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Molecular and Cellular Biology Volume 22, 2002 - Issue 10
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Transcriptional Regulation

Multiple Nucleosome Positioning Sites Regulate the CTCF-Mediated Insulator Function of the H19 Imprinting Control Region†

Meena Kanduri1 Department of Development & Genetics, Evolution Biology Centre, Uppsala University, S-752 36Uppsala, Sweden
,
Chandrasekhar Kanduri1 Department of Development & Genetics, Evolution Biology Centre, Uppsala University, S-752 36Uppsala, Sweden
,
Piero Mariano1 Department of Development & Genetics, Evolution Biology Centre, Uppsala University, S-752 36Uppsala, Sweden
,
Alexander A. Vostrov2 Department of Psychiatry and Behavioral Science, State University of New York at Stony Brook, Stony Brook, New York11794-8101
,
Wolfgang Quitschke2 Department of Psychiatry and Behavioral Science, State University of New York at Stony Brook, Stony Brook, New York11794-8101
,
Victor Lobanenkov3 Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland20892
&
Rolf Ohlsson1 Department of Development & Genetics, Evolution Biology Centre, Uppsala University, S-752 36Uppsala, SwedenCorrespondence[email protected]
 show all
Pages 3339-3344 | Received 05 Nov 2001, Accepted 17 Jan 2002, Published online: 27 Mar 2023

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Jose Paolo Magbanua, Estelle Runneburger, Steven Russell & Robert White. (2015) A Variably Occupied CTCF Binding Site in the Gene in the Bithorax Complex. Molecular and Cellular Biology 35:1, pages 318-330.
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Jianrong Lu & Ming Tang. (2012) CTCF-dependent chromatin insulator as a built-in attenuator of angiogenesis. Transcription 3:2, pages 73-77.
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Claudia Gebert, David Kunkel, Alexander Grinberg & Karl Pfeifer. (2010) H19 Imprinting Control Region Methylation Requires an Imprinted Environment Only in the Male Germ Line. Molecular and Cellular Biology 30:5, pages 1108-1115.
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Francine E. Garrett, Alexander V. Emelyanov, Manuel A. Sepulveda, Patrick Flanagan, Sabrina Volpi, Fubin Li, Dmitry Loukinov, Laurel A. Eckhardt, Victor V. Lobanenkov & Barbara K. Birshtein. (2005) Chromatin Architecture near a Potential 3′ End of the Igh Locus Involves Modular Regulation of Histone Modifications during B-Cell Development and In Vivo Occupancy at CTCF Sites. Molecular and Cellular Biology 25:4, pages 1511-1525.
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Vinod Pant, Sreenivasulu Kurukuti, Elena Pugacheva, Shaharum Shamsuddin, Piero Mariano, Rainer Renkawitz, Elena Klenova, Victor Lobanenkov & Rolf Ohlsson. (2004) Mutation of a Single CTCF Target Site within the H19 Imprinting Control Region Leads to Loss of Igf2 Imprinting and Complex Patterns of De Novo Methylation upon Maternal Inheritance. Molecular and Cellular Biology 24:8, pages 3497-3504.
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Articles from other publishers (34)

Manthan Patel, Divyesh Patel, Subhamoy Datta & Umashankar Singh. (2020) CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity. BMC Genetics 21:1.
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Suja Subramanian & Tessamma Thomas. (2019) Regular expression based pattern extraction from a cell - Specific gene expression data. Informatics in Medicine Unlocked 17, pages 100269.
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F. Y. Ideraabdullah, J. L. Thorvaldsen, J. A. Myers & M. S. Bartolomei. (2014) Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region. Human Molecular Genetics 23:23, pages 6246-6259.
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Kristin D. Kernohan, Douglas Vernimmen, Gregory B. Gloor & Nathalie G. Bérubé. (2014) Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping. Nucleic Acids Research 42:13, pages 8356-8368.
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Sajad H. Ahanger, Katharina Günther, Oliver Weth, Marek Bartkuhn, Ramesh R. Bhonde, Yogesh S. Shouche & Rainer Renkawitz. (2014) Ectopically tethered CP190 induces large-scale chromatin decondensation. Scientific Reports 4:1.
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Yoko Ito, Raffaella Nativio & Adele Murrell. (2013) Induced DNA demethylation can reshape chromatin topology at the IGF2-H19 locus. Nucleic Acids Research 41:10, pages 5290-5302.
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Vladimir B Teif, Yevhen Vainshtein, Maïwen Caudron-Herger, Jan-Philipp Mallm, Caroline Marth, Thomas Höfer & Karsten Rippe. (2012) Genome-wide nucleosome positioning during embryonic stem cell development. Nature Structural & Molecular Biology 19:11, pages 1185-1192.
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Bum-Kyu Lee & Vishwanath R. Iyer. (2012) Genome-wide Studies of CCCTC-binding Factor (CTCF) and Cohesin Provide Insight into Chromatin Structure and Regulation. Journal of Biological Chemistry 287:37, pages 30906-30913.
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Erin N. McMurray & Jennifer V. Schmidt. (2012) Identification of imprinting regulators at the Meg3 differentially methylated region. Genomics 100:3, pages 184-194.
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Francesco Paolo Fiorentino & Antonio Giordano. (2012) The tumor suppressor role of CTCF. Journal of Cellular Physiology 227:2, pages 479-492.
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H. Takagi, Y. Inai, S.-i. Watanabe, S. Tatemoto, M. Yajima, K. Akasaka, T. Yamamoto & N. Sakamoto. (2011) Nucleosome exclusion from the interspecies-conserved central AT-rich region of the Ars insulator. Journal of Biochemistry 151:1, pages 75-87.
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Caryn S Ross-Innes, Gordon D Brown & Jason S Carroll. (2011) A co-ordinated interaction between CTCF and ER in breast cancer cells. BMC Genomics 12:1.
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Radha Raman Pandey & Chandrasekhar Kanduri. 2011. Long Non-Coding RNAs. Long Non-Coding RNAs 1 27 .
Dong-Hoon Lee, Purnima Singh, Walter M. K. Tsark & Piroska E. Szabó. (2010) Complete Biallelic Insulation at the H19/Igf2 Imprinting Control Region Position Results in Fetal Growth Retardation and Perinatal Lethality. PLoS ONE 5:9, pages e12630.
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Rolf Ohlsson, Marek Bartkuhn & Rainer Renkawitz. (2010) CTCF shapes chromatin by multiple mechanisms: the impact of 20 years of CTCF research on understanding the workings of chromatin. Chromosoma 119:4, pages 351-360.
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Rolf Ohlsson, Victor Lobanenkov & Elena Klenova. (2010) Does CTCF mediate between nuclear organization and gene expression?. BioEssays 32:1, pages 37-50.
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Suresh Cuddapah, Raja Jothi, Dustin E. Schones, Tae-Young Roh, Kairong Cui & Keji Zhao. (2009) Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Research 19:1, pages 24-32.
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Folami Y. Ideraabdullah, Sebastien Vigneau & Marisa S. Bartolomei. (2008) Genomic imprinting mechanisms in mammals. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 647:1-2, pages 77-85.
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Pascal Lefevre, James Witham, Claire E. Lacroix, Peter N. Cockerill & Constanze Bonifer. (2008) The LPS-Induced Transcriptional Upregulation of the Chicken Lysozyme Locus Involves CTCF Eviction and Noncoding RNA Transcription. Molecular Cell 32:1, pages 129-139.
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Chin-Tong Ong & Victor G. Corces. (2008) Modulation of CTCF Insulator Function by Transcription of a Noncoding RNA. Developmental Cell 15:4, pages 489-490.
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Yutao Fu, Manisha Sinha, Craig L. Peterson & Zhiping Weng. (2008) The Insulator Binding Protein CTCF Positions 20 Nucleosomes around Its Binding Sites across the Human Genome. PLoS Genetics 4:7, pages e1000138.
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Julian Roberts, Alison C. Scott, Mark R. Howard, Gerome Breen, Vivien J. Bubb, Elena Klenova & John P. Quinn. (2007) Differential Regulation of the Serotonin Transporter Gene by Lithium Is Mediated by Transcription Factors, CCCTC Binding Protein and Y-Box Binding Protein 1, through the Polymorphic Intron 2 Variable Number Tandem Repeat. The Journal of Neuroscience 27:11, pages 2793-2801.
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Galina N. Filippova. 2007. 337 360 .
Hui Zhao, AeRi Kim, Sang-hyun Song & Ann Dean. (2006) Enhancer Blocking by Chicken β-Globin 5′-HS4. Journal of Biological Chemistry 281:41, pages 30573-30580.
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C. Lavelle & A. Benecke. (2006) Chromatin physics: Replacing multiple, representation-centered descriptions at discrete scales by a continuous, function-dependent self-scaled model. The European Physical Journal E 19:3, pages 379-384.
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Dirk Prawitt, Thorsten Enklaar, Barbara Gärtner-Rupprecht, Christian Spangenberg, Ekkehart Lausch, Dirk Reutzel, Stephan Fees, Maria Korzon, Izabela Brozek, Janusz Limon, David E Housman, Jerry Pelletier & Bernhard Zabel. (2005) Microdeletion and IGF2 loss of imprinting in a cascade causing Beckwith-Wiedemann syndrome with Wilms' tumor. Nature Genetics 37:8, pages 785-786.
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Megumi Kato, Yoshiaki Onishi, Yuko Wada-Kiyama & Ryoiti Kiyama. (2005) Biochemical Screening of Stable Dinucleosomes Using DNA Fragments from a Dinucleosome DNA Library. Journal of Molecular Biology 350:2, pages 215-227.
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Wenqiang Yu, Vasudeva Ginjala, Vinod Pant, Igor Chernukhin, Joanne Whitehead, France Docquier, Dawn Farrar, Gholamreza Tavoosidana, Rituparna Mukhopadhyay, Chandrasekhar Kanduri, Mitsuo Oshimura, Andrew P Feinberg, Victor Lobanenkov, Elena Klenova & Rolf Ohlsson. (2004) Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation. Nature Genetics 36:10, pages 1105-1110.
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C Davey & J Allan. (2003) Nucleosome positioning signals and potential H–DNA within the DNA sequence of the imprinting control region of the mouse Igf2r gene. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1630:2-3, pages 103-116.
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Vinod Pant, Piero Mariano, Chandrasekhar Kanduri, Anita Mattsson, Victor Lobanenkov, Rainer Heuchel & Rolf Ohlsson. (2003) The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains . Genes & Development 17:5, pages 586-590.
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Rolf Ohlsson, Chandrasekhar Kanduri, Joanne Whitehead, Susan Pfeifer, Victor Lobanenkov & Andrew P. Feinberg. 2003. 145 168 .
C. Davey, R. Fraser, M. Smolle, M.W. Simmen & J. Allan. (2003) Nucleosome Positioning Signals in the DNA Sequence of the Human and Mouse H19 Imprinting Control Regions. Journal of Molecular Biology 325:5, pages 873-887.
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Micaela Caserta, Loredana Verdone & Ernesto Di Mauro. (2002) Aspects of Nucleosomal Positional Flexibility and Fluidity. ChemBioChem 3:12, pages 1172-1182.
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L.J. Burke, R. Zhang, M. Lutz & R. Renkawitz. (2002) The thyroid hormone receptor and the insulator protein CTCF: two different factors with overlapping functions. The Journal of Steroid Biochemistry and Molecular Biology 83:1-5, pages 49-57.
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