Advanced search
Publication Cover
Molecular and Cellular Biology Volume 21, 2001 - Issue 9
Submit an article Journal homepage
25
Views
37
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Sequences Flanking Hypersensitive Sites of the β-Globin Locus Control Region Are Required for Synergistic Enhancement

Joseph M. Molete1 Department of Biochemistry and Molecular Biology
,
Hanna Petrykowska1 Department of Biochemistry and Molecular Biology
,
Eric E. Bouhassira3 Department of Medicine, Division of Hematology, Albert Einstein College of Medicine, Bronx, New York
,
Yong-Qing Feng3 Department of Medicine, Division of Hematology, Albert Einstein College of Medicine, Bronx, New York
,
Webb Miller2 Department of Computer Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania
&
Ross C. Hardison1 Department of Biochemistry and Molecular BiologyCorrespondence[email protected]
Pages 2969-2980 | Received 19 Oct 2000, Accepted 09 Feb 2001, Published online: 28 Mar 2023

Citations (37)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Yong-Qing Feng, Renaud Warin, Taihao Li, Emmanuel Olivier, Arnaud Besse, Amanda Lobell, Haiqing Fu, Chii Mei Lin, Mirit I. Aladjem & Eric E. Bouhassira. (2005) The Human β-Globin Locus Control Region Can Silence as Well as Activate Gene Expression. Molecular and Cellular Biology 25:10, pages 3864-3874.
Read now

Articles from other publishers (36)

Richard A. Morgan, Feiyang Ma, Mildred J. Unti, Devin Brown, Paul George Ayoub, Curtis Tam, Lindsay Lathrop, Bamidele Aleshe, Ryo Kurita, Yukio Nakamura, Shantha Senadheera, Ryan L. Wong, Roger P. Hollis, Matteo Pellegrini & Donald B. Kohn. (2020) Creating New β-Globin-Expressing Lentiviral Vectors by High-Resolution Mapping of Locus Control Region Enhancer Sequences. Molecular Therapy - Methods & Clinical Development 17, pages 999-1013.
Crossref
Rachael Davis, Aishwarya Gurumurthy, Mir A. Hossain, Eliot M. Gunn & Jörg Bungert. (2019) Engineering Globin Gene Expression. Molecular Therapy - Methods & Clinical Development 12, pages 102-110.
Crossref
Leslie Weber, Valentina Poletti, Elisa Magrin, Chiara Antoniani, Samia Martin, Charles Bayard, Hanem Sadek, Tristan Felix, Vasco Meneghini, Michael N. Antoniou, Wassim El-Nemer, Fulvio Mavilio, Marina Cavazzana, Isabelle Andre-Schmutz & Annarita Miccio. (2018) An Optimized Lentiviral Vector Efficiently Corrects the Human Sickle Cell Disease Phenotype. Molecular Therapy - Methods & Clinical Development 10, pages 268-280.
Crossref
Troels T. Marstrand & John D. Storey. (2014) Identifying and mapping cell-type-specific chromatin programming of gene expression. Proceedings of the National Academy of Sciences 111:6.
Crossref
Jeremy W. Rupon, Shou Zhen Wang, Merlin Gnanapragasam, Stefanos Labropoulos & Gordon D. Ginder. (2011) MBD2 contributes to developmental silencing of the human ε-globin gene. Blood Cells, Molecules, and Diseases 46:3, pages 212-219.
Crossref
Véronique Adoue, Stéphane Chavanas, Fanny Coudane, Marie-Claire Méchin, Cécile Caubet, Shibo Ying, Sijun Dong, Hélène Duplan, Marie Charveron, Hidenari Takahara, Guy Serre & Michel Simon. (2008) Long-Range Enhancer Differentially Regulated by c-Jun and JunD Controls Peptidylarginine Deiminase-3 Gene in Keratinocytes. Journal of Molecular Biology 384:5, pages 1048-1057.
Crossref
Janelle R. Keys, Michael R. Tallack, Ye Zhan, Peter Papathanasiou, Christopher C. Goodnow, Karin M. Gaensler, Merlin Crossley, Job Dekker & Andrew C. Perkins. (2008) A mechanism for Ikaros regulation of human globin gene switching. British Journal of Haematology 0:0, pages 080305033838221-???.
Crossref
Dagmar Wirth, Leonor Gama-Norton, Pamela Riemer, Upneet Sandhu, Roland Schucht & Hansjörg Hauser. (2007) Road to precision: recombinase-based targeting technologies for genome engineering. Current Opinion in Biotechnology 18:5, pages 411-419.
Crossref
Hao Wang, Ying Zhang, Yong Cheng, Yuepin Zhou, David C. King, James Taylor, Francesca Chiaromonte, Jyotsna Kasturi, Hanna Petrykowska, Brian Gibb, Christine Dorman, Webb Miller, Louis C. Dore, John Welch, Mitchell J. Weiss & Ross C. Hardison. (2006) Experimental validation of predicted mammalian erythroid cis -regulatory modules . Genome Research 16:12, pages 1480-1492.
Crossref
Yong-Qing Feng, Romain Desprat, Haiqing Fu, Emmanuel Olivier, Chii Mei Lin, Amanda Lobell, Shilpa N Gowda, Mirit I Aladjem & Eric E Bouhassira. (2006) DNA Methylation Supports Intrinsic Epigenetic Memory in Mammalian Cells. PLoS Genetics 2:4, pages e65.
Crossref
Xiao HuMichael BulgerM. A. BenderJennifer FieldsMark GroudineSteven Fiering. (2006) Deletion of the core region of 5′ HS2 of the mouse β-globin locus control region reveals a distinct effect in comparison with human β-globin transgenes. Blood 107:2, pages 821-826.
Crossref
K.C. Ehrlich, J. Yu & P.J. Cotty. (2005) Aflatoxin biosynthesis gene clusters and flanking regions. Journal of Applied Microbiology 99:3, pages 518-527.
Crossref
David C. King, James Taylor, Laura Elnitski, Francesca Chiaromonte, Webb Miller & Ross C. Hardison. (2005) Evaluation of regulatory potential and conservation scores for detecting cis -regulatory modules in aligned mammalian genome sequences . Genome Research 15:8, pages 1051-1060.
Crossref
Melissa L. Martowicz, Jeffrey A. Grass, Meghan E. Boyer, Hamza Guend & Emery H. Bresnick. (2005) Dynamic GATA Factor Interplay at a Multicomponent Regulatory Region of the GATA-2 Locus. Journal of Biological Chemistry 280:3, pages 1724-1732.
Crossref
Patrick E. Fields, Gap Ryol Lee, Sean T. Kim, Victor V. Bartsevich & Richard A. Flavell. (2004) Th2-Specific Chromatin Remodeling and Enhancer Activity in the Th2 Cytokine Locus Control Region. Immunity 21:6, pages 865-876.
Crossref
Sung-Hae Lee Kang, Padraic P. Levings, Felicie Andersen, Philip J. Laipis, Kenneth I. Berns, Robert T. Zori & Jörg Bungert. (2004) Locus control region elements HS2 and HS3 in combination with chromatin boundaries confer high-level expression of a human β-globin transgene in a centromeric region. Genes to Cells 9:11, pages 1043-1053.
Crossref
Karen F. Vieira, Padraic P. Levings, Meredith A. Hill, Valerie J. Crusselle, Sung-Hae Lee Kang, James Douglas Engel & Jörg Bungert. (2004) Recruitment of Transcription Complexes to the β-Globin Gene Locus in Vivo and in Vitro. Journal of Biological Chemistry 279:48, pages 50350-50357.
Crossref
Hideki HanawaPhillip W. HargroveSteven KepesDeo K. SrivastavaArthur W. NienhuisDerek A. Persons. (2004) Extended β-globin locus control region elements promote consistent therapeutic expression of a γ-globin lentiviral vector in murine β-thalassemia. Blood 104:8, pages 2281-2290.
Crossref
Derek A. Persons & John F. Tisdale. (2004) Gene therapy for the hemoglobin disorders. Seminars in Hematology 41:4, pages 279-286.
Crossref
Michel Sadelain, Stefano Rivella, Leszek Lisowski, Selda Samakoglu & Isabelle Rivière. (2004) Globin gene transfer for treatment of the β-thalassemias and sickle cell disease. Best Practice & Research Clinical Haematology 17:3, pages 517-534.
Crossref
Neil Davies, John Freebody & Vincent Murray. (2004) Chromatin structure at the flanking regions of the human beta-globin locus control region DNase I hypersensitive site-2: proposed nucleosome positioning by DNA-binding proteins including GATA-1. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1679:3, pages 201-213.
Crossref
Faith Harrow, Jeanne U. Amuta, Shauna R. Hutchinson, Frank Akwaa & Benjamin D. Ortiz. (2004) Factors Binding a Non-classical Cis-element Prevent Heterochromatin Effects on Locus Control Region Activity. Journal of Biological Chemistry 279:17, pages 17842-17849.
Crossref
Chun-Ping Jia, Shu-Zhen Huang, Jing-Bin Yan, Yan-Ping Xiao, Zhao-Rui Ren & Yi-Tao Zeng. (2003) Effects of human locus control region elements HS2 and HS3 on human β-globin gene expression in transgenic mouse. Blood Cells, Molecules, and Diseases 31:3, pages 360-369.
Crossref
ARTHUR W. NIENHUIS, HIDEKI HANAWA, NOBUKUNI SAWAI, BRIAN P. SORRENTINO & DEREK A. PERSONS. (2003) Development of Gene Therapy for Hemoglobin Disorders. Annals of the New York Academy of Sciences 996:1, pages 101-111.
Crossref
Stefano RivellaChad MayAmy ChadburnIsabelle RivièreMichel Sadelain. (2003) A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human β-globin gene transfer. Blood 101:8, pages 2932-2939.
Crossref
Derek A. PersonsPhillip W. HargroveEsther R. AllayHideki HanawaArthur W. Nienhuis. (2003) The degree of phenotypic correction of murine β-thalassemia intermedia following lentiviral-mediated transfer of a human γ-globin gene is influenced by chromosomal position effects and vector copy number. Blood 101:6, pages 2175-2183.
Crossref
Nathan B. Sutter, David Scalzo, Steven Fiering, Mark Groudine & David I. K. Martin. (2003) Chromatin insulation by a transcriptional activator. Proceedings of the National Academy of Sciences 100:3, pages 1105-1110.
Crossref
R.C. HARDISON, F. CHIAROMONTE, D. KOLBE, H. WANG, H. PETRYKOWSKA, L. ELNITSKI, S. YANG, B. GIARDINE, Y. ZHANG, C. RIEMER, S. SCHWARTZ, D. HAUSSLER, K.M. ROSKIN, R.J. WEBER, M. DIEKHANS, W. J. KENT, M.J. WEISS, J. WELCH & W. MILLER. (2003) Global Predictions and Tests of Erythroid Regulatory Regions. Cold Spring Harbor Symposia on Quantitative Biology 68:0, pages 335-344.
Crossref
Sergey V Razin, Catherine M Farrell & Félix Recillas-Targa. 2003. 63 125 .
Xiang Lv, Dong-dong Xu, De-pei Liu, Lei Li, De-long Hao & Chih-chuan Liang. (2002) High-mobility group protein 2 may be involved in the locus control region regulation of the β-globin gene cluster. Biochemistry and Cell Biology 80:6, pages 765-770.
Crossref
S.J.E Routledge & N.J Proudfoot. (2002) Definition of Transcriptional Promoters in the Human β Globin Locus Control Region. Journal of Molecular Biology 323:4, pages 601-611.
Crossref
Yi Tang, De-pei Liu & Chih-Chuan Liang. (2002) Further understanding of the β-globin locus regulation at the molecular level: looping or linking models?. Genes to Cells 7:9, pages 889-900.
Crossref
Padraic P. Levings & Jörg Bungert. (2002) The human β-globin locus control region. European Journal of Biochemistry 269:6, pages 1589-1599.
Crossref
Mark C. Walters, Arthur W. Nienhuis & Elliott Vichinsky. (2002) Novel Therapeutic Approaches in Sickle Cell Disease. Hematology 2002:1, pages 10-34.
Crossref
Joseph M. Molete, Hanna Petrykowska, Martin Sigg, Webb Miller & Ross Hardison. (2002) Functional and binding studies of HS3.2 of the beta-globin locus control region. Gene 283:1-2, pages 185-197.
Crossref
Dirk Schübeler, Mark Groudine & M. A. Bender. (2001) The murine β-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes. Proceedings of the National Academy of Sciences 98:20, pages 11432-11437.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.