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Molecular and Cellular Biology Volume 22, 2002 - Issue 10
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Mammalian Genetic Models with Minimal or Complex Phenotypes

Generation and Characterization of Smac/DIABLO-Deficient Mice

Hitoshi Okada1 Amgen Institute and Ontario Cancer Institute;2 Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario, CanadaM5G 2C1
,
Woong-Kyung Suh1 Amgen Institute and Ontario Cancer Institute;2 Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario, CanadaM5G 2C1
,
Jianping Jin3 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York11724
,
Minna Woo1 Amgen Institute and Ontario Cancer Institute;2 Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario, CanadaM5G 2C1
,
Chunying Du4 Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas75390
,
Andrew Elia1 Amgen Institute and Ontario Cancer Institute;2 Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario, CanadaM5G 2C1
,
Gordon S. Duncan1 Amgen Institute and Ontario Cancer Institute;2 Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario, CanadaM5G 2C1
,
Andrew Wakeham1 Amgen Institute and Ontario Cancer Institute;2 Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario, CanadaM5G 2C1
,
Annick Itie1 Amgen Institute and Ontario Cancer Institute;2 Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario, CanadaM5G 2C1
,
Scott W. Lowe3 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York11724
,
Xiaodong Wang4 Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas75390
&
Tak W. Mak1 Amgen Institute and Ontario Cancer Institute;2 Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario, CanadaM5G 2C1Correspondence[email protected]
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Pages 3509-3517 | Received 30 Nov 2001, Accepted 06 Feb 2002, Published online: 27 Mar 2023

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Simone Fulda. (2007) Inhibitor of apoptosis proteins as targets for anticancer therapy. Expert Review of Anticancer Therapy 7:9, pages 1255-1264.
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Andrew T. Ho, Qin H. Li, Hitoshi Okada, Tak W. Mak & Eldad Zacksenhaus. (2007) XIAP Activity Dictates Apaf-1 Dependency for Caspase 9 Activation. Molecular and Cellular Biology 27:16, pages 5673-5685.
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Georg Häcker & Stefan A Paschen. (2007) Therapeutic targets in the mitochondrial apoptotic pathway. Expert Opinion on Therapeutic Targets 11:4, pages 515-526.
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L. Miguel Martins, Alastair Morrison, Kristina Klupsch, Valentina Fedele, Nicoleta Moisoi, Peter Teismann, Alejandro Abuin, Evelyn Grau, Martin Geppert, George P. Livi, Caretha L. Creasy, Alison Martin, Iain Hargreaves, Simon J. Heales, Hitoshi Okada, Sebastian Brandner, Jörg B. Schulz, Tak Mak & Julian Downward. (2004) Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice. Molecular and Cellular Biology 24:22, pages 9848-9862.
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Olivier E. Pardo, Adeline Lesay, Alexandre Arcaro, Rita Lopes, Bee Ling Ng, Patricia H. Warne, Iain A. McNeish, Teresa D. Tetley, Nicholas R. Lemoine, Huseyin Mehmet, Michael J. Seckl & Julian Downward. (2003) Fibroblast Growth Factor 2-Mediated Translational Control of IAPs Blocks Mitochondrial Release of Smac/DIABLO and Apoptosis in Small Cell Lung Cancer Cells. Molecular and Cellular Biology 23:21, pages 7600-7610.
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