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Molecular and Cellular Biology Volume 20, 2000 - Issue 3
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Mammalian Genetic Models with Minimal or Complex Phenotypes

Normal Hematopoiesis and Inflammatory Responses Despite Discrete Signaling Defects in Gα15 Knockout Mice

I. Davignon1 Pharmacology Department, UT Southwestern, DallasTX 75235-9041
,
M. D. Catalina2 Pathology Department, UT Southwestern, DallasTX 75235-9072
,
D. Smith1 Pharmacology Department, UT Southwestern, DallasTX 75235-9041
,
J. Montgomery3 Biology Department, Center for Parasitology, UT Arlington, Arlington, TX76019
,
J. Swantek1 Pharmacology Department, UT Southwestern, DallasTX 75235-9041
,
J. Croy4 Physiology Department, UT Southwestern, DallasTX 75235-9040
,
M. Siegelman2 Pathology Department, UT Southwestern, DallasTX 75235-9072
&
T. M. Wilkie1 Pharmacology Department, UT Southwestern, DallasTX 75235-9041Correspondence[email protected]
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Pages 797-804 | Received 01 Nov 1999, Accepted 04 Nov 1999, Published online: 28 Mar 2023

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J Vidya Sarma & Peter A Ward. (2012) New developments in C5a receptor signaling. Cell Health and Cytoskeleton 4, pages 73-82.
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Masaaki Ishii & Bärbel Rohrer. (2023) Anaphylatoxin C5a receptor signaling induces mitochondrial fusion and sensitizes retinal pigment epithelial cells to oxidative stress. Biochimica et Biophysica Acta (BBA) - General Subjects 1867:8, pages 130374.
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Yudong D. He, Eric M. Wohlford, Florian Uhle, Ljubomir Buturovic, Oliver Liesenfeld & Timothy E. Sweeney. (2021) The Optimization and Biological Significance of a 29-Host-Immune-mRNA Panel for the Diagnosis of Acute Infections and Sepsis. Journal of Personalized Medicine 11:8, pages 735.
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Esther van den Bos, Benjamin Ambrosy, Markus Horsthemke, Stefan Walbaum, Anne C. Bachg, Nina Wettschureck, Giulio Innamorati, Thomas M. Wilkie & Peter J. Hanley. (2020) Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor–mediated chemotaxis. Journal of Biological Chemistry 295:22, pages 7726-7742.
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Frode Selheim, Elise Aasebø, Catalina Ribas & Anna M. Aragay. (2019) An Overview on G Protein-coupled Receptor-induced Signal Transduction in Acute Myeloid Leukemia. Current Medicinal Chemistry 26:28, pages 5293-5316.
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Cédric Boularan & John H. Kehrl. (2014) Implications of non-canonical G-protein signaling for the immune system. Cellular Signalling 26:6, pages 1269-1282.
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Kylie S. Chew, Tiffany M. Schmidt, Alan C. Rupp, Paulo Kofuji & Jeffrey M. Trimarchi. (2014) Loss of Gq/11 Genes Does Not Abolish Melanopsin Phototransduction. PLoS ONE 9:5, pages e98356.
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Manoj Kumar Pandey. (2013) Molecular Basis for Downregulation of C5a-Mediated Inflammation by IgG1 Immune Complexes in Allergy and Asthma. Current Allergy and Asthma Reports 13:6, pages 596-606.
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Yantang Wang, Yan Li & Guixiu Shi. (2013) The Regulating Function of Heterotrimeric G Proteins in the Immune System. Archivum Immunologiae et Therapiae Experimentalis 61:4, pages 309-319.
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Francesco Giovinazzo, Giorgio Malpeli, Sara Zanini, Marco Parenti, Lorenzo Piemonti, Marco Colombatti, Maria Teresa Valenti, Luca Dalle Carbonare, Aldo Scarpa, James Sinnett-Smith, Enrique Rozengurt, Claudio Bassi & Giulio Innamorati. (2013) Ectopic expression of the heterotrimeric G15 protein in pancreatic carcinoma and its potential in cancer signal transduction. Cellular Signalling 25:3, pages 651-659.
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Andreas Klos, Elisabeth Wende, Kathryn J. Wareham & Peter N. Monk. (2013) International Union of Basic and Clinical Pharmacology. LXXXVII. Complement Peptide C5a, C4a, and C3a Receptors. Pharmacological Reviews 65:1, pages 500-543.
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Lawrence F. Brass, Debra K. Newman, Kenneth M. Wannermacher, Li Zhu & Timothy J. Stalker. 2013. Platelets. Platelets 367 398 .
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Stefan Offermanns. 2012. G Protein-Coupled Receptors. G Protein-Coupled Receptors 125 144 .
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Jacob Ngai, Trond Methi, Kjetil Wessel Andressen, Finn Olav Levy, Knut Martin Torgersen, Torkel Vang, Nina Wettschureck & Kjetil Taskén. (2008) The heterotrimeric G-protein α-subunit Gαq regulates TCR-mediated immune responses through an Lck-dependent pathway. European Journal of Immunology 38:11, pages 3208-3218.
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Tamara I.A. Roach, Robert A. Rebres, Iain D.C. Fraser, Dianne L. DeCamp, Keng-Mean Lin, Paul C. Sternweis, Mel I. Simon & William E. Seaman. (2008) Signaling and Cross-talk by C5a and UDP in Macrophages Selectively Use PLCβ3 to Regulate Intracellular Free Calcium. Journal of Biological Chemistry 283:25, pages 17351-17361.
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Lawrence F. Brass, Timothy J. Stalker, Li Zhu & Donna S. Woulfe. 2007. Platelets. Platelets 319 346 .
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Katherine B. Hubbard & John R. Hepler. (2006) Cell signalling diversity of the Gqα family of heterotrimeric G proteins. Cellular Signalling 18:2, pages 135-150.
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Peter J. Atkinson, Kenneth W. Young, Steven J. Ennion, James N. C. Kew, Stefan R. Nahorski & R. A. John Challiss. (2006) Altered Expression of G q/11 α Protein Shapes mGlu1 and mGlu5 Receptor-Mediated Single Cell Inositol 1,4,5-Trisphosphate and Ca 2+ Signaling . Molecular Pharmacology 69:1, pages 174-184.
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Nina Wettschureck & Stefan Offermanns. (2005) Mammalian G Proteins and Their Cell Type Specific Functions. Physiological Reviews 85:4, pages 1159-1204.
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Reinhold E. Schmidt & J. Engelbert Gessner. (2005) Fc receptors and their interaction with complement in autoimmunity. Immunology Letters 100:1, pages 56-67.
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Julia Skokowa, Syed R. Ali, Olga Felda, Varsha Kumar, Stephanie Konrad, Nelli Shushakova, Reinhold E. Schmidt, Roland P. Piekorz, Bernd Nürnberg, Karsten Spicher, Lutz Birnbaumer, Jörg Zwirner, Jill W. C. Claassens, Josef S. Verbeek, Nico van Rooijen, Jörg Köhl & J. Engelbert Gessner. (2005) Macrophages Induce the Inflammatory Response in the Pulmonary Arthus Reaction through Gαi2 Activation That Controls C5aR and Fc Receptor Cooperation. The Journal of Immunology 174:5, pages 3041-3050.
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Nina Wettschureck, Alexandra Moers & Stefan Offermanns. (2004) Mouse models to study G-protein-mediated signaling. Pharmacology & Therapeutics 101:1, pages 75-89.
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Jennifer L. Gu, Wei Lu, Chunzhi Xia, Xiushan Wu & Mingyao Liu. (2003) Regulation of hematopoietic-specific G-protein G?15 and G?16 by protein kinase C. Journal of Cellular Biochemistry 88:6, pages 1101-1111.
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