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Mammalian Genetic Models with Minimal or Complex Phenotypes

Reduced Hepatic Uptake and Intestinal Excretion of Organic Cations in Mice with a Targeted Disruption of the Organic Cation Transporter 1 (Oct1 [Slc22a1]) Gene

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Pages 5471-5477 | Received 07 Feb 2001, Accepted 23 May 2001, Published online: 28 Mar 2023

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Lucie Hyrsova, Tomas Smutny, Frantisek Trejtnar & Petr Pavek. (2016) Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulation. Drug Metabolism Reviews 48:2, pages 139-158.
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R. J. Riley, S. A. Foley, P. Barton, M. G. Soars & B. Williamson. (2016) Hepatic drug transporters: the journey so far. Expert Opinion on Drug Metabolism & Toxicology 12:2, pages 201-216.
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Xiaoyan Chu, Kelly Bleasby & Raymond Evers. (2013) Species differences in drug transporters and implications for translating preclinical findings to humans. Expert Opinion on Drug Metabolism & Toxicology 9:3, pages 237-252.
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Frantisek Staud, Lukas Cerveny & Martina Ceckova. (2012) Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure. Journal of Drug Targeting 20:9, pages 736-763.
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Xi-Ling Jiang, Frank J. Gonzalez & Ai-Ming Yu. (2011) Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models. Drug Metabolism Reviews 43:1, pages 27-40.
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Giuliano Ciarimboli. (2011) Role of organic cation transporters in drug-induced toxicity. Expert Opinion on Drug Metabolism & Toxicology 7:2, pages 159-174.
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Norma Jung & Dirk Taubert. (2009) Organic cation transporters and their roles in antiretroviral drug disposition. Expert Opinion on Drug Metabolism & Toxicology 5:7, pages 773-787.
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G. Ciarimboli. (2008) Organic cation transporters. Xenobiotica 38:7-8, pages 936-971.
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Adrian Vella & Michael Camilleri. (2008) Pharmacogenetics: potential role in the treatment of diabetes and obesity. Expert Opinion on Pharmacotherapy 9:7, pages 1109-1119.
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Isa E. L. M. Kuppens, P. Breedveld, J. H. Beijnen & J. H. M. Schellens. (2005) Modulation of Oral Drug Bioavailability: From Preclinical Mechanism to Therapeutic Application. Cancer Investigation 23:5, pages 443-464.
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Johan W. Jonker, Els Wagenaar, Sven van Eijl & Alfred H. Schinkel. (2003) Deficiency in the Organic Cation Transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in Mice Abolishes Renal Secretion of Organic Cations. Molecular and Cellular Biology 23:21, pages 7902-7908.
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