Molecular and Cellular Biology, Volume 20, Issue 3 (2000)

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Molecular and Cellular Biology, Volume 20, Issue 3 (2000)

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Cell Growth and Development

Article
Stimulation of p53 DNA Binding by c-Abl Requires the p53 C Terminus and Tetramerization
Ying Nie, Heng-Hong Li, Craig M. Bula & Xuan Liu
Pages: 741-748
Published online: 28 Mar 2023
AbstractforStimulation of p53 DNA Binding by c-Abl Requires the p53 C Terminus and Tetramerization | Full Text | References | PDF (1.3 MB)
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Article
Cdc37 Promotes the Stability of Protein Kinases Cdc28 and Cak1
Alison Farrell & David O. Morgan
Pages: 749-754
Published online: 28 Mar 2023
AbstractforCdc37 Promotes the Stability of Protein Kinases Cdc28 and Cak1 | Full Text | References | PDF (666.3 KB)
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Article
p53 Mutants Have Selective Dominant-Negative Effects on Apoptosis but Not Growth Arrest in Human Cancer Cell Lines
Oscar N. Aurelio, Xiao-Tang Kong, Swati Gupta & Eric J. Stanbridge
Pages: 770-778
Published online: 28 Mar 2023
Abstractforp53 Mutants Have Selective Dominant-Negative Effects on Apoptosis but Not Growth Arrest in Human Cancer Cell Lines | Full Text | References | PDF (358.6 KB)
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Article
Sequential Regulation of the Small GTPase Rap1 in Human Platelets
Barbara Franke, Miranda van Triest, Kim M. T. de Bruijn, Gijsbert van Willigen, H. Karel Nieuwenhuis, Claude Negrier, Jan-Willem N. Akkerman & Johannes L. Bos
Pages: 779-785
Published online: 28 Mar 2023
AbstractforSequential Regulation of the Small GTPase Rap1 in Human Platelets | Full Text | References | PDF (1.8 MB)
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Article
The Cbl Proto-Oncogene Product Negatively Regulates the Src-Family Tyrosine Kinase Fyn by Enhancing Its Degradation
Christopher E. Andoniou, Nancy L. Lill, Christine B. Thien, Mark L. Lupher Jr., Satoshi Ota, David D. L. Bowtell, Robin M. Scaife, Wallace Y. Langdon & Hamid Band
Pages: 851-867
Published online: 28 Mar 2023
AbstractforThe Cbl Proto-Oncogene Product Negatively Regulates the Src-Family Tyrosine Kinase Fyn by Enhancing Its Degradation | Full Text | References | PDF (3.2 MB)
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Article
Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane
Robert Eskes, Solange Desagher, Bruno Antonsson & Jean-Claude Martinou
Pages: 929-935
Published online: 28 Mar 2023
AbstractforBid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane | Full Text | References | PDF (976.5 KB)
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Article
Activation of p38 Mitogen-Activated Protein Kinase In Vivo Selectively Induces Apoptosis of CD8+ but Not CD4+ T Cells
Chris Merritt, Hervé Enslen, Nicole Diehl, Dietrich Conze, Roger J. Davis & Mercedes Rincón
Pages: 936-946
Published online: 28 Mar 2023
AbstractforActivation of p38 Mitogen-Activated Protein Kinase In Vivo Selectively Induces Apoptosis of CD8+ but Not CD4+ T Cells | Full Text | References | PDF (791.9 KB)
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Article
Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains
Min Chen, Alan Cheng, Fabio Candotti, Yong-Jie Zhou, Anka Hymel, Anders Fasth, Luigi D. Notarangelo & John J. O'Shea
Pages: 947-956
Published online: 28 Mar 2023
AbstractforComplex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains | Full Text | References | PDF (1.5 MB)
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Article
RIM101-Dependent and -Independent Pathways Govern pH Responses in Candida albicans
Dana Davis, R. Bryce Wilson & Aaron P. Mitchell
Pages: 971-978
Published online: 28 Mar 2023
AbstractforRIM101-Dependent and -Independent Pathways Govern pH Responses in Candida albicans | Full Text | References | PDF (823 KB)
  • 63 Views
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Article
FRS2 Proteins Recruit Intracellular Signaling Pathways by Binding to Diverse Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors
S. H. Ong, G. R. Guy, Y. R. Hadari, S. Laks, N. Gotoh, J. Schlessinger & I. Lax
Pages: 979-989
Published online: 28 Mar 2023
AbstractforFRS2 Proteins Recruit Intracellular Signaling Pathways by Binding to Diverse Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors | Full Text | References | PDF (1.2 MB)
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Article
MdmX Protects p53 from Mdm2-Mediated Degradation
Mark W. Jackson & Steven J. Berberich
Pages: 1001-1007
Published online: 28 Mar 2023
AbstractforMdmX Protects p53 from Mdm2-Mediated Degradation | Full Text | References | PDF (1.9 MB)
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Article
CREB Activation Induces Adipogenesis in 3T3-L1 Cells
Jane E. B. Reusch, Lilliester A. Colton & Dwight J. Klemm
Pages: 1008-1020
Published online: 28 Mar 2023
AbstractforCREB Activation Induces Adipogenesis in 3T3-L1 Cells | Full Text | References | PDF (2 MB)
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Article
PR48, a Novel Regulatory Subunit of Protein Phosphatase 2A, Interacts with Cdc6 and Modulates DNA Replication in Human Cells
Zhen Yan, Sergei A. Fedorov, Marc C. Mumby & R. Sanders Williams
Pages: 1021-1029
Published online: 28 Mar 2023
AbstractforPR48, a Novel Regulatory Subunit of Protein Phosphatase 2A, Interacts with Cdc6 and Modulates DNA Replication in Human Cells | Full Text | References | PDF (997 KB)
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Article
Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3
Nyaya Kelkar, Shashi Gupta, Martin Dickens & Roger J. Davis
Pages: 1030-1043
Published online: 28 Mar 2023
AbstractforInteraction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3 | Full Text | References | PDF (2.7 MB)
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Article
Death-Associated Protein Kinase-Related Protein 1, a Novel Serine/Threonine Kinase Involved in Apoptosis
Boaz Inbal, Gidi Shani, Ofer Cohen, Joseph L. Kissil & Adi Kimchi
Pages: 1044-1054
Published online: 28 Mar 2023
AbstractforDeath-Associated Protein Kinase-Related Protein 1, a Novel Serine/Threonine Kinase Involved in Apoptosis | Full Text | References | PDF (4.3 MB)
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Article
Bag1 Functions In Vivo as a Negative Regulator of Hsp70 Chaperone Activity
Ellen A. A. Nollen, Jeanette F. Brunsting, Jaewhan Song, Harm H. Kampinga & Richard I. Morimoto
Pages: 1083-1088
Published online: 28 Mar 2023
AbstractforBag1 Functions In Vivo as a Negative Regulator of Hsp70 Chaperone Activity | Full Text | References | PDF (1.1 MB)
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Mammalian Genetic Models With Minimal Or Complex Phenotypes

Article
Normal Development, Wound Healing, and Adenovirus Susceptibility in β5-Deficient Mice
Xiaozhu Huang, Mark Griffiths, Jianfeng Wu, Robert V. Farese Jr. & Dean Sheppard
Pages: 755-759
Published online: 28 Mar 2023
AbstractforNormal Development, Wound Healing, and Adenovirus Susceptibility in β5-Deficient Mice | Full Text | References | PDF (277.9 KB)
  • 25 Views
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Article
Normal Hematopoiesis and Inflammatory Responses Despite Discrete Signaling Defects in Gα15 Knockout Mice
I. Davignon, M. D. Catalina, D. Smith, J. Montgomery, J. Swantek, J. Croy, M. Siegelman & T. M. Wilkie
Pages: 797-804
Published online: 28 Mar 2023
AbstractforNormal Hematopoiesis and Inflammatory Responses Despite Discrete Signaling Defects in Gα15 Knockout Mice | Full Text | References | PDF (623.8 KB)
  • 19 Views
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Article
Targeted Deletion of the tub Mouse Obesity Gene Reveals that tubby Is a Loss-of-Function Mutation
Hilde Stubdal, Catherine A. Lynch, Ann Moriarty, Qing Fang, Troy Chickering, James D. Deeds, Victoria Fairchild-Huntress, Olga Charlat, Judy H. Dunmore, Patrick Kleyn, Dennis Huszar & Rosana Kapeller
Pages: 878-882
Published online: 28 Mar 2023
AbstractforTargeted Deletion of the tub Mouse Obesity Gene Reveals that tubby Is a Loss-of-Function Mutation | Full Text | References | PDF (693.1 KB)
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Article
Peri-Implantation Lethality in Mice Lacking the Sm Motif-Containing Protein Lsm4
Emilio Hirsch, Toshitaka Oohashi, Marianne Ahmad, Stefan Stamm & Reinhard Fässler
Pages: 1055-1062
Published online: 28 Mar 2023
AbstractforPeri-Implantation Lethality in Mice Lacking the Sm Motif-Containing Protein Lsm4 | Full Text | References | PDF (2.6 MB)
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Article
Targeted Disruption of Mouse Fibroblast Activation Protein
J. Niedermeyer, M. Kriz, F. Hilberg, P. Garin-Chesa, U. Bamberger, M. C. Lenter, J. Park, B. Viertel, H. Püschner, M. Mauz, W. J. Rettig & A. Schnapp
Pages: 1089-1094
Published online: 28 Mar 2023
AbstractforTargeted Disruption of Mouse Fibroblast Activation Protein | Full Text | References | PDF (1.9 MB)
  • 137 Views
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Gene Expression

Article
HuR Regulates p21 mRNA Stabilization by UV Light
Wengong Wang, Henry Furneaux, Huiming Cheng, M. Craig Caldwell, Dorothy Hutter, Yusen Liu, Nikki Holbrook & Myriam Gorospe
Pages: 760-769
Published online: 28 Mar 2023
AbstractforHuR Regulates p21 mRNA Stabilization by UV Light | Full Text | References | PDF (4 MB)
  • 92 Views
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Article
Tight Control of Respiration by NADH Dehydrogenase ND5 Subunit Gene Expression in Mouse Mitochondria
Yidong Bai, Rebecca M. Shakeley & Giuseppe Attardi
Pages: 805-815
Published online: 28 Mar 2023
AbstractforTight Control of Respiration by NADH Dehydrogenase ND5 Subunit Gene Expression in Mouse Mitochondria | Full Text | References | PDF (914.6 KB)
  • 38 Views
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Article
Biochemical and Genetic Conservation of Fission Yeast Dsk1 and Human SR Protein-Specific Kinase 1
Zhaohua Tang, Tiffany Kuo, Jenny Shen & Ren-Jang Lin
Pages: 816-824
Published online: 28 Mar 2023
AbstractforBiochemical and Genetic Conservation of Fission Yeast Dsk1 and Human SR Protein-Specific Kinase 1 | Full Text | References | PDF (2.7 MB)
  • 17 Views
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Article
The Properties of a tRNA-Specific Adenosine Deaminase from Drosophila melanogaster Support an Evolutionary Link between Pre-mRNA Editing and tRNA Modification
Liam P. Keegan, André P. Gerber, Jim Brindle, Ronny Leemans, Angela Gallo, Walter Keller & Mary A. O'Connell
Pages: 825-833
Published online: 28 Mar 2023
AbstractforThe Properties of a tRNA-Specific Adenosine Deaminase from Drosophila melanogaster Support an Evolutionary Link between Pre-mRNA Editing and tRNA Modification | Full Text | References | PDF (727.3 KB)
  • 51 Views
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Article
A Composite Polyadenylation Signal with TATA Box Function
Nir Paran, Assaf Ori, Izhak Haviv & Yosef Shaul
Pages: 834-841
Published online: 28 Mar 2023
AbstractforA Composite Polyadenylation Signal with TATA Box Function | Full Text | References | PDF (743.6 KB)
  • 25 Views
  • 12 CrossRef citations
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Article
Trypanosoma brucei Guide RNA Poly(U) Tail Formation Is Stabilized by Cognate mRNA
Michael T. McManus, Brian K. Adler, Victoria W. Pollard & Stephen L. Hajduk
Pages: 883-891
Published online: 28 Mar 2023
AbstractforTrypanosoma brucei Guide RNA Poly(U) Tail Formation Is Stabilized by Cognate mRNA | Full Text | References | PDF (1.4 MB)
  • 7 Views
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Article
The Regulator of the Yeast Proline Utilization Pathway Is Differentially Phosphorylated in Response to the Quality of the Nitrogen Source
Hoching L. Huang & Marjorie C. Brandriss
Pages: 892-899
Published online: 28 Mar 2023
AbstractforThe Regulator of the Yeast Proline Utilization Pathway Is Differentially Phosphorylated in Response to the Quality of the Nitrogen Source | Full Text | References | PDF (467.6 KB)
  • 13 Views
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Article
Exonic Splicing Enhancer Motif Recognized by Human SC35 under Splicing Conditions
Hong-Xiang Liu, Shern L. Chew, Luca Cartegni, Michael Q. Zhang & Adrian R. Krainer
Pages: 1063-1071
Published online: 28 Mar 2023
AbstractforExonic Splicing Enhancer Motif Recognized by Human SC35 under Splicing Conditions | Full Text | References | PDF (1.5 MB)
  • 57 Views
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Dna Dynamics and Chromosome Structure

Article
The Function of DNA Polymerase α at Telomeric G Tails Is Important for Telomere Homeostasis
Aegina Adams Martin, Isabelle Dionne, Raymund J. Wellinger & Connie Holm
Pages: 786-796
Published online: 28 Mar 2023
AbstractforThe Function of DNA Polymerase α at Telomeric G Tails Is Important for Telomere Homeostasis | Full Text | References | PDF (3 MB)
  • 17 Views
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Article
Modulated Binding of SATB1, a Matrix Attachment Region Protein, to the AT-Rich Sequence Flanking the Major Breakpoint Region of BCL2
Meera Ramakrishnan, Wen-Man Liu, Patricia A. DiCroce, Aleza Posner, Jian Zheng, Terumi Kohwi-Shigematsu & Theodore G. Krontiris
Pages: 868-877
Published online: 28 Mar 2023
AbstractforModulated Binding of SATB1, a Matrix Attachment Region Protein, to the AT-Rich Sequence Flanking the Major Breakpoint Region of BCL2 | Full Text | References | PDF (2.8 MB)
  • 8 Views
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Article
Triple-Helix Formation Induces Recombination in Mammalian Cells via a Nucleotide Excision Repair-Dependent Pathway
A. Fawad Faruqi, Hirock J. Datta, Dana Carroll, Michael M. Seidman & Peter M. Glazer
Pages: 990-1000
Published online: 28 Mar 2023
AbstractforTriple-Helix Formation Induces Recombination in Mammalian Cells via a Nucleotide Excision Repair-Dependent Pathway | Full Text | References | PDF (383.5 KB)
  • 34 Views
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Transcriptional Regulation

Article
Dynamic Analysis of Proviral Induction and De Novo Methylation: Implications for a Histone Deacetylase-Independent, Methylation Density-Dependent Mechanism of Transcriptional Repression
Matthew C. Lorincz, Dirk Schübeler, Scott C. Goeke, Mark Walters, Mark Groudine & David I. K. Martin
Pages: 842-850
Published online: 28 Mar 2023
AbstractforDynamic Analysis of Proviral Induction and De Novo Methylation: Implications for a Histone Deacetylase-Independent, Methylation Density-Dependent Mechanism of Transcriptional Repression | Full Text | References | PDF (732.8 KB)
  • 20 Views
  • 96 CrossRef citations
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Article
The Homeodomain of PDX-1 Mediates Multiple Protein-Protein Interactions in the Formation of a Transcriptional Activation Complex on the Insulin Promoter
Kinuko Ohneda, Raghavendra G. Mirmira, Juehu Wang, Jeffrey D. Johnson & Michael S. German
Pages: 900-911
Published online: 28 Mar 2023
AbstractforThe Homeodomain of PDX-1 Mediates Multiple Protein-Protein Interactions in the Formation of a Transcriptional Activation Complex on the Insulin Promoter | Full Text | References | PDF (3.4 MB)
  • 16 Views
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Article
Tumor Necrosis Factor Alpha Inhibits Type I Collagen Synthesis through Repressive CCAAT/Enhancer-Binding Proteins
Patricia Greenwel, Shizuko Tanaka, Dmitri Penkov, Wen Zhang, Michelle Olive, Jonathan Moll, Charles Vinson, Maurizio Di Liberto & Francesco Ramirez
Pages: 912-918
Published online: 28 Mar 2023
AbstractforTumor Necrosis Factor Alpha Inhibits Type I Collagen Synthesis through Repressive CCAAT/Enhancer-Binding Proteins | Full Text | References | PDF (1.5 MB)
  • 34 Views
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Article
Mutations in Host Cell Factor 1 Separate Its Role in Cell Proliferation from Recruitment of VP16 and LZIP
Shahana S. Mahajan & Angus C. Wilson
Pages: 919-928
Published online: 28 Mar 2023
AbstractforMutations in Host Cell Factor 1 Separate Its Role in Cell Proliferation from Recruitment of VP16 and LZIP | Full Text | References | PDF (1.1 MB)
  • 32 Views
  • 23 CrossRef citations
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Article
Orphan Receptor COUP-TF Is Required for Induction of Retinoic Acid Receptor β, Growth Inhibition, and Apoptosis by Retinoic Acid in Cancer Cells
Bingzhen Lin, Guo-quan Chen, Dongmei Xiao, Siva Kumar Kolluri, Xihua Cao, Hong Su & Xiao-kun Zhang
Pages: 957-970
Published online: 28 Mar 2023
AbstractforOrphan Receptor COUP-TF Is Required for Induction of Retinoic Acid Receptor β, Growth Inhibition, and Apoptosis by Retinoic Acid in Cancer Cells | Full Text | References | PDF (2.5 MB)
  • 33 Views
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Article
Covalent Modification of the Transcriptional Repressor Tramtrack by the Ubiquitin-Related Protein Smt3 in Drosophila Flies
François Lehembre, Paul Badenhorst, Stefan Müller, Andrew Travers, François Schweisguth & Anne Dejean
Pages: 1072-1082
Published online: 28 Mar 2023
AbstractforCovalent Modification of the Transcriptional Repressor Tramtrack by the Ubiquitin-Related Protein Smt3 in Drosophila Flies | Full Text | References | PDF (3.6 MB)
  • 29 Views
  • 80 CrossRef citations
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