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Read on this site (8)
Xavier Thomas & Maël Heiblig. (2016) The development of agents targeting the BCR-ABL tyrosine kinase as Philadelphia chromosome-positive acute lymphoblastic leukemia treatment. Expert Opinion on Drug Discovery 11:11, pages 1061-1070.
Read now
Read now
Qiangui Bu, Lijing Cui, Juan Li, Xin Du, Waiyi Zou, Ke Ding & Jingxuan Pan. (2014) SAHA and S116836, a novel tyrosine kinase inhibitor, synergistically induce apoptosis in imatinib-resistant chronic myelogenous leukemia cells. Cancer Biology & Therapy 15:7, pages 951-962.
Read now
Read now
Manabu Kurokawa, Chen Zhao, Tannishtha Reya & Sally Kornbluth. (2008) Inhibition of Apoptosome Formation by Suppression of Hsp90β Phosphorylation in Tyrosine Kinase-Induced Leukemias. Molecular and Cellular Biology 28:17, pages 5494-5506.
Read now
Read now
Shu-yue Ren, Elisabeth Bolton, M. Golam Mohi, Andrea Morrione, Benjamin G. Neel & Tomasz Skorski. (2005) Phosphatidylinositol 3-Kinase p85α Subunit-Dependent Interaction with BCR/ABL-Related Fusion Tyrosine Kinases: Molecular Mechanisms and Biological Consequences. Molecular and Cellular Biology 25:18, pages 8001-8008.
Read now
Read now
I Szumiel. (2005) L5178Y sublines: a look back from 40 years. Part 2: Response to ionizing radiation. International Journal of Radiation Biology 81:5, pages 353-365.
Read now
Read now
Shaoguang Li. (2005) Src kinases as targets for Bcell acute lymphoblastic leukaemia therapy. Expert Opinion on Therapeutic Targets 9:2, pages 329-341.
Read now
Read now
Paula B. Deming, Zachary T. Schafer, Jessica S. Tashker, Malia B. Potts, Mohanish Deshmukh & Sally Kornbluth. (2004) Bcr-Abl-Mediated Protection from Apoptosis Downstream of Mitochondrial Cytochrome c Release. Molecular and Cellular Biology 24:23, pages 10289-10299.
Read now
Read now
Géraldine Guasch, Vincent Ollendorff, Jean-Paul Borg, Daniel Birnbaum & Marie-Josèphe Pébusque. (2001) 8p12 Stem Cell Myeloproliferative Disorder: the FOP-Fibroblast Growth Factor Receptor 1 Fusion Protein of the t(6;8) Translocation Induces Cell Survival Mediated by Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt/mTOR Pathways. Molecular and Cellular Biology 21:23, pages 8129-8142.
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Articles from other publishers (120)
Gabriela Brumatti, Deeksha Kaloni, Fabíola Attié Castro & Gustavo P. Amarante-Mendes. (2023) BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia. Biochemical Journal 480:2, pages 161-176.
Crossref
Crossref
John C. Reed. 2017. Holland‐Frei Cancer Medicine. Holland‐Frei Cancer Medicine
1
16
.
Sameer Ahmad Guru, Mamta Pervin Sumi, Rashid Mir, Mirza Masroor Ali Beg, Bidhan Chandra koner & Alpana Saxena. (2022) Aberrant hydroxymethylation in promoter CpG regions of genes related to the cell cycle and apoptosis characterizes advanced chronic myeloid leukemia disease, poor imatinib respondents and poor survival. BMC Cancer 22:1.
Crossref
Crossref
Gustavo P. Amarante-Mendes, Aamir Rana, Tarcila Santos Datoguia, Nelson Hamerschlak & Gabriela Brumatti. (2022) BCR-ABL1 Tyrosine Kinase Complex Signaling Transduction: Challenges to Overcome Resistance in Chronic Myeloid Leukemia. Pharmaceutics 14:1, pages 215.
Crossref
Crossref
Enrico Bracco, M. Shahzad Ali, Stefano Magnati & Giuseppe Saglio. 2021. Advances in Precision Medicine Oncology. Advances in Precision Medicine Oncology.
Naranie Shanmuganathan, Bradley Chereda & Junia V. Melo. 2021. Chronic Myeloid Leukemia. Chronic Myeloid Leukemia
17
36
.
Ngoc-Linh-Chi Bui, Vijay Pandey, Tao Zhu, Lan Ma, Basappa & Peter E. Lobie. (2018) Bad phosphorylation as a target of inhibition in oncology. Cancer Letters 415, pages 177-186.
Crossref
Crossref
Bei Jin, Chengyan Wang, Yingying Shen & Jingxuan Pan. (2018) Anthelmintic niclosamide suppresses transcription of BCR-ABL fusion oncogene via disabling Sp1 and induces apoptosis in imatinib-resistant CML cells harboring T315I mutant. Cell Death & Disease 9:2.
Crossref
Crossref
Qiaoli Zheng, Jiang Cao, Nada Hamad, Hyeoung-Joon Kim, Joon Ho Moon, Sang Kyun Sohn, Chul Won Jung, Jeffrey H. Lipton & Dennis Dong Hwan Kim. (2016) Single nucleotide polymorphisms in apoptosis pathway are associated with response to imatinib therapy in chronic myeloid leukemia. Journal of Translational Medicine 14:1.
Crossref
Crossref
Mohamed A. M. Ali. (2016) Chronic Myeloid Leukemia in the Era of Tyrosine Kinase Inhibitors: An Evolving Paradigm of Molecularly Targeted Therapy. Molecular Diagnosis & Therapy 20:4, pages 315-333.
Crossref
Crossref
C M Lucas, M Milani, M Butterworth, N Carmell, L J Scott, R E Clark, G M Cohen & S Varadarajan. (2016) High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia. Leukemia 30:6, pages 1273-1281.
Crossref
Crossref
Bradley Chereda & Junia V. Melo. 2016. Chronic Myeloid Leukemia. Chronic Myeloid Leukemia
17
39
.
Ran Cao, Yanli Wang & Niu Huang. (2015) Discovery of 2-Acylaminothiophene-3-Carboxamides as Multitarget Inhibitors for BCR-ABL Kinase and Microtubules. Journal of Chemical Information and Modeling 55:11, pages 2435-2442.
Crossref
Crossref
Ting Song, Gaobo Chai, Yubo Liu, Mingzhou Xie, Qingbin Chen, Xiaoyan Yu, Hongkun Sheng & Zhichao Zhang. (2015) Mechanism of synergy of BH3 mimetics and paclitaxel in chronic myeloid leukemia cells: Mcl-1 inhibition. European Journal of Pharmaceutical Sciences 70, pages 64-71.
Crossref
Crossref
Bradley Chereda & Junia V. Melo. (2015) Natural course and biology of CML. Annals of Hematology 94:S2, pages 107-121.
Crossref
Crossref
Hong-Bin Xu, Lu-Zhong Xu, Xia-Ping Mao & Jun Fu. (2014) Guggulsterone of Commiphora mukul resin reverses drug resistance in imatinib-resistant leukemic cells by inhibiting cyclooxygenase-2 and P-glycoprotein. Phytomedicine 21:7, pages 1004-1009.
Crossref
Crossref
Christine Victoria Ichim. (2014) Kinase-Independent Mechanisms of Resistance of Leukemia Stem Cells to Tyrosine Kinase Inhibitors. Stem Cells Translational Medicine 3:4, pages 405-415.
Crossref
Crossref
Zheng-Lan Huang, Miao Gao, Qian-Yin Li, Kun Tao, Qing Xiao, Wei-Xi Cao & Wen-Li Feng. (2013) Induction of apoptosis by directing oncogenic Bcr-Abl into the nucleus. Oncotarget 4:12, pages 2249-2260.
Crossref
Crossref
Cesarina Giallongo, Piera La Cava, Daniele Tibullo, Ignazio Barbagallo, Nunziatina Parrinello, Alessandra Cupri, Fabio Stagno, Carla Consoli, Annalisa Chiarenza, Giuseppe A Palumbo & Francesco Di Raimondo. (2013) SPARC expression in CML is associated to imatinib treatment and to inhibition of leukemia cell proliferation. BMC Cancer 13:1.
Crossref
Crossref
J G Harb, P Neviani, B J Chyla, J J Ellis, G J Ferenchak, J J Oaks, C J Walker, P Hokland, D C Roy, M A Caligiuri, G Marcucci, C S Huettner & D Perrotti. (2013) Bcl-xL anti-apoptotic network is dispensable for development and maintenance of CML but is required for disease progression where it represents a new therapeutic target. Leukemia 27:10, pages 1996-2005.
Crossref
Crossref
Haojian Zhang & Shaoguang Li. (2013) Molecular mechanisms for survival regulation of chronic myeloid leukemia stem cells. Protein & Cell 4:3, pages 186-196.
Crossref
Crossref
Da-Wei Lin, Benjamin P. Chung & Peter Kaiser. (2013) S-adenosylmethionine limitation induces p38 mitogen activated protein kinase and triggers cell cycle arrest in G1. Journal of Cell Science.
Crossref
Crossref
Daniela Antunes Montani, Fernanda Bertuccez Cordeiro, Thaís Regiani, Amanda Begati Victorino, Eduardo Jorge Pilau, Fábio Cesar Gozzo, Christina Ramires Ferreira, Renato Fraietta & Edson Guimarães Lo Turco. (2012) The follicular microenviroment as a predictor of pregnancy: MALDI-TOF MS lipid profile in cumulus cells. Journal of Assisted Reproduction and Genetics 29:11, pages 1289-1297.
Crossref
Crossref
Flora Tzifi, Christina Economopoulou, Dimitrios Gourgiotis, Alexandros Ardavanis, Sotirios Papageorgiou & Andreas Scorilas. (2012) The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias. Advances in Hematology 2012, pages 1-15.
Crossref
Crossref
Michael A. Dengler, Annette M. Staiger, Matthias Gutekunst, Ute Hofmann, Malgorzata Doszczak, Peter Scheurich, Matthias Schwab, Walter E. Aulitzky & Heiko van der Kuip. (2011) Oncogenic Stress Induced by Acute Hyper-Activation of Bcr-Abl Leads to Cell Death upon Induction of Excessive Aerobic Glycolysis. PLoS ONE 6:9, pages e25139.
Crossref
Crossref
S. Wilson. 2011. New Agents for the Treatment of Acute Lymphoblastic Leukemia. New Agents for the Treatment of Acute Lymphoblastic Leukemia
203
219
.
Antonio Valeri, Maria Eugenia Alonso-Ferrero, Paula Río, María Roser Pujol, José A. Casado, Laura Pérez, Ariana Jacome, Xabier Agirre, Maria José Calasanz, Helmut Hanenberg, Jordi Surrallés, Felipe Prosper, Beatriz Albella & Juan A. Bueren. (2010) Bcr/Abl Interferes with the Fanconi Anemia/BRCA Pathway: Implications in the Chromosomal Instability of Chronic Myeloid Leukemia Cells. PLoS ONE 5:12, pages e15525.
Crossref
Crossref
Olga Sala‐Torra & Jerald P. Radich. 2010. Leukemias: Principles and Practice of Therapy. Leukemias: Principles and Practice of Therapy
228
243
.
Zainab Jagani, Keli Song, Jeffery L. Kutok, M. Rajan Dewar, Armelle Melet, Tanya Santos, Alexandra Grassian, Saghi Ghaffari, Catherine Wu, Ruibao Ren, Heather Yeckes Rodin, Kenneth Miller & Roya Khosravi-Far. (2009) Proteasome Inhibition Causes Regression of Leukemia and Abrogates BCR-ABL–Induced Evasion of Apoptosis in Part through Regulation of Forkhead Tumor Suppressors. Cancer Research 69:16, pages 6546-6555.
Crossref
Crossref
Junya Kuroda & Masafumi Taniwaki. (2009) Involvement of BH3-only proteins in hematologic malignancies. Critical Reviews in Oncology/Hematology 71:2, pages 89-101.
Crossref
Crossref
Lori A. Hazlehurst, Nadine N. BewryRajesh R. Nair & Javier Pinilla-Ibarz. (2009) Signaling Networks Associated with BCR–ABL–Dependent Transformation. Cancer Control 16:2, pages 100-107.
Crossref
Crossref
T Pene-Dumitrescu, L F Peterson, N J Donato & T E Smithgall. (2008) An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259. Oncogene 27:56, pages 7055-7069.
Crossref
Crossref
Jean E. Vance. (2008) Thematic Review Series: Glycerolipids. Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids. Journal of Lipid Research 49:7, pages 1377-1387.
Crossref
Crossref
Kalle M. Arunasree, Karnati R. Roy, Kotha Anilkumar, A. Aparna, Gorla Venkateswara Reddy & Pallu Reddanna. (2008) Imatinib-resistant K562 cells are more sensitive to celecoxib, a selective COX-2 inhibitor: Role of COX-2 and MDR-1. Leukemia Research 32:6, pages 855-864.
Crossref
Crossref
Michael Savona & Moshe Talpaz. (2008) Getting to the stem of chronic myeloid leukaemia. Nature Reviews Cancer 8:5, pages 341-350.
Crossref
Crossref
Hee-Yong Kim. (2008) Biochemical and biological functions of docosahexaenoic acid in the nervous system: modulation by ethanol. Chemistry and Physics of Lipids 153:1, pages 34-46.
Crossref
Crossref
H Konig, M Holtz, H Modi, P Manley, T L Holyoake, S J Forman & R Bhatia. (2008) Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors. Leukemia 22:4, pages 748-755.
Crossref
Crossref
Zainab Jagani, Amrik Singh & Roya Khosravi-Far. (2008) FoxO tumor suppressors and BCR–ABL-induced leukemia: A matter of evasion of apoptosis. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1785:1, pages 63-84.
Crossref
Crossref
VICTORIA EMUSS & RICHARD MARAIS. 2008. Cancer Drug Design and Discovery. Cancer Drug Design and Discovery
382
402
.
Shaoguang Li. 2008. Mouse Models of Human Blood Cancers. Mouse Models of Human Blood Cancers
157
177
.
James A. McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Ellis W.T. Wong, Fumin Chang, Brian Lehmann, David M. Terrian, Michele Milella, Agostino Tafuri, Franca Stivala, Massimo Libra, Jorg Basecke, Camilla Evangelisti, Alberto M. Martelli & Richard A. Franklin. (2007) Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773:8, pages 1263-1284.
Crossref
Crossref
Girija Dasmahapatra, Nitin Yerram, Yun Dai, Paul Dent & Steven Grant. (2007) Synergistic Interactions between Vorinostat and Sorafenib in Chronic Myelogenous Leukemia Cells Involve Mcl-1 and p21CIP1 Down-Regulation. Clinical Cancer Research 13:14, pages 4280-4290.
Crossref
Crossref
Shaoguang Li. (2007) Src kinase signaling in leukaemia. The International Journal of Biochemistry & Cell Biology 39:7-8, pages 1483-1488.
Crossref
Crossref
Chikashi YoshidaFumiko YoshidaDaniel E. SearsStephen M. HartDai IkebeAkihiko MutoSubham Basu, Kazuhiko IgarashiJunia V. Melo. (2006) Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1. Blood 109:3, pages 1211-1219.
Crossref
Crossref
James A. McCubrey, Fred E. Bertrand, Linda S. Steelman, Fumin Chang, David M. Terrian & Richard A. Franklin. 2007. Apoptosis, Cell Signaling, and Human Diseases. Apoptosis, Cell Signaling, and Human Diseases
101
134
.
Maoyin LiRuth WeltiXuemin Wang. (2006)
Quantitative Profiling of Arabidopsis Polar Glycerolipids in Response to Phosphorus Starvation. Roles of Phospholipases D
ζ1
and D
ζ2
in Phosphatidylcholine Hydrolysis and Digalactosyldiacylglycerol Accumulation in Phosphorus-Starved Plants
. Plant Physiology 142:2, pages 750-761.
Crossref
Crossref
Romano SilvestriGabriella MarfèMarino ArticoGiuseppe La ReginaAntonio LavecchiaEttore NovellinoManuela MorganteCarla Di StefanoGianfranco CatalanoGiuseppe FilomeniElisabetta AbruzzeseMaria Rosa CirioloMatteo Antonio RussoSergio AmadoriRoberto CirilliFrancesco La TorrePaola Sinibaldi Salimei. (2006)
Pyrrolo[1,2-
b
][1,2,5]benzothiadiazepines (PBTDs): A New Class of Agents with High Apoptotic Activity in Chronic Myelogenous Leukemia K562 Cells and in Cells from Patients at Onset and Who Were Imatinib-Resistant
. Journal of Medicinal Chemistry 49:19, pages 5840-5844.
Crossref
Crossref
Yuyoshi Yanagita, Howard Knapp & Yung-Sheng HuangSusumu Kanno, Kiyotaka Nakagawa, Takahiro Eitsuka & Teruo Miyazawa. 2006. Dietary Fats and Risk of Chronic Disease. Dietary Fats and Risk of Chronic Disease
196
202
.
James A. McCubrey, Linda S. Steelman, Steven L. Abrams, John T. Lee, Fumin Chang, Fred E. Bertrand, Patrick M. Navolanic, David M. Terrian, Richard A. Franklin, Antonio B. D’Assoro, Jeffrey L. Salisbury, Maria Clorinda Mazzarino, Franca Stivala & Massimo Libra. (2006) Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance. Advances in Enzyme Regulation 46:1, pages 249-279.
Crossref
Crossref
C Yu, G Dasmahapatra, P Dent & S Grant. (2005) Synergistic interactions between MEK1/2 and histone deacetylase inhibitors in BCR/ABL+ human leukemia cells. Leukemia 19:9, pages 1579-1589.
Crossref
Crossref
Shenghao Jin, Ya Zhuo, Weining Guo & Jeffrey Field. (2005) p21-activated Kinase 1 (Pak1)-dependent Phosphorylation of Raf-1 Regulates Its Mitochondrial Localization, Phosphorylation of BAD, and Bcl-2 Association. Journal of Biological Chemistry 280:26, pages 24698-24705.
Crossref
Crossref
Stephen B. MARLEYMyrtle Y. GORDON. (2005) Chronic myeloid leukaemia: stem cell derived but progenitor cell driven. Clinical Science 109:1, pages 13-25.
Crossref
Crossref
Matthias Mayerhofer, Karl J. Aichberger, Stefan Florian, Maria‐Theresa Krauth, Alexander W. Hauswirth, Sophia Derdak, Wolfgang R. Sperr, Harald Esterbauer, Oswald Wagner, Christine Marosi, Winfried F. Pickl, Michael Deininger, Ellen Weisberg, Brian J. Druker, James D. Griffin, Christian Sillaber & Peter Valent. (2005) Identification of mTOR as a novel bifunctional target in chronic myeloid leukemia: dissection of growth‐inhibitory and VEGF‐suppressive effects of rapamycin in leukemic cells. The FASEB Journal 19:8, pages 960-962.
Crossref
Crossref
Ping-Hui TsengHo-Pi LinJiuxiang ZhuKuen-Feng ChenErinn M. HadeDonn C. YoungJohn C. ByrdMichael GreverKara JohnsonBrian J. DrukerChing-Shih Chen. (2005) Synergistic interactions between imatinib mesylate and the novel phosphoinositide-dependent kinase-1 inhibitor OSU-03012 in overcoming imatinib mesylate resistance. Blood 105:10, pages 4021-4027.
Crossref
Crossref
Zhi Xin WANG, Chun Sun JIANG, Lei LIU, Xiao Hui WANG, Hai Jing JIN, Qiao WU & Quan CHEN. (2005) The role of Akt on Arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation. Cell Research 15:5, pages 379-386.
Crossref
Crossref
Víctor Javier SÁNCHEZ-ARÉVALO LOBO, Clara Isabel ACEVES LUQUERO, Luis ÁLVAREZ-VALLINA, Alex J. TIPPINGJuan Guinea VINIEGRA, Javier HERNÁNDEZ LOSA, Carlos PARADA COBO, Eva María GALÁN MOYA, Jorge GAYOSO CRUZ, Junia V. MELOSantiago RAMÓN y CAJAL & Ricardo SÁNCHEZ-PRIETO. (2005) Modulation of the p38 MAPK (mitogen-activated protein kinase) pathway through Bcr/Abl: implications in the cellular response to Ara-C. Biochemical Journal 387:1, pages 231-238.
Crossref
Crossref
Michael G. Kharas & David A. Fruman. (2005)
ABL
Oncogenes and Phosphoinositide 3-Kinase: Mechanism of Activation and Downstream Effectors
. Cancer Research 65:6, pages 2047-2053.
Crossref
Crossref
G Biswas, H K Anandatheerthavarada & N G Avadhani. (2005) Mechanism of mitochondrial stress-induced resistance to apoptosis in mitochondrial DNA-depleted C2C12 myocytes. Cell Death & Differentiation 12:3, pages 266-278.
Crossref
Crossref
Prince GeorgePurva BaliSrinivas AnnavarapuAnna ScutoWarren FiskusFei GuoCelia SiguaGautam SondarvaLynn MoscinskiPeter AtadjaKapil Bhalla. (2005) Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3. Blood 105:4, pages 1768-1776.
Crossref
Crossref
Linda B. Baughn & Naomi Rosenberg. (2005) Disruption of the Shc/Grb2 Complex during Abelson Virus Transformation Affects Proliferation, but Not Apoptosis. Journal of Virology 79:4, pages 2325-2334.
Crossref
Crossref
Fei GuoCelia SiguaPurva BaliPrince GeorgeWarren FiskusAnna ScutoSrinivas AnnavarapuAbdelmoughite MouttakiGautam SondarvaSheng WeiJie WuJulie DjeuKapil Bhalla. (2005) Mechanistic role of heat shock protein 70 in Bcr-Abl–mediated resistance to apoptosis in human acute leukemia cells. Blood 105:3, pages 1246-1255.
Crossref
Crossref
E Deutsch, L Maggiorella, B Wen, M L Bonnet, K Khanfir, V Frascogna, A G Turhan & J Bourhis. (2004) Tyrosine kinase inhibitor AG1024 exerts antileukaemic effects on STI571-resistant Bcr-Abl expressing cells and decreases AKT phosphorylation. British Journal of Cancer 91:9, pages 1735-1741.
Crossref
Crossref
Thomas O'HareRoy PollockEric P. StoffregenJeffrey A. KeatsOmar M. AbdullahErika M. MosesonVictor M. RiveraHao TangChester A. MetcalfIIIIIIRegine S. BohacekYihan WangRaji SundaramoorthiWilliam C. ShakespeareDavid DalgarnoTim ClacksonTomi K. SawyerMichael W. DeiningerBrian J. Druker. (2004) Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML. Blood 104:8, pages 2532-2539.
Crossref
Crossref
Yun Dai, Mohamed Rahmani, Seth J. Corey, Paul Dent & Steven Grant. (2004) A Bcr/Abl-independent, Lyn-dependent Form of Imatinib Mesylate (STI-571) Resistance Is Associated with Altered Expression of Bcl-2. Journal of Biological Chemistry 279:33, pages 34227-34239.
Crossref
Crossref
Yun DaiMohamed RahmaniXin-Yan PeiPaul DentSteven Grant. (2004) Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms. Blood 104:2, pages 509-518.
Crossref
Crossref
Natasa Kukoc-Zivojnov, Elena Puccetti, Kai U Chow, Marion Bergmann, Martin Ruthardt, Dieter Hoelzer, Paris S Mitrou, Eckhart Weidmann & Simone Boehrer. (2004) Prostate apoptosis response gene-4 (par-4) abrogates the survival function of p185BCR-ABL in hematopoietic cells. Experimental Hematology 32:7, pages 649-656.
Crossref
Crossref
Junia V Melo & Michael W.N Deininger. (2004) Biology of chronic myelogenous leukemia—signaling pathways of initiation and transformation. Hematology/Oncology Clinics of North America 18:3, pages 545-568.
Crossref
Crossref
S. B. Marley, J. L. Lewis, H. Schneider, C. E. Rudd & M. Y. Gordon. (2004) Phosphatidylinositol-3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells. British Journal of Haematology 125:4, pages 500-511.
Crossref
Crossref
Stephane WongOwen N. Witte. (2004) The BCR-ABL Story: Bench to Bedside and Back. Annual Review of Immunology 22:1, pages 247-306.
Crossref
Crossref
Jamil Dierov, Raia Dierova & Martin Carroll. (2004) BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint. Cancer Cell 5:3, pages 275-285.
Crossref
Crossref
Iris T. Chan, Jeffery L. Kutok, Ifor R. Williams, Sarah Cohen, Lauren Kelly, Hirokazu Shigematsu, Leisa Johnson, Koichi Akashi, David A. Tuveson, Tyler Jacks & D. Gary Gilliland. (2004) Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease. Journal of Clinical Investigation 113:4, pages 528-538.
Crossref
Crossref
L S Steelman, S C Pohnert, J G Shelton, R A Franklin, F E Bertrand & J A McCubrey. (2004) JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 18:2, pages 189-218.
Crossref
Crossref
S Zhao, M Konopleva, M Cabreira-Hansen, Z Xie, W Hu, M Milella, Z Estrov, G B Mills & M Andreeff. (2003) Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias. Leukemia 18:2, pages 267-275.
Crossref
Crossref
Laura Pattacini, Manuela Mancini, Lucia Mazzacurati, Gianluca Brusa, Michela Benvenuti, Giovanni Martinelli, Michele Baccarani & Maria Alessandra Santucci. (2004) Endoplasmic reticulum stress initiates apoptotic death induced by STI571 inhibition of p210 bcr–abl tyrosine kinase. Leukemia Research 28:2, pages 191-202.
Crossref
Crossref
Bin Yan, Marina Zemskova, Sheldon Holder, Vernon Chin, Andrew Kraft, Paivi J. Koskinen & Michael Lilly. (2003) The PIM-2 Kinase Phosphorylates BAD on Serine 112 and Reverses BAD-induced Cell Death. Journal of Biological Chemistry 278:46, pages 45358-45367.
Crossref
Crossref
Scott H Kaufmann & David L Vaux. (2003) Alterations in the apoptotic machinery and their potential role in anticancer drug resistance. Oncogene 22:47, pages 7414-7430.
Crossref
Crossref
Karen Keeshan, Thomas G. Cotter & Sharon L. McKenna. (2003)
Bcr-Abl upregulates cytosolic p21
WAF-1/CIP-1
by a phosphoinositide-3-kinase (PI3K)-independent pathway
. British Journal of Haematology 123:1, pages 34-44.
Crossref
Crossref
T Kindler, F Breitenbuecher, S Kasper, T Stevens, B Carius, H Gschaidmeier, C Huber & T Fischer. (2003) In BCR-ABL-positive cells, STAT-5 tyrosine-phosphorylation integrates signals induced by imatinib mesylate and Ara-C. Leukemia 17:6, pages 999-1009.
Crossref
Crossref
Saghi Ghaffari, Zainab Jagani, Claire Kitidis, Harvey F. Lodish & Roya Khosravi-Far. (2003) Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor. Proceedings of the National Academy of Sciences 100:11, pages 6523-6528.
Crossref
Crossref
Stephane WongJami McLaughlinDonghui ChengOwen N. Witte. (2003) Cell context–specific effects of the BCR-ABL oncogene monitored in hematopoietic progenitors. Blood 101:10, pages 4088-4097.
Crossref
Crossref
Ramadevi NimmanapalliLianne FuinoCorinne StobaughVictoria RichonKapil Bhalla. (2003) Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl–positive human acute leukemia cells. Blood 101:8, pages 3236-3239.
Crossref
Crossref
Nicholas J. DonatoJi Yuan WuJonathan StapleyGary GallickHui LinRalph ArlinghausMoshe Talpaz. (2003) BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood 101:2, pages 690-698.
Crossref
Crossref
Tomasz Skorski. (2002) BCR/ABL regulates response to DNA damage: the role in resistance to genotoxic treatment and in genomic instability. Oncogene 21:56, pages 8591-8604.
Crossref
Crossref
Matthew B Wilson, Steven J Schreiner, Hyun-Jung Choi, Joanne Kamens & Thomas E Smithgall. (2002) Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr–Abl signal transduction and oncogenesis. Oncogene 21:53, pages 8075-8088.
Crossref
Crossref
Duncan L. Smith, Caroline A. Evans, Andrew Pierce, Simon J. Gaskell & Anthony D. Whetton. (2002) Changes in the Proteome Associated with the Action of Bcr-Abl Tyrosine Kinase Are Not Related to Transcriptional Regulation. Molecular & Cellular Proteomics 1:11, pages 876-884.
Crossref
Crossref
K Keeshan, TG Cotter & SL McKenna. (2002) High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion. Leukemia 16:9, pages 1725-1734.
Crossref
Crossref
Patricia Hess, German Pihan, Charles L. Sawyers, Richard A. Flavell & Roger J. Davis. (2002) Survival signaling mediated by c-Jun NH2-terminal kinase in transformed B lymphoblasts. Nature Genetics 32:1, pages 201-205.
Crossref
Crossref
Agata Klejman, Lori Rushen, Andrea Morrione, Artur Slupianek & Tomasz Skorski. (2002) Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571. Oncogene 21:38, pages 5868-5876.
Crossref
Crossref
Pierre Dos Santos, Alicia J. Kowaltowski, Muriel N. Laclau, Subramanian Seetharaman, Petr Paucek, Sihem Boudina, Jean-Benoit Thambo, Liliane Tariosse & Keith D. Garlid. (2002)
Mechanisms by which opening the mitochondrial ATP- sensitive K
+
channel protects the ischemic heart
. American Journal of Physiology-Heart and Circulatory Physiology 283:1, pages H284-H295.
Crossref
Crossref
Blanca Scheijen & James D Griffin. (2002) Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease. Oncogene 21:21, pages 3314-3333.
Crossref
Crossref
Tomasz Skorski. (2002) Oncogenic tyrosine kinases and the dna-damage response. Nature Reviews Cancer 2:5, pages 351-360.
Crossref
Crossref
Alison Hindley & Walter Kolch. (2002) Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases. Journal of Cell Science 115:8, pages 1575-1581.
Crossref
Crossref
Jamil DierovQing XuRaia DierovaMartin Carroll. (2002) TEL/platelet-derived growth factor receptor β activates phosphatidylinositol 3 (PI3) kinase and requires PI3 kinase to regulate the cell cycle. Blood 99:5, pages 1758-1765.
Crossref
Crossref
Junko Sonoyama, Itaru Matsumura, Sachiko Ezoe, Yusuke Satoh, Xian Zhang, Yoshihisa Kataoka, Emi Takai, Masao Mizuki, Takashi Machii, Hiroshi Wakao & Yuzuru Kanakura. (2002) Functional Cooperation among Ras, STAT5, and Phosphatidylinositol 3-Kinase Is Required for Full Oncogenic Activities of BCR/ABL in K562 Cells. Journal of Biological Chemistry 277:10, pages 8076-8082.
Crossref
Crossref
Jay F. DorseyJess M. CunnickShrikant M. ManeJie Wu. (2002) Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl+ K562 leukemic cells by Gab2. Blood 99:4, pages 1388-1397.
Crossref
Crossref
David J. Barnes & Junia V. Melo. (2002) Cytogenetic and Molecular Genetic Aspects of Chronic Myeloid Leukaemia. Acta Haematologica 108:4, pages 180-202.
Crossref
Crossref
Aaron D. SchimmerDavid W. HedleyLinda Z. PennMark D. Minden. (2001) Receptor- and mitochondrial-mediated apoptosis in acute leukemia: a translational view. Blood 98:13, pages 3541-3553.
Crossref
Crossref
Vasily M. GelfanovGem S. BurgessSara Litz-JacksonAlastair J. KingMark S. MarshallHarikrishna NakshatriH. Scott Boswell. (2001) Transformation of interleukin-3–dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor κB–mediated antiapoptosis involving c-IAP2. Blood 98:8, pages 2508-2517.
Crossref
Crossref
Heiko van der KuipAlexander W. GoetzCornelius MiethingJustus DuysterWalter E. Aulitzky. (2001) Adhesion to fibronectin selectively protects Bcr-Abl+cells from DNA damage–induced apoptosis. Blood 98:5, pages 1532-1541.
Crossref
Crossref
Melody H.-H. Nguyen, Jenny M.-Y. Ho, Bryan K. Beattie & Dwayne L. Barber. (2001) TEL-JAK2 Mediates Constitutive Activation of the Phosphatidylinositol 3′-Kinase/Protein Kinase B Signaling Pathway. Journal of Biological Chemistry 276:35, pages 32704-32713.
Crossref
Crossref
Yelena Parada, Lolita Banerji, Janet Glassford, Nicholas C. Lea, Manuel Collado, Carmen Rivas, John L. Lewis, Myrtle Y. Gordon, N. Shaun B. Thomas & Eric W.-F. Lam. (2001) BCR-ABL and Interleukin 3 Promote Haematopoietic Cell Proliferation and Survival through Modulation of Cyclin D2 and p27Kip1 Expression. Journal of Biological Chemistry 276:26, pages 23572-23580.
Crossref
Crossref
Michael J. Mauro & Brian J. Druker. (2001) STI571: A gene product-targeted therapy for leukemia. Current Oncology Reports 3:3, pages 223-227.
Crossref
Crossref
Nicholas J. DonatoJi Y. WuLing ZhangHagop KantarjianMoshe Talpaz. (2001) Down-regulation of interleukin-3/granulocyte-macrophage colony-stimulating factor receptor β-chain in BCR-ABL+human leukemic cells: association with loss of cytokine-mediated Stat-5 activation and protection from apoptosis after BCR-ABL inhibition. Blood 97:9, pages 2846-2853.
Crossref
Crossref
Susana Constantino Rosa Santos, Virginie Lacronique, Isabelle Bouchaert, Richard Monni, Olivier Bernard, Sylvie Gisselbrecht & Fabrice Gouilleux. (2001) Constitutively active STAT5 variants induce growth and survival of hematopoietic cells through a PI 3-kinase/Akt dependent pathway. Oncogene 20:17, pages 2080-2090.
Crossref
Crossref
Yoshiro Maru. (2001) Molecular Biology of Chronic Myeloid Leukemia. International Journal of Hematology 73:3, pages 308-322.
Crossref
Crossref
Martin Sattler & James D. Griffin. (2001) Mechanisms of Transformation by the BCR/ABL Oncogene. International Journal of Hematology 73:3, pages 278-291.
Crossref
Crossref
Wilhelm Woessmann & Nahid F. Mivechi. (2001) Role of ERK Activation in Growth and Erythroid Differentiation of K562 Cells. Experimental Cell Research 264:2, pages 193-200.
Crossref
Crossref
Michael H. TomassonIfor R. WilliamsShaoguang LiJeffrey KutokDanielle CainSilke GillessenGlenn DranoffRichard A. Van EttenD. Gary Gilliland. (2001) Induction of myeloproliferative disease in mice by tyrosine kinase fusion oncogenes does not require granulocyte-macrophage colony-stimulating factor or interleukin-3. Blood 97:5, pages 1435-1441.
Crossref
Crossref
H. H. Grunicke, S. Kampfer, M. Spitaler, F. Hochholdinger, G. Baier & F. Überall. 2001. Data Mining in Structural Biology. Data Mining in Structural Biology
81
99
.
Franck Gesbert, William R. Sellers, Sabina Signoretti, Massimo Loda & James D. Griffin. (2000) BCR/ABL Regulates Expression of the Cyclin-dependent Kinase Inhibitor p27Kip1 through the Phosphatidylinositol 3-Kinase/AKT Pathway. Journal of Biological Chemistry 275:50, pages 39223-39230.
Crossref
Crossref
RA Franklin & JA McCubrey. (2000) Kinases: positive and negative regulators of apoptosis. Leukemia 14:12, pages 2019-2034.
Crossref
Crossref
Michael E O'Dwyer & Brian J Druker. (2000) STI571: an inhibitor of the BCR-ABL tyrosine kinase for the treatment of chronic myelogenous leukaemia. The Lancet Oncology 1:4, pages 207-211.
Crossref
Crossref
Michael W. N. DeiningerJohn M. GoldmanJunia V. Melo. (2000) The molecular biology of chronic myeloid leukemia. Blood 96:10, pages 3343-3356.
Crossref
Crossref
Michael W. N. DeiningerJohn M. GoldmanJunia V. Melo. (2000) The molecular biology of chronic myeloid leukemia. Blood 96:10, pages 3343-3356.
Crossref
Crossref
Hee-Yong Kim, Mohammed Akbar, Audrey Lau & Lisa Edsall. (2000) Inhibition of Neuronal Apoptosis by Docosahexaenoic Acid (22:6n-3). Journal of Biological Chemistry 275:45, pages 35215-35223.
Crossref
Crossref
Janusz H. S. Kabarowski & Owen N. Witte. (2009) Consequences of BCR‐ABL Expression within the Hematopoietic Stem Cell in Chronic Myeloid Leukemia. STEM CELLS 18:6, pages 399-408.
Crossref
Crossref
Scott H. Kaufmann & Gregory J. Gores. (2000) Apoptosis in cancer: cause and cure. BioEssays 22:11, pages 1007-1017.
Crossref
Crossref
Franck GesbertJames D. Griffin. (2000) Bcr/Abl activates transcription of theBcl-X gene through STAT5. Blood 96:6, pages 2269-2276.
Crossref
Crossref
Franck GesbertJames D. Griffin. (2000) Bcr/Abl activates transcription of theBcl-X gene through STAT5. Blood 96:6, pages 2269-2276.
Crossref
Crossref
M Nieborowska-Skorska, A Slupianek & T Skorski. (2000) Progressive changes in the leukemogenic signaling in BCR/ABL-transformed cells. Oncogene 19:36, pages 4117-4124.
Crossref
Crossref