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Phelps J Lambert, Aniqa Z Shahrier, Audy G Whitman, Ossie F Dyson, Adrian J Reber, James A McCubrey & Shaw M Akula. (2007) Targeting the PI3K and MAPK pathways to treat Kaposi’s sarcoma-associated herpes virus infection and pathogenesis. Expert Opinion on Therapeutic Targets 11:5, pages 589-599.
Read now
Read now
Matthew L. Edin & Rudy L. Juliano. (2005) Raf-1 Serine 338 Phosphorylation Plays a Key Role in Adhesion-Dependent Activation of Extracellular Signal-Regulated Kinase by Epidermal Growth Factor. Molecular and Cellular Biology 25:11, pages 4466-4475.
Read now
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Kathryn Balmanno, Tracy Millar, Martin McMahon & Simon J. Cook. (2003) ΔRaf-1:ER* Bypasses the Cyclic AMP Block of Extracellular Signal-Regulated Kinase 1 and 2 Activation but Not CDK2 Activation or Cell Cycle Reentry. Molecular and Cellular Biology 23:24, pages 9303-9317.
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Read now
Amardeep S. Dhillon, Sharon Meikle, Carole Peyssonnaux, Joan Grindlay, Christian Kaiser, Helge Steen, Peter E. Shaw, Harald Mischak, Alain Eychène & Walter Kolch. (2003) A Raf-1 Mutant That Dissociates MEK/Extracellular Signal-Regulated Kinase Activation from Malignant Transformation and Differentiation but Not Proliferation. Molecular and Cellular Biology 23:6, pages 1983-1993.
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Articles from other publishers (60)
Pritha Mukherjee, Arka Bagchi, Ananya Banerjee, Himansu Roy, Arijit Bhattacharya, Arunima Biswas & Urmi Chatterji. (2022) PDE4 inhibitor eliminates breast cancer stem cells via noncanonical activation of mTOR. Journal of Cellular Biochemistry 123:12, pages 1980-1996.
Crossref
Crossref
Xixi Tao, Ronglu Du, Shumin Guo, Xiangling Feng, Tingting Yu, Qian OuYang, Qiaoli Chen, Xutong Fan, Xueqi Wang, Chen Guo, Xiaozhou Li, Fengxia Xue, Shuai Chen, Minghan Tong, Michael Lazarus, Shengkai Zuo, Ying Yu & Yujun Shen. (2022)
PGE
2
‐EP3
axis promotes brown adipose tissue formation through stabilization of
WTAP RNA
methyltransferase
. The EMBO Journal 41:16.
Crossref
Crossref
Weijie Li, Chenhao Hu, Xingnan Zhang, Binbin Wang, Zhen Li, Miao Ling, Shengqiao Sun, Chao Guo, Dezhi Li & Song Liu. (2021) SUZ12 Loss Amplifies the Ras/ERK Pathway by Activating Adenylate Cyclase 1 in NF1-Associated Neurofibromas. Frontiers in Oncology 11.
Crossref
Crossref
Maxine J. Roberts, Lauren T. May, Alastair C. Keen, Bonan Liu, Terrance Lam, Steven J. Charlton, Elizabeth M. Rosethorne & Michelle L. Halls. (2021) Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus. Frontiers in Pharmacology 12.
Crossref
Crossref
Julie Delyon, Céleste Lebbe & Nicolas Dumaz. (2020) Targeted therapies in melanoma beyond BRAF: targeting NRAS-mutated and KIT-mutated melanoma. Current Opinion in Oncology 32:2, pages 79-84.
Crossref
Crossref
Jenna L Jewell, Vivian Fu, Audrey W Hong, Fa-Xing Yu, Delong Meng, Chase H Melick, Huanyu Wang, Wai-Ling Macrina Lam, Hai-Xin Yuan, Susan S Taylor & Kun-Liang Guan. (2019) GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. eLife 8.
Crossref
Crossref
Birte Möhlendick, Kurt W Schmid & Winfried Siffert. (2019)
The
GNAS
SNP c.393C>T (rs7121) as a marker for disease progression and survival in cancer
. Pharmacogenomics 20:7, pages 553-562.
Crossref
Crossref
Shannon M. White, Maria Laura Avantaggiati, Ivan Nemazanyy, Cristina Di Poto, Yang Yang, Mario Pende, Geoffrey T. Gibney, Habtom W. Ressom, Jeffery Field, Michael B. Atkins & Chunling Yi. (2019) YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor Cells. Developmental Cell 49:3, pages 425-443.e9.
Crossref
Crossref
Shraddha Tiwari & Jata Shankar. (2018) Integrated proteome and HPLC analysis revealed quercetin-mediated inhibition of aflatoxin B1 biosynthesis in Aspergillus flavus. 3 Biotech 8:1.
Crossref
Crossref
J Delyon, A Servy, F Laugier, J André, N Ortonne, M Battistella, S Mourah, A Bensussan, C Lebbé & N Dumaz. (2017) PDE4D promotes FAK-mediated cell invasion in BRAF-mutated melanoma. Oncogene 36:23, pages 3252-3262.
Crossref
Crossref
IJsbrand M. Kramer. 2016. Signal Transduction. Signal Transduction
589
654
.
Lisandra Castro, Sara Alves, Susana R. Chaves, José Luis Costa, Paula Soares & Ana Preto. (2015) RAF-1 promotes survival of thyroid cancer cells harboring RET/PTC1 rearrangement independently of ERK activation. Molecular and Cellular Endocrinology 415, pages 64-75.
Crossref
Crossref
D Liu, Y Huang, D Bu, A D Liu, L Holmberg, Y Jia, C Tang, J Du & H Jin. (2014) Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling. Cell Death & Disease 5:5, pages e1251-e1251.
Crossref
Crossref
Yanping Li, Maho Takahashi & Philip J.S. Stork. (2013) Ras-mutant Cancer Cells Display B-Raf Binding to Ras That Activates Extracellular Signal-regulated Kinase and Is Inhibited by Protein Kinase A Phosphorylation. Journal of Biological Chemistry 288:38, pages 27646-27657.
Crossref
Crossref
Jesse Lyons, Boris C. Bastian & Frank McCormick. (2013) MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells. Proceedings of the National Academy of Sciences 110:34, pages 13845-13850.
Crossref
Crossref
Artacho-Cordón Francisco, Salinas-Asensio Mar, Calvente Irene, Ríos-Arrabal Sandra, León Josefa, Román-Marinetto Elisa, Olea Nicolás & Núñez Isabel. (2013) Could Radiotherapy Effectiveness Be Enhanced by Electromagnetic Field Treatment?. International Journal of Molecular Sciences 14:7, pages 14974-14995.
Crossref
Crossref
I V Fedorenko, G T Gibney & K S M Smalley. (2012) NRAS mutant melanoma: biological behavior and future strategies for therapeutic management. Oncogene 32:25, pages 3009-3018.
Crossref
Crossref
Franco Oreste Ranelletti & Giovanni Monego. 2012. Cell Signaling & Molecular Targets in Cancer. Cell Signaling & Molecular Targets in Cancer
53
85
.
Tung-Ti Chang, Kuan-Chung Chen, Kai-Wei Chang, Hsin-Yi Chen, Fuu-Jen Tsai, Mao-Feng Sun & Calvin Yu-Chian Chen. (2011) In silico pharmacology suggests ginger extracts may reduce stroke risks. Molecular BioSystems 7:9, pages 2702.
Crossref
Crossref
Alexandra A. Anderson, Emma S. Child, Aarathi Prasad, Lucy M. Elphick & David J. Mann. (2010) Cyclin D1 and cyclin D3 show divergent responses to distinct mitogenic stimulation. Journal of Cellular Physiology 225:3, pages 638-645.
Crossref
Crossref
Philip Bidwell, Kiwon Joh, H. Anne Leaver & Maria Teresa Rizzo. (2010) Prostaglandin E2 activates cAMP response element-binding protein in glioma cells via a signaling pathway involving PKA-dependent inhibition of ERK. Prostaglandins & Other Lipid Mediators 91:1-2, pages 18-29.
Crossref
Crossref
Michael C. Velarde, Lusine Aghajanova, Camran R. Nezhat & Linda C. Giudice. (2009) Increased Mitogen-Activated Protein Kinase Kinase/Extracellularly Regulated Kinase Activity in Human Endometrial Stromal Fibroblasts of Women with Endometriosis Reduces 3′,5′-Cyclic Adenosine 5′-Monophosphate Inhibition of Cyclin D1. Endocrinology 150:10, pages 4701-4712.
Crossref
Crossref
Andrés Norambuena, Claudia Metz, Lucas Vicuña, Antonia Silva, Evelyn Pardo, Claudia Oyanadel, Loreto Massardo, Alfonso González & Andrea Soza. (2009) Galectin-8 Induces Apoptosis in Jurkat T Cells by Phosphatidic Acid-mediated ERK1/2 Activation Supported by Protein Kinase A Down-regulation. Journal of Biological Chemistry 284:19, pages 12670-12679.
Crossref
Crossref
Shujie Han & Kathryn E. Meier. (2009) Integrated modulation of phorbol ester-induced Raf activation in EL4 lymphoma cells. Cellular Signalling 21:5, pages 793-800.
Crossref
Crossref
Adam P. Klausner, Keith F. Rourke, Amy S. Miner & Paul H. Ratz. (2009) Potentiation of carbachol-induced detrusor smooth muscle contractions by β-adrenoceptor activation. European Journal of Pharmacology 606:1-3, pages 191-198.
Crossref
Crossref
Bastien D. Gomperts, IJsbrand M. Kramer & Peter E.R. Tatham. 2009. Signal Transduction. Signal Transduction
315
374
.
Goetz F. Lehnerdt, Peter Franz, Sebastian Winterhoff, Agnes Bankfalvi, Sara Grehl, Stephan Lang, Kurt W. Schmid, Winfried Siffert, Klaus Jahnke & Ulrich H. Frey. (2008) The GNAS1 T393C Polymorphism Predicts Survival in Patients With Advanced Squamous Cell Carcinoma of the Larynx. The Laryngoscope 118:12, pages 2172-2176.
Crossref
Crossref
Ana Sofia Rocha, Sabine Paternot, Katia Coulonval, Jacques E. Dumont, Paula Soares & Pierre P. Roger. (2008) Cyclic AMP Inhibits the Proliferation of Thyroid Carcinoma Cell Lines through Regulation of CDK4 Phosphorylation. Molecular Biology of the Cell 19:11, pages 4814-4825.
Crossref
Crossref
Angela Baljuls, Werner Schmitz, Thomas Mueller, René P. Zahedi, Albert Sickmann, Mirko Hekman & Ulf R. Rapp. (2008) Positive Regulation of A-RAF by Phosphorylation of Isoform-specific Hinge Segment and Identification of Novel Phosphorylation Sites. Journal of Biological Chemistry 283:40, pages 27239-27254.
Crossref
Crossref
Catherine Noble, Kathryn Mercer, Jahan Hussain, Linda Carragher, Susan Giblett, Robert Hayward, Cam Patterson, Richard Marais & Catrin A. Pritchard. (2008) CRAF Autophosphorylation of Serine 621 Is Required to Prevent Its Proteasome-Mediated Degradation. Molecular Cell 31:6, pages 862-872.
Crossref
Crossref
Nancy Gerits, Sergiy Kostenko, Alexey Shiryaev, Mona Johannessen & Ugo Moens. (2008) Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: Comradeship and hostility. Cellular Signalling 20:9, pages 1592-1607.
Crossref
Crossref
Christy A. Barlow, Kajorn Kitiphongspattana, Nazli Siddiqui, Michael W. Roe, Brooke T. Mossman & Karen M. Lounsbury. (2008) Protein kinase A-mediated CREB phosphorylation is an oxidant-induced survival pathway in alveolar type II cells. Apoptosis 13:5, pages 681-692.
Crossref
Crossref
Ying Sun, Fan Wu, Fengqiang Sun & Pingbo Huang. (2008) Adenosine Promotes IL-6 Release in Airway Epithelia. The Journal of Immunology 180:6, pages 4173-4181.
Crossref
Crossref
Goetz F. Lehnerdt, Peter Franz, Anwar Zaqoul, Klaus J. Schmitz, Sara Grehl, Stephan Lang, Kurt W. Schmid, Winfried Siffert, Klaus Jahnke & Ulrich H. Frey. (2008)
Overall and Relapse-Free Survival in Oropharyngeal and Hypopharyngeal Squamous Cell Carcinoma Are Associated with Genotypes of T393C Polymorphism of the
GNAS1
Gene
. Clinical Cancer Research 14:6, pages 1753-1758.
Crossref
Crossref
Sang K. Kim & Raymond F. Novak. (2007) The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression. Pharmacology & Therapeutics 113:1, pages 88-120.
Crossref
Crossref
Nicolas Dumaz, Robert Hayward, Jan Martin, Lesley Ogilvie, Douglas Hedley, John A. Curtin, Boris C. Bastian, Caroline Springer & Richard Marais. (2006)
In Melanoma,
RAS
Mutations Are Accompanied by Switching Signaling from BRAF to CRAF and Disrupted Cyclic AMP Signaling
. Cancer Research 66:19, pages 9483-9491.
Crossref
Crossref
Patrick Michl, Beate Knobel & Julian Downward. (2006) CUTL1 Is Phosphorylated by Protein Kinase A, Modulating Its Effects on Cell Proliferation and Motility. Journal of Biological Chemistry 281:22, pages 15138-15144.
Crossref
Crossref
Ye Fang, Ann M. Ferrie & Guangshan Li. (2006) Cellular functions of cholesterol probed with optical biosensors. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1763:2, pages 254-261.
Crossref
Crossref
Ye Fang, Ann M. Ferrie, Norman H. Fontaine & Po Ki Yuen. (2005) Characteristics of Dynamic Mass Redistribution of Epidermal Growth Factor Receptor Signaling in Living Cells Measured with Label-Free Optical Biosensors. Analytical Chemistry 77:17, pages 5720-5725.
Crossref
Crossref
Nicolas Dumaz & Richard Marais. (2005) Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on The Anniversary Prize of the Gesellschaft fur Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels. FEBS Journal 272:14, pages 3491-3504.
Crossref
Crossref
Algirdas Ziogas, Karin Moelling & Gerald Radziwill. (2005) CNK1 Is a Scaffold Protein That Regulates Src-mediated Raf-1 Activation. Journal of Biological Chemistry 280:25, pages 24205-24211.
Crossref
Crossref
Ziqiu Wang, Meifang Wang & Brian I. Carr. (2005) Hepatocyte growth factor enhances protein phosphatase Cdc25A inhibitor compound 5-induced hepatoma cell growth inhibition via Akt-mediated MAPK pathway. Journal of Cellular Physiology 203:3, pages 510-519.
Crossref
Crossref
H Bea Kuiperij, Armando van der Horst, Judith Raaijmakers, Sanne Weijzen, Rene H Medema, Johannes L Bos, Boudewijn M T Burgering & Fried J T Zwartkruis. (2005) Activation of FoxO transcription factors contributes to the antiproliferative effect of cAMP. Oncogene 24:12, pages 2087-2095.
Crossref
Crossref
Mirko Hekman, Andreas Fischer, Lawrence P. Wennogle, Y. Karen Wang, Sharon L. Campbell & Ulf R. Rapp. (2005) Novel C-Raf phosphorylation sites: serine 296 and 301 participate in Raf regulation. FEBS Letters 579:2, pages 464-468.
Crossref
Crossref
Susana Minguet, Michael Huber, Lisa Rosenkranz, Wolfgang?W.?A. Schamel, Michael Reth & Tilman Brummer. (2005) Adenosine and cAMP are potent inhibitors of the NF-?B pathway downstream of immunoreceptors. European Journal of Immunology 35:1, pages 31-41.
Crossref
Crossref
Jingfei Cheng, Michael A. Thompson, Henry J. Walker, Catherine E. Gray, Montserrat M. Diaz Encarnacion, Gina M. Warner & Joseph P. Grande. (2004) Differential regulation of mesangial cell mitogenesis by cAMP phosphodiesterase isozymes 3 and 4. American Journal of Physiology-Renal Physiology 287:5, pages F940-F953.
Crossref
Crossref
Claudia Wellbrock, Maria Karasarides & Richard Marais. (2004) The RAF proteins take centre stage. Nature Reviews Molecular Cell Biology 5:11, pages 875-885.
Crossref
Crossref
Motoyuki Otsuka, Naoya Kato, Run-Xuan Shao, Yujin Hoshida, Hideaki Ijichi, Yukihiro Koike, Hiroyoshi Taniguchi, Masaru Moriyama, Yasushi Shiratori, Takao Kawabe & Masao Omata. (2004)
Vitamin K
2
inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation
. Hepatology 40:1, pages 243-251.
Crossref
Crossref
L S Steelman, S C Pohnert, J G Shelton, R A Franklin, F E Bertrand & J A McCubrey. (2004) JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 18:2, pages 189-218.
Crossref
Crossref
Antonio Porcellini, Samantha Messina, Giorgia De Gregorio, Antonio Feliciello, Annalisa Carlucci, Mariavittoria Barone, Antonietta Picascia, Antonio De Blasi & Enrico V. Avvedimento. (2003) The Expression of the Thyroid-stimulating Hormone (TSH) Receptor and the cAMP-dependent Protein Kinase RII β Regulatory Subunit Confers TSH-cAMP-dependent Growth to Mouse Fibroblasts. Journal of Biological Chemistry 278:42, pages 40621-40630.
Crossref
Crossref
Usha Kasid & Anatoly Dritschilo. (2003) RAF antisense oligonucleotide as a tumor radiosensitizer. Oncogene 22:37, pages 5876-5884.
Crossref
Crossref
Johannes L. Bos. (2003) Epac: a new cAMP target and new avenues in cAMP research. Nature Reviews Molecular Cell Biology 4:9, pages 733-738.
Crossref
Crossref
Nicolas Dumaz & Richard Marais. (2003) Protein Kinase A Blocks Raf-1 Activity by Stimulating 14-3-3 Binding and Blocking Raf-1 Interaction with Ras. Journal of Biological Chemistry 278:32, pages 29819-29823.
Crossref
Crossref
Charles E. Wenner & Shaochun Yan. (2003) Biphasic role of TGF-?1 in signal transduction and crosstalk. Journal of Cellular Physiology 196:1, pages 42-50.
Crossref
Crossref
Hilde Abrahamsen, Torkel Vang & Kjetil Taskén. (2003) Protein Kinase A Intersects Src Signaling in Membrane Microdomains. Journal of Biological Chemistry 278:19, pages 17170-17177.
Crossref
Crossref
Keiran S.M. Smalley. (2003) A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?. International Journal of Cancer 104:5, pages 527-532.
Crossref
Crossref
Chris J. Vlahos, Susan A. McDowell & Angela Clerk. (2003) Kinases as therapeutic targets for heart failure. Nature Reviews Drug Discovery 2:2, pages 99-113.
Crossref
Crossref
Jens Henrik Norum, Kent Hart & Finn Olav Levy. (2003) Ras-dependent ERK Activation by the Human Gs-coupled Serotonin Receptors 5-HT4(b) and 5-HT7(a). Journal of Biological Chemistry 278:5, pages 3098-3104.
Crossref
Crossref
Jorrit M. Enserink, Anne E. Christensen, Johan de Rooij, Miranda van Triest, Frank Schwede, Hans Gottfried Genieser, Stein O. Døskeland, Jonathan L. Blank & Johannes L. Bos. (2002) A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nature Cell Biology 4:11, pages 901-906.
Crossref
Crossref
Amardeep S Dhillon & Walter Kolch. (2002) Untying the regulation of the Raf-1 kinase. Archives of Biochemistry and Biophysics 404:1, pages 3-9.
Crossref
Crossref