c-Mpl. Journal of Biological Chemistry 275:41, pages 32214-32219.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.