Advanced search
Publication Cover
Molecular and Cellular Biology Volume 20, 2000 - Issue 22
Submit an article Journal homepage
73
Views
270
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation

Manuel S. Rodriguez1 School of Biology, University of St. Andrews, St. Andrews FifeKY16 9ST
,
Joana M. P. Desterro1 School of Biology, University of St. Andrews, St. Andrews FifeKY16 9ST
,
Sonia Lain2 Surgery and Molecular Oncology, University of Dundee, Ninewells Hospital and Medical School, DundeeDD1 9SY, Scotland, United Kingdom
,
David P. Lane2 Surgery and Molecular Oncology, University of Dundee, Ninewells Hospital and Medical School, DundeeDD1 9SY, Scotland, United Kingdom
&
Ronald T. Hay1 School of Biology, University of St. Andrews, St. Andrews FifeKY16 9STCorrespondence[email protected]
Pages 8458-8467 | Received 13 Apr 2000, Accepted 14 Aug 2000, Published online: 28 Mar 2023

Citations (270)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (13)

Suzanne Camus, Sergio Menéndez, Kenneth Fernandes, Nelly Kua, Geng Liu, Dimitris P. Xirodimas, David P. Lane & Jean-Christophe Bourdon. (2012) The p53 isoforms are differentially modified by Mdm2. Cell Cycle 11:8, pages 1646-1655.
Read now
Nicolas L Young, Mariana D Plazas-Mayorca & Benjamin A Garcia. (2010) Systems-wide proteomic characterization of combinatorial post-translational modification patterns. Expert Review of Proteomics 7:1, pages 79-92.
Read now
Peter Martin$suffix/text()$suffix/text() & John P Leonard$suffix/text()$suffix/text(). (2007) Novel therapeutic targets in mantle cell lymphoma. Expert Opinion on Therapeutic Targets 11:7, pages 929-940.
Read now
Luciana E. Giono & James J. Manfredi. (2007) Mdm2 Is Required for Inhibition of Cdk2 Activity by p21, Thereby Contributing to p53-Dependent Cell Cycle Arrest. Molecular and Cellular Biology 27:11, pages 4166-4178.
Read now
Connie Chao, Zhiqun Wu, Sharlyn J. Mazur, Helena Borges, Matteo Rossi, Tongxiang Lin, Jean Y. J. Wang, Carl W. Anderson, Ettore Appella & Yang Xu. (2006) Acetylation of Mouse p53 at Lysine 317 Negatively Regulates p53 Apoptotic Activities after DNA Damage. Molecular and Cellular Biology 26:18, pages 6859-6869.
Read now
Lijin Feng, Tongxiang Lin, Hiroaki Uranishi, Wei Gu & Yang Xu. (2005) Functional Analysis of the Roles of Posttranslational Modifications at the p53 C Terminus in Regulating p53 Stability and Activity. Molecular and Cellular Biology 25:13, pages 5389-5395.
Read now
Philippe Coulombe, Geneviève Rodier, Eric Bonneil, Pierre Thibault & Sylvain Meloche. (2004) N-Terminal Ubiquitination of Extracellular Signal-Regulated Kinase 3 and p21 Directs Their Degradation by the Proteasome. Molecular and Cellular Biology 24:14, pages 6140-6150.
Read now
Valeria Giandomenico, Maria Simonsson, Eva Grünroos & Johan Ericsson. (2003) Coactivator-Dependent Acetylation Stabilizes Members of the SREBP Family of Transcription Factors. Molecular and Cellular Biology 23:7, pages 2587-2599.
Read now
Christine Blattner, Trevor Hay, David W. Meek & David P. Lane. (2002) Hypophosphorylation of Mdm2 Augments p53 Stability. Molecular and Cellular Biology 22:17, pages 6170-6182.
Read now
Penny G. Ard, Chandrima Chatterjee, Sudeesha Kunjibettu, Leon R. Adside, Lisa E. Gralinski & Steven B. McMahon. (2002) Transcriptional Regulation of the mdm2 Oncogene by p53 Requires TRRAP Acetyltransferase Complexes. Molecular and Cellular Biology 22:16, pages 5650-5661.
Read now
Jijie Gu, Linghu Nie, Dmitri Wiederschain & Zhi-Min Yuan. (2001) Identification of p53 Sequence Elements That Are Required for MDM2-Mediated Nuclear Export. Molecular and Cellular Biology 21:24, pages 8533-8546.
Read now
Marion A. E. Lohrum, Douglas B. Woods, Robert L. Ludwig, Éva Bálint & Karen H. Vousden. (2001) C-Terminal Ubiquitination of p53 Contributes to Nuclear Export. Molecular and Cellular Biology 21:24, pages 8521-8532.
Read now
Longchuan Bai & Juanita L. Merchant. (2001) ZBP-89 Promotes Growth Arrest through Stabilization of p53. Molecular and Cellular Biology 21:14, pages 4670-4683.
Read now

Articles from other publishers (257)

Avik Ghosh, Poushali Chakraborty & Debabrata Biswas. (2023) Fine tuning of the transcription juggernaut: A sweet and sour saga of acetylation and ubiquitination. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1866:3, pages 194944.
Crossref
Qingsheng Yan, Jingyi Ding, Sumbul Jawed Khan, Lee N. Lawton & Margaret A. Shipp. (2023) DTX3L E3 ligase targets p53 for degradation at poly ADP-ribose polymerase-associated DNA damage sites. iScience 26:4, pages 106444.
Crossref
H. Helena Wu, Sarah Leng, Yasser Abuetabh, Consolato Sergi, David D. Eisenstat & Roger Leng. (2023) The SWIB/MDM2 motif of UBE4B activates the p53 pathway. Molecular Therapy - Nucleic Acids 31, pages 466-481.
Crossref
Christopher L. Brooks. 2023. Encyclopedia of Cell Biology. Encyclopedia of Cell Biology 327 335 .
Shuang Shang, Jing Liu & Fang Hua. (2022) Protein acylation: mechanisms, biological functions and therapeutic targets. Signal Transduction and Targeted Therapy 7:1.
Crossref
Stefania Pieroni, Marilena Castelli, Danilo Piobbico, Simona Ferracchiato, Damiano Scopetti, Nicola Di-Iacovo, Maria Agnese Della-Fazia & Giuseppe Servillo. (2022) The Four Homeostasis Knights: In Balance upon Post-Translational Modifications. International Journal of Molecular Sciences 23:22, pages 14480.
Crossref
Zeenat Farooq, Shahnawaz Wani, Vijay Avin Balaji Ragunathrao, Rakesh Kochhar & Mumtaz Anwar. 2022. p53 - A Guardian of the Genome and Beyond. p53 - A Guardian of the Genome and Beyond.
Mayra A. Marques, Guilherme C. de Andrade, Jerson L. Silva & Guilherme A. P. de Oliveira. (2022) Protein of a thousand faces: The tumor-suppressive and oncogenic responses of p53. Frontiers in Molecular Biosciences 9.
Crossref
Min‐Sung Lee, Sang‐Ok Lee, Joonhyeok Choi, Minju Ryu, Mi‐Kyung Lee, Ji‐Hun Kim, Eunha Hwang, Chong‐Kil Lee, Seung‐Wook Chi & Kyoung‐Seok Ryu. (2022) MUL1‐RING recruits the substrate, p53‐TAD as a complex with UBE2D2–UB conjugate. The FEBS Journal 289:12, pages 3568-3586.
Crossref
Zhangchuan Xia, Ning Kon, Alyssa P. Gu, Omid Tavana & Wei Gu. (2022) Deciphering the acetylation code of p53 in transcription regulation and tumor suppression. Oncogene 41:22, pages 3039-3050.
Crossref
Le Zhang, Ningning Hou, Bing Chen, Chengxia Kan, Fang Han, Jingwen Zhang & Xiaodong Sun. (2022) Post-Translational Modifications of p53 in Ferroptosis: Novel Pharmacological Targets for Cancer Therapy. Frontiers in Pharmacology 13.
Crossref
James S. Clark, Rakez Kayed, Giulia Abate, Daniela Uberti, Paul Kinnon & Simona Piccirella. (2022) Post-translational Modifications of the p53 Protein and the Impact in Alzheimer’s Disease: A Review of the Literature. Frontiers in Aging Neuroscience 14.
Crossref
Alexandra Julier, Vanessa Radtke, Andreas Marx & Martin Scheffner. (2022) Generation and Characterization of Site‐Specifically Mono‐Ubiquitylated p53. ChemBioChem 23:6.
Crossref
Ying Wang, Chenlu Zhang, Jiabao Wang & Jiang Liu. (2022) p53 regulation by ubiquitin and ubiquitin-like modifications. Genome Instability & Disease 3:4, pages 179-198.
Crossref
Che-Pei Kung & Jason D. Weber. (2022) It’s Getting Complicated—A Fresh Look at p53-MDM2-ARF Triangle in Tumorigenesis and Cancer Therapy. Frontiers in Cell and Developmental Biology 10.
Crossref
Doris Loh & Russel J. Reiter. (2022) Melatonin: Regulation of Prion Protein Phase Separation in Cancer Multidrug Resistance. Molecules 27:3, pages 705.
Crossref
Jia Wen & Donglai Wang. (2021) Deciphering the PTM codes of the tumor suppressor p53. Journal of Molecular Cell Biology 13:11, pages 774-785.
Crossref
Meilan Hu, Fule He, Erik W. Thompson, Kostya (Ken) Ostrikov & Xiaofeng Dai. (2022) Lysine Acetylation, Cancer Hallmarks and Emerging Onco-Therapeutic Opportunities. Cancers 14:2, pages 346.
Crossref
Lu Yang, Yun Li, Arup Bhattacharya & Yuesheng Zhang. (2021) Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants. Communications Biology 4:1.
Crossref
. (2021) Computational detection, analysis and interpretations of genomic variants in human diseases associated GENEMDM 2. Biomedical Letters 7:2, pages 141-154.
Crossref
Jayanthi P. Gudikote, Tina Cascone, Alissa Poteete, Piyada Sitthideatphaiboon, Qiuyu Wu, Naoto Morikawa, Fahao Zhang, Shaohua Peng, Pan Tong, Lerong Li, Li Shen, Monique Nilsson, Phillip Jones, Erik P. Sulman, Jing Wang, Jean-Christophe Bourdon, Faye M. Johnson & John V. Heymach. (2021) Inhibition of nonsense-mediated decay rescues p53β/γ isoform expression and activates the p53 pathway in MDM2-overexpressing and select p53-mutant cancers. Journal of Biological Chemistry 297:5, pages 101163.
Crossref
Sinem Usluer, Emil Spreitzer, Benjamin Bourgeois & Tobias Madl. (2021) p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR. International Journal of Molecular Sciences 22:21, pages 11431.
Crossref
Dennis M. Timmerman, Tessa L. Remmers, Sanne Hillenius & Leendert H. J. Looijenga. (2021) Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis. International Journal of Molecular Sciences 22:10, pages 5377.
Crossref
Helge M. Magnussen & Danny T. Huang. (2021) Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant. Journal of Molecular Biology 433:5, pages 166807.
Crossref
Mengwu Pan & Christine Blattner. (2021) Regulation of p53 by E3s. Cancers 13:4, pages 745.
Crossref
Jiang Liu, Di Guan, Maogong Dong, Jingjing Yang, Haibin Wei, Qian Liang, Lizhi Song, Lu Xu, Junjie Bai, Cui Liu, Jian Mao, Qian Zhang, Junzhi Zhou, Xiaoying Wu, Miao Wang & Yu-Sheng Cong. (2020) UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination. Nature Cell Biology 22:9, pages 1056-1063.
Crossref
Ling Chen, Shuang Liu & Yongguang Tao. (2020) Regulating tumor suppressor genes: post-translational modifications. Signal Transduction and Targeted Therapy 5:1.
Crossref
Marius Bruer, Dirk Reinhardt, Karl Welte & Basant Kumar Thakur. (2020) Insights into the limitations of transient expression systems for the functional study of p53 acetylation site and oncogenic mutants. Biochemical and Biophysical Research Communications 524:4, pages 990-995.
Crossref
Arun Upadhyay. (2019) Structure of proteins: Evolution with unsolved mysteries. Progress in Biophysics and Molecular Biology 149, pages 160-172.
Crossref
Vivek Tripathi, Ekjot Kaur, Suhas Sampat Kharat, Mansoor Hussain, Arun Prasath Damodaran, Swati Kulshrestha & Sagar Sengupta. (2019) Abrogation of FBW7α-dependent p53 degradation enhances p53’s function as a tumor suppressor. Journal of Biological Chemistry 294:36, pages 13224-13232.
Crossref
Yanqing Liu, Omid Tavana & Wei Gu. (2019) p53 modifications: exquisite decorations of the powerful guardian. Journal of Molecular Cell Biology 11:7, pages 564-577.
Crossref
Yang Wang, Qi Ding, Yu‐Chen Lu, Shi‐Yang Cao, Qing‐Xue Liu & Lei Zhang. (2018) Interferon‐stimulated gene 15 enters posttranslational modifications of p53. Journal of Cellular Physiology 234:5, pages 5507-5518.
Crossref
Liwei Zhang, Yue Jin, Hao Yang, Yu Li, Chao Wang, Yongheng Shi & Yu Wang. (2019) SMYD3 promotes epithelial ovarian cancer metastasis by downregulating p53 protein stability and promoting p53 ubiquitination. Carcinogenesis.
Crossref
Xiaolei Bi, Qing Ye, Daoyuan Li, Qisheng Peng, Zhe Wang, Xiao Wu, Yun Zhang, Qunye Zhang & Fan Jiang. (2019) Inhibition of nucleolar stress response by Sirt1: A potential mechanism of acetylation-independent regulation of p53 accumulation. Aging Cell 18:2, pages e12900.
Crossref
Antonina Hafner, Martha L. Bulyk, Ashwini Jambhekar & Galit Lahav. (2019) The multiple mechanisms that regulate p53 activity and cell fate. Nature Reviews Molecular Cell Biology 20:4, pages 199-210.
Crossref
Zhenping Chen, Paul J. Boor, Celeste C. Finnerty, David N. Herndon & Thomas Albrecht. (2019) Calpain-mediated cleavage of p53 in human cytomegalovirus-infected lung fibroblasts. FASEB BioAdvances 1:3, pages 151-166.
Crossref
Robbert Q. Kim, Paul P. Geurink, Monique P. C. Mulder, Alexander Fish, Reggy Ekkebus, Farid El Oualid, Willem J. van Dijk, Duco van Dalen, Huib Ovaa, Hugo van Ingen & Titia K. Sixma. (2019) Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity. Nature Communications 10:1.
Crossref
Xinyang Yu & Michael J. Buck. (2019) Defining TP53 pioneering capabilities with competitive nucleosome binding assays. Genome Research 29:1, pages 107-115.
Crossref
Ashfaq Ur Rehman, Mueed Ur Rahman, Taaha Arshad & Hai-Feng Chen. 2019. Protein Allostery in Drug Discovery. Protein Allostery in Drug Discovery 335 357 .
Tatsuya Kawase, Yu Chen & Rieko Ohki. 2019. Heat Shock Proteins in Signaling Pathways. Heat Shock Proteins in Signaling Pathways 253 272 .
Kosuke Funato, Tomoatsu Hayashi, Kanae Echizen, Lumi Negishi, Naomi Shimizu, Ryo Koyama‐Nasu, Yukiko Nasu‐Nishimura, Yasuyuki Morishita, Viviane Tabar, Tomoki Todo, Yasushi Ino, Akitake Mukasa, Nobuhito Saito & Tetsu Akiyama. (2018) SIRT 2‐mediated inactivation of p73 is required for glioblastoma tumorigenicity . EMBO reports 19:11.
Crossref
Maxime Parisotto, Elise Grelet, Rana El Bizri, Yongyuan Dai, Julie Terzic, Doriane Eckert, Laetitia Gargowitsch, Jean-Marc Bornert & Daniel Metzger. (2018) PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo. Journal of Experimental Medicine 215:6, pages 1749-1763.
Crossref
Benjamin Bourgeois & Tobias Madl. (2018) Regulation of cellular senescence via the FOXO4-p53 axis . FEBS Letters 592:12, pages 2083-2097.
Crossref
Fernando M. Simabuco, Mirian G. Morale, Isadora C.B. Pavan, Ana P. Morelli, Fernando R. Silva & Rodrigo E. Tamura. (2018) p53 and metabolism: from mechanism to therapeutics. Oncotarget 9:34, pages 23780-23823.
Crossref
Taskeen Fathima Docrat, Savania Nagiah, Anand Krishnan, Dhaneshree B. Naidoo & Anil A. Chuturgoon. (2018) Atorvastatin induces MicroRNA-145 expression in HEPG2 cells via regulation of the PI3K/AKT signalling pathway. Chemico-Biological Interactions 287, pages 32-40.
Crossref
Chen Katz, Ana Maria Low-Calle, Joshua H. Choe, Oleg Laptenko, David Tong, Jazmine-Saskya N. Joseph-Chowdhury, Francesca Garofalo, Yan Zhu, Assaf Friedler & Carol Prives. (2018) Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers. Genes & Development 32:5-6, pages 430-447.
Crossref
Ibraheem Ali, Ryan J. Conrad, Eric Verdin & Melanie Ott. (2018) Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics. Chemical Reviews 118:3, pages 1216-1252.
Crossref
Ishita Gupta, Kanika Singh, Nishant K. Varshney & Sameena Khan. (2018) Delineating Crosstalk Mechanisms of the Ubiquitin Proteasome System That Regulate Apoptosis. Frontiers in Cell and Developmental Biology 6.
Crossref
Janaki Parameswaran & Barbara Burtness. 2018. Molecular Determinants of Head and Neck Cancer. Molecular Determinants of Head and Neck Cancer 249 274 .
Lu Yang, Yun Li, Arup Bhattacharya & Yuesheng Zhang. (2017) PEPD is a pivotal regulator of p53 tumor suppressor. Nature Communications 8:1.
Crossref
Veronica Tisato, Rebecca Voltan, Arianna Gonelli, Paola Secchiero & Giorgio Zauli. (2017) MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer. Journal of Hematology & Oncology 10:1.
Crossref
Terisha Ghazi, Savania Nagiah, Charlette Tiloke, Naeem Sheik Abdul & Anil A. Chuturgoon. (2017) Fusaric Acid Induces DNA Damage and Post‐Translational Modifications of p53 in Human Hepatocellular Carcinoma (HepG 2 ) Cells . Journal of Cellular Biochemistry 118:11, pages 3866-3874.
Crossref
Miguel Martin-Perez & Judit Villén. (2017) Determinants and Regulation of Protein Turnover in Yeast. Cell Systems 5:3, pages 283-294.e5.
Crossref
Jindong Zhang, Chuanxia Zhang, Jun Cui, Jiayu Ou, Jing Han, Yunfei Qin, Feng Zhi & Rong-Fu Wang. (2017) TRIM45 functions as a tumor suppressor in the brain via its E3 ligase activity by stabilizing p53 through K63-linked ubiquitination. Cell Death & Disease 8:5, pages e2831-e2831.
Crossref
Naoe T. Nihira, Kohei OguraKouhei Shimizu, Brian J. North, Jinfang ZhangDaming GaoHiroyuki Inuzuka & Wenyi Wei. (2017) Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function. Science Signaling 10:466.
Crossref
Nitin Raj & Laura D. Attardi. (2017) The Transactivation Domains of the p53 Protein. Cold Spring Harbor Perspectives in Medicine 7:1, pages a026047.
Crossref
Md. Zubbair Malik, Md. Jahoor Alam, Romana Ishrat, Subhash M. Agarwal & R. K. Brojen Singh. (2017) Control of apoptosis by SMAR1. Molecular BioSystems 13:2, pages 350-362.
Crossref
Mathieu Neault, Florence Couteau, Éric Bonneau, Vincent De Guire & Frédérick A. Mallette. 2017. MiRNAs in Aging and Cancer. MiRNAs in Aging and Cancer 27 98 .
Jian Zhu, Ting Zhuang, Huijie Yang, Xin Li, Huandi Liu & Hui Wang. (2016) Atypical ubiquitin ligase RNF31: the nuclear factor modulator in breast cancer progression. BMC Cancer 16:1.
Crossref
M. V. Glazova. (2016) The Role of p53 Protein in the Regulation of Neuronal Differentiation. Neuroscience and Behavioral Physiology 46:9, pages 984-991.
Crossref
Guoqiang Ai, Rakesh Dachineni, D. Ramesh Kumar, Srinivasan Marimuthu, Lloyd F. Alfonso & G. Jayarama Bhat. (2015) Aspirin acetylates wild type and mutant p53 in colon cancer cells: identification of aspirin acetylated sites on recombinant p53. Tumor Biology 37:5, pages 6007-6016.
Crossref
J H Kang, J-S Lee, D Hong, S-H Lee, N Kim, W-K Lee, T-W Sung, Y-D Gong & S-Y Kim. (2016) Renal cell carcinoma escapes death by p53 depletion through transglutaminase 2-chaperoned autophagy. Cell Death & Disease 7:3, pages e2163-e2163.
Crossref
Yoshikazu Johmura, Jia Sun, Kyoko Kitagawa, Keiko Nakanishi, Toshiya Kuno, Aya Naiki-Ito, Yumi Sawada, Tomomi Miyamoto, Atsushi Okabe, Hiroyuki Aburatani, ShengFan Li, Ichiro Miyoshi, Satoru Takahashi, Masatoshi Kitagawa & Makoto Nakanishi. (2016) SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence. Nature Communications 7:1.
Crossref
Toshiyuki Takasugi, Seiji Minegishi, Akiko Asada, Taro Saito, Hiroyuki Kawahara & Shin-ichi Hisanaga. (2016) Two Degradation Pathways of the p35 Cdk5 (Cyclin-dependent Kinase) Activation Subunit, Dependent and Independent of Ubiquitination. Journal of Biological Chemistry 291:9, pages 4649-4657.
Crossref
Cheng Du, Hong Wu & Roger P. Leng. (2015) UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation. Oncotarget 7:3, pages 2823-2836.
Crossref
Melissa Monson, Carol Cardona, Roger Coulombe & Kent Reed. (2016) Hepatic Transcriptome Responses of Domesticated and Wild Turkey Embryos to Aflatoxin B1. Toxins 8:1, pages 16.
Crossref
Shilu Mathew, Hany Abdel-Hafiz, Abbas Raza, Kaneez Fatima & Ishtiaq Qadri. (2016) Host nucleotide polymorphism in hepatitis B virus-associated hepatocellular carcinoma. World Journal of Hepatology 8:10, pages 485.
Crossref
Carman K.M. Ip, Jun Yin, Patrick K.S. Ng, Shiaw-Yih Lin & Gordon B. Mills. (2016) Genomic-Glycosylation Aberrations in Tumor Initiation, Progression and Management. AIMS Medical Science 3:4, pages 386-416.
Crossref
P.-Y. Jean-Charles, N.J. Freedman & S.K. Shenoy. 2016. Ubiquitination and Transmembrane Signaling. Ubiquitination and Transmembrane Signaling 339 369 .
C.L. Brooks. 2016. Encyclopedia of Cell Biology. Encyclopedia of Cell Biology 504 510 .
Patrick Beaudette, Oliver Popp & Gunnar Dittmar. (2016) Proteomic techniques to probe the ubiquitin landscape. PROTEOMICS 16:2, pages 273-287.
Crossref
Shalini Menon, Nicholas Patrick Boyer, Cortney Chelise Winkle, Leslie Marie McClain, Christopher Carey Hanlin, Dharmendra Pandey, Simon Rothenfußer, Anne Marion Taylor & Stephanie Lynn Gupton. (2015) The E3 Ubiquitin Ligase TRIM9 Is a Filopodia Off Switch Required for Netrin-Dependent Axon Guidance. Developmental Cell 35:6, pages 698-712.
Crossref
Anna E. Dart, Gary M. Box, William Court, Madeline E. Gale, John P. Brown, Sarah E. Pinder, Suzanne A. Eccles & Claire M. Wells. (2015) PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. Journal of Cell Biology 211:4, pages 863-879.
Crossref
David W. Meek. (2015) Regulation of the p53 response and its relationship to cancer. Biochemical Journal 469:3, pages 325-346.
Crossref
Michael P. Endsley, Georgette Moyle-Heyrman, Subbulakshmi Karthikeyan, Daniel D. Lantvit, David A. Davis, Jian-Jun Wei & Joanna E. Burdette. (2015) Spontaneous Transformation of Murine Oviductal Epithelial Cells: A Model System to Investigate the Onset of Fallopian-Derived Tumors. Frontiers in Oncology 5.
Crossref
Xiao-Jian Sun, Na Man, Yurong Tan, Stephen D. Nimer & Lan Wang. (2015) The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis. Frontiers in Oncology 5.
Crossref
Sayed Mohammad Shafiee, Mozhgan Rasti, Atefeh Seghatoleslam, Tayebeh Azimi & Ali Akbar Owji. (2015) UBE2Q1 in a Human Breast Carcinoma Cell Line: Overexpression and Interaction with p53. Asian Pacific Journal of Cancer Prevention 16:9, pages 3723-3727.
Crossref
Soline Aubry, William Shin, John F. Crary, Roger Lefort, Yasir H. Qureshi, Celine Lefebvre, Andrea Califano & Michael L. Shelanski. (2015) Assembly and Interrogation of Alzheimer’s Disease Genetic Networks Reveal Novel Regulators of Progression. PLOS ONE 10:3, pages e0120352.
Crossref
Oleg Laptenko, Idit Shiff, Will Freed-Pastor, Andrew Zupnick, Melissa Mattia, Ella Freulich, Inbal Shamir, Noam Kadouri, Tamar Kahan, James Manfredi, Itamar Simon & Carol Prives. (2015) The p53 C Terminus Controls Site-Specific DNA Binding and Promotes Structural Changes within the Central DNA Binding Domain. Molecular Cell 57:6, pages 1034-1046.
Crossref
Chuck C.-K. Chao. (2015) Mechanisms of p53 degradation. Clinica Chimica Acta 438, pages 139-147.
Crossref
Sara Reed & Dawn Quelle. (2014) p53 Acetylation: Regulation and Consequences. Cancers 7:1, pages 30-69.
Crossref
Ingvild Haaland, Jill A Opsahl, Frode S Berven, Håkon Reikvam, Hanne K Fredly, Ragnhild Haugse, Bernd Thiede, Emmet McCormack, Sonia Lain, Øystein Bruserud & Bjørn Tore Gjertsen. (2014) Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia. Molecular Cancer 13:1.
Crossref
Naïma Hanoun, Samuel Fritsch, Odile Gayet, Véronique Gigoux, Pierre Cordelier, Nelson Dusetti, Jérôme Torrisani & Marlène Dufresne. (2014) The E3 Ubiquitin Ligase Thyroid Hormone Receptor-interacting Protein 12 Targets Pancreas Transcription Factor 1a for Proteasomal Degradation. Journal of Biological Chemistry 289:51, pages 35593-35604.
Crossref
Johanna Pflaum, Sophie Schlosser & Martina Müller. (2014) p53 Family and Cellular Stress Responses in Cancer. Frontiers in Oncology 4.
Crossref
Vinod Pant & Guillermina Lozano. (2014) Limiting the power of p53 through the ubiquitin proteasome pathway. Genes & Development 28:16, pages 1739-1751.
Crossref
Jose A. Rodríguez. (2014) Interplay between nuclear transport and ubiquitin/SUMO modifications in the regulation of cancer-related proteins. Seminars in Cancer Biology 27, pages 11-19.
Crossref
Valérie Lang, Chiara Pallara, Amaia Zabala, Sofia Lobato-Gil, Fernando Lopitz-Otsoa, Rosa Farrás, Roland Hjerpe, Monica Torres-Ramos, Lorea Zabaleta, Christine Blattner, Ronald T. Hay, Rosa Barrio, Arkaitz Carracedo, Juan Fernandez-Recio, Manuel S. Rodríguez & Fabienne Aillet. (2014) Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity. Molecular Oncology 8:5, pages 1026-1042.
Crossref
Fabian D Mairinger, Robert FH Walter, Saskia Ting, Claudia Vollbrecht, Jens Kollmeier, Sergei Griff, Thomas Hager, Thomas Mairinger, Daniel C Christoph, Dirk Theegarten, Kurt Werner Schmid & Jeremias Wohlschlaeger. (2014) Mdm2 protein expression is strongly associated with survival in malignant pleural mesothelioma. Future Oncology 10:6, pages 995-1005.
Crossref
Martin L. Read, Robert I. Seed, Jim C.W. Fong, Bhavika Modasia, Gavin A. Ryan, Rachel J Watkins, Teresa Gagliano, Vicki E. Smith, Anna L. Stratford, Perkin K Kwan, Neil Sharma, Olivia M. Dixon, John C. Watkinson, Kristien Boelaert, Jayne A. Franklyn, Andrew S. Turnell & Christopher J. McCabe. (2014) The PTTG1-Binding Factor (PBF/PTTG1IP) Regulates p53 Activity in Thyroid Cells. Endocrinology 155:4, pages 1222-1234.
Crossref
Francesca Mattiroli & Titia K Sixma. (2014) Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways. Nature Structural & Molecular Biology 21:4, pages 308-316.
Crossref
Francesca Mattiroli, Michael Uckelmann, Danny D. Sahtoe, Willem J. van Dijk & Titia K. Sixma. (2014) The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A. Nature Communications 5:1.
Crossref
Ruichuan Chen, Jasper H. N. Yik, Qiao Jing Lew & Sheng-Hao Chao. (2014) Brd4 and HEXIM1: Multiple Roles in P-TEFb Regulation and Cancer. BioMed Research International 2014, pages 1-11.
Crossref
Caroline J. DeHart, Jasdave S. Chahal, S.J. Flint & David H. Perlman. (2014) Extensive Post-translational Modification of Active and Inactivated Forms of Endogenous p53. Molecular & Cellular Proteomics 13:1, pages 1-17.
Crossref
Aaron Ciechanover & Ariel Stanhill. (2014) The complexity of recognition of ubiquitinated substrates by the 26S proteasome. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:1, pages 86-96.
Crossref
Andreas K. Hock & Karen H. Vousden. (2014) The role of ubiquitin modification in the regulation of p53. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:1, pages 137-149.
Crossref
Qiao Lew, Kai Chu, Yi Chia, Nge Cheong & Sheng-Hao Chao. (2013) HEXIM1, a New Player in the p53 Pathway. Cancers 5:4, pages 838-856.
Crossref
Jie Xu, Xiaolin Zhou, Jilin Wang, Zhaoli Li, Xuan Kong, Jin Qian, Ye Hu & Jing-Yuan Fang. (2013) RhoGAPs Attenuate Cell Proliferation by Direct Interaction with p53 Tetramerization Domain. Cell Reports 3:5, pages 1526-1538.
Crossref
Ronald T. Hay. (2013) Decoding the SUMO signal. Biochemical Society Transactions 41:2, pages 463-473.
Crossref
Lindsey N. MicelJohn J. TentlerPeter G. SmithGail S. Eckhardt. (2013) Role of Ubiquitin Ligases and the Proteasome in Oncogenesis: Novel Targets for Anticancer Therapies. Journal of Clinical Oncology 31:9, pages 1231-1238.
Crossref
A. Zoric, A. Horvat & N. Slade. (2012) Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis. Carcinogenesis 34:3, pages 522-529.
Crossref
Shuangbing Xu, Yuanzhong Wu, Qiong Chen, Jingying Cao, Kaishun Hu, Jianjun Tang, Yi Sang, Fenju Lai, Li Wang, Ruhua Zhang, Sheng-Ping Li, Yi-Xin Zeng, Yuxin Yin & Tiebang Kang. (2012) hSSB1 regulates both the stability and the transcriptional activity of p53. Cell Research 23:3, pages 423-435.
Crossref
Elisabeth Silden, Sigrun M. Hjelle, Line Wergeland, André Sulen, Vibeke Andresen, Jean-Christophe Bourdon, David R. Micklem, Emmet McCormack & Bjørn Tore Gjertsen. (2013) Expression of TP53 Isoforms p53β or p53γ Enhances Chemosensitivity in TP53null Cell Lines. PLoS ONE 8:2, pages e56276.
Crossref
Yelena Kravtsova-Ivantsiv, Thomas Sommer & Aaron Ciechanover. (2013) The Lysine48-Based Polyubiquitin Chain Proteasomal Signal: Not a Single Child Anymore. Angewandte Chemie International Edition 52:1, pages 192-198.
Crossref
Marco Retzlaff, Julia Rohrberg, Natascha Jennifer Küpper, Stephan Lagleder, Alexander Bepperling, Florian Manzenrieder, Jirka Peschek, Horst Kessler & Johannes Buchner. (2013) The Regulatory Domain Stabilizes the p53 Tetramer by Intersubunit Contacts with the DNA Binding Domain. Journal of Molecular Biology 425:1, pages 144-155.
Crossref
Qiao Jing Lew, Yi Ling Chia, Kai Ling Chu, Yuen Ting Lam, Meera Gurumurthy, Shengli Xu, Kong Peng Lam, Nge Cheong & Sheng-Hao Chao. (2012) Identification of HEXIM1 as a Positive Regulator of p53. Journal of Biological Chemistry 287:43, pages 36443-36454.
Crossref
L. M. M. Jenkins, S. R. Durell, S. J. Mazur & E. Appella. (2012) p53 N-terminal phosphorylation: a defining layer of complex regulation. Carcinogenesis 33:8, pages 1441-1449.
Crossref
Sachiko Yamada, Hiroshi Kanno & Nobutaka Kawahara. (2012) Trans-membrane peptide therapy for malignant glioma by use of a peptide derived from the MDM2 binding site of p53. Journal of Neuro-Oncology 109:1, pages 7-14.
Crossref
Liat Spasser & Ashraf Brik. (2012) Chemistry and Biology of the Ubiquitin Signal. Angewandte Chemie International Edition 51:28, pages 6840-6862.
Crossref
Liat Spasser & Ashraf Brik. (2012) Die Chemie und Biologie des Ubiquitin-Signals. Angewandte Chemie 124:28, pages 6946-6969.
Crossref
Qiang ZhouTiandao LiDavid H. Price. (2012) RNA Polymerase II Elongation Control. Annual Review of Biochemistry 81:1, pages 119-143.
Crossref
Lauren E. Nelson, Rudy J. Valentine, José M. Cacicedo, Marie-Soleil Gauthier, Yasuo Ido & Neil B. Ruderman. (2012) A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. American Journal of Physiology-Cell Physiology 303:1, pages C4-C13.
Crossref
Yan Li, Xu Li, Guangyu Fan, Jun-ichi Fukushi, Yoshihiro Matsumoto, Yukihide Iwamoto & Yue Zhu. (2012) Impairment of p53 acetylation by EWS-Fli1 chimeric protein in Ewing Family Tumors. Cancer Letters 320:1, pages 14-22.
Crossref
L Y Ching, Bonnie H Y Yeung & Chris K C Wong. (2012) Synergistic effect of p53 on TSA-induced stanniocalcin 1 expression in human nasopharyngeal carcinoma cells, CNE2. Journal of Molecular Endocrinology 48:3, pages 241-250.
Crossref
Takashi Hitsuda, Hiroyuki Michiue, Mizuki Kitamatsu, Atsushi Fujimura, Feifei Wang, Takahiro Yamamoto, Xiao-Jian Han, Hiroshi Tazawa, Atsuhito Uneda, Iori Ohmori, Tei-ichi Nishiki, Kazuhito Tomizawa & Hideki Matsui. (2012) A protein transduction method using oligo-arginine (3R) for the delivery of transcription factors into cell nuclei. Biomaterials 33:18, pages 4665-4672.
Crossref
Blair C. R. Dancy, Shonoi A. Ming, Romeo Papazyan, Christine A. Jelinek, Ananya Majumdar, Yan Sun, Beverley M. Dancy, William J. DruryIIIIII, Robert J. Cotter, Sean D. Taverna & Philip A. Cole. (2012) Azalysine Analogues as Probes for Protein Lysine Deacetylation and Demethylation. Journal of the American Chemical Society 134:11, pages 5138-5148.
Crossref
Yao E. Wang, Olivier Pernet & Benhur Lee. (2012) Regulation of the nucleocytoplasmic trafficking of viral and cellular proteins by ubiquitin and small ubiquitin-related modifiers. Biology of the Cell 104:3, pages 121-138.
Crossref
Andrea L. Portbury, Sarah M. Ronnebaum, Makhosazane Zungu, Cam Patterson & Monte S. Willis. (2012) Back to your heart: Ubiquitin proteasome system-regulated signal transduction. Journal of Molecular and Cellular Cardiology 52:3, pages 526-537.
Crossref
W Ma, Y Lin, W Xuan, P L Iversen, L J Smith & S Benchimol. (2011) Inhibition of p53 expression by peptide-conjugated phosphorodiamidate morpholino oligomers sensitizes human cancer cells to chemotherapeutic drugs. Oncogene 31:8, pages 1024-1033.
Crossref
Xiao-Xin Sun, Kishore B Challagundla & Mu-Shui Dai. (2012) Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. The EMBO Journal 31:3, pages 576-592.
Crossref
Monte S. Willis, Andrea Portbury, Sarah Ronnebaum, Makhosazane Zungu, W. H. Davin Townley-Tilson & Cam Patterson. 2012. Translational Cardiology. Translational Cardiology 251 289 .
Yael David, Nicola Ternette, Mariola J. Edelmann, Tamar Ziv, Batya Gayer, Rotem Sertchook, Yakir Dadon, Benedikt M. Kessler & Ami Navon. (2011) E3 Ligases Determine Ubiquitination Site and Conjugate Type by Enforcing Specificity on E2 Enzymes. Journal of Biological Chemistry 286:51, pages 44104-44115.
Crossref
J H Jung, S Bae, J Y Lee, S R Woo, H J Cha, Y Yoon, K-S Suh, S-J Lee, I-C Park, Y-W Jin, K-H Lee, S An & J H Lee. (2011) E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. Cell Death & Differentiation 18:12, pages 1865-1875.
Crossref
Christopher L. Brooks & Wei Gu. (2011) p53 regulation by ubiquitin. FEBS Letters 585:18, pages 2803-2809.
Crossref
Sung-Keum Seo, Hyeon-Ok Jin, Sang-Hyeok Woo, Young-Sun Kim, Sungkwan An, Jae-Ho Lee, Seok-Il Hong, Kee-Ho Lee, Tae-Boo Choe & In-Chul Park. (2011) Histone Deacetylase Inhibitors Sensitize Human Non-small Cell Lung Cancer Cells to Ionizing Radiation Through Acetyl p53-Mediated c-myc Down-Regulation. Journal of Thoracic Oncology 6:8, pages 1313-1319.
Crossref
Yunyuan V. Wang, Mathias Leblanc, Norma Fox, Jian-Hua Mao, Kelsey L. Tinkum, Kurt Krummel, Dannielle Engle, David Piwnica-Worms, Helen Piwnica-Worms, Allan Balmain, Kenneth Kaushansky & Geoffrey M. Wahl. (2011) Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes & Development 25:13, pages 1426-1438.
Crossref
Christopher L. Brooks & Wei Gu. (2011) The impact of acetylation and deacetylation on the p53 pathway. Protein & Cell 2:6, pages 456-462.
Crossref
Toshinori Ozaki & Akira Nakagawara. (2011) Role of p53 in Cell Death and Human Cancers. Cancers 3:1, pages 994-1013.
Crossref
Rachel Damico, Tiffany Simms, Bo S. Kim, Zenar Tekeste, Henry Amankwan, Mahendra Damarla & Paul M. Hassoun. (2011) p53 Mediates Cigarette Smoke–Induced Apoptosis of Pulmonary Endothelial Cells. American Journal of Respiratory Cell and Molecular Biology 44:3, pages 323-332.
Crossref
Hong Wu, Scott L Pomeroy, Manuel Ferreira, Natalia Teider, Juliana Mariani, Keiichi I Nakayama, Shigetsugu Hatakeyama, Victor A Tron, Linda F Saltibus, Leo Spyracopoulos & Roger P Leng. (2011) UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53. Nature Medicine 17:3, pages 347-355.
Crossref
Jonathan Shloush, John E. Vlassov, Ian Engson, Shili Duan, Vivian Saridakis, Sirano Dhe-paganon, Brian Raught, Yi Sheng & Cheryl H. Arrowsmith. (2011) Structural and Functional Comparison of the RING Domains of Two p53 E3 Ligases, Mdm2 and Pirh2. Journal of Biological Chemistry 286:6, pages 4796-4808.
Crossref
M K Lee, W M Tong, Z Q Wang & K Sabapathy. (2010) Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo. Cell Death & Differentiation 18:2, pages 214-221.
Crossref
Toshinori Ozaki & Akira Nakagawara. (2011) p53: The Attractive Tumor Suppressor in the Cancer Research Field. Journal of Biomedicine and Biotechnology 2011, pages 1-13.
Crossref
Jian Liu, Guowu Yu, Yanyan Zhao, Dengpan Zhao, Ying Wang, Lu Wang, Jiang Liu, Lei Li, Yu Zeng, Yongyan Dang, Chuangui Wang, Guang Gao, Weiwen Long, David M. Lonard, Shanlou Qiao, Ming-Jer Tsai, Bianhong Zhang, Honglin Luo & Xiaotao Li. (2010) REGγ modulates p53 activity by regulating its cellular localization. Journal of Cell Science 123:23, pages 4076-4084.
Crossref
Kaori Fujita, Izumi Horikawa, Abdul M. Mondal, Lisa M. Miller Jenkins, Ettore Appella, Borivoj Vojtesek, Jean-Christophe Bourdon, David P. Lane & Curtis C. Harris. (2010) Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence. Nature Cell Biology 12:12, pages 1205-1212.
Crossref
Meike Broemer, Tencho Tenev, Kristoffer T.G. Rigbolt, Sophie Hempel, Blagoy Blagoev, John Silke, Mark Ditzel & Pascal Meier. (2010) Systematic In Vivo RNAi Analysis Identifies IAPs as NEDD8-E3 Ligases. Molecular Cell 40:5, pages 810-822.
Crossref
Y. Zhang, J. Wang, Y. Yuan, W. Zhang, W. Guan, Z. Wu, C. Jin, H. Chen, L. Zhang, X. Yang & F. He. (2010) Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26. Nucleic Acids Research 38:19, pages 6544-6554.
Crossref
Pingli Mo, Hongbo Wang, Hua Lu, Douglas D. Boyd & Chunhong Yan. (2010) MDM2 Mediates Ubiquitination and Degradation of Activating Transcription Factor 3. Journal of Biological Chemistry 285:35, pages 26908-26915.
Crossref
Masha V Poyurovsky, Chen Katz, Oleg Laptenko, Rachel Beckerman, Maria Lokshin, Jinwoo Ahn, In-Ja L Byeon, Ronen Gabizon, Melissa Mattia, Andrew Zupnick, Lewis M Brown, Assaf Friedler & Carol Prives. (2010) The C terminus of p53 binds the N-terminal domain of MDM2. Nature Structural & Molecular Biology 17:8, pages 982-989.
Crossref
Gabriel N Maine, Haiying Li, Iram W Zaidi, Venkatesha Basrur, Kojo S J Elenitoba-Johnson & Ezra Burstein. (2010) A bimolecular affinity purification method under denaturing conditions for rapid isolation of a ubiquitinated protein for mass spectrometry analysis. Nature Protocols 5:8, pages 1447-1459.
Crossref
Hirofumi Noguchi, Masayuki Matsushita, Naoya Kobayashi, Marlon F. Levy & Shinichi Matsumoto. (2010) Recent Advances in Protein Transduction Technology. Cell Transplantation 19:6-7, pages 649-654.
Crossref
Sabire Özcan, Sreenath S. Andrali & Jamie E.L. Cantrell. (2010) Modulation of transcription factor function by O-GlcNAc modification. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1799:5-6, pages 353-364.
Crossref
Jin Hyuk Jung, Sun-Mi Lee, Seunghee Bae, Su-Jae Lee, In-Chul Park, Young-Woo Jin, Jae Ho Lee & Sungkwan An. (2010) Triad 1 induces apoptosis by p53 activation. FEBS Letters 584:8, pages 1565-1570.
Crossref
Kenneth D. Eichenbaum, Yoel Rodríguez, Mihaly Mezei & Roman Osman. (2010) The energetics of the acetylation switch in p53-mediated transcriptional activation. Proteins: Structure, Function, and Bioinformatics 78:2, pages 447-456.
Crossref
Predrag Radivojac, Vladimir Vacic, Chad Haynes, Ross R. Cocklin, Amrita Mohan, Joshua W. Heyen, Mark G. Goebl & Lilia M. Iakoucheva. (2010) Identification, analysis, and prediction of protein ubiquitination sites. Proteins: Structure, Function, and Bioinformatics 78:2, pages 365-380.
Crossref
J T Lee & W Gu. (2009) The multiple levels of regulation by p53 ubiquitination. Cell Death & Differentiation 17:1, pages 86-92.
Crossref
J-C Marine & G Lozano. (2009) Mdm2-mediated ubiquitylation: p53 and beyond. Cell Death & Differentiation 17:1, pages 93-102.
Crossref
Takashi Suzuki, Toru Ezure, Eiji Ando, Osamu Nishimura, Toshihiko Utsumi & Susumu Tsunasawa. (2010) Preparation of ubiquitin-conjugated proteins using an insect cell-free protein synthesis system. Journal of Biotechnology 145:1, pages 73-78.
Crossref
Ayeda Ayed & Theodore HuppJeremy Blaydes. 2010. p53. p53 85 99 .
Dimitris P. Xirodimas & Martin Scheffner. 2010. Conjugation and Deconjugation of Ubiquitin Family Modifiers. Conjugation and Deconjugation of Ubiquitin Family Modifiers 116 135 .
Eun-Woo Lee, Min-Sik Lee, Suzanne Camus, Jaewang Ghim, Mi-Ran Yang, Wonkyung Oh, Nam-Chul Ha, David P Lane & Jaewhan Song. (2009) Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis. The EMBO Journal 28:14, pages 2100-2113.
Crossref
Anita Joubel, Robert J. Chalkley, Katalin F. Medzihradszky, Hubert Hondermarck & Alma L. Burlingame. (2009) Identification of New p53 Acetylation Sites in COS-1 Cells. Molecular & Cellular Proteomics 8:6, pages 1167-1173.
Crossref
Shwu-Yuan Wu & Cheng-Ming Chiang. (2009) Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. The EMBO Journal 28:9, pages 1246-1259.
Crossref
Paola Blanchette & Philip E. Branton. (2009) Manipulation of the ubiquitin–proteasome pathway by small DNA tumor viruses. Virology 384:2, pages 317-323.
Crossref
Chrysoula Daskalogianni, Sébastien Apcher, Marco M. Candeias, Nadia Naski, Fabien Calvo & Robin Fåhraeus. (2008) Gly-Ala Repeats Induce Position- and Substrate-specific Regulation of 26 S Proteasome-dependent Partial Processing. Journal of Biological Chemistry 283:44, pages 30090-30100.
Crossref
Fiona Murray-Zmijewski, Elizabeth A. Slee & Xin Lu. (2008) A complex barcode underlies the heterogeneous response of p53 to stress. Nature Reviews Molecular Cell Biology 9:9, pages 702-712.
Crossref
K Linke, P D Mace, C A Smith, D L Vaux, J Silke & C L Day. (2008) Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans. Cell Death & Differentiation 15:5, pages 841-848.
Crossref
Rong-gang XI, Jian HUANG, Dan LI, Xiao-bo WANG & Li-jun WU. (2008) Roles of PI3-K/Akt pathways in nanoparticle realgar powders-induced apoptosis in U937 cells. Acta Pharmacologica Sinica 29:3, pages 355-363.
Crossref
Anwarul Ferdous, Melissa O’Neal, Kip Nalley, Devanjan Sikder, Thomas Kodadek & Stephen Albert Johnston. (2008) Phosphorylation of the Gal4 DNA-binding domain is essential for activator mono-ubiquitylation and efficient promoter occupancy. Molecular BioSystems 4:11, pages 1116.
Crossref
Roya Khosravi-Far & Eileen WhiteKageaki Kuribayashi & Wafik S. El-Deiry. 2008. Programmed Cell Death in Cancer Progression and Therapy. Programmed Cell Death in Cancer Progression and Therapy 201 221 .
Siu Chiu Chan, Sheng-Cai Lin & Peng Li. (2007) Regulation of Cidea protein stability by the ubiquitin-mediated proteasomal degradation pathway. Biochemical Journal 408:2, pages 259-266.
Crossref
Ha Young Hwang, Joo-Young Kim, Joong-Yeon Lim, Sun-Ku Chung, Jae-Hwan Nam & Sang Ick Park. (2007) Coxsackievirus B3 modulates cell death by downregulating activating transcription factor 3 in HeLa cells. Virus Research 130:1-2, pages 10-17.
Crossref
Jing Li, Yuequn Wang, Xiongwei Fan, Xiaoyang Mo, Zequn Wang, Yongqing Li, Zhaochu Yin, Yun Deng, Na Luo, Chuanbing Zhu, Mingyao Liu, Qian Ma, Karen Ocorr, Wuzhou Yuan & Xiushan Wu. (2007) ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway. Biochemical and Biophysical Research Communications 363:4, pages 895-900.
Crossref
Dimitris P. Xirodimas. 2007. Protein Degradation. Protein Degradation 21 45 .
Jun Zou, Jasna Marjanovic, Marina V. Kisseleva, Monita Wilson & Philip W. Majerus. (2007) Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis. Proceedings of the National Academy of Sciences 104:43, pages 16834-16839.
Crossref
Adriaan D. Bins, Monika C. Wolkers, Marly D. van den Boom, John B. A. G. Haanen & Ton N. M. Schumacher. (2007) In Vivo Antigen Stability Affects DNA Vaccine Immunogenicity. The Journal of Immunology 179:4, pages 2126-2133.
Crossref
Christopher L. Brooks, Muyang Li & Wei Gu. (2007) Mechanistic Studies of MDM2-mediated Ubiquitination in p53 Regulation. Journal of Biological Chemistry 282:31, pages 22804-22815.
Crossref
K Becker, N D Marchenko, M Maurice & U M Moll. (2007) Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma. Cell Death & Differentiation 14:7, pages 1350-1360.
Crossref
T Iwakuma & G Lozano. (2007) Crippling p53 activities via knock-in mutations in mouse models. Oncogene 26:15, pages 2177-2184.
Crossref
Toru Sasaki, Eugene C. Gan, Andrew Wakeham, Sally Kornbluth, Tak W. Mak & Hitoshi Okada. (2007) HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. Genes & Development 21:7, pages 848-861.
Crossref
Masha V Poyurovsky, Christina Priest, Alex Kentsis, Katherine L B Borden, Zhen-Qiang Pan, Nikola Pavletich & Carol Prives. (2006) The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. The EMBO Journal 26:1, pages 90-101.
Crossref
Wassim M. Abida, Anatoly Nikolaev, Wenhui Zhao, Wenzhu Zhang & Wei Gu. (2007) FBXO11 Promotes the Neddylation of p53 and Inhibits Its Transcriptional Activity. Journal of Biological Chemistry 282:3, pages 1797-1804.
Crossref
Geoffrey M. Wahl, Jayne M. Stommel, Kurt Krummel & Mark Wade. 2007. 25 Years of p53 Research. 25 Years of p53 Research 73 113 .
Kristine McKinney & Carol Prives. 2007. 25 Years of p53 Research. 25 Years of p53 Research 27 51 .
Venugopalan D. Nair, Kevin St. P. McNaught, Javier González-Maeso, Stuart C. Sealfon & C. Warren Olanow. (2006) p53 Mediates Nontranscriptional Cell Death in Dopaminergic Cells in Response to Proteasome Inhibition. Journal of Biological Chemistry 281:51, pages 39550-39560.
Crossref
Franck Toledo & Geoffrey M. Wahl. (2006) Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nature Reviews Cancer 6:12, pages 909-923.
Crossref
A Saxena, C J Rorie, D Dimitrova, Y Daniely & J A Borowiec. (2006) Nucleolin inhibits Hdm2 by multiple pathways leading to p53 stabilization. Oncogene 25:55, pages 7274-7288.
Crossref
Ian R. Watson, Alvaro Blanch, Dan C.C. Lin, Michael Ohh & Meredith S. Irwin. (2006) Mdm2-mediated NEDD8 Modification of TAp73 Regulates Its Transactivation Function. Journal of Biological Chemistry 281:45, pages 34096-34103.
Crossref
Laurent Le Cam, Laëtitia K. Linares, Conception Paul, Eric Julien, Matthieu Lacroix, Elodie Hatchi, Robinson Triboulet, Guillaume Bossis, Ayelet Shmueli, Manuel S. Rodriguez, Olivier Coux & Claude Sardet. (2006) E4F1 Is an Atypical Ubiquitin Ligase that Modulates p53 Effector Functions Independently of Degradation. Cell 127:4, pages 775-788.
Crossref
Alicia Salcedo, Federico Mayor & Petronila Penela. (2006) Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. The EMBO Journal 25:20, pages 4752-4762.
Crossref
Won Ho Yang, Ji Eun Kim, Hyung Wook Nam, Jung Won Ju, Hoe Suk Kim, Yu Sam Kim & Jin Won Cho. (2006) Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability. Nature Cell Biology 8:10, pages 1074-1083.
Crossref
Jian Yuan, Wenwen Tang, Kuntian Luo, Xinya Chen, Xiuting Gu, Bo Wan & Long Yu. (2006) Cloning and characterization of the human gene DERP6, which activates transcriptional activities of p53. Molecular Biology Reports 33:3, pages 151-158.
Crossref
Mu-Shui Dai, Yetao Jin, Jayme R. Gallegos & Hua Lu. (2006) Balance of Yin and Yang: Ubiquitylation-Mediated Regulation of p53 and c-Myc. Neoplasia 8:8, pages 630-644.
Crossref
Sue Haupt & Ygal Haupt. (2006) Importance of p53 for cancer onset and therapy. Anti-Cancer Drugs 17:7, pages 725-732.
Crossref
Harumi ShimizuDavid SalibaMaura WallaceLee FinlanPatrick R. R. Langridge-SmithTed R. Hupp. (2006) Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo . Biochemical Journal 397:2, pages 355-367.
Crossref
Agata M. Bogusz, Deanna R. Brickley, Travis Pew & Suzanne D. Conzen. (2006) A novel N-terminal hydrophobic motif mediates constitutive degradation of serum- and glucocorticoid-induced kinase-1 by the ubiquitin-proteasome pathway. FEBS Journal 273:13, pages 2913-2928.
Crossref
O Laptenko & C Prives. (2006) Transcriptional regulation by p53: one protein, many possibilities. Cell Death & Differentiation 13:6, pages 951-961.
Crossref
G M Wahl. (2006) Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo. Cell Death & Differentiation 13:6, pages 973-983.
Crossref

Displaying 200 of 270 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.