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Gene Expression

Upf1p, Nmd2p, and Upf3p Regulate the Decapping and Exonucleolytic Degradation of both Nonsense-Containing mRNAs and Wild-Type mRNAs

Feng HeDepartment of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts01655-0122
&
Allan JacobsonDepartment of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts01655-0122Correspondence[email protected]
Pages 1515-1530 | Received 04 Oct 2000, Accepted 29 Nov 2000, Published online: 28 Mar 2023

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Sebastian Grosse, Yen-Yun Lu, Ivo Coban, Bettina Neumann & Heike Krebber. (2021) Nuclear SR-protein mediated mRNA quality control is continued in cytoplasmic nonsense-mediated decay. RNA Biology 18:10, pages 1390-1407.
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Feng He, Robin Ganesan & Allan Jacobson. (2013) Intra- and Intermolecular Regulatory Interactions in Upf1, the RNA Helicase Central to Nonsense-Mediated mRNA Decay in Yeast. Molecular and Cellular Biology 33:23, pages 4672-4684.
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Hua Jin, Mi Ra Suh, Jinju Han, Kyu-Hyeon Yeom, Yoontae Lee, Inha Heo, Minju Ha, Seogang Hyun & V. Narry Kim. (2009) Human UPF1 Participates in Small RNA-Induced mRNA Downregulation. Molecular and Cellular Biology 29:21, pages 5789-5799.
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Hudan Liu & Megerditch Kiledjian. (2005) Scavenger Decapping Activity Facilitates 5′ to 3′ mRNA Decay. Molecular and Cellular Biology 25:22, pages 9764-9772.
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Shinichiro Enomoto, Lynn Glowczewski, Jodi Lew-Smith & Judith G. Berman. (2004) Telomere Cap Components Influence the Rate of Senescence in Telomerase-Deficient Yeast Cells. Molecular and Cellular Biology 24:2, pages 837-845.
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Andrew T. Bond, David A. Mangus, Feng He & Allan Jacobson. (2001) Absence of Dbp2p Alters Both Nonsense-Mediated mRNA Decay and rRNA Processing. Molecular and Cellular Biology 21:21, pages 7366-7379.
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Articles from other publishers (64)

Feng He & Allan Jacobson. (2022) Eukaryotic mRNA decapping factors: molecular mechanisms and activity . The FEBS Journal.
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Feng He, Chan Wu & Allan Jacobson. (2022) Dcp2 C-terminal cis-binding elements control selective targeting of the decapping enzyme by forming distinct decapping complexes. eLife 11.
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Michael R. Lawson, Laura N. Lessen, Jinfan Wang, Arjun Prabhakar, Nicholas C. CorsepiusRachel Green & Joseph D. Puglisi. (2021) Mechanisms that ensure speed and fidelity in eukaryotic translation termination. Science 373:6557, pages 876-882.
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Feng He, Alper Celik, Chan Wu & Allan Jacobson. (2018) General decapping activators target different subsets of inefficiently translated mRNAs. eLife 7.
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Marine Dehecq, Laurence Decourty, Abdelkader Namane, Caroline Proux, Joanne Kanaan, Hervé Le Hir, Alain Jacquier & Cosmin Saveanu. (2018) Nonsense‐mediated mRNA decay involves two distinct Upf1‐bound complexes . The EMBO Journal 37:21.
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Claudio Falcone & Cristina Mazzoni. (2018) RNA stability and metabolism in regulated cell death, aging and diseases. FEMS Yeast Research 18:6.
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Alper Celik, Richard Baker, Feng He & Allan Jacobson. (2017) High-resolution profiling of NMD targets in yeast reveals translational fidelity as a basis for substrate selection. RNA 23:5, pages 735-748.
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Emiliano Altamura, Monica Borgatti, Alessia Finotti, Jessica Gasparello, Roberto Gambari, Mariangela Spinelli, Rosa Castaldo & Nicola Altamura. (2016) Chemical-Induced Read-Through at Premature Termination Codons Determined by a Rapid Dual-Fluorescence System Based on S. cerevisiae. PLOS ONE 11:4, pages e0154260.
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Feng He & Allan Jacobson. (2015) Control of mRNA decapping by positive and negative regulatory elements in the Dcp2 C-terminal domain. RNA 21:9, pages 1633-1647.
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