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Cell Growth and Development

Identification of Novel Isoforms of the BH3 Domain Protein Bim Which Directly Activate Bax To Trigger Apoptosis

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Pages 3577-3589 | Received 06 Aug 2001, Accepted 04 Mar 2002, Published online: 27 Mar 2023

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Hidenobu Sato, Yunyan Wu, Yukio Kato, Qiang Liu, Hideaki Hirai, Tadashi Yoshizawa, Satoko Morohashi, Jun Watanabe & Hiroshi Kijima. (2017) DEC2 expression antagonizes cisplatin-induced apoptosis in human esophageal squamous cell carcinoma. Molecular Medicine Reports 16:1, pages 43-48.
Crossref
Hamida Thakur & Abid R. Mattoo. 2017. Drug Resistance in Bacteria, Fungi, Malaria, and Cancer. Drug Resistance in Bacteria, Fungi, Malaria, and Cancer 475 482 .
Rosalia de Necochea-Campion, Geoffrey P. Shouse, Qi Zhou, Saied Mirshahidi & Chien-Shing Chen. (2016) Aberrant splicing and drug resistance in AML. Journal of Hematology & Oncology 9:1.
Crossref
Na Wei, Lin Xiao, Rui Xue, Dandan Zhang, Jun Zhou, Huayan Ren, Si Guo & Jingjing Xu. (2015) MicroRNA-9 Mediates the Cell Apoptosis by Targeting Bcl2l11 in Ischemic Stroke. Molecular Neurobiology 53:10, pages 6809-6817.
Crossref
Sheng-Wei Luo, Wei-Na Wang, Zuo-Ming Sun, Fu-Xing Xie, Jing-Rong Kong, Yuan Liu & Chang-Hong Cheng. (2016) Molecular cloning, characterization and expression analysis of (B-cell lymphoma-2 associated X protein) Bax in the orange-spotted grouper (Epinephelus coioides) after the Vibrio alginolyticus challenge. Developmental & Comparative Immunology 60, pages 66-79.
Crossref
Shuaizhen Yuan, Ning Zhang, Lei Xu, Lei Zhou, Xinna Ge, Xin Guo & Hanchun Yang. (2016) Induction of Apoptosis by the Nonstructural Protein 4 and 10 of Porcine Reproductive and Respiratory Syndrome Virus. PLOS ONE 11:6, pages e0156518.
Crossref
Sharad Verma, Sukriti Goyal, Chetna Tyagi, Salma Jamal, Aditi Singh & Abhinav Grover. (2016) BIM (BCL-2 interacting mediator of cell death) SAHB (stabilized α helix of BCL2) not always convinces BAX (BCL-2-associated X protein) for apoptosis. Journal of Molecular Graphics and Modelling 67, pages 94-101.
Crossref
Luwei He, Junjie Han, Baowei Li, Li Huang, Ke Ma, Quan Chen, Xinzhong Liu, Li Bao & Hongwei Liu. (2016) Identification of a new cyathane diterpene that induces mitochondrial and autophagy-dependent apoptosis and shows a potent in vivo anti-colorectal cancer activity. European Journal of Medicinal Chemistry 111, pages 183-192.
Crossref
Zhiqing Liu, Ye Ding, Na Ye, Christopher Wild, Haiying Chen & Jia Zhou. (2016) Direct Activation of Bax Protein for Cancer Therapy. Medicinal Research Reviews 36:2, pages 313-341.
Crossref
Ashish Kumar, Soma Ghosh & Sudhir Chandna. (2015) Evidence for microRNA-31 dependent Bim-Bax interaction preceding mitochondrial Bax translocation during radiation-induced apoptosis. Scientific Reports 5:1.
Crossref
Ronit Vogt Sionov, Spiros A. Vlahopoulos & Zvi Granot. (2015) Regulation of Bim in Health and Disease. Oncotarget 6:27, pages 23058-23134.
Crossref
XU DENG, KE XIA, PO CHEN, MD SAYED ALI SHEIKH, DA-FENG YANG, SI-MIN LI & TIAN-LUN YANG. (2015) Reversion of left ventricle remodeling in spontaneously hypertensive rats by valsartan is associated with the inhibition of caspase-3, -8 and -9 activities. Biomedical Reports 3:4, pages 533-536.
Crossref
Lijun Ye, Gang Yuan, Fei Xu, Yueli Sun, Ziyan Chen, Miaohong Chen, Tianxiao Li, Pingping Sun, Shuxia Li & Jian Sun. (2014) The small-molecule compound BM-1197 inhibits the antiapoptotic regulators Bcl-2/Bcl-xL and triggers apoptotic cell death in human colorectal cancer cells. Tumor Biology 36:5, pages 3447-3455.
Crossref
Hui Tian, Jin-Xia Wu, Feng-Xiao Shan, Shang-Nuan Zhang, Qian Cheng, Jun-Nian Zheng & Dong-Sheng Pei. (2014) Gamma-Aminobutyric Acid Induces Tumor Cells Apoptosis via GABABR1·β-Arrestins·JNKs Signaling Module. Cell Biochemistry and Biophysics 71:2, pages 679-688.
Crossref
A Mühleisen, M Giaisi, R Köhler, P H Krammer & M Li-Weber. (2014) Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression. Cell Death & Disease 5:12, pages e1575-e1575.
Crossref
Ying Zhou, Zhiming Cui, Xiaopeng Xia, Chun Liu, Xinhui Zhu, Jianhua Cao, Yuanyuan Wu, Li Zhou, Zhiyun Ben, Yan Song, Haiyan Zhang & Dongmei Zhang. (2014) Matrix Metalloproteinase-1 (MMP-1) Expression in Rat Spinal Cord Injury Model. Cellular and Molecular Neurobiology 34:8, pages 1151-1163.
Crossref
Decheng Ren, Juan Sun, Liqun Mao, Honggang Ye & Kenneth S. Polonsky. (2014) BH3-Only Molecule Bim Mediates β-Cell Death in IRS2 Deficiency. Diabetes 63:10, pages 3378-3387.
Crossref
C Reynolds, J E Roderick, J L LaBelle, G Bird, R Mathieu, K Bodaar, D Colon, U Pyati, K E Stevenson, J Qi, M Harris, L B Silverman, S E Sallan, J E Bradner, D S Neuberg, A T Look, L D Walensky, M A Kelliher & A Gutierrez. (2014) Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. Leukemia 28:9, pages 1819-1827.
Crossref
Stephanie Campbell, John Thibault, Ninad Mehta, Peter M. Colman, Michele Barry & Marc Kvansakul. (2014) Structural Insight into BH3 Domain Binding of Vaccinia Virus Antiapoptotic F1L. Journal of Virology 88:15, pages 8667-8677.
Crossref
Megan E. MurrayCatherine M. GavileJayakumar R. NairChandana KoorellaLouise M. CarlsonDaniela BuacAdam UtleyMarta Chesi, P. Leif Bergsagel, Lawrence H. BoiseKelvin P. Lee. (2014) CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma. Blood 123:24, pages 3770-3779.
Crossref
Fangjing Chen, Li Zhang, Yueping OuYang, Huapeng Guan, Qi Liu & Bin Ni. (2014) Glucocorticoid Induced Osteoblast Apoptosis by Increasing E4BP4 Expression via Up-regulation of Bim. Calcified Tissue International 94:6, pages 640-647.
Crossref
Jie Yao, Jibing Wu, Xue Yang, Jiaxi Yang, Yuxing Zhang & Linfang Du. (2014) Oleuropein Induced Apoptosis in HeLa Cells via a Mitochondrial Apoptotic Cascade Associated With Activation of the c-Jun NH2-Terminal Kinase. Journal of Pharmacological Sciences 125:3, pages 300-311.
Crossref
Marc Kvansakul & Mark G. Hinds. 2014. Regulated Cell Death Part A: Apoptotic Mechanisms. Regulated Cell Death Part A: Apoptotic Mechanisms 49 74 .
Yu Wang & Nico Tjandra. (2013) Structural Insights of tBid, the Caspase-8-activated Bid, and Its BH3 Domain. Journal of Biological Chemistry 288:50, pages 35840-35851.
Crossref
Robert Meller, Lorena Galvan, Jing Quan Lan, Esther Han, Jason Bauer & Katherine T. Morris. (2013) Programmed Cell Death in a Patient with Hepatocellular Carcinoma Treated with Yttrium-90 and Doxorubicin-loaded Beads. Journal of Vascular and Interventional Radiology 24:10, pages 1537-1542.e2.
Crossref
Christopher von Roretz & Imed-Eddine Gallouzi. 2006. Encyclopedia of Molecular Cell Biology and Molecular Medicine. Encyclopedia of Molecular Cell Biology and Molecular Medicine 1 43 .
Daoxiong Lei, Faqian Li, Huabo Su, Jinbao Liu, Ning Wei & Xuejun Wang. (2013) Hepatic Deficiency of COP9 Signalosome Subunit 8 Induces Ubiquitin-Proteasome System Impairment and Bim-Mediated Apoptosis in Murine Livers. PLoS ONE 8:7, pages e67793.
Crossref
Krishnendu Sinha, Joydeep Das, Pabitra Bikash Pal & Parames C. Sil. (2013) Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis. Archives of Toxicology 87:7, pages 1157-1180.
Crossref
Chao Li, Jin Wei, Ying Li, Xiao He, Qian Zhou, Jie Yan, Jing Zhang, Ying Liu, Yu Liu & Hong-Bing Shu. (2013) Transmembrane Protein 214 (TMEM214) Mediates Endoplasmic Reticulum Stress-induced Caspase 4 Enzyme Activation and Apoptosis. Journal of Biological Chemistry 288:24, pages 17908-17917.
Crossref
R Peng, J-S Tong, H Li, B Yue, F Zou, J Yu & L Zhang. (2013) Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation. Cell Death & Differentiation 20:5, pages 744-754.
Crossref
Leonie Klingenbeck, Rita A. Eckart, Christian Berens & Anja Lührmann. (2013) The Coxiella burnetii type IV secretion system substrate CaeB inhibits intrinsic apoptosis at the mitochondrial level . Cellular Microbiology 15:4, pages 675-687.
Crossref
María Rosa López-Huertas, Elena Mateos, María Sánchez del Cojo, Francisco Gómez-Esquer, Gema Díaz-Gil, Sara Rodríguez-Mora, Juan Antonio López, Enrique Calvo, Guillermo López-Campos, José Alcamí & Mayte Coiras. (2013) The Presence of HIV-1 Tat Protein Second Exon Delays Fas Protein-mediated Apoptosis in CD4+ T Lymphocytes. Journal of Biological Chemistry 288:11, pages 7626-7644.
Crossref
Jinlong Zhang, Debao Li, Aiguo Shen, Hui Mao, Huricha Jin, Wei Huang, Dawei Xu, Jianbo Fan, Jiajia Chen, Longfei Yang & Zhiming Cui. (2012) Expression of RBMX After Spinal Cord Injury in Rats. Journal of Molecular Neuroscience 49:2, pages 417-429.
Crossref
Raghu Gogada, Neelu Yadav, Junwei Liu, Shaohua Tang, Dianmu Zhang, Andrea Schneider, Athul Seshadri, Leimin Sun, C. Marcelo Aldaz, Dean G. Tang & Dhyan Chandra. (2013) Bim, a Proapoptotic Protein, Up-regulated via Transcription Factor E2F1-dependent Mechanism, Functions as a Prosurvival Molecule in Cancer. Journal of Biological Chemistry 288:1, pages 368-381.
Crossref
Christos K. Kontos & Andreas Scorilas. (2012) Molecular cloning of novel alternatively spliced variants of BCL2L12, a new member of the BCL2 gene family, and their expression analysis in cancer cells. Gene 505:1, pages 153-166.
Crossref
C Clybouw, D Merino, T Nebl, F Masson, M Robati, L O'Reilly, A Hübner, R J Davis, A Strasser & P Bouillet. (2012) Alternative splicing of Bim and Erk-mediated BimEL phosphorylation are dispensable for hematopoietic homeostasis in vivo. Cell Death & Differentiation 19:6, pages 1060-1068.
Crossref
Xian-Long Wang, Yi Wu, Lu-Bin Tan, Zhen Tian, Jing-Hao Liu, De-Sheng Zhu & Shen-Ming Zeng. (2012) Follicle-stimulating Hormone Regulates Pro-apoptotic Protein Bcl-2-interacting Mediator of Cell Death-Extra Long (BimEL)-induced Porcine Granulosa Cell Apoptosis. Journal of Biological Chemistry 287:13, pages 10166-10177.
Crossref
Kenji Takeuchi, Anh Ho Viet, Katsumi Kawasaki, Kazuto Nishio & Fumiaki Ito. (2012) JNK-Mediated FOXO Expression Plays a Critical Role in EGFR Tyrosine Kinase Inhibitor-Induced BIM Expression and Apoptosis. Journal of Cancer Therapy 03:04, pages 424-434.
Crossref
Yunyan Wu, Fuyuki Sato, Ujjal Kumar Bhawal, Takeshi Kawamoto, Katsumi Fujimoto, Mitsuhide Noshiro, Hiroko Seino, Satoko Morohashi, Yukio Kato & Hiroshi Kijima. (2012) BHLH transcription factor DEC2 regulates pro-apoptotic factor Bim in human oral cancer HSC-3 cells. Biomedical Research 33:2, pages 75-82.
Crossref
Lixia Zhao, Feng He, Haiyang Liu, Yushan Zhu, Weili Tian, Ping Gao, Hongping He, Wen Yue, Xiaobo Lei, Biyun Ni, Xiaohui Wang, Haijing Jin, Xiaojiang Hao, Jialing Lin & Quan Chen. (2012) Natural Diterpenoid Compound Elevates Expression of Bim Protein, Which Interacts with Antiapoptotic Protein Bcl-2, Converting It to Proapoptotic Bax-like Molecule. Journal of Biological Chemistry 287:2, pages 1054-1065.
Crossref
Carlos Maluquer de Motes, Samantha Cooray, Hongwei Ren, Gabriel M. F. Almeida, Kieran McGourty, Mohammad W. Bahar, David I. Stuart, Jonathan M. Grimes, Stephen C. Graham & Geoffrey L. Smith. (2011) Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence. PLoS Pathogens 7:12, pages e1002430.
Crossref
Rachel Bar-Shavit, Hagit Turm, Zaidoun Salah, Myriam Maoz, Irit Cohen, Einat Weiss, Beatrice Uziely & Sorina Grisaru-Granovsky. (2011) PAR1 plays a role in epithelial malignancies: Transcriptional regulation and novel signaling pathway. IUBMB Life 63:6, pages 397-402.
Crossref
Thomas Landes & Jean-Claude Martinou. (2011) Mitochondrial outer membrane permeabilization during apoptosis: The role of mitochondrial fission. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813:4, pages 540-545.
Crossref
Aisha Shamas-Din, Hetal Brahmbhatt, Brian Leber & David W. Andrews. (2011) BH3-only proteins: Orchestrators of apoptosis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813:4, pages 508-520.
Crossref
Maria Teresa Vento, Valeria Zazzu, Alessia Loffreda, Justin R. Cross, Julian Downward, Maria Patrizia Stoppelli & Ingram Iaccarino. (2010) Praf2 Is a Novel Bcl-xL/Bcl-2 Interacting Protein with the Ability to Modulate Survival of Cancer Cells. PLoS ONE 5:12, pages e15636.
Crossref
Sarah E. Aiyar, Hoyong Park, Paulomi B. Aldo, Gil Mor, John J. Gildea, Aaron L. Miller, E. Brad Thompson, J. David Castle, Sanghee Kim & Richard J. Santen. (2010) TMS, a chemically modified herbal derivative of Resveratrol, induces cell death by targeting Bax. Breast Cancer Research and Treatment 124:1, pages 265-277.
Crossref
Qinhong Wang, Shi-Yong Sun, Fadlo Khuri, Walter J. Curran & Xingming Deng. (2010) Mono- or Double-Site Phosphorylation Distinctly Regulates the Proapoptotic Function of Bax. PLoS ONE 5:10, pages e13393.
Crossref
Yinyuan Wu, Yinyin Wang, Yang Sun, Liying Zhang, Dianjun Wang, Fangli Ren, Donald Chang, Zhijie Chang & Baoqing Jia. (2010) RACK1 promotes Bax oligomerization and dissociates the interaction of Bax and Bcl-XL. Cellular Signalling 22:10, pages 1495-1501.
Crossref
Sylvie Montessuit, Syam Prakash Somasekharan, Oihana Terrones, Safa Lucken-Ardjomande, Sébastien Herzig, Robert Schwarzenbacher, Dietmar J. Manstein, Ella Bossy-Wetzel, Gorka Basañez, Paolo Meda & Jean-Claude Martinou. (2010) Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization. Cell 142:6, pages 889-901.
Crossref
Lubomir Prochazka, Lan-Feng Dong, Karel Valis, Ruth Freeman, Stephen J. Ralph, Jaroslav Turanek & Jiri Neuzil. (2010) α-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels. Apoptosis 15:7, pages 782-794.
Crossref
Ceri M. Wiggins, Mark Johnson & Simon J. Cook. (2010) Refining the minimal sequence required for ERK1/2-dependent poly-ubiquitination and proteasome-dependent turnover of BIM. Cellular Signalling 22:5, pages 801-808.
Crossref
Gilles J. P. Rautureau, Catherine L. Day & Mark G. Hinds. (2010) Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis. International Journal of Molecular Sciences 11:4, pages 1808-1824.
Crossref
E C Bunk, H-G König, T Bernas, T Engel, D C Henshall, B P Kirby & J H M Prehn. (2010) BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus. Cell Death & Disease 1:1, pages e15-e15.
Crossref
Claudia Cerella, Marc Diederich & Lina Ghibelli. (2010) The Dual Role of Calcium as Messenger and Stressor in Cell Damage, Death, and Survival. International Journal of Cell Biology 2010, pages 1-14.
Crossref
Kenji Takeuchi & Fumiaki Ito. (2010) EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors. FEBS Journal 277:2, pages 316-326.
Crossref
Stephanie E. Brock, Chi Li & Binks W. Wattenberg. (2009) The Bax carboxy-terminal hydrophobic helix does not determine organelle-specific targeting but is essential for maintaining Bax in an inactive state and for stable mitochondrial membrane insertion. Apoptosis 15:1, pages 14-27.
Crossref
Thanh-Trang Vo & Anthony Letai. 2010. BCL-2 Protein Family. BCL-2 Protein Family 49 63 .
Lydia Lartigue, Yulia Kushnareva, Youngmo Seong, Helen Lin, Benjamin Faustin & Donald D. Newmeyer. (2009) Caspase-independent Mitochondrial Cell Death Results from Loss of Respiration, Not Cytotoxic Protein Release. Molecular Biology of the Cell 20:23, pages 4871-4884.
Crossref
Diana Hippe, Arnim Weber, Liying Zhou, Donald C. Chang, Georg Häcker & Carsten G. K. Lüder. (2009) Toxoplasma gondii infection confers resistance against BimS-induced apoptosis by preventing the activation and mitochondrial targeting of pro-apoptotic Bax . Journal of Cell Science 122:19, pages 3511-3521.
Crossref
Alexis Jourdain & Jean-Claude Martinou. (2009) Mitochondrial outer-membrane permeabilization and remodelling in apoptosis. The International Journal of Biochemistry & Cell Biology 41:10, pages 1884-1889.
Crossref
Tongli Zhang, Paul Brazhnik & John J. Tyson. (2009) Computational Analysis of Dynamical Responses to the Intrinsic Pathway of Programmed Cell Death. Biophysical Journal 97:2, pages 415-434.
Crossref
Xianwang Wang, Da Xing, Lei Liu & Wei R. Chen. (2009) BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis. FEBS Letters 583:12, pages 1873-1879.
Crossref
Maciej W. Ludwinski, Jing Sun, Brendan Hilliard, Shunyou Gong, Fan Xue, Ruaidhri J. Carmody, Jennifer DeVirgiliis & Youhai H. Chen. (2009) Critical roles of Bim in T cell activation and T cell–mediated autoimmune inflammation in mice. Journal of Clinical Investigation 119:6, pages 1706-1713.
Crossref
Cyril Clybouw, Abbas Hadji, Bouchra ElMchichi, Marie-Thérèse Auffredou, Gérald Leca & Aimé Vazquez. (2009) BimL upregulation induced by BCR cross-linking in BL41 Burkitt’s lymphoma results from a splicing mechanism of the BimEL mRNA. Biochemical and Biophysical Research Communications 383:1, pages 32-36.
Crossref
Lindsay M. Morton, Mark P. Purdue, Tongzhang Zheng, Sophia S. Wang, Bruce Armstrong, Yawei Zhang, Idan Menashe, Nilanjan Chatterjee, Scott Davis, Qing Lan, Claire M. Vajdic, Richard K. Severson, Theodore R. Holford, Anne Kricker, James R. Cerhan, Brian Leaderer, Andrew Grulich, Meredith Yeager, Wendy Cozen, Shelia Hoar Zahm, Stephen J. Chanock, Nathaniel Rothman & Patricia Hartge. (2009) Risk of Non–Hodgkin Lymphoma Associated with Germline Variation in Genes that Regulate the Cell Cycle, Apoptosis, and Lymphocyte Development. Cancer Epidemiology, Biomarkers & Prevention 18:4, pages 1259-1270.
Crossref
Lu Yang, Dingfang Wu, Kewang Luo, Shihua Wu & Ping Wu. (2009) Andrographolide enhances 5-fluorouracil-induced apoptosis via caspase-8-dependent mitochondrial pathway involving p53 participation in hepatocellular carcinoma (SMMC-7721) cells. Cancer Letters 276:2, pages 180-188.
Crossref
Nai Yang Fu, Sunil K. Sukumaran, Sze Yen Kerk & Victor C. Yu. (2009) Baxβ: A Constitutively Active Human Bax Isoform that Is under Tight Regulatory Control by the Proteasomal Degradation Mechanism. Molecular Cell 33:1, pages 15-29.
Crossref
Wen-Xing Ding & Xiao-Ming Yin. 2009. Essentials of Apoptosis. Essentials of Apoptosis 25 61 .
J Hutcheson & H Perlman. (2009) BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention. Oncogene 27:S1, pages S168-S175.
Crossref
M Giam, D C S Huang & P Bouillet. (2009) BH3-only proteins and their roles in programmed cell death. Oncogene 27:S1, pages S128-S136.
Crossref
E Lomonosova & G Chinnadurai. (2009) BH3-only proteins in apoptosis and beyond: an overview. Oncogene 27:S1, pages S2-S19.
Crossref
Jonathan F. Lovell, Lieven P. Billen, Scott Bindner, Aisha Shamas-Din, Cecile Fradin, Brian Leber & David W. Andrews. (2008) Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax. Cell 135:6, pages 1074-1084.
Crossref
D N Dhanasekaran & E P Reddy. (2008) JNK signaling in apoptosis. Oncogene 27:48, pages 6245-6251.
Crossref
Evripidis Gavathiotis, Motoshi Suzuki, Marguerite L. Davis, Kenneth Pitter, Gregory H. Bird, Samuel G. Katz, Ho-Chou Tu, Hyungjin Kim, Emily H.-Y. Cheng, Nico Tjandra & Loren D. Walensky. (2008) BAX activation is initiated at a novel interaction site. Nature 455:7216, pages 1076-1081.
Crossref
Sneha Ramesh, Xiao‐Jun Qi, Gary M Wildey, Janet Robinson, Jeffery Molkentin, John Letterio & Philip H Howe. (2008) TGFβ‐mediated BIM expression and apoptosis are regulated through SMAD3‐dependent expression of the MAPK phosphatase MKP2. EMBO reports 9:10, pages 990-997.
Crossref
Isabel Marzo & Javier Naval. (2008) Bcl-2 family members as molecular targets in cancer therapy. Biochemical Pharmacology 76:8, pages 939-946.
Crossref
Inmaculada Galindo, Bruno Hernaez, Gema Díaz-Gil, Jose M. Escribano & Covadonga Alonso. (2008) A179L, a viral Bcl-2 homologue, targets the core Bcl-2 apoptotic machinery and its upstream BH3 activators with selective binding restrictions for Bid and Noxa. Virology 375:2, pages 561-572.
Crossref
C Clybouw, B E L Mchichi, A Hadji, A Portier, M T Auffredou, D Arnoult, G Leca & A Vazquez. (2008) TGFβ-mediated apoptosis of Burkitt's lymphoma BL41 cells is associated with the relocation of mitochondrial BimEL. Oncogene 27:24, pages 3446-3456.
Crossref
W Zhang, M Konopleva, V R Ruvolo, T McQueen, R L Evans, W G Bornmann, J McCubrey, J Cortes & M Andreeff. (2008) Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway. Leukemia 22:4, pages 808-818.
Crossref
Ritu Aneja, Min Liu, Clayton Yates, Jinmin Gao, Xin Dong, Binfei Zhou, Surya N. Vangapandu, Jun Zhou & Harish C. Joshi. (2008) Multidrug Resistance-Associated Protein–Overexpressing Teniposide-Resistant Human Lymphomas Undergo Apoptosis by a Tubulin-Binding Agent. Cancer Research 68:5, pages 1495-1503.
Crossref
Ilse Decordier, Enrico Cundari & Micheline Kirsch-Volders. (2008) Survival of aneuploid, micronucleated and/or polyploid cells: Crosstalk between ploidy control and apoptosis. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 651:1-2, pages 30-39.
Crossref
D A Fennell, A Chacko & L Mutti. (2007) BCL-2 family regulation by the 20S proteasome inhibitor bortezomib. Oncogene 27:9, pages 1189-1197.
Crossref
Anthony G. Letai. (2008) Diagnosing and exploiting cancer's addiction to blocks in apoptosis. Nature Reviews Cancer 8:2, pages 121-132.
Crossref
Yin-Shan Yeung, Chi-Wai Yip, Chung-Chau Hon, Ken Y.C. Chow, Iris C.M. Ma, Fanya Zeng & Frederick C.C. Leung. (2008) Transcriptional profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: Insights on viral regulation of apoptosis and proliferation. Virology 371:1, pages 32-43.
Crossref
Kathleen N. NemecAnnette R. Khaled. (2008) Therapeutic Modulation of Apoptosis: Targeting the BCL-2 Family at the Interface of the Mitochondrial Membrane. Yonsei Medical Journal 49:5, pages 689.
Crossref
Andreas Strasser, Hamsa Puthalakath, Lorraine A O'Reilly & Philippe Bouillet. (2007) What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain. Immunology & Cell Biology 86:1, pages 57-66.
Crossref
Francisco Gómez-Esquer, Ma. Angustias Palomar, Inés Rivas, José Delcán, Rafael Linares & Gema Díaz-Gil. (2008) Characterization of the BH3 protein Bmf in Gallus gallus: Identification of a novel chicken-specific isoform. Gene 407:1-2, pages 21-29.
Crossref
Ki Deok Shin, Young Ju Yoon, Yeong-Rim Kang, Kwang-Hee Son, Hwan Mook Kim, Byoung-Mog Kwon & Dong Cho Han. (2008) KRIBB3, a novel microtubule inhibitor, induces mitotic arrest and apoptosis in human cancer cells. Biochemical Pharmacology 75:2, pages 383-394.
Crossref
Karen S. Yee & Karen H. Vousden. (2007) Contribution of membrane localization to the apoptotic activity of PUMA. Apoptosis 13:1, pages 87-95.
Crossref
Andrea J. Dowling, Nicholas R. Waterfield, Michelle C. Hares, Gaëlle Le Goff, Charles H. Streuli & Richard H. ffrench-Constant. (2007) The Mcf1 toxin induces apoptosis via the mitochondrial pathway and apoptosis is attenuated by mutation of the BH3-like domain. Cellular Microbiology 9:10, pages 2470-2484.
Crossref
M. Yano, K. Terada, T. Gotoh & M. Mori. (2007) In vitro analysis of Bcl-2 proteins in mitochondria and endoplasmic reticulum: Similarities in anti-apoptotic functions and differences in regulation. Experimental Cell Research 313:17, pages 3767-3778.
Crossref
Chenghao Xuan, Wentao Qiao, Jinmin Gao, Min Liu, Xihui Zhang, Youjia Cao, Qimin Chen, Yunqi Geng & Jun Zhou. (2007) Regulation of Microtubule Assembly and Stability by the Transactivator of Transcription Protein of Jembrana Disease Virus. Journal of Biological Chemistry 282:39, pages 28800-28806.
Crossref
Jing Deng, Nicole Carlson, Kunihiko Takeyama, Paola Dal Cin, Margaret Shipp & Anthony Letai. (2007) BH3 Profiling Identifies Three Distinct Classes of Apoptotic Blocks to Predict Response to ABT-737 and Conventional Chemotherapeutic Agents. Cancer Cell 12:2, pages 171-185.
Crossref
Ji Miao, George G. Chen, Jing-Ping Yun, Suk-Ying Chun, Zi-Zheng Zheng, Rocky L. K. Ho, Ernest C. W. Chak, Ning-Shao Xia & Paul B. S. Lai. (2007) Identification and characterization of BH3 domain protein Bim and its isoforms in human hepatocellular carcinomas. Apoptosis 12:9, pages 1691-1701.
Crossref
Chenghao Xuan, Wentao Qiao, Jian Li, Guoyuan Peng, Min Liu, Qimin Chen, Jun Zhou & Yunqi Geng. (2007) BTat, a trans-acting regulatory protein, contributes to bovine immunodeficiency virus-induced apoptosis. Cellular Microbiology 0:0, pages 070723152042001-???.
Crossref
Arnaud Autret, Sandra Martin-Latil, Laurence Mousson, Aurélie Wirotius, Frédéric Petit, Damien Arnoult, Florence Colbère-Garapin, Jérôme Estaquier & Bruno Blondel. (2007) Poliovirus Induces Bax-Dependent Cell Death Mediated by c-Jun NH 2 -Terminal Kinase . Journal of Virology 81:14, pages 7504-7516.
Crossref
Massimo Donadelli, Chiara Costanzo, Stefania Beghelli, Maria Teresa Scupoli, Mario Dandrea, Antonio Bonora, Paolo Piacentini, Alfredo Budillon, Michele Caraglia, Aldo Scarpa & Marta Palmieri. (2007) Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773:7, pages 1095-1106.
Crossref
S. Emanuele, M. Lauricella, D. Carlisi, B. Vassallo, A. D’Anneo, P. Di Fazio, R. Vento & G. Tesoriere. (2007) SAHA induces apoptosis in hepatoma cells and synergistically interacts with the proteasome inhibitor Bortezomib. Apoptosis 12:7, pages 1327-1338.
Crossref
Katherine E Ewings, Kathryn Hadfield-Moorhouse, Ceri M Wiggins, Julie A Wickenden, Kathryn Balmanno, Rebecca Gilley, Kurt Degenhardt, Eileen White & Simon J Cook. (2007) ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL. The EMBO Journal 26:12, pages 2856-2867.
Crossref
Chun Chen, Jun Cui, Haizhu Lu, Rui Wang, Shuai Zhang & Pingping Shen. (2007) Modeling of the Role of a Bax-Activation Switch in the Mitochondrial Apoptosis Decision. Biophysical Journal 92:12, pages 4304-4315.
Crossref
Miaojuan Chen, Da Xing, Tongsheng Chen & Lan Zhang. (2007) BimL involvement in Bax activation during UV irradiation-induced apoptosis. Biochemical and Biophysical Research Communications 358:2, pages 559-565.
Crossref
Georg Häcker & Arnim Weber. (2007) BH3-only proteins trigger cytochrome c release, but how?. Archives of Biochemistry and Biophysics 462:2, pages 150-155.
Crossref
Arnim Weber, Stefan A. Paschen, Klaus Heger, Florian Wilfling, Tobias Frankenberg, Heike Bauerschmitt, Barbara M. Seiffert, Susanne Kirschnek, Hermann Wagner & Georg Häcker. (2007) BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins. Journal of Cell Biology 177:4, pages 625-636.
Crossref
Brian Leber, Jialing Lin & David W. Andrews. (2007) Embedded together: The life and death consequences of interaction of the Bcl-2 family with membranes. Apoptosis 12:5, pages 897-911.
Crossref
Zaidoun Salah, Myriam Maoz, Elisheva Pokroy, Michal Lotem, Rachel Bar-Shavit & Beatrice Uziely. (2007) Protease-Activated Receptor-1 ( hPar1 ), A Survival Factor Eliciting Tumor Progression . Molecular Cancer Research 5:3, pages 229-240.
Crossref
Huiyan Wang & Jagjit S. Yadav. (2006) Global gene expression changes underlying Stachybotrys chartarum toxin-induced apoptosis in murine alveolar macrophages: Evidence of multiple signal transduction pathways. Apoptosis 12:3, pages 535-548.
Crossref
Simon N. WillisJamie I. FletcherThomas KaufmannMark F. van DelftLin ChenPeter E. CzabotarHelen IerinoErinna F. LeeW. Douglas FairliePhilippe BouilletAndreas StrasserRuth M. KluckJerry M. AdamsDavid C. S. Huang. (2007) Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak. Science 315:5813, pages 856-859.
Crossref
Mingzhong Yao, Thuy-Vi V. Nguyen & Christian J. Pike. (2007) Estrogen Regulates Bcl-w and Bim Expression: Role in Protection against β-Amyloid Peptide-Induced Neuronal Death. The Journal of Neuroscience 27:6, pages 1422-1433.
Crossref
Victoria Del Gaizo Moore, Jennifer R. Brown, Michael Certo, Tara M. Love, Carl D. Novina & Anthony Letai. (2007) Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. Journal of Clinical Investigation 117:1, pages 112-121.
Crossref
M. L. McEwen & J. E. Springer. 2007. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology 515 550 .
John M. Taylor, Douglas Quilty, Logan Banadyga & Michele Barry. (2006) The Vaccinia Virus Protein F1L Interacts with Bim and Inhibits Activation of the Pro-apoptotic Protein Bax. Journal of Biological Chemistry 281:51, pages 39728-39739.
Crossref
Joseph Pierce, Jules Rir-Sima-Ah, Isaac Estrada, Julie Wilder, Andreas Strasser & Yohannes Tesfaigzi. (2006) Loss of pro-apoptotic Bim promotes accumulation of pulmonary T lymphocytes and enhances allergen-induced goblet cell metaplasia. American Journal of Physiology-Lung Cellular and Molecular Physiology 291:5, pages L862-L870.
Crossref
Gina M Leinninger, James L Edwards, Matthew J Lipshaw & Eva L Feldman. (2006) Mechanisms of Disease: mitochondria as new therapeutic targets in diabetic neuropathy. Nature Clinical Practice Neurology 2:11, pages 620-628.
Crossref
Eiko Takada, Kikumi Hata & Junichiro Mizuguchi. (2006) Requirement for JNK-dependent upregulation of BimL in anti-IgM-induced apoptosis in murine B lymphoma cell lines WEHI-231 and CH31. Experimental Cell Research 312:19, pages 3728-3738.
Crossref
Loren D. Walensky, Kenneth Pitter, Joel Morash, Kyoung Joon Oh, Scott Barbuto, Jill Fisher, Eric Smith, Gregory L. Verdine & Stanley J. Korsmeyer. (2006) A Stapled BID BH3 Helix Directly Binds and Activates BAX. Molecular Cell 24:2, pages 199-210.
Crossref
Alison J. Butt, Caroline G. Roberts, Alan A. Seawright, Peter B. Oelrichs, John K. MacLeod, Tracy Y.E. Liaw, Maria Kavallaris, Tiffany J. Somers-Edgar, Gillian M. Lehrbach, Colin K. Watts & Robert L. Sutherland. (2006) A novel plant toxin, persin, with in vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells . Molecular Cancer Therapeutics 5:9, pages 2300-2309.
Crossref
Violeta Gómez-Vicente, Francesca Doonan, Maryanne Donovan & Thomas G. Cotter. (2006) Induction of BIM EL following growth factor withdrawal is a key event in caspase-dependent apoptosis of 661W photoreceptor cells . European Journal of Neuroscience 24:4, pages 981-990.
Crossref
L D Walensky. (2006) BCL-2 in the crosshairs: tipping the balance of life and death. Cell Death & Differentiation 13:8, pages 1339-1350.
Crossref
Michael Certo, Victoria Del Gaizo Moore, Mari Nishino, Guo Wei, Stanley Korsmeyer, Scott A. Armstrong & Anthony Letai. (2006) Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 9:5, pages 351-365.
Crossref
Kirsten Canté-Barrett, Elena M. Gallo, Monte M. Winslow & Gerald R. Crabtree. (2006) Thymocyte Negative Selection Is Mediated by Protein Kinase C- and Ca2+-Dependent Transcriptional Induction of Bim. The Journal of Immunology 176:4, pages 2299-2306.
Crossref
Christopher E Andoniou & Mariapia A Degli‐Esposti. (2006) Insights into the mechanisms of CMV‐mediated interference with cellular apoptosis. Immunology & Cell Biology 84:1, pages 99-106.
Crossref
Mark F van Delft & David CS Huang. (2006) How the Bcl-2 family of proteins interact to regulate apoptosis. Cell Research 16:2, pages 203-213.
Crossref
Lucy M. Elphick, Annika Meinander, Andrey Mikhailov, Morgiane Richard, Nick J. Toms, John E. Eriksson & George E.N. Kass. (2006) Live cell detection of caspase-3 activation by a Discosoma-red-fluorescent-protein-based fluorescence resonance energy transfer construct. Analytical Biochemistry 349:1, pages 148-155.
Crossref
Xiao-Jun Qi, Gary M. Wildey & Philip H. Howe. (2006) Evidence That Ser87 of BimEL Is Phosphorylated by Akt and Regulates BimEL Apoptotic Function. Journal of Biological Chemistry 281:2, pages 813-823.
Crossref
Lori A. Hazlehurst. 2006. Cell Adhesion and Cytoskeletal Molecules in Metastasis. Cell Adhesion and Cytoskeletal Molecules in Metastasis 163 177 .
Simon N Willis & Jerry M Adams. (2005) Life in the balance: how BH3-only proteins induce apoptosis. Current Opinion in Cell Biology 17:6, pages 617-625.
Crossref
Sarah A. Molton, Claire Weston, Kathryn Balmanno, Catherine Newson, Daniel E. Todd, Andrew P. Garner & Simon J. Cook. (2005) The conditional kinase ΔMEKK1:ER* selectively activates the JNK pathway and protects against serum withdrawal-induced cell death. Cellular Signalling 17:11, pages 1412-1422.
Crossref
Natsumi Abe, Kazuyoshi Kohu, Hidetaka Ohmori, Keitaro Hayashi, Toshio Watanabe, Katsuto Hozumi, Takehito Sato, Sonoko Habu & Masanobu Satake. (2005) Reduction of Runx1 Transcription Factor Activity Up-Regulates Fas and Bim Expression and Enhances the Apoptotic Sensitivity of Double Positive Thymocytes. The Journal of Immunology 175:7, pages 4475-4482.
Crossref
Cyril Clybouw, Bouchra Mchichi, Shahul Mouhamad, Marie Thérèse Auffredou, Marie Françoise Bourgeade, Surendra Sharma, Gerald Leca & Aimé Vazquez. (2005) EBV Infection of Human B Lymphocytes Leads to Down-Regulation of Bim Expression: Relationship to Resistance to Apoptosis. The Journal of Immunology 175:5, pages 2968-2973.
Crossref
Jonathan GilleyJonathan Ham. (2005) Evidence for Increased Complexity in the Regulation of Bim Expression in Sympathetic Neurons: Involvement of Novel Transcriptional and Translational Mechanisms. DNA and Cell Biology 24:9, pages 563-573.
Crossref
Angela K. Zimmermann, F. Alexandra Loucks, Shoshona S. Le, Brent D. Butts, Maria L. Florez-McClure, Ron J. Bouchard, Kim A. Heidenreich & Daniel A. Linseman. (2005) Distinct mechanisms of neuronal apoptosis are triggered by antagonism of Bcl-2/Bcl-x(L) versus induction of the BH3-only protein Bim. Journal of Neurochemistry 94:1, pages 22-36.
Crossref
Qingnan Li, Liyu Wu, Denise K. Oelschlager, Mei Wan, Cecil R. Stockard, William E. Grizzle, Ning Wang, Huaiqing Chen, Yi Sun & Xu Cao. (2005) Smad4 Inhibits Tumor Growth by Inducing Apoptosis in Estrogen Receptor-α-positive Breast Cancer Cells. Journal of Biological Chemistry 280:29, pages 27022-27028.
Crossref
Christian Schwerk & Klaus Schulze-Osthoff. (2005) Regulation of Apoptosis by Alternative Pre-mRNA Splicing. Molecular Cell 19:1, pages 1-13.
Crossref
Safa Lucken-Ardjomande & Jean-Claude Martinou. (2005) Regulation of Bcl-2 proteins and of the permeability of the outer mitochondrial membrane. Comptes Rendus Biologies 328:7, pages 616-631.
Crossref
Rebecca Ley, Kathryn Hadfield, Elizabeth Howes & Simon J. Cook. (2005) Identification of a DEF-type Docking Domain for Extracellular Signal-regulated Kinases 1/2 That Directs Phosphorylation and Turnover of the BH3-only Protein BimEL. Journal of Biological Chemistry 280:18, pages 17657-17663.
Crossref
T Lund, T Stokke, Ø E Olsen & Ø Fodstad. (2005) Garlic arrests MDA-MB-435 cancer cells in mitosis, phosphorylates the proapoptotic BH3-only protein BimEL and induces apoptosis. British Journal of Cancer 92:9, pages 1773-1781.
Crossref
Frederic Luciano, Dayong Zhai, Xiuwen Zhu, Beatrice Bailly-Maitre, Jean-Ehrland Ricci, Arnold C. Satterthwait & John C. Reed. (2005) Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL. Journal of Biological Chemistry 280:16, pages 15825-15835.
Crossref
Yaping Sun & Douglas W. Leaman. (2005) Involvement of Noxa in Cellular Apoptotic Responses to Interferon, Double-stranded RNA, and Virus Infection. Journal of Biological Chemistry 280:16, pages 15561-15568.
Crossref
T A Precht, R A Phelps, D A Linseman, B D Butts, S S Le, T A Laessig, R J Bouchard & K A Heidenreich. (2005) The permeability transition pore triggers Bax translocation to mitochondria during neuronal apoptosis. Cell Death & Differentiation 12:3, pages 255-265.
Crossref
Andreas Strasser. (2005) The role of BH3-only proteins in the immune system. Nature Reviews Immunology 5:3, pages 189-200.
Crossref
Patricia Gomez-Bougie, R�gis Bataille & Martine Amiot. (2005) Endogenous association of Bim BH3-only protein with Mcl-1, Bcl-xL and Bcl-2 on mitochondria in human B cells. European Journal of Immunology 35:3, pages 971-976.
Crossref
Safa Lucken-Ardjomande & Jean-Claude Martinou. (2005) Newcomers in the process of mitochondrial permeabilization. Journal of Cell Science 118:3, pages 473-483.
Crossref
Dehua Wang, Maureen A. McDonnell & Ameeta Kelekar. (2005) Multi-probe RPA template sets to study RNA modulation and transcriptional control of BH3-only members of the Bcl-2 family. Cancer Detection and Prevention 29:2, pages 189-200.
Crossref
Sanjeev Shangary, Christopher L. Oliver & Daniel E. Johnson. 2005. Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases. Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases 107 135 .
Dragana Milojković, Stephen Devereux, Nigel B. Westwood, Ghulam J. Mufti, N. Shaun B. Thomas & Andrea G. S. Buggins. (2004) Antiapoptotic Microenvironment of Acute Myeloid Leukemia. The Journal of Immunology 173:11, pages 6745-6752.
Crossref
Marc T. Abrams, Noreen M. Robertson, Kyonggeun Yoon & Eric Wickstrom. (2004) Inhibition of Glucocorticoid-induced Apoptosis by Targeting the Major Splice Variants of BIM mRNA with Small Interfering RNA and Short Hairpin RNA. Journal of Biological Chemistry 279:53, pages 55809-55817.
Crossref
Michael H. Malone, Zhengqi Wang & Clark W. Distelhorst. (2004) The Glucocorticoid-induced Gene tdag8 Encodes a Pro-apoptotic G Protein-coupled Receptor Whose Activation Promotes Glucocorticoid-induced Apoptosis. Journal of Biological Chemistry 279:51, pages 52850-52859.
Crossref
Grant R. Campbell, Eddy Pasquier, Jennifer Watkins, Veronique Bourgarel-Rey, Vincent Peyrot, Didier Esquieu, Pascale Barbier, Jean de Mareuil, Diane Braguer, Pontiano Kaleebu, David L. Yirrell & Erwann P. Loret. (2004) The Glutamine-rich Region of the HIV-1 Tat Protein Is Involved in T-cell Apoptosis. Journal of Biological Chemistry 279:46, pages 48197-48204.
Crossref
Hisashi Harada, Bonnie Quearry, Antonio Ruiz-Vela & Stanley J. Korsmeyer. (2004) Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. Proceedings of the National Academy of Sciences 101:43, pages 15313-15317.
Crossref
Hidesuke Fukazawa, Kohji Noguchi, Atsuko Masumi, Yuko Murakami & Yoshimasa Uehara. (2004) BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors. Molecular Cancer Therapeutics 3:10, pages 1281-1288.
Crossref
Kenneth W. Yip, Anna Li, Jian-Hua Li, Wei Shi, Marie C. Chia, Shahnaz Al Rashid, Joseph D. Mocanu, Alexander V. Louie, Otto Sanchez, Dolly Huang, Pierre Busson, Wen-Chen Yeh, Ralph Gilbert, Brian O'sullivan, Patrick Gullane & Fei-Fei Liu. (2004) Potential Utility of BimS as a Novel Apoptotic Therapeutic Molecule. Molecular Therapy 10:3, pages 533-544.
Crossref
Patrick S. Moore, Stefano Barbi, Massimo Donadelli, Chiara Costanzo, Claudio Bassi, Marta Palmieri & Aldo Scarpa. (2004) Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro- and anti-apoptotic genes in pancreatic adenocarcinoma cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1693:3, pages 167-176.
Crossref
Jin-Zhong Chen, Chao-Neng Ji, Shao-Hua Gu, Ji-Xi Li, En-Peng Zhao, Yan Huang, Lu Huang, Kang Ying, Yi Xie & Yu-Min Mao. (2004) Over-expression of Bim α3, a novel isoform of human Bim, result in cell apoptosis. The International Journal of Biochemistry & Cell Biology 36:8, pages 1554-1561.
Crossref
Oihana Terrones, Bruno Antonsson, Hirohito Yamaguchi, Hong-Gang Wang, Jihua Liu, Ray M. Lee, Andreas Herrmann & Gorka Basañez. (2004) Lipidic Pore Formation by the Concerted Action of Proapoptotic BAX and tBID. Journal of Biological Chemistry 279:29, pages 30081-30091.
Crossref
John C. ReedKutbuddin S. DoctorAdam Godzik. (2004) The Domains of Apoptosis: A Genomics Perspective. Science's STKE 2004:239.
Crossref
David A. Hildeman. (2004) Regulation of T-cell apoptosis by reactive oxygen species. Free Radical Biology and Medicine 36:12, pages 1496-1504.
Crossref
Michela Marani, David Hancock, Rita Lopes, Tencho Tenev, Julian Downward & Nicholas R Lemoine. (2003) Role of Bim in the survival pathway induced by Raf in epithelial cells. Oncogene 23:14, pages 2431-2441.
Crossref
Shing-Leng Chan & Victor C Yu. (2004) PROTEINS OF THE BCL-2 FAMILY IN APOPTOSIS SIGNALLING: FROM MECHANISTIC INSIGHTS TO THERAPEUTIC OPPORTUNITIES. Clinical and Experimental Pharmacology and Physiology 31:3, pages 119-128.
Crossref
Rebecca Ley, Katherine E. Ewings, Kathryn Hadfield, Elizabeth Howes, Kathryn Balmanno & Simon J. Cook. (2004) Extracellular Signal-regulated Kinases 1/2 Are Serum-stimulated “BimEL Kinases” That Bind to the BH3-only Protein BimEL Causing Its Phosphorylation and Turnover. Journal of Biological Chemistry 279:10, pages 8837-8847.
Crossref
Rizwan S. Akhtar, Jayne M. Ness & Kevin A. Roth. (2004) Bcl-2 family regulation of neuronal development and neurodegeneration. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1644:2-3, pages 189-203.
Crossref
Nathalie M. Droin & Douglas R. Green. (2004) Role of Bcl-2 family members in immunity and disease. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1644:2-3, pages 179-188.
Crossref
Shahul Mouhamad, Laurence Besnault, Marie Thérèse Auffredou, Corinne Leprince, Marie Françoise Bourgeade, Gérald Leca & Aimé Vazquez. (2004) B Cell Receptor-Mediated Apoptosis of Human Lymphocytes Is Associated with a New Regulatory Pathway of Bim Isoform Expression. The Journal of Immunology 172:4, pages 2084-2091.
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