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Gene Expression

Shared Pathways of IκB Kinase-Induced SCFβTrCP-Mediated Ubiquitination and Degradation for the NF-κB Precursor p105 and IκBα

Vigo HeissmeyerMax-Delbrück-Center for Molecular Medicine, 13122Berlin, Germany
,
Daniel KrappmannMax-Delbrück-Center for Molecular Medicine, 13122Berlin, Germany
,
Eunice N. HatadaMax-Delbrück-Center for Molecular Medicine, 13122Berlin, Germany
&
Claus ScheidereitMax-Delbrück-Center for Molecular Medicine, 13122Berlin, GermanyCorrespondence[email protected]
Pages 1024-1035 | Received 02 Aug 2000, Accepted 15 Nov 2000, Published online: 28 Mar 2023

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Yelena Kravtsova-Ivantsiv & Aaron Ciechanover. (2015) The ubiquitin-proteasome system and activation of NF-κB: involvement of the ubiquitin ligase KPC1 in p105 processing and tumor suppression. Molecular & Cellular Oncology 2:4.
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S. Beinke, M. J. Robinson, M. Hugunin & S. C. Ley. (2004) Lipopolysaccharide Activation of the TPL-2/MEK/Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Cascade Is Regulated by IκB Kinase-Induced Proteolysis of NF-κB1 p105. Molecular and Cellular Biology 24:21, pages 9658-9667.
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Yasusei Kudo, Daniele Guardavaccaro, Patricia G. Santamaria, Ryo Koyama-Nasu, Esther Latres, Roderick Bronson, Lili Yamasaki & Michele Pagano. (2004) Role of F-Box Protein βTrcp1 in Mammary Gland Development and Tumorigenesis. Molecular and Cellular Biology 24:18, pages 8184-8194.
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Michael Waterfield, Wei Jin, William Reiley, Minying Zhang & Shao-Cong Sun. (2004) IκB Kinase Is an Essential Component of the Tpl2 Signaling Pathway. Molecular and Cellular Biology 24:13, pages 6040-6048.
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V. Lang, A. Symons, S. J. Watton, J. Janzen, Y. Soneji, S. Beinke, S. Howell & S. C. Ley. (2004) ABIN-2 Forms a Ternary Complex with TPL-2 and NF-κB1 p105 and Is Essential for TPL-2 Protein Stability. Molecular and Cellular Biology 24:12, pages 5235-5248.
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Shai Cohen, Hillit Achbert-Weiner & Aaron Ciechanover. (2004) Dual Effects of IκB Kinase β-Mediated Phosphorylation on p105 Fate: SCFβ-TrCP-Dependent Degradation and SCFβ-TrCP-Independent Processing. Molecular and Cellular Biology 24:1, pages 475-486.
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Sebastian Tegethoff, Joachim Behlke & Claus Scheidereit. (2003) Tetrameric Oligomerization of IκB Kinase γ (IKKγ) Is Obligatory for IKK Complex Activity and NF-κB Activation. Molecular and Cellular Biology 23:6, pages 2029-2041.
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Valerie Lang, Julia Janzen, Gregory Zvi Fischer, Yasmina Soneji, Sören Beinke, Andres Salmeron, Hamish Allen, Ronald T. Hay, Yinon Ben-Neriah & Steven C. Ley. (2003) βTrCP-Mediated Proteolysis of NF-κB1 p105 Requires Phosphorylation of p105 Serines 927 and 932. Molecular and Cellular Biology 23:1, pages 402-413.
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Daniel Krappmann, Alina Patke, Vigo Heissmeyer & Claus Scheidereit. (2001) B-Cell Receptor- and Phorbol Ester-Induced NF-κB and c-Jun N-Terminal Kinase Activation in B Cells Requires Novel Protein Kinase C's. Molecular and Cellular Biology 21:19, pages 6640-6650.
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