Advanced search
Publication Cover
Molecular and Cellular Biology Volume 21, 2001 - Issue 11
Submit an article Journal homepage
8
Views
57
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Activation of the Ral and Phosphatidylinositol 3′ Kinase Signaling Pathways by the Ras-Related Protein TC21

Marta RosárioCRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, Institute of Cancer Research, LondonSW3 6JB, United Kingdom
,
Hugh F. PatersonCRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, Institute of Cancer Research, LondonSW3 6JB, United Kingdom
&
Christopher J. MarshallCRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, Institute of Cancer Research, LondonSW3 6JB, United KingdomCorrespondence[email protected]
Pages 3750-3762 | Received 06 Nov 2000, Accepted 09 Mar 2001, Published online: 27 Mar 2023

Citations (57)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

Balbino Alarcón & Nuria Martínez-Martín. (2012) RRas2, RhoG and T-cell phagocytosis. Small GTPases 3:2, pages 97-101.
Read now
Geng-Xian Shi, Ling Jin & Douglas A. Andres. (2008) Pituitary Adenylate Cyclase-Activating Polypeptide 38-Mediated Rin Activation Requires Src and Contributes to the Regulation of Hsp27 Signaling during Neuronal Differentiation. Molecular and Cellular Biology 28:16, pages 4940-4951.
Read now
Geng-Xian Shi, Holger Rehmann & Douglas A. Andres. (2006) A Novel Cyclic AMP-Dependent Epac-Rit Signaling Pathway Contributes to PACAP38-Mediated Neuronal Differentiation. Molecular and Cellular Biology 26:23, pages 9136-9147.
Read now
Geng-Xian Shi & Douglas A. Andres. (2005) Rit Contributes to Nerve Growth Factor-Induced Neuronal Differentiation via Activation of B-Raf-Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Cascades. Molecular and Cellular Biology 25:2, pages 830-846.
Read now
Pablo Rodriguez-Viciana, Celine Sabatier & Frank McCormick. (2004) Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate. Molecular and Cellular Biology 24:11, pages 4943-4954.
Read now
Gladys Mirey, Maria Balakireva, Sébastien L'Hoste, Carine Rossé, Stéphanie Voegeling & Jacques Camonis. (2003) A Ral Guanine Exchange Factor-Ral Pathway Is Conserved in Drosophila melanogaster and Sheds New Light on the Connectivity of the Ral, Ras, and Rap Pathways. Molecular and Cellular Biology 23:3, pages 1112-1124.
Read now

Articles from other publishers (51)

Isabel Fernández-Pisonero, Laura Clavaín, Javier Robles-Valero, L. Francisco Lorenzo-Martín, Rubén Caloto, Blanca Nieto, Carmen García-Macías, Clara L. Oeste, Manuel Sánchez-Martín, Antonio Abad, Alejandro Hortal, Dolores Caballero, Marcos González, Mercedes Dosil, Balbino Alarcón & Xosé R. Bustelo. (2022) A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors. Cell Reports 38:11, pages 110522.
Crossref
Shannon M. Weber & Steven L. Carroll. (2021) The Role of R-Ras Proteins in Normal and Pathologic Migration and Morphologic Change. The American Journal of Pathology 191:9, pages 1499-1510.
Crossref
Berta Alcover-Sanchez, Gonzalo Garcia-Martin, Francisco Wandosell & Beatriz Cubelos. (2020) R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases. International Journal of Molecular Sciences 21:16, pages 5911.
Crossref
Patricia Vega-Cuesta, Ana Ruiz-Gómez, Cristina Molnar, Maria F. Organista, Martín Resnik-Docampo, Julia Falo-Sanjuan, Ana López-Varea & Jose F. de Celis. (2020) Ras2, the TC21/R-Ras2 Drosophila homologue, contributes to insulin signalling but is not required for organism viability. Developmental Biology 461:2, pages 172-183.
Crossref
Sida Liao, Ophélia Maertens, Karen Cichowski & Stephen J. Elledge. (2018) Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is. Genes & Development 32:17-18, pages 1188-1200.
Crossref
S. Janapati, J. Wurtzel, C. Dangelmaier, B.K. Manne, D. Bhavanasi, J.C. Kostyak, S. Kim, M. Holinstat, S.P. Kunapuli & L.E. Goldfinger. (2018) TC21/RRas2 regulates glycoprotein VI–FcRγ‐mediated platelet activation and thrombus stability. Journal of Thrombosis and Haemostasis 16:8, pages 1632-1645.
Crossref
Miriam Sanz-Rodriguez, Agnès Gruart, Juan Escudero-Ramirez, Fernando de Castro, José María Delgado-García, Francisco Wandosell & Beatriz Cubelos. (2018) R-Ras1 and R-Ras2 Are Essential for Oligodendrocyte Differentiation and Survival for Correct Myelination in the Central Nervous System. The Journal of Neuroscience 38:22, pages 5096-5110.
Crossref
Pilar Mendoza, Nuria Martínez-Martín, Elena R. BovolentaDiana Reyes-Garau, Pablo Hernansanz-AgustínPilar Delgado, Manuel D. Diaz-Muñoz, Clara L. Oeste, Isabel Fernández-Pisonero, Ester CastellanoAntonio Martínez-Ruiz, Diego Alonso-Lopez, Eugenio Santos, Xosé R. Bustelo, Tomohiro Kurosaki & Balbino Alarcón. (2018) R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes. Science Signaling 11:532.
Crossref
Xiaoyu Zhang, Nicole A Spiegelman, Ornella D Nelson, Hui Jing & Hening Lin. (2017) SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation. eLife 6.
Crossref
Matthew T Chang, Saurabh Asthana, Sizhi Paul Gao, Byron H Lee, Jocelyn S Chapman, Cyriac Kandoth, JianJiong Gao, Nicholas D Socci, David B Solit, Adam B Olshen, Nikolaus Schultz & Barry S Taylor. (2015) Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. Nature Biotechnology 34:2, pages 155-163.
Crossref
Jerry L. Spivak, Michael Considine, Donna M. Williams, Conover C. TalbotJr.Jr., Ophelia Rogers, Alison R. Moliterno, Chunfa Jie & Michael F. Ochs. (2014) Two Clinical Phenotypes in Polycythemia Vera. New England Journal of Medicine 371:9, pages 808-817.
Crossref
Romain M. Larive, Giulia Moriggi, Mauricio Menacho-Márquez, Marta Cañamero, Enrique de Álava, Balbino Alarcón, Mercedes Dosil & Xosé R. Bustelo. (2014) Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease. Nature Communications 5:1.
Crossref
Lauren P. Huff, Molly J. DeCristo & Adrienne D. Cox. 2014. Ras Signaling. Ras Signaling 263 283 .
Sylvia Gutierrez-Erlandsson, Pedro Herrero-Vidal, Marcos Fernandez-Alfara, Susana Hernandez-Garcia, Sandra Gonzalo-Flores, Alberto Mudarra-Rubio, Manuel Fresno & Beatriz Cubelos. (2013) R-RAS2 overexpression in tumors of the human central nervous system. Molecular Cancer 12:1.
Crossref
Zhengbing Lv, Tao Wang, Wenhua Zhuang, Dan Wang, Jian Chen, Zuoming Nie, Lili Liu, Wenping Zhang, Lisha Wang, Deming Wang, Xiangfu Wu, Jun Li, Lian Qian & Yaozhou Zhang. (2013) The Expression, Purification, and Characterization of a Ras Oncogene (Bras2) in Silkworm ( Bombyx mori ) . International Journal of Genomics 2013, pages 1-8.
Crossref
Audrey Claing. 2013. The Molecular Biology of Arrestins. The Molecular Biology of Arrestins 149 174 .
Romain M. Larive, Antonio Abad, Clara M. Cardaba, Teresa Hernández, Marta Cañamero, Enrique de Álava, Eugenio Santos, Balbino Alarcón & Xosé R. Bustelo. (2012) The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development. Molecular Biology of the Cell 23:12, pages 2373-2387.
Crossref
Nuria Martínez-Martín, Elena Fernández-Arenas, Saso Cemerski, Pilar Delgado, Martin Turner, John Heuser, Darrell J. Irvine, Bonnie Huang, Xosé R. Bustelo, Andrey Shaw & Balbino Alarcón. (2011) T Cell Receptor Internalization from the Immunological Synapse Is Mediated by TC21 and RhoG GTPase-Dependent Phagocytosis. Immunity 35:2, pages 208-222.
Crossref
Elisa Ferro & Lorenza Trabalzini. (2010) RalGDS family members couple Ras to Ral signalling and that's not all. Cellular Signalling 22:12, pages 1804-1810.
Crossref
Nagaraj Balasubramanian, Jeremy A. Meier, David W. Scott, Andrés Norambuena, Michael A. White & Martin Alexander Schwartz. (2010) RalA-Exocyst Complex Regulates Integrin-Dependent Membrane Raft Exocytosis and Growth Signaling. Current Biology 20:1, pages 75-79.
Crossref
Gretchen A. Repasky, Adrienne D. Cox, Ariella B. Hanker, Natalia Mitin & Channing J. Der. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 1753 1762 .
Fernando Calvo & Piero Crespo. (2009) Structural and Spatial Determinants Regulating TC21 Activation by RasGRF Family Nucleotide Exchange Factors. Molecular Biology of the Cell 20:20, pages 4289-4302.
Crossref
Pilar Delgado, Beatriz Cubelos, Enrique Calleja, Nuria Martínez-Martín, Angel Ciprés, Isabel Mérida, Carmen Bellas, Xosé R Bustelo & Balbino Alarcón. (2009) Essential function for the GTPase TC21 in homeostatic antigen receptor signaling. Nature Immunology 10:8, pages 880-888.
Crossref
Timothy T. Li, Mistre Alemayehu, Adel I. Aziziyeh, Cynthia Pape, Macarena Pampillo, Lynne-Marie Postovit, Gordon B. Mills, Andy V. Babwah & Moshmi Bhattacharya. (2009) β-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells. Molecular Cancer Research 7:7, pages 1064-1077.
Crossref
Matjaž Rokavec, Werner Schroth, Sandra M.C. Amaral, Peter Fritz, Lydia Antoniadou, Damjan Glavač, Wolfgang Simon, Matthias Schwab, Michel Eichelbaum & Hiltrud Brauch. (2008) A Polymorphism in the TC21 Promoter Associates with an Unfavorable Tamoxifen Treatment Outcome in Breast Cancer . Cancer Research 68:23, pages 9799-9808.
Crossref
Mete Erdogan, Ambra Pozzi, Neil Bhowmick, Harold L Moses & Roy Zent. (2007) Signaling Pathways Regulating TC21-induced Tumorigenesis. Journal of Biological Chemistry 282:38, pages 27713-27720.
Crossref
Marta Rosário, Renate Franke, Christien Bednarski & Walter Birchmeier. (2007) The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42. Journal of Cell Biology 178:3, pages 503-516.
Crossref
C.A.F. Teixeira, S. Lin, M. Mangas, R. Quinta, C.J.P. Bessa, C. Ferreira, M.C. Sá Miranda, R-M.N. Boustany & M.G. Ribeiro. (2006) Gene expression profiling in vLINCL CLN6-deficient fibroblasts: Insights into pathobiology. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1762:7, pages 637-646.
Crossref
Ambra Pozzi, Sergio Coffa, Nada Bulus, Wenqin Zhu, Dong Chen, Xiwu Chen, Glenda Mernaugh, Yan Su, Songmin Cai, Amar Singh, Marcela Brissova & Roy Zent. (2006) H-Ras, R-Ras, and TC21 Differentially Regulate Ureteric Bud Cell Branching Morphogenesis. Molecular Biology of the Cell 17:4, pages 2046-2056.
Crossref
Jean De Gunzburg. 2006. RAS Family GTPases. RAS Family GTPases 295 339 .
Kian-Huat Lim & Christopher M. Counter. 2006. RAS Family GTPases. RAS Family GTPases 257 272 .
Rong Rong, JoAnne Montalbano, Weixin Jin, Jennifer Zhang, Maria Garling, M Saeed Sheikh & Ying Huang. (2005) Oncogenic Ras-mediated downregulation of Gadd153/CHOP is required for Ras-induced cellular transformation. Oncogene 24:30, pages 4867-4872.
Crossref
Ana González-García, Catrin A. Pritchard, Hugh F. Paterson, Georgia Mavria, Gordon Stamp & Christopher J. Marshall. (2005) RalGDS is required for tumor formation in a model of skin carcinogenesis. Cancer Cell 7:3, pages 219-226.
Crossref
Shilpi Arora, Ajay Matta, Nootan Kumar Shukla, S.V.S. Deo & Ranju Ralhan. (2005) Identification of differentially expressed genes in oral squamous cell carcinoma. Molecular Carcinogenesis 42:2, pages 97-108.
Crossref
Paul Frankel, Ami Aronheim, Emma Kavanagh, Maria S Balda, Karl Matter, Tom D Bunney & Christopher J Marshall. (2004) RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity. The EMBO Journal 24:1, pages 54-62.
Crossref
John Colicelli. (2004) Human RAS Superfamily Proteins and Related GTPases. Science's STKE 2004:250.
Crossref
Mathew L. Coleman, Christopher J. Marshall & Michael F. Olson. (2004) RAS and RHO GTPases in G1-phase cell-cycle regulation. Nature Reviews Molecular Cell Biology 5:5, pages 355-366.
Crossref
Weicheng Liu, Xiaoyun Shen, Yanzhong Yang, Xianglei Yin, Jianhui Xie, Jun Yan, Jianhai Jiang, Wenjin Liu, Hanzhou Wang, Maoyun Sun, Ying Zheng & Jianxin Gu. (2004) Trihydrophobin 1 Is a New Negative Regulator of A-Raf Kinase. Journal of Biological Chemistry 279:11, pages 10167-10175.
Crossref
Yuan Huang, Fatima Rangwala, Patricia C Fulkerson, Bo Ling, Erin Reed, Adrienne D Cox, John Kamholz & Nancy Ratner. (2004) Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells. Oncogene 23:2, pages 368-378.
Crossref
Yuchen Chien & Michael A White. (2003) RAL GTPases are linchpin modulators of human tumour‐cell proliferation and survival. EMBO reports 4:8, pages 800-806.
Crossref
Larry A Feig. (2003) Ral-GTPases: approaching their 15 minutes of fame. Trends in Cell Biology 13:8, pages 419-425.
Crossref
Sandeep K. Gill, Moshmi Bhattacharya, Stephen S.G. Ferguson & R. Jane Rylett. (2003) Identification of a Novel Nuclear Localization Signal Common to 69- and 82-kDa Human Choline Acetyltransferase. Journal of Biological Chemistry 278:22, pages 20217-20224.
Crossref
Rachel Kim, Alla Trubetskoy, Takeshi Suzuki, Nancy A. Jenkins, Neal G. Copeland & Jack Lenz. (2003) Genome-Based Identification of Cancer Genes by Proviral Tagging in Mouse Retrovirus-Induced T-Cell Lymphomas. Journal of Virology 77:3, pages 2056-2062.
Crossref
Gretchen A. Murphy, Adrienne D. Cox & Channing J. Der. 2003. Handbook of Cell Signaling. Handbook of Cell Signaling 681 688 .
David Vaudry, Yun Chen, Aurélia Ravni, Carol Hamelink, Abdel G. Elkahloun & Lee E. Eiden. (2002) Analysis of the PC12 cell transcriptome after differentiation with pituitary adenylate cyclase-activating polypeptide (PACAP). Journal of Neurochemistry 83:6, pages 1272-1284.
Crossref
Tao Zhu, Ling Ling & Peter E. Lobie. (2002) Identification of a JAK2-independent Pathway Regulating Growth Hormone (GH)-stimulated p44/42 Mitogen-activated Protein Kinase Activity. Journal of Biological Chemistry 277:47, pages 45592-45603.
Crossref
Yi Yu & Larry A Feig. (2002) Involvement of R-Ras and Ral GTPases in estrogen-independent proliferation of breast cancer cells. Oncogene 21:49, pages 7557-7568.
Crossref
Annette Ehrhardt, Götz R.A Ehrhardt, Xuecui Guo & John W Schrader. (2002) Ras and relatives—job sharing and networking keep an old family together. Experimental Hematology 30:10, pages 1089-1106.
Crossref
Richard R. Clough, Ranjinder S. Sidhu & Rajinder P. Bhullar. (2002) Calmodulin Binds RalA and RalB and Is Required for the Thrombin-induced Activation of Ral in Human Platelets. Journal of Biological Chemistry 277:32, pages 28972-28980.
Crossref
Moshmi Bhattacharya, Pieter H. Anborgh, Andy V. Babwah, Lianne B. Dale, Tomas Dobransky, Jeffery L. Benovic, Ross D. Feldman, Joseph M. Verdi, R. Jane Rylett & Stephen S. G. Ferguson. (2002) β-Arrestins regulate a Ral-GDS–Ral effector pathway that mediates cytoskeletal reorganization. Nature Cell Biology 4:8, pages 547-555.
Crossref
Gretchen A. Murphy, Suzanne M. Graham, Staeci Morita, Sarah E. Reks, Kelley Rogers-Graham, Anne Vojtek, Grant G. Kelley & Channing J. Der. (2002) Involvement of Phosphatidylinositol 3-Kinase, but Not RalGDS, in TC21/R-Ras2-mediated Transformation. Journal of Biological Chemistry 277:12, pages 9966-9975.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.