Advanced search
Publication Cover
Molecular and Cellular Biology Volume 21, 2001 - Issue 1
Submit an article Journal homepage
16
Views
67
CrossRef citations to date
0
Altmetric
DNA Dynamics and Chromosome Structure

Insertion of a Telomere Repeat Sequence into a Mammalian Gene Causes Chromosome Instability

April E. Kilburn1 Verna and Marrs McLean Department of Biochemistry and Molecular Biology;2 Cell and Molecular Biology Program
,
Martin J. Shea3 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas77030
,
R. Geoffrey Sargent1 Verna and Marrs McLean Department of Biochemistry and Molecular Biology
&
John H. Wilson1 Verna and Marrs McLean Department of Biochemistry and Molecular Biology;2 Cell and Molecular Biology Program;3 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas77030Correspondence[email protected]
Pages 126-135 | Received 15 Aug 2000, Accepted 03 Oct 2000, Published online: 28 Mar 2023

Citations (67)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Olga Shubernetskaya, Dmitry Skvortsov, Sergey Evfratov, Maria Rubtsova, Elena Belova, Olga Strelkova, Varvara Cherepaninets, Oxana Zhironkina, Alexey Olovnikov, Maria Zvereva, Olga Dontsova & Igor Kireev. (2017) Interstitial telomeric repeats-associated DNA breaks. Nucleus 8:6, pages 641-653.
Read now
James L. Meservy, R. Geoffrey Sargent, Ravi R. Iyer, Fung Chan, Gregory J. McKenzie, Robert D. Wells & John H. Wilson. (2003) Long CTG Tracts from the Myotonic Dystrophy Gene Induce Deletions and Rearrangements during Recombination at the APRT Locus in CHO Cells. Molecular and Cellular Biology 23:9, pages 3152-3162.
Read now

Articles from other publishers (65)

Willam Oliveira da Silva, Celina Coelho Rosa, Malcolm Andrew Ferguson-Smith, Patricia Caroline Mary O’Brien, Juliane Saldanha, Rogério Vieira Rossi, Julio Cesar Pieczarka & Cleusa Yoshiko Nagamachi. (2022) The emergence of a new sex-system (XX/XY1Y2) suggests a species complex in the “monotypic” rodent Oecomys auyantepui (Rodentia, Sigmodontinae). Scientific Reports 12:1.
Crossref
Anna Y. Aksenova, Anna S. Zhuk, Artem G. Lada, Irina V. Zotova, Elena I. Stepchenkova, Ivan I. Kostroma, Sergey V. Gritsaev & Youri I. Pavlov. (2021) Genome Instability in Multiple Myeloma: Facts and Factors. Cancers 13:23, pages 5949.
Crossref
Elizabeth A Stivison, Kati J Young & Lorraine S Symington. (2020) Interstitial telomere sequences disrupt break-induced replication and drive formation of ectopic telomeres. Nucleic Acids Research 48:22, pages 12697-12710.
Crossref
Stephen Frenk, Evan H. Lister-Shimauchi & Shawn Ahmed. (2019) Telomeric small RNAs in the genus Caenorhabditis . RNA 25:9, pages 1061-1077.
Crossref
Anna Y. Aksenova & Sergei M. Mirkin. (2019) At the Beginning of the End and in the Middle of the Beginning: Structure and Maintenance of Telomeric DNA Repeats and Interstitial Telomeric Sequences. Genes 10:2, pages 118.
Crossref
Patrizia Russo, Giulia Prinzi, Stefania Proietti, Palma Lamonaca, Alessandra Frustaci, Stefania Boccia, Rosarita Amore, Maria Lorenzi, Graziano Onder, Emanuele Marzetti, Vanessa Valdiglesias, Fiorella Guadagni, Maria Giovanna Valente, Gerland Lo Cascio, Sara Fraietta, Giuseppe Ducci & Stefano Bonassi. (2018) Shorter telomere length in schizophrenia: Evidence from a real-world population and meta-analysis of most recent literature. Schizophrenia Research 202, pages 37-45.
Crossref
Haojing Shao, Chenxi Zhou, Minh Duc Cao & Lachlan J. M. Coin. (2018) Ongoing human chromosome end extension revealed by analysis of BioNano and nanopore data. Scientific Reports 8:1.
Crossref
L. M. Buschiazzo, D. A. Caraballo, E. Cálcena, M. L. Longarzo, C. A. Labaroni, J. M. Ferro, M. S. Rossi, A. D. Bolzán & Cecilia Lanzone. (2018) Integrative analysis of chromosome banding, telomere localization and molecular genetics in the highly variable Ctenomys of the Corrientes group (Rodentia; Ctenomyidae). Genetica 146:4-5, pages 403-414.
Crossref
Pingping Jia & Weihang Chai. (2018) The MLH1 ATPase domain is needed for suppressing aberrant formation of interstitial telomeric sequences. DNA Repair 65, pages 20-25.
Crossref
Joanna Majka, Zbigniew Zwierzykowski, Maciej Majka & Arkadiusz Kosmala. (2017) Karyotype reshufflings of Festuca pratensis × Lolium perenne hybrids. Protoplasma 255:2, pages 451-458.
Crossref
Kirsty Jamieson, Kevin J McNaught, Tereza Ormsby, Neena A Leggett, Shinji Honda & Eric U Selker. (2018) Telomere repeats induce domains of H3K27 methylation in Neurospora. eLife 7.
Crossref
Aleksandar Ilic, Sumin Lu, Vikram Bhatia, Farhana Begum, Thomas Klonisch, Prasoon Agarwal, Wayne Xu & James R. Davie. (2017) Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites. Epigenetics & Chromatin 10:1.
Crossref
Alejandro D. Bolzán. (2017) Interstitial telomeric sequences in vertebrate chromosomes: Origin, function, instability and evolution. Mutation Research/Reviews in Mutation Research 773, pages 51-65.
Crossref
Alain Victor Barros, Michele Andressa Vier Wolski, Viviane Nogaroto, Mara Cristina Almeida, Orlando Moreira-Filho & Marcelo Ricardo Vicari. (2017) Fragile sites, dysfunctional telomere and chromosome fusions: What is 5S rDNA role?. Gene 608, pages 20-27.
Crossref
Pingping Jia, Megan Chastain, Ying Zou, Chengtao Her & Weihang Chai. (2017) Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells. Nucleic Acids Research 45:3, pages 1219-1232.
Crossref
Mélanie V. Larcher, Emeline Pasquier, R. Stephen MacDonald & Raymund J. Wellinger. (2016) Ku Binding on Telomeres Occurs at Sites Distal from the Physical Chromosome Ends. PLOS Genetics 12:12, pages e1006479.
Crossref
Hilda A Pickett & Roger R Reddel. (2015) Molecular mechanisms of activity and derepression of alternative lengthening of telomeres. Nature Structural & Molecular Biology 22:11, pages 875-880.
Crossref
Anna Y. Aksenova, Gil Han, Alexander A. Shishkin, Kirill V. Volkov & Sergei M. Mirkin. (2015) Expansion of Interstitial Telomeric Sequences in Yeast. Cell Reports 13:8, pages 1545-1551.
Crossref
Els Atema, Ellis Mulder, Hannah L. Dugdale, Michael Briga, Arie J. van Noordwijk & Simon Verhulst. (2015) Heritability of telomere length in the Zebra Finch. Journal of Ornithology 156:4, pages 1113-1123.
Crossref
Paulina Marzec, Claudia Armenise, Gaëlle Pérot, Fani-Marlen Roumelioti, Eugenia Basyuk, Sarantis Gagos, Frédéric Chibon & Jérôme Déjardin. (2015) Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancers. Cell 160:5, pages 913-927.
Crossref
Daniel Pacheco Bruschi, Miryan Rivera, Albertina Pimentel Lima, Ailín Blasco Zúñiga & Shirlei Maria Recco-Pimentel. (2014) Interstitial Telomeric Sequences (ITS) and major rDNA mapping reveal insights into the karyotypical evolution of Neotropical leaf frogs species (Phyllomedusa, Hylidae, Anura). Molecular Cytogenetics 7:1.
Crossref
Anna Y. Aksenova, Patricia W. Greenwell, Margaret Dominska, Alexander A. Shishkin, Jane C. Kim, Thomas D. Petes & Sergei M. Mirkin. (2013) Genome rearrangements caused by interstitial telomeric sequences in yeast. Proceedings of the National Academy of Sciences 110:49, pages 19866-19871.
Crossref
Eva Sýkorová, Miloslava Fojtová & Vratislav Peška. (2013) A polymerase chain reaction-based approach for evaluation of telomere-associated sequences and interstitial telomeric sequences. Analytical Biochemistry 439:1, pages 8-10.
Crossref
Christopher G. Foote, David Vleck & Carol M. Vleck. (2013) Extent and variability of interstitial telomeric sequences and their effects on estimates of telomere length. Molecular Ecology Resources 13:3, pages 417-428.
Crossref
Nazario Bosco & Titia de Lange. (2012) A TRF1-controlled common fragile site containing interstitial telomeric sequences. Chromosoma 121:5, pages 465-474.
Crossref
Kamila Oliveira Rosa, Kaline Ziemniczak, Alain Victor de Barros, Viviane Nogaroto, Mara Cristina Almeida, Marta Margarete Cestari, Roberto Ferreira Artoni & Marcelo Ricardo Vicari. (2011) Numeric and structural chromosome polymorphism in Rineloricaria lima (Siluriformes: Loricariidae): fusion points carrying 5S rDNA or telomere sequence vestiges. Reviews in Fish Biology and Fisheries 22:3, pages 739-749.
Crossref
David W. Clark, Tzu Phang, Michael G. Edwards, Mark W. Geraci & Mark N. Gillespie. (2012) Promoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription. Free Radical Biology and Medicine 53:1, pages 51-59.
Crossref
A. D. Bolzan. (2011) Chromosomal aberrations involving telomeres and interstitial telomeric sequences. Mutagenesis 27:1, pages 1-15.
Crossref
Jennifer J. Rahn, Gerald M. Adair & Rodney S. Nairn. 2012. DNA Repair Protocols. DNA Repair Protocols 445 470 .
Aswini S, Venkata O Padmalatha, Saranya G, Durgadatta T, Raseswari T, Kanakavalli M Kulashekaran, Meena J, Chandra N, Lalji S & Lakshmi R Kandukuri. (2011) De novo 7p partial trisomy characterized by subtelomeric FISH and whole-genome array in a girl with mental retardation. Molecular Cytogenetics 4:1.
Crossref
M. Th. Rovatsos, J. A. Marchal, I. Romero-Fernández, F. J. Fernández, E. B. Giagia-Athanosopoulou & Antonio Sánchez. (2011) Rapid, independent, and extensive amplification of telomeric repeats in pericentromeric regions in karyotypes of arvicoline rodents. Chromosome Research 19:7, pages 869-882.
Crossref
Déborah Revaud, Luis M. Martins, François D. Boussin, Laure Sabatier & Chantal Desmaze. (2011) Different DNA-PKcs functions in the repair of radiation-induced and spontaneous DSBs within interstitial telomeric sequences. Chromosoma 120:3, pages 309-319.
Crossref
Agnel Sfeir, Settapong T. Kosiyatrakul, Dirk Hockemeyer, Sheila L. MacRae, Jan Karlseder, Carl L. Schildkraut & Titia de Lange. (2009) Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication. Cell 138:1, pages 90-103.
Crossref
Eli S. Williams, Rebekah Klingler, Brian Ponnaiya, Tanja Hardt, Evelin Schrock, Susan P. Lees-Miller, Katheryn Meek, Robert L. Ullrich & Susan M. Bailey. (2009) Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence. Cancer Research 69:5, pages 2100-2107.
Crossref
Susan M. Bailey, Eli S. Williams & Robert L. Ullrich. 2009. Radiation Health Risk Sciences. Radiation Health Risk Sciences 199 203 .
Vincent Dion, Yunfu Lin, Brandee A. Price, Sharyl L. Fyffe, Andrei Seluanov, Vera Gorbunova & John H. Wilson. (2008) Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination. DNA Repair 7:2, pages 313-320.
Crossref
Kah Wai Lin & Ju Yan. (2008) Endings in the middle: Current knowledge of interstitial telomeric sequences. Mutation Research/Reviews in Mutation Research 658:1-2, pages 95-110.
Crossref
N.S. Zhdanova, J.M. Minina, T.V. Karamysheva & N.B. Rubtsov. (2007) The distributions of telomeric and ribosomal DNA on the chromosomes of two closely related species, Sorex araneus and Sorex granarius (Soricidae, Eulipotyphla). Russian Journal of Theriology 6:1, pages 007-013.
Crossref
N. S. Zhdanova, N. B. Rubtsov & Yu. M. Minina. (2007) Terminal regions of mammal chromosomes: Plasticity and role in evolution. Russian Journal of Genetics 43:7, pages 721-732.
Crossref
Susan M. Bailey, Eli S. Williams & Robert L. Ullrich. (2007) The role of telomere dysfunction in driving genomic instability. International Congress Series 1299, pages 146-149.
Crossref
Acacia Alcivar-Warren, Dawn Meehan-Meola, Yongping Wang, Ximing Guo, Linghua Zhou, Jianhai Xiang, Shaun Moss, Steve Arce, William Warren, Zhenkang Xu & Kireina Bell. (2006) Isolation and Mapping of Telomeric Pentanucleotide (TAACC) n Repeats of the Pacific Whiteleg Shrimp, Penaeus vannamei, Using Fluorescence In Situ Hybridization. Marine Biotechnology 8:5, pages 467-480.
Crossref
Johanna Eddy & Nancy Maizels. (2006) Gene function correlates with potential for G4 DNA formation in the human genome. Nucleic Acids Research 34:14, pages 3887-3896.
Crossref
Susan M. Bailey & Joel S. Bedford. (2006) Studies on chromosome aberration induction: What can they tell us about DNA repair?. DNA Repair 5:9-10, pages 1171-1181.
Crossref
Ying S. Zou, Daniel L. Van Dyke, Erik C. Thorland, Harinderpal S. Chhabra, Virginia V. Michels, Jeannette G. Keefe, Melanie A. Lega, Molly A. Feely, Timothy S. Uphoff & Syed M. Jalal. (2006) Mosaic ring 20 with no detectable deletion by FISH analysis: Characteristic seizure disorder and literature review. American Journal of Medical Genetics Part A 140A:15, pages 1696-1706.
Crossref
Alejandro D. Bolzán & Martha S. Bianchi. (2006) Telomeres, interstitial telomeric repeat sequences, and chromosomal aberrations. Mutation Research/Reviews in Mutation Research 612:3, pages 189-214.
Crossref
Núria Camats, Aurora Ruiz-Herrera, Juan José Parrilla, Maribel Acien, Pilar Payá, Elena Giulotto, Josep Egozcue, Francisca García & Montserrat Garcia. (2006) Genomic instability in rat: Breakpoints induced by ionising radiation and interstitial telomeric-like sequences. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 595:1-2, pages 156-166.
Crossref
Natalia S. Zhdanova, Tatjana V. Karamisheva, Julia Minina, Natalia M. Astakhova, Peter Lansdorp, Makoto Kammori, Nikolai B. Rubtsov & Jeremy B. Searle. (2005) Unusual distribution pattern of telomeric repeats in the shrews Sorex araneus and Sorex granarius. Chromosome Research 13:6, pages 617-625.
Crossref
Svetlana Galkina, Natalia Lukina, Ksenya Zakharova & Alexander V. Rodionov. (2005) Interstitial (TTAGGG)n sequences are not hot spots of recombination in the chicken lampbrush macrochromosomes 1–3. Chromosome Research 13:6, pages 551-557.
Crossref
A. Macieira-Coelho. 2005. Developmental Biology of Neoplastic Growth. Developmental Biology of Neoplastic Growth 217 250 .
K. Ocalewicz, A. Sliwinska & M. Jankun. (2004) Autosomal localization of interstitial telomeric sites (ITS) in brook trout, <i>Salvelinus fontinalis</i> (Pisces, Salmonidae). Cytogenetic and Genome Research 105:1, pages 79-82.
Crossref
H.-P. Wong, H. Mozdarani, C. Finnegan, J. McIlrath, P.E. Bryant & P. Slijepcevic. (2004) Lack of spontaneous and radiation-induced chromosome breakage at interstitial telomeric sites in murine <i>scid</i> cells. Cytogenetic and Genome Research 104:1-4, pages 131-136.
Crossref
C. Desmaze, L.M. Pirzio, R. Blaise, C. Mondello, E. Giulotto, J.P. Murnane & L. Sabatier. (2004) Interstitial telomeric repeats are not preferentially involved in radiation-induced chromosome aberrations in human cells. Cytogenetic and Genome Research 104:1-4, pages 123-130.
Crossref
A Macieira-Coelho. (2003) From Weismann’s theory to present day gerontology 1889–2003. Pathologie Biologie 51:10, pages 550-562.
Crossref
Raisa Ivanovna Krutilina, Alexandra Nikolaevna Smirnova, Olga Stanislavovna Mudrak, Nadezhda Mikhailovna Pleskach, Maria Pavlovna Svetlova, Shiao-Li Oei, Peter M Yau, Edwin Morton Bradbury, Andrey Olegovich Zalensky & Nikolai Viktorovich Tomilin. (2003) Protection of internal (TTAGGG)n repeats in Chinese hamster cells by telomeric protein TRF1. Oncogene 22:43, pages 6690-6698.
Crossref
H Würtele, K C E Little & P Chartrand. (2003) Illegitimate DNA integration in mammalian cells. Gene Therapy 10:21, pages 1791-1799.
Crossref
Alvaro Macieira-Coelho. (2003) The Decline of the Clinical Incidence of Cancers during Human Senescence. Gerontology 49:6, pages 341-349.
Crossref
. 2003. Genetic Recombination in Cancer. Genetic Recombination in Cancer 170 236 .
JR Vermeesch, E Baten, J-P Fryns & K Devriendt. (2002) Ring syndrome caused by ring chromosome 7 without loss of subtelomeric sequences. Clinical Genetics 62:5, pages 415-417.
Crossref
Jacintha N. O'Sullivan, Mary P. Bronner, Teresa A. Brentnall, Jennifer C. Finley, Wen-Tang Shen, Scott Emerson, Mary J. Emond, Katherine A. Gollahon, Alexander H. Moskovitz, David A. Crispin, John D. Potter & Peter S. Rabinovitch. (2002) Chromosomal instability in ulcerative colitis is related to telomere shortening. Nature Genetics 32:2, pages 280-284.
Crossref
Étienne Kaszás, Akio Kato & James A Birchler. (2002) Cytological and molecular analysis of centromere misdivision in maize. Genome 45:4, pages 759-768.
Crossref
Maura Faravelli, Claus M Azzalin, Livia Bertoni, Olga Chernova, Carmen Attolini, Chiara Mondello & Elena Giulotto. (2002) Molecular organization of internal telomeric sequences in Chinese hamster chromosomes. Gene 283:1-2, pages 11-16.
Crossref
Jason G Wood & David A Sinclair. (2002) TPE or not TPE? It's no longer a question. Trends in Pharmacological Sciences 23:1, pages 1-4.
Crossref
Bryn A. Bridges. (2001) Radiation and Germline Mutation at Repeat Sequences: Are We in the Middle of a Paradigm Shift?. Radiation Research 156:5, pages 631-641.
Crossref
Joseph A. BaurYing ZouJerry W. ShayWoodring E. Wright. (2001) Telomere Position Effect in Human Cells. Science 292:5524, pages 2075-2077.
Crossref
. (2001) Anti-Aging Medicine LiteratureWatch. Journal of Anti-Aging Medicine 4:2, pages 157-179.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.