Advanced search
Publication Cover
Molecular and Cellular Biology Volume 21, 2001 - Issue 9
Submit an article Journal homepage
12
Views
52
CrossRef citations to date
0
Altmetric
Cell Growth and Development

AP-1 Repressor Protein JDP-2: Inhibition of UV-Mediated Apoptosis through p53 Down-Regulation

Fabrice Piu1 Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California at San Diego, La Jolla, California92093-0636;2 Acadia Pharmaceuticals Inc., San Diego, California92121Correspondence[email protected]
,
Ami Aronheim1 Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California at San Diego, La Jolla, California92093-0636;3 Department of Molecular Genetics, The B. Rappaport Faculty of Medicine, Technion, Bat Galim, Haifa31096, Israel
,
Sigal Katz3 Department of Molecular Genetics, The B. Rappaport Faculty of Medicine, Technion, Bat Galim, Haifa31096, Israel
&
Michael Karin1 Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California at San Diego, La Jolla, California92093-0636
Pages 3012-3024 | Received 12 Oct 2000, Accepted 08 Feb 2001, Published online: 28 Mar 2023

Citations (52)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Suzanne E. Wardell, Viroj Boonyaratanakornkit, James S. Adelman, Ami Aronheim & Dean P. Edwards. (2002) Jun Dimerization Protein 2 Functions as a Progesterone Receptor N-Terminal Domain Coactivator. Molecular and Cellular Biology 22:15, pages 5451-5466.
Read now
Chunyuan Jin, Hongjie Li, Takehide Murata, Kailai Sun, Masami Horikoshi, Robert Chiu & Kazunari K. Yokoyama. (2002) JDP2, a Repressor of AP-1, Recruits a Histone Deacetylase 3 Complex To Inhibit the Retinoic Acid-Induced Differentiation of F9 Cells. Molecular and Cellular Biology 22:13, pages 4815-4826.
Read now

Articles from other publishers (50)

Miso Park, Keon Wook Kang & Ji Won Kim. (2023) The role and application of transcriptional repressors in cancer treatment. Archives of Pharmacal Research 46:1, pages 1-17.
Crossref
Daniel J. de Klerk, Mark J. de Keijzer, Lionel M. Dias, Jordi Heemskerk, Lianne R. de Haan, Tony G. Kleijn, Leonardo P. Franchi & Michal Heger. 2022. Photodynamic Therapy. Photodynamic Therapy 405 480 .
Raffaella Nativio, Yemin Lan, Greg Donahue, Simone Sidoli, Amit Berson, Ananth R. Srinivasan, Oksana Shcherbakova, Alexandre Amlie-Wolf, Ji Nie, Xiaolong Cui, Chuan He, Li-San Wang, Benjamin A. Garcia, John Q. Trojanowski, Nancy M. Bonini & Shelley L. Berger. (2020) An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease. Nature Genetics 52:10, pages 1024-1035.
Crossref
Amy Guimaraes-Young, Charlotte R. Feddersen & Adam J. Dupuy. (2019) Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics. Frontiers in Oncology 9.
Crossref
Nathalie Fuentes & Patricia Silveyra. 2019. Intracellular Signalling Proteins. Intracellular Signalling Proteins 135 170 .
Koji Nakade, Chang-Shen Lin, Xiao-Yu Chen, Ming-Ho Tsai, Kenly Wuputra, Zhi-Wei Zhu, Jian-Zhi Pan & Kazunari K. Yokoyama. (2017) Jun dimerization protein 2 controls hypoxia-induced replicative senescence via both the p16 Ink4a -pRb and Arf-p53 pathways . FEBS Open Bio 7:11, pages 1793-1804.
Crossref
P. S. Sushma, P. UdayKumar & Aliya Sheik. 2017. Role of Transcription Factors in Gastrointestinal Malignancies. Role of Transcription Factors in Gastrointestinal Malignancies 19 32 .
Staci L. Haney, G. Michael Upchurch, Jana Opavska, David Klinkebiel, Ryan A. Hlady, Sohini Roy, Samikshan Dutta, Kaustubh Datta & Rene Opavsky. (2016) Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma. PLOS Genetics 12:9, pages e1006334.
Crossref
Ming-Ho Tsai, Kenly Wuputra, Yin-Chu Lin, Chang-Shen Lin & Kazunari K. Yokoyama. (2016) Multiple functions of the histone chaperone Jun dimerization protein 2. Gene 590:2, pages 193-200.
Crossref
Jing Liu, Qingkai Han, Tianran Peng, Meixiu Peng, Bei Wei, Dongwei Li, Xiaoshan Wang, Shengyong Yu, Jiaqi Yang, Shangtao Cao, Kaimeng Huang, Andrew Paul Hutchins, He Liu, Junqi Kuang, Zhiwei Zhou, Jing Chen, Haoyu Wu, Lin Guo, Yongqiang Chen, You Chen, Xuejia Li, Hongling Wu, Baojian Liao, Wei He, Hong Song, Hongjie Yao, Guangjin Pan, Jiekai Chen & Duanqing Pei. (2015) The oncogene c-Jun impedes somatic cell reprogramming. Nature Cell Biology 17:7, pages 856-867.
Crossref
Yuanhong Xu, Chunyuan Jin, Zhe Liu, Jianzhi Pan, Hongjie Li, Zhongbo Zhang, Shulong Bi & Kazunari K. Yokoyama. (2014) Cloning and characterization of the mouse JDP2 gene promoter reveal negative regulation by p53. Biochemical and Biophysical Research Communications 450:4, pages 1531-1536.
Crossref
Batya Barkan, Adrienne D. Cox & Yoel Kloog. (2013) Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis. Oncotarget 4:2, pages 256-268.
Crossref
L van der Weyden, A G Rust, R E McIntyre, C D Robles-Espinoza, M del Castillo Velasco-Herrera, R Strogantsev, A C Ferguson-Smith, S McCarthy, T M Keane, M J Arends & D J Adams. (2012) Jdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosity. Oncogene 32:3, pages 397-402.
Crossref
Zhe Liu, Ruixia Du, Jin Long, Anbing Dong, Jianpeng Fan, Kejian Guo & Yuanhong Xu. (2012) JDP2 inhibits the epithelial-to-mesenchymal transition in pancreatic cancer BxPC3 cells. Tumor Biology 33:5, pages 1527-1534.
Crossref
Krishnaveni Mohareer, Sudhir Sahdev & Seyed E. Hasnain. (2011) Baculovirus p35 gene is oppositely regulated by P53 and AP-1 like factors in Spodoptera frugiperda. Biochemical and Biophysical Research Communications 414:4, pages 688-693.
Crossref
Keren Weidenfeld-Baranboim, Lilach Koren & Ami Aronheim. (2011) Phosphorylation of JDP2 on threonine-148 by the c-Jun N-terminal kinase targets it for proteosomal degradation. Biochemical Journal 436:3, pages 661-669.
Crossref
Takayuki Murata, Chieko Noda, Shinichi Saito, Daisuke Kawashima, Atsuko Sugimoto, Hiroki Isomura, Teru Kanda, Kazunari K. Yokoyama & Tatsuya Tsurumi. (2011) Involvement of Jun Dimerization Protein 2 (JDP2) in the Maintenance of Epstein-Barr Virus Latency. Journal of Biological Chemistry 286:25, pages 22007-22016.
Crossref
Yu-Chang Huang, Hitomi Hasegawa, Shin-Wei Wang, Chia-Chen Ku, Ying-Chu Lin, Shyh-Shin Chiou, Ming-Feng Hou, Deng-Chyang Wu, Eing-Mei Tsai, Shigeo Saito, Naoto Yamaguchi & Kazunari K. Yokoyama. (2011) Jun Dimerization Protein 2 Controls Senescence and Differentiation via Regulating Histone Modification. Journal of Biomedicine and Biotechnology 2011, pages 1-13.
Crossref
Keren Bitton-Worms, Eli Pikarsky & Ami Aronheim. (2010) The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice. Molecular Cancer 9:1.
Crossref
J Pan, K Nakade, Y-C Huang, Z-W Zhu, S Masuzaki, H Hasegawa, T Murata, A Yoshiki, N Yamaguchi, C-H Lee, W-C Yang, E-M Tsai, Y Obata & K K Yokoyama. (2010) Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2. Oncogene 29:47, pages 6245-6256.
Crossref
Yu‐Chang Huang, Shigeo Saito & Kazunari Kzaushige Yokoyama. (2010) Histone Chaperone Jun Dimerization Protein 2 (JDP2): Role in Cellular Senescence and Aging. The Kaohsiung Journal of Medical Sciences 26:10, pages 515-531.
Crossref
Koji Nakade, Bohdan Wasylyk & Kazunari K. Yokoyama. (2010) Epigenetic regulation of p16Ink4a and Arf by JDP2 in cellular senescence. BioMolecular Concepts 1:1, pages 49-58.
Crossref
Yu-Chang Huang, I-Liang Lee, Yu-Fang Tsai, Shigeo Saito, Ying-Chu Lin, Shyh-Shin Chiou, Eing-Mei Tsai & Kazunari K. Yokoyama. (2010) Role of Jun dimerization protein 2 (JDP2) in cellular senescence. Inflammation and Regeneration 30:6, pages 507-519.
Crossref
Petra Sekyrova, Dirk Bohmann, Marek Jindra & Mirka Uhlirova. (2010) Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis . Development 137:1, pages 141-150.
Crossref
Mads Heilskov Rasmussen, Bruce Wang, Matthias Wabl, Anders Lade Nielsen & Finn Skou Pedersen. (2009) Activation of alternative Jdp2 promoters and functional protein isoforms in T-cell lymphomas by retroviral insertion mutagenesis. Nucleic Acids Research 37:14, pages 4657-4671.
Crossref
Sonyo Shin, Takayuki Asano, Yixin Yao, Ronghua Zhang, Francois-Xavier Claret, Murray Korc, Kanaga Sabapathy, David G. Menter, James L. Abbruzzese & Shrikanth A.G. Reddy. (2009) Activator Protein-1 Has an Essential Role in Pancreatic Cancer Cells and Is Regulated by a Novel Akt-Mediated Mechanism. Molecular Cancer Research 7:5, pages 745-754.
Crossref
K. Weidenfeld-Baranboim, T. Hasin, I. Darlyuk, R. Heinrich, O. Elhanani, J. Pan, K. K. Yokoyama & A. Aronheim. (2009) The ubiquitously expressed bZIP inhibitor, JDP2, suppresses the transcription of its homologue immediate early gene counterpart, ATF3. Nucleic Acids Research 37:7, pages 2194-2203.
Crossref
Xin Pan, Jie Zhao, Wei-Na Zhang, Hui-Yan Li, Rui Mu, Tao Zhou, Hai-Ying Zhang, Wei-Li Gong, Ming Yu, Jiang-Hong Man, Pei-Jing Zhang, Ai-Ling Li & Xue-Min Zhang. (2009) Induction of SOX4 by DNA damage is critical for p53 stabilization and function. Proceedings of the National Academy of Sciences 106:10, pages 3788-3793.
Crossref
Qiang Shen, Ivan P. Uray, Yuxin Li, Yun Zhang, Jamal Hill, Xiao-Chun Xu, Matthew R. Young, Edward J. Gunther, Susan G. Hilsenbeck, Nancy H. Colburn, Lewis A. Chodosh & Powel H. Brown. (2008) Targeting the Activator Protein 1 Transcription Factor for the Prevention of Estrogen Receptor–Negative Mammary Tumors. Cancer Prevention Research 1:1, pages 45-55.
Crossref
K. Weidenfeld-Baranboim, K. Bitton-Worms & A. Aronheim. (2008) TRE-dependent transcription activation by JDP2-CHOP10 association. Nucleic Acids Research 36:11, pages 3608-3619.
Crossref
Johanna De-Castro Arce, Elke Göckel-Krzikalla & Frank Rösl. (2007) Retinoic Acid Receptor β Silences Human Papillomavirus-18 Oncogene Expression by Induction of de Novo Methylation and Heterochromatinization of the Viral Control Region. Journal of Biological Chemistry 282:39, pages 28520-28529.
Crossref
K Nakade, J Pan, A Yoshiki, H Ugai, M Kimura, B Liu, H Li, Y Obata, M Iwama, S Itohara, T Murata & K K Yokoyama. (2007) JDP2 suppresses adipocyte differentiation by regulating histone acetylation. Cell Death & Differentiation 14:8, pages 1398-1405.
Crossref
A. Schlieper, M. Anwar, J. Heger, H. M. Piper & G. Euler. (2006) Repression of anti-apoptotic genes via AP-1 as a mechanism of apoptosis induction in ventricular cardiomyocytes. Pflügers Archiv - European Journal of Physiology 454:1, pages 53-61.
Crossref
Kongming WuManran LiuAnping LiHoward DonningerMahadev Rao, Xuanmao JiaoMichael P. LisantiAles Cvekl, Michael BirrerRichard G. Pestell. (2007) Cell Fate Determination Factor DACH1 Inhibits c-Jun–induced Contact-independent Growth. Molecular Biology of the Cell 18:3, pages 755-767.
Crossref
Chunyuan Jin, Kohsuke Kato, Takahiko Chimura, Takahito Yamasaki, Koji Nakade, Takehide Murata, Hongjie Li, Jianzhi Pan, Mujun Zhao, Kailai Sun, Robert Chiu, Takashi Ito, Kyosuke Nagata, Masami Horikoshi & Kazunari K Yokoyama. (2006) Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2. Nature Structural & Molecular Biology 13:4, pages 331-338.
Crossref
Chunhua Lu, Qiang Shen, Elizabeth DuPré, Heetae Kim, Susan Hilsenbeck & Powel H Brown. (2005) cFos is critical for MCF-7 breast cancer cell growth. Oncogene 24:43, pages 6516-6524.
Crossref
M. Lerdrup, C. Holmberg, N. Dietrich, E. Shaulian, T. Herdegen, M. Jäättelä & T. Kallunki. (2005) Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1745:1, pages 29-37.
Crossref
M.H. Rasmussen, A.B. Sørensen, D.W. Morris, J.C. Dutra, E.K. Engelhard, C.L. Wang, J. Schmidt & F.S. Pedersen. (2005) Tumor model-specific proviral insertional mutagenesis of the Fos/Jdp2/Batf locus. Virology 337:2, pages 353-364.
Crossref
Jochen Hess, Peter Angel & Marina Schorpp-Kistner. (2004) AP-1 subunits: quarrel and harmony among siblings. Journal of Cell Science 117:25, pages 5965-5973.
Crossref
Sandrine Chamboredon, Joseph Briggs, Emmanuel Vial, Julien Hurault, Federico Galvagni, Salvatore Oliviero, Timothy Bos & Marc Castellazzi. (2004) v-Jun downregulates the SPARC target gene by binding to the proximal promoter indirectly through Sp1/3. Oncogene 22:26, pages 4047-4061.
Crossref
Erik Blazek, Sibylle Wasmer, Ulrich Kruse, Ami Aronheim, Masahiro Aoki & Peter K Vogt. (2003) Partial oncogenic transformation of chicken embryo fibroblasts by Jun dimerization protein 2, a negative regulator of TRE- and CRE-dependent transcription. Oncogene 22:14, pages 2151-2159.
Crossref
Dean P. Edwards, Suzanne E. Wardell & Viroj Boonyaratanakornkit. (2002) Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways. The Journal of Steroid Biochemistry and Molecular Biology 83:1-5, pages 173-186.
Crossref
Makiko Hamada, Toshiaki Ohtsuka, Reimi Kawaida, Makoto Koizumi, Koji Morita, Hidehiko Furukawa, Takeshi Imanishi, Makoto Miyagishi & Kazunari Taira. (2002) Effects on RNA Interference in Gene Expression (RNAi) in Cultured Mammalian Cells of Mismatches and the Introduction of Chemical Modifications at the 3′-Ends of siRNAs. Antisense and Nucleic Acid Drug Development 12:5, pages 301-309.
Crossref
Junya Kawauchi, Chun Zhang, Kiyoshi Nobori, Yoshinori Hashimoto, Mimi T. Adachi, Asao Noda, Makoto Sunamori & Shigetaka Kitajima. (2002) Transcriptional Repressor Activating Transcription Factor 3 Protects Human Umbilical Vein Endothelial Cells from Tumor Necrosis Factor-α-induced Apoptosis through Down-regulation ofp53 Transcription. Journal of Biological Chemistry 277:41, pages 39025-39034.
Crossref
Kiyoshi Nobori, Hiroshi Ito, Mimi Tamamori-Adachi, Susumu Adachi, Yuichi Ono, Junya Kawauchi, Shigetaka Kitajima, Fumiaki Marumo & Mitsuaki Isobe. (2002) ATF3 Inhibits Doxorubicin-induced Apoptosis in Cardiac Myocytes: A Novel Cardioprotective Role of ATF3. Journal of Molecular and Cellular Cardiology 34:10, pages 1387-1397.
Crossref
Harry C. Hwang, Carla P. Martins, Yvon Bronkhorst, Erin Randel, Anton Berns, Matthew Fero & Bruce E. Clurman. (2002) Identification of oncogenes collaborating with p27 Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis . Proceedings of the National Academy of Sciences 99:17, pages 11293-11298.
Crossref
Fabrice Piu, Michael Magnani & Max E Ader. (2002) Dissection of the cytoplasmic domains of cytokine receptors involved in STAT and Ras dependent proliferation. Oncogene 21:22, pages 3579-3591.
Crossref
Alena Pance, Aurelie Chantome, Sylvie Reveneau, Fatima Bentrari & Jean-François Jeannin. (2002) A repressor in the proximal human inducible nitric oxide synthase promoter modulates transcriptional activation. The FASEB Journal 16:6, pages 631-633.
Crossref
Karen H Vousden. (2002) Activation of the p53 tumor suppressor protein. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1602:1, pages 47-59.
Crossref
Sigal Katz, Ronit Heinrich & Ami Aronheim. (2001) The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase. FEBS Letters 506:3, pages 196-200.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.