Molecular and Cellular Biology, Volume 20, Issue 2 (2000)

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Molecular and Cellular Biology, Volume 20, Issue 2 (2000)

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Minireviews

Article
Helix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms
Mark Eben Massari & Cornelis Murre
Pages: 429-440
Published online: 28 Mar 2023
First Page PreviewforHelix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms | Full Text | References | PDF (406.7 KB)
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Gene Expression

Article
Yeast Exosome Mutants Accumulate 3′-Extended Polyadenylated Forms of U4 Small Nuclear RNA and Small Nucleolar RNAs
Ambro van Hoof, Pascal Lennertz & Roy Parker
Pages: 441-452
Published online: 28 Mar 2023
AbstractforYeast Exosome Mutants Accumulate 3′-Extended Polyadenylated Forms of U4 Small Nuclear RNA and Small Nucleolar RNAs | Full Text | References | PDF (1.5 MB)
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Article
Eukaryotic Translation Initiation Factor 4E (eIF4E) Binding Site and the Middle One-Third of eIF4GI Constitute the Core Domain for Cap-Dependent Translation, and the C-Terminal One-Third Functions as a Modulatory Region
Shigenobu Morino, Hiroaki Imataka, Yuri V. Svitkin, Tatyana V. Pestova & Nahum Sonenberg
Pages: 468-477
Published online: 28 Mar 2023
AbstractforEukaryotic Translation Initiation Factor 4E (eIF4E) Binding Site and the Middle One-Third of eIF4GI Constitute the Core Domain for Cap-Dependent Translation, and the C-Terminal One-Third Functions as a Modulatory Region | Full Text | References | PDF (2 MB)
  • 73 Views
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Article
A Nuclear 3′-5′ Exonuclease Involved in mRNA Degradation Interacts with Poly(A) Polymerase and the hnRNA Protein Npl3p
Karina T. D. Burkard & J. Scott Butler
Pages: 604-616
Published online: 28 Mar 2023
AbstractforA Nuclear 3′-5′ Exonuclease Involved in mRNA Degradation Interacts with Poly(A) Polymerase and the hnRNA Protein Npl3p | Full Text | References | PDF (2 MB)
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Cell Growth and Development

Article
p21-Activated Kinase 1 Phosphorylates the Death Agonist Bad and Protects Cells from Apoptosis
A. Schürmann, A. F. Mooney, L. C. Sanders, M. A. Sells, H. G. Wang, J. C. Reed & G. M. Bokoch
Pages: 453-461
Published online: 28 Mar 2023
Abstractforp21-Activated Kinase 1 Phosphorylates the Death Agonist Bad and Protects Cells from Apoptosis | Full Text | References | PDF (934.8 KB)
  • 34 Views
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Article
Phospholipase D and RalA Cooperate with the Epidermal Growth Factor Receptor To Transform 3Y1 Rat Fibroblasts
Zhimin Lu, Armand Hornia, Troy Joseph, Taiko Sukezane, Paul Frankel, Minghao Zhong, Sergei Bychenok, Lizhong Xu, Larry A. Feig & David A. Foster
Pages: 462-467
Published online: 28 Mar 2023
AbstractforPhospholipase D and RalA Cooperate with the Epidermal Growth Factor Receptor To Transform 3Y1 Rat Fibroblasts | Full Text | References | PDF (842.6 KB)
  • 13 Views
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Article
CLN1 and Its Repression by Xbp1 Are Important for Efficient Sporulation in Budding Yeast
Bernard Mai & Linda Breeden
Pages: 478-487
Published online: 28 Mar 2023
AbstractforCLN1 and Its Repression by Xbp1 Are Important for Efficient Sporulation in Budding Yeast | Full Text | References | PDF (893.9 KB)
  • 23 Views
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Article
A Novel Form of DAP5 Protein Accumulates in Apoptotic Cells as a Result of Caspase Cleavage and Internal Ribosome Entry Site-Mediated Translation
Sivan Henis-Korenblit, Naomi Levy Strumpf, Dan Goldstaub & Adi Kimchi
Pages: 496-506
Published online: 28 Mar 2023
AbstractforA Novel Form of DAP5 Protein Accumulates in Apoptotic Cells as a Result of Caspase Cleavage and Internal Ribosome Entry Site-Mediated Translation | Full Text | References | PDF (1.7 MB)
  • 54 Views
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Article
Role of the Distal Half of the c-Mpl Intracellular Domain in Control of Platelet Production by Thrombopoietin In Vivo
Shiuh-Ming Luoh, Eric Stefanich, Gregg Solar, Hope Steinmetz, Terry Lipari, Tamara I. Pestina, Carl W. Jackson & Frederic J. de Sauvage
Pages: 507-515
Published online: 28 Mar 2023
AbstractforRole of the Distal Half of the c-Mpl Intracellular Domain in Control of Platelet Production by Thrombopoietin In Vivo | Full Text | References | PDF (797.1 KB)
  • 7 Views
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Article
The Transmembrane Mutation G380R in Fibroblast Growth Factor Receptor 3 Uncouples Ligand-Mediated Receptor Activation from Down-Regulation
E. Monsonego-Ornan, R. Adar, T. Feferman, O. Segev & A. Yayon
Pages: 516-522
Published online: 28 Mar 2023
AbstractforThe Transmembrane Mutation G380R in Fibroblast Growth Factor Receptor 3 Uncouples Ligand-Mediated Receptor Activation from Down-Regulation | Full Text | References | PDF (851.3 KB)
  • 59 Views
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Article
The HAND1 Basic Helix-Loop-Helix Transcription Factor Regulates Trophoblast Differentiation via Multiple Mechanisms
Ian C. Scott, Lynn Anson-Cartwright, Paul Riley, Danny Reda & James C. Cross
Pages: 530-541
Published online: 28 Mar 2023
AbstractforThe HAND1 Basic Helix-Loop-Helix Transcription Factor Regulates Trophoblast Differentiation via Multiple Mechanisms | Full Text | References | PDF (3.2 MB)
  • 72 Views
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Article
Distinct Subcellular Localization Patterns Contribute to Functional Specificity of the Cln2 and Cln3 Cyclins of Saccharomyces cerevisiae
Mary E. Miller & Frederick R. Cross
Pages: 542-555
Published online: 28 Mar 2023
AbstractforDistinct Subcellular Localization Patterns Contribute to Functional Specificity of the Cln2 and Cln3 Cyclins of Saccharomyces cerevisiae | Full Text | References | PDF (2.4 MB)
  • 17 Views
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Article
Feedback Phosphorylation of the Yeast a-Factor Receptor Requires Activation of the Downstream Signaling Pathway from G Protein through Mitogen-Activated Protein Kinase
Ying Feng & Nicholas G. Davis
Pages: 563-574
Published online: 28 Mar 2023
AbstractforFeedback Phosphorylation of the Yeast a-Factor Receptor Requires Activation of the Downstream Signaling Pathway from G Protein through Mitogen-Activated Protein Kinase | Full Text | References | PDF (1.7 MB)
  • 13 Views
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Article
c-Jun-Dependent CD95-L Expression Is a Rate-Limiting Step in the Induction of Apoptosis by Alkylating Agents
Andrea Kolbus, Ingrid Herr, Martin Schreiber, Klaus-Michael Debatin, Erwin F. Wagner & Peter Angel
Pages: 575-582
Published online: 28 Mar 2023
Abstractforc-Jun-Dependent CD95-L Expression Is a Rate-Limiting Step in the Induction of Apoptosis by Alkylating Agents | Full Text | References | PDF (498.5 KB)
  • 29 Views
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Article
Alternatively Spliced Products CC3 and TC3 Have Opposing Effects on Apoptosis
Stephanie Whitman, Xia Wang, Refaat Shalaby & Emma Shtivelman
Pages: 583-593
Published online: 28 Mar 2023
AbstractforAlternatively Spliced Products CC3 and TC3 Have Opposing Effects on Apoptosis | Full Text | References | PDF (1.5 MB)
  • 18 Views
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Article
Activation of p38 Mitogen-Activated Protein Kinase and c-Jun NH2-Terminal Kinase by Double-Stranded RNA and Encephalomyocarditis Virus: Involvement of RNase L, Protein Kinase R, and Alternative Pathways
Mihail S. Iordanov, Jayashree M. Paranjape, Aimin Zhou, John Wong, Bryan R. G. Williams, Eliane F. Meurs, Robert H. Silverman & Bruce E. Magun
Pages: 617-627
Published online: 28 Mar 2023
AbstractforActivation of p38 Mitogen-Activated Protein Kinase and c-Jun NH2-Terminal Kinase by Double-Stranded RNA and Encephalomyocarditis Virus: Involvement of RNase L, Protein Kinase R, and Alternative Pathways | Full Text | References | PDF (1.8 MB)
  • 72 Views
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Article
p53 Deficiency Increases Transformation by v-Abl and Rescues the Ability of a C-Terminally Truncated v-Abl Mutant To Induce Pre-B Lymphoma In Vivo
Xiaoming Zou, Feng Cong, Margaret Coutts, Giorgio Cattoretti, Stephen P. Goff & Kathryn Calame
Pages: 628-633
Published online: 28 Mar 2023
Abstractforp53 Deficiency Increases Transformation by v-Abl and Rescues the Ability of a C-Terminally Truncated v-Abl Mutant To Induce Pre-B Lymphoma In Vivo | Full Text | References | PDF (649.8 KB)
  • 3 Views
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Article
Cyclin D1 Is Required for Transformation by Activated Neu and Is Induced through an E2F-Dependent Signaling Pathway
Richard J. Lee, Chris Albanese, Maofu Fu, Mark D'Amico, Bing Lin, Genichi Watanabe, George K. Haines III, Peter M. Siegel, Mien-Chie Hung, Yosef Yarden, Jonathan M. Horowitz, William J. Muller & Richard G. Pestell
Pages: 672-683
Published online: 28 Mar 2023
AbstractforCyclin D1 Is Required for Transformation by Activated Neu and Is Induced through an E2F-Dependent Signaling Pathway | Full Text | References | PDF (1.6 MB)
  • 33 Views
  • 264 CrossRef citations
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Article
Caspase 3 Cleavage of the Ste20-Related Kinase SLK Releases and Activates an Apoptosis-Inducing Kinase Domain and an Actin-Disassembling Region
Luc A. Sabourin, Patrick Seale, Julian Wagner & Michael A. Rudnicki
Pages: 684-696
Published online: 28 Mar 2023
AbstractforCaspase 3 Cleavage of the Ste20-Related Kinase SLK Releases and Activates an Apoptosis-Inducing Kinase Domain and an Actin-Disassembling Region | Full Text | References | PDF (2.1 MB)
  • 43 Views
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Article
Integration of Calcium and Cyclic AMP Signaling Pathways by 14-3-3
Chi-Wing Chow & Roger J. Davis
Pages: 702-712
Published online: 28 Mar 2023
AbstractforIntegration of Calcium and Cyclic AMP Signaling Pathways by 14-3-3 | Full Text | References | PDF (1.7 MB)
  • 16 Views
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Article
Fibroblast Growth Factor Receptor-Mediated Rescue of x-Ephrin B1-Induced Cell Dissociation in XenopusEmbryos
Lisa D. Chong, Eui Kyun Park, Erin Latimer, Robert Friesel & Ira O. Daar
Pages: 724-734
Published online: 28 Mar 2023
AbstractforFibroblast Growth Factor Receptor-Mediated Rescue of x-Ephrin B1-Induced Cell Dissociation in XenopusEmbryos | Full Text | References | PDF (1.8 MB)
  • 16 Views
  • 70 CrossRef citations
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Transcriptional Regulation

Article
A Novel Subunit of Yeast RNA Polymerase III Interacts with the TFIIB-Related Domain of TFIIIB70
Maria-Laura Ferri, Gérald Peyroche, Magali Siaut, Olivier Lefebvre, Christophe Carles, Christine Conesa & André Sentenac
Pages: 488-495
Published online: 28 Mar 2023
AbstractforA Novel Subunit of Yeast RNA Polymerase III Interacts with the TFIIB-Related Domain of TFIIIB70 | Full Text | References | PDF (1.1 MB)
  • 16 Views
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Article
The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc
Steven B. McMahon, Marcelo A. Wood & Michael D. Cole
Pages: 556-562
Published online: 28 Mar 2023
AbstractforThe Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc | Full Text | References | PDF (915.5 KB)
  • 102 Views
  • 358 CrossRef citations
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Article
Inhibition of TATA-Binding Protein Function by SAGA Subunits Spt3 and Spt8 at Gcn4-Activated Promoters
Rimma Belotserkovskaya, David E. Sterner, Min Deng, Michael H. Sayre, Paul M. Lieberman & Shelley L. Berger
Pages: 634-647
Published online: 28 Mar 2023
AbstractforInhibition of TATA-Binding Protein Function by SAGA Subunits Spt3 and Spt8 at Gcn4-Activated Promoters | Full Text | References | PDF (3.2 MB)
  • 38 Views
  • 108 CrossRef citations
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Article
A GATA Box in the GATA-1 Gene Hematopoietic Enhancer Is a Critical Element in the Network of GATA Factors and Sites That Regulate This Gene
Shigeko Nishimura, Satoru Takahashi, Takashi Kuroha, Naruyoshi Suwabe, Toshiro Nagasawa, Cecelia Trainor & Masayuki Yamamoto
Pages: 713-723
Published online: 28 Mar 2023
AbstractforA GATA Box in the GATA-1 Gene Hematopoietic Enhancer Is a Critical Element in the Network of GATA Factors and Sites That Regulate This Gene | Full Text | References | PDF (1.4 MB)
  • 30 Views
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Dna Dynamics and Chromosome Structure

Article
Histone H1 Is a Specific Repressor of Core Histone Acetylation in Chromatin
Julio E. Herrera, Katherine L. West, R. Louis Schiltz, Yoshihiro Nakatani & Michael Bustin
Pages: 523-529
Published online: 28 Mar 2023
AbstractforHistone H1 Is a Specific Repressor of Core Histone Acetylation in Chromatin | Full Text | References | PDF (2.1 MB)
  • 24 Views
  • 59 CrossRef citations
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Article
An Antitumor Drug-Induced Topoisomerase Cleavage Complex Blocks a Bacteriophage T4 Replication Fork In Vivo
George Hong & Kenneth N. Kreuzer
Pages: 594-603
Published online: 28 Mar 2023
AbstractforAn Antitumor Drug-Induced Topoisomerase Cleavage Complex Blocks a Bacteriophage T4 Replication Fork In Vivo | Full Text | References | PDF (3.8 MB)
  • 9 Views
  • 24 CrossRef citations
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Article
Engineering Mouse Chromosomes with Cre-loxP: Range, Efficiency, and Somatic Applications
Binhai Zheng, Marijke Sage, Elizabeth A. Sheppeard, Vesna Jurecic & Allan Bradley
Pages: 648-655
Published online: 28 Mar 2023
AbstractforEngineering Mouse Chromosomes with Cre-loxP: Range, Efficiency, and Somatic Applications | Full Text | References | PDF (1.1 MB)
  • 240 Views
  • 145 CrossRef citations
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Article
A Cell Cycle-Specific Requirement for the XRCC1 BRCT II Domain during Mammalian DNA Strand Break Repair
Richard M. Taylor, David J. Moore, Jenna Whitehouse, Penny Johnson & Keith W. Caldecott
Pages: 735-740
Published online: 28 Mar 2023
AbstractforA Cell Cycle-Specific Requirement for the XRCC1 BRCT II Domain during Mammalian DNA Strand Break Repair | Full Text | References | PDF (3 MB)
  • 27 Views
  • 87 CrossRef citations
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Mammalian Genetic Models With Minimal Or Complex Phenotypes

Article
Extracellular Matrix-Associated Protein Sc1 Is Not Essential for Mouse Development
Peter J. McKinnon, Susan K. McLaughlin, Manuela Kapsetaki & Robert F. Margolskee
Pages: 656-660
Published online: 28 Mar 2023
AbstractforExtracellular Matrix-Associated Protein Sc1 Is Not Essential for Mouse Development | Full Text | References | PDF (821.6 KB)
  • 18 Views
  • 38 CrossRef citations
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Article
Gastric Hyperplasia in Mice Lacking the Putative Cdc42 Effector IQGAP1
Shihong Li, Qiujuan Wang, Abhijit Chakladar, Roderick T. Bronson & André Bernards
Pages: 697-701
Published online: 28 Mar 2023
AbstractforGastric Hyperplasia in Mice Lacking the Putative Cdc42 Effector IQGAP1 | Full Text | References | PDF (892.1 KB)
  • 55 Views
  • 116 CrossRef citations
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Nucleocytoplasmic Communication

Article
A Novel PF/PN Motif Inhibits Nuclear Localization and DNA Binding Activity of the ESX1 Homeoprotein
Yu-Ting Yan, Stacey M. Stein, Jixiang Ding, Michael M. Shen & Cory Abate-Shen
Pages: 661-671
Published online: 28 Mar 2023
AbstractforA Novel PF/PN Motif Inhibits Nuclear Localization and DNA Binding Activity of the ESX1 Homeoprotein | Full Text | References | PDF (2.4 MB)
  • 9 Views
  • 15 CrossRef citations
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