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DNA Dynamics and Chromosome Structure

The Nicking Step in V(D)J Recombination Is Independent of Synapsis: Implications for the Immune Repertoire

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Pages 7914-7921 | Received 12 Apr 2000, Accepted 09 Aug 2000, Published online: 28 Mar 2023

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Read on this site (13)

Joydeep K. Banerjee & David G. Schatz. (2014) Synapsis Alters RAG-Mediated Nicking at Tcrb Recombination Signal Sequences: Implications for the “Beyond 12/23” Rule. Molecular and Cellular Biology 34:14, pages 2566-2580.
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Noriko Shimazaki, Amjad Askary, Patrick C. Swanson & Michael R. Lieber. (2012) Mechanistic Basis for RAG Discrimination between Recombination Sites and the Off-Target Sites of Human Lymphomas. Molecular and Cellular Biology 32:2, pages 365-375.
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Julien Bischerour, Catherine Lu, David B. Roth & Ronald Chalmers. (2009) Base Flipping in V(D)J Recombination: Insights into the Mechanism of Hairpin Formation, the 12/23 Rule, and the Coordination of Double-Strand Breaks. Molecular and Cellular Biology 29:21, pages 5889-5899.
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Anna H. Drejer-Teel, Sebastian D. Fugmann & David G. Schatz. (2007) The Beyond 12/23 Restriction Is Imposed at the Nicking and Pairing Steps of DNA Cleavage during V(D)J Recombination. Molecular and Cellular Biology 27:18, pages 6288-6299.
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Sathees C. Raghavan, Chih-Lin Hsieh & Michael R. Lieber. (2005) Both V(D)J Coding Ends but Neither Signal End Can Recombine at the bcl-2 Major Breakpoint Region, and the Rejoining Is Ligase IV Dependent. Molecular and Cellular Biology 25:15, pages 6475-6484.
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Sathees C. Raghavan, Patrick C. Swanson, Yunmei Ma & Michael R. Lieber. (2005) Double-Strand Break Formation by the RAG Complex at the Bcl-2 Major Breakpoint Region and at Other Non-B DNA Structures In Vitro. Molecular and Cellular Biology 25:14, pages 5904-5919.
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Mihai Ciubotaru & David G. Schatz. (2004) Synapsis of Recombination Signal Sequences Located in cis and DNA Underwinding in V(D)J Recombination. Molecular and Cellular Biology 24:19, pages 8727-8744.
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Karen Lipkow, Nicolas Buisine, David J. Lampe & Ronald Chalmers. (2004) Early Intermediates of mariner Transposition: Catalysis without Synapsis of the Transposon Ends Suggests a Novel Architecture of the Synaptic Complex. Molecular and Cellular Biology 24:18, pages 8301-8311.
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Pallabi De, Mandy M. Peak & Karla K. Rodgers. (2004) DNA Cleavage Activity of the V(D)J Recombination Protein RAG1 Is Autoregulated. Molecular and Cellular Biology 24:15, pages 6850-6860.
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Jianhua Yu, Kelly Marshall, Miyuki Yamaguchi, James E. Haber & Clifford F. Weil. (2004) Microhomology-Dependent End Joining and Repair of Transposon-Induced DNA Hairpins by Host Factors in Saccharomyces cerevisiae. Molecular and Cellular Biology 24:3, pages 1351-1364.
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Patrick C. Swanson. (2002) Fine Structure and Activity of Discrete RAG-HMG Complexes on V(D)J Recombination Signals. Molecular and Cellular Biology 22:5, pages 1340-1351.
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Cynthia L. Mundy, Nadja Patenge, Adam G. W. Matthews & Marjorie A. Oettinger. (2002) Assembly of the RAG1/RAG2 Synaptic Complex. Molecular and Cellular Biology 22:1, pages 69-77.
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Philipp C. Rommel, Thiago Y. Oliveira, Michel C. Nussenzweig & Davide F. Robbiani. (2017) RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks. Journal of Experimental Medicine 214:3, pages 815-831.
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Yongming Wang, Diana Pryputniewicz-Dobrinska, Enikö Éva Nagy, Christopher D. Kaufman, Manvendra Singh, Steve Yant, Jichang Wang, Anna Dalda, Mark A. Kay, Zoltán Ivics & Zsuzsanna Izsvák. (2017) Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition . Nucleic Acids Research 45:1, pages 311-326.
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Chao Lu, Alyssa Ward, John Bettridge, Yun Liu & Stephen Desiderio. (2015) An Autoregulatory Mechanism Imposes Allosteric Control on the V(D)J Recombinase by Histone H3 Methylation. Cell Reports 10:1, pages 29-38.
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Corentin Claeys Bouuaert, Neil Walker, Danxu Liu & Ronald Chalmers. (2014) Crosstalk between transposase subunits during cleavage of the mariner transposon. Nucleic Acids Research 42:9, pages 5799-5808.
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Amjad Askary, Noriko Shimazaki, Niki Bayat & Michael R. Lieber. (2014) Modeling of the RAG Reaction Mechanism. Cell Reports 7:2, pages 307-315.
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Julien Briffotaux & Kerri Kobryn. (2010) Preventing Broken Borrelia Telomeres. Journal of Biological Chemistry 285:52, pages 41010-41018.
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Noriko Shimazaki, Albert G. Tsai & Michael R. Lieber. (2009) H3K4me3 Stimulates the V(D)J RAG Complex for Both Nicking and Hairpinning in trans in Addition to Tethering in cis: Implications for Translocations. Molecular Cell 34:5, pages 535-544.
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Fang Fang Yin, Scott Bailey, C Axel Innis, Mihai Ciubotaru, Satwik Kamtekar, Thomas A Steitz & David G Schatz. (2009) Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nature Structural & Molecular Biology 16:5, pages 499-508.
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Shuying Zhao, Lori M. Gwyn, Pallabi De & Karla K. Rodgers. (2009) A Non-Sequence-Specific DNA Binding Mode of RAG1 Is Inhibited by RAG2. Journal of Molecular Biology 387:3, pages 744-758.
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Pallabi De, Shuying Zhao, Lori M Gwyn, LeAnn J Godderz, Mandy M Peak & Karla K Rodgers. (2008) Thermal dependency of RAG1 self-association properties. BMC Biochemistry 9:1.
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Jeffrey W. Pavlicek, Yuri L. Lyubchenko & Yung Chang. (2008) Quantitative Analyses of RAG−RSS Interactions and Conformations Revealed by Atomic Force Microscopy. Biochemistry 47:43, pages 11204-11211.
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Tadashi Nishihara, Fumikiyo Nagawa, Takeshi Imai & Hitoshi Sakano. (2008) RAG-Heptamer Interaction in the Synaptic Complex Is a Crucial Biochemical Checkpoint for the 12/23 Recombination Rule. Journal of Biological Chemistry 283:8, pages 4877-4885.
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