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Molecular and Cellular Biology Volume 21, 2001 - Issue 8
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Cell Growth and Development

The Insert Region of Rac1 Is Essential for Membrane Ruffling but Not Cellular Transformation

Antoine E. Karnoub1 Department of Biochemistry and Biophysics
,
Channing J. Der2 Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599Correspondence[email protected]
&
Sharon L. Campbell1 Department of Biochemistry and Biophysics
Pages 2847-2857 | Received 23 Jan 2001, Accepted 26 Jan 2001, Published online: 28 Mar 2023

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B. Daniel Lam & Peter L. Hordijk. (2013) The Rac1 hypervariable region in targeting and signaling. Small GTPases 4:2, pages 78-89.
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Hui Zong, Kozo Kaibuchi & Lawrence A. Quilliam. (2001) The Insert Region of RhoA Is Essential for Rho Kinase Activation and Cellular Transformation. Molecular and Cellular Biology 21:16, pages 5287-5298.
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Articles from other publishers (27)

Qingqing Huang, Jiarong Xie & Jayaraman Seetharaman. (2022) Crystal Structure of Schizosaccharomyces pombe Rho1 Reveals Its Evolutionary Relationship with Other Rho GTPases. Biology 11:11, pages 1627.
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Niloufar Mosaddeghzadeh, Silke Pudewell, Farhad Bazgir, Neda S. Kazemein Jasemi, Oliver H. F. Krumbach, Lothar Gremer, Dieter Willbold, Radovan Dvorsky & Mohammad R. Ahmadian. (2022) CDC42-IQGAP Interactions Scrutinized: New Insights into the Binding Properties of the GAP-Related Domain. International Journal of Molecular Sciences 23:16, pages 8842.
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Nikolaus Dietz, Markus Huber, Isabel Sorg, Arnaud Goepfert, Alexander Harms, Tilman Schirmer & Christoph Dehio. (2021) Structural basis for selective AMPylation of Rac-subfamily GTPases by Bartonella effector protein 1 (Bep1) . Proceedings of the National Academy of Sciences 118:12.
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Whitney M. Cleghorn, Nada Bulus, Seunghyi Kook, Vsevolod V. Gurevich, Roy Zent & Eugenia V. Gurevich. (2018) Non-visual arrestins regulate the focal adhesion formation via small GTPases RhoA and Rac1 independently of GPCRs. Cellular Signalling 42, pages 259-269.
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Daria Bloch, Gil Feiguelman, Ella Buriakovsky & Shaul Yalovsky. 2020. Cell Biology. Cell Biology 1 24 .
Ki Young Choi, Min Sup Lee, Young Jun Cho, Myong Ho Jeong, Seung Jin Han & Seung Hwan Hong. (2014) p104 Binds to Rac1 and Reduces Its Activity during Myotube Differentiation of C2C12 Cell. The Scientific World Journal 2014, pages 1-12.
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Thomas B. Kuhn. (2014) Oxygen Radicals Elicit Paralysis and Collapse of Spinal Cord Neuron Growth Cones upon Exposure to Proinflammatory Cytokines. BioMed Research International 2014, pages 1-20.
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Si-Cai Zhang, Kazem Nouri, Ehsan Amin, Mohamed S. Taha, Hossein Nakhaeizadeh, Saeideh Nakhaei-Rad, Radovan Dvorsky & Mohammad Reza Ahmadian. 2014. Ras Superfamily Small G Proteins: Biology and Mechanisms 1. Ras Superfamily Small G Proteins: Biology and Mechanisms 1 327 340 .
Lauren MitchellG. Aaron HobbsAmir AghajanianSharon L. Campbell. (2013) Redox Regulation of Ras and Rho GTPases: Mechanism and Function. Antioxidants & Redox Signaling 18:3, pages 250-258.
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Helen R. Mott & Darerca Owen. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 1827 1842 .
Christoph Thomas & Antje Berken. 2010. Integrated G Proteins Signaling in Plants. Integrated G Proteins Signaling in Plants 49 69 .
Brian M. Barth, Shelli Stewart-Smeets & Thomas B. Kuhn. (2009) Proinflammatory cytokines provoke oxidative damage to actin in neuronal cells mediated by Rac1 and NADPH oxidase. Molecular and Cellular Neuroscience 41:2, pages 274-285.
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Dulguun Dorjgotov, Manuela E. Jurca, Csilla Fodor-Dunai, Attila Szűcs, Krisztina Ötvös, Éva Klement, Judit Bíró & Attila Fehér. (2009) Plant Rho-type (Rop) GTPase-dependent activation of receptor-like cytoplasmic kinases in vitro. FEBS Letters 583:7, pages 1175-1182.
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Inka Fricke & Antje Berken. (2009) Molecular basis for the substrate specificity of plant guanine nucleotide exchange factors for ROP. FEBS Letters 583:1, pages 75-80.
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Michael Lammers, Simon Meyer, Dorothee Kühlmann & Alfred Wittinghofer. (2008) Specificity of Interactions between mDia Isoforms and Rho Proteins. Journal of Biological Chemistry 283:50, pages 35236-35246.
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Darerca Owen, Louise J. Campbell, Keily Littlefield, Katrina A. Evetts, Zhigang Li, David B. Sacks, Peter N. Lowe & Helen R. Mott. (2008) The IQGAP1-Rac1 and IQGAP1-Cdc42 Interactions. Journal of Biological Chemistry 283:3, pages 1692-1704.
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Patricia J. Keller, Christyn M. Gable, Michele R. Wing & Adrienne D. Cox. (2005) Rac3-Mediated Transformation Requires Multiple Effector Pathways. Cancer Research 65:21, pages 9883-9890.
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Darerca Owen & Helen R. Mott. 2005. RHO Family GTPases. RHO Family GTPases 31 72 .
Lars Blumenstein & Mohammad Reza Ahmadian. (2004) Models of the Cooperative Mechanism for Rho Effector Recognition. Journal of Biological Chemistry 279:51, pages 53419-53426.
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Marius Pop, Klaus Aktories & Gudula Schmidt. (2004) Isotype-specific Degradation of Rac Activated by the Cytotoxic Necrotizing Factor 1. Journal of Biological Chemistry 279:34, pages 35840-35848.
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Antoine E. Karnoub, Marc Symons, Sharon L. Campbell & Channing J. Der. (2004) Molecular Basis for Rho GTPase Signaling Specificity. Breast Cancer Research and Treatment 84:1, pages 61-71.
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Erica Werner. (2004) GTPases and reactive oxygen species: switches for killing and signaling. Journal of Cell Science 117:2, pages 143-153.
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Helen R. Mott & Darerca Owen. 2003. Handbook of Cell Signaling. Handbook of Cell Signaling 745 750 .
Frederik Vilhardt, Olivier Plastre, Makoto Sawada, Kazuo Suzuki, Maciej Wiznerowicz, Etsuko Kiyokawa, Didier Trono & Karl-Heinz Krause. (2002) The HIV-1 Nef Protein and Phagocyte NADPH Oxidase Activation. Journal of Biological Chemistry 277:44, pages 42136-42143.
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Gary M. BokochBecky A. Diebold. (2002) Current molecular models for NADPH oxidase regulation by Rac GTPase. Blood 100:8, pages 2692-2695.
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Pallavi Sachdev, Liyu Zeng & L.H. Wang. (2002) Distinct Role of Phosphatidylinositol 3-Kinase and Rho Family GTPases in Vav3-induced Cell Transformation, Cell Motility, and Morphological Changes. Journal of Biological Chemistry 277:20, pages 17638-17648.
Crossref
Aron B. Jaffe & Alan Hall. 2002. 57 80 .

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