Advanced search
Publication Cover
Molecular and Cellular Biology Volume 22, 2002 - Issue 2
Submit an article Journal homepage
7
Views
46
CrossRef citations to date
0
Altmetric
DNA Dynamics and Chromosome Structure

hpr1Δ Affects Ribosomal DNA Recombination and Cell Life Span in Saccharomyces cerevisiae

Robert J. MerkerDepartment of Biochemistry and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York10016
&
Hannah L. KleinDepartment of Biochemistry and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York10016Correspondence[email protected]
Pages 421-429 | Received 19 Jun 2001, Accepted 08 Oct 2001, Published online: 28 Mar 2023

Citations (46)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Hugo Wurtele, Gitte Schalck Kaiser, Julien Bacal, Edlie St-Hilaire, Eun-Hye Lee, Sarah Tsao, Jonas Dorn, Paul Maddox, Michael Lisby, Philippe Pasero & Alain Verreault. (2012) Histone H3 Lysine 56 Acetylation and the Response to DNA Replication Fork Damage. Molecular and Cellular Biology 32:1, pages 154-172.
Read now
Xiaoling Wang, Meenalakshmi Chinnam, Jianmin Wang, Yanqing Wang, Xiaojing Zhang, Edyta Marcon, Peter Moens & David W. Goodrich. (2009) Thoc1 Deficiency Compromises Gene Expression Necessary for Normal Testis Development in the Mouse. Molecular and Cellular Biology 29:10, pages 2794-2803.
Read now
Brett N. Tomson, Damien D'Amours, Brittany S. Adamson, Luis Aragon & Angelika Amon. (2006) Ribosomal DNA Transcription-Dependent Processes Interfere with Chromosome Segregation. Molecular and Cellular Biology 26:16, pages 6239-6247.
Read now
Xiaoling Wang, Yanjie Chang, Yanping Li, Xiaojing Zhang & David W. Goodrich. (2006) Thoc1/Hpr1/p84 Is Essential for Early Embryonic Development in the Mouse. Molecular and Cellular Biology 26:11, pages 4362-4367.
Read now
Takehiko Kobayashi. (2003) The Replication Fork Barrier Site Forms a Unique Structure with Fob1p and Inhibits the Replication Fork. Molecular and Cellular Biology 23:24, pages 9178-9188.
Read now

Articles from other publishers (41)

Mei Hattori, Chihiro Horigome, Théo Aspert, Gilles Charvin & Takehiko Kobayashi. (2022) Changed life course upon defective replication of ribosomal RNA genes. Genes & Genetic Systems 97:6, pages 285-295.
Crossref
Delaney Farris, Daniel S Saxton & Jasper Rine. (2021) A novel allele of SIR2 reveals a heritable intermediate state of gene silencing . Genetics 218:1.
Crossref
Olga Vydzhak, Brian Luke & Natalie Schindler. (2020) Non-coding RNAs at the Eukaryotic rDNA Locus: RNA–DNA Hybrids and Beyond. Journal of Molecular Biology 432:15, pages 4287-4304.
Crossref
Richard O'Laughlin, Meng Jin, Yang Li, Lorraine Pillus, Lev S. Tsimring, Jeff Hasty & Nan Hao. (2020) Advances in quantitative biology methods for studying replicative aging in Saccharomyces cerevisiae. Translational Medicine of Aging 4, pages 151-160.
Crossref
Jessica Smith & Brandt L. Schneider. 2018. Conn's Handbook of Models for Human Aging. Conn's Handbook of Models for Human Aging 389 415 .
Jun Liu, Ming-Hong He, Jing Peng, Yi-Min Duan, Yi-Si Lu, Zhenfang Wu, Ting Gong, Hong-Tao Li & Jin-Qiu Zhou. (2016) Tethering telomerase to telomeres increases genome instability and promotes chronological aging in yeast. Aging 8:11, pages 2827-2847.
Crossref
Renata Zadrag-Tecza & Adrianna Skoneczna. (2016) Reproductive potential and instability of the rDNA region of the Saccharomyces cerevisiae yeast: Common or separate mechanisms of regulation?. Experimental Gerontology 84, pages 29-39.
Crossref
Sandra Gavaldá, José M. Santos-Pereira, María L. García-Rubio, Rosa Luna & Andrés Aguilera. (2016) Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening. PLOS Genetics 12:4, pages e1005966.
Crossref
Peter Kolesar, Veronika Altmannova, Sonia Silva, Michael Lisby & Lumir Krejci. (2016) Pro-recombination Role of Srs2 Protein Requires SUMO (Small Ubiquitin-like Modifier) but Is Independent of PCNA (Proliferating Cell Nuclear Antigen) Interaction. Journal of Biological Chemistry 291:14, pages 7594-7607.
Crossref
Anna Lewinska, Beata Miedziak, Klaudia Kulak, Mateusz Molon & Maciej Wnuk. (2014) Links between nucleolar activity, rDNA stability, aneuploidy and chronological aging in the yeast Saccharomyces cerevisiae. Biogerontology 15:3, pages 289-316.
Crossref
Annina Denoth Lippuner, Thomas Julou & Yves Barral. (2014) Budding yeast as a model organism to study the effects of age. FEMS Microbiology Reviews 38:2, pages 300-325.
Crossref
Austen R. D. Ganley & Takehiko Kobayashi. (2014) Ribosomal DNA and cellular senescence: new evidence supporting the connection between rDNA and aging. FEMS Yeast Research 14:1, pages 49-59.
Crossref
Byung-Ho Rhie, Young-Ha Song, Hong-Yeoul Ryu & Seong Hoon Ahn. (2013) Cellular aging is associated with increased ubiquitylation of histone H2B in yeast telomeric heterochromatin. Biochemical and Biophysical Research Communications 439:4, pages 570-575.
Crossref
Joe R. Delaney, Annie Chou, Brady Olsen, Daniel Carr, Christopher Murakami, Umema Ahmed, Sylvia Sim, Elroy H. An, Anthony S. Castanza, Marissa Fletcher, Sean Higgins, Mollie Holmberg, Jessica Hui, Monika Jelic, Ki-Soo Jeong, Jin R. Kim, Shannon Klum, Eric Liao, Michael S. Lin, Winston Lo, Hillary Miller, Richard Moller, Zhao J. Peng, Tom Pollard, Prarthana Pradeep, Dillon Pruett, Dilreet Rai, Vanessa Ros, Jennifer Schleit, Alex Schuster, Minnie Singh, Benjamin L. Spector, George L. Sutphin, Adrienne M. Wang, Brian M. Wasko, Helen Vander Wende, Brian K. Kennedy & Matt Kaeberlein. (2013) End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging. FEMS Yeast Research 13:3, pages 267-276.
Crossref
Monika Aggarwal & Robert M. BroshJr.Jr.. (2012) Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast genetics. DNA Repair 11:4, pages 335-348.
Crossref
Jonathan Houseley & David Tollervey. (2011) Repeat expansion in the budding yeast ribosomal DNA can occur independently of the canonical homologous recombination machinery. Nucleic Acids Research 39:20, pages 8778-8791.
Crossref
William C. Burhans & Martin Weinberger. 2012. Aging Research in Yeast. Aging Research in Yeast 187 206 .
Xiuzhong Zheng, Anastasiya Epstein & Hannah L. Klein. 2011. DNA Recombination. DNA Recombination 3 13 .
Veronika Altmannova, Nadine Eckert-Boulet, Milica Arneric, Peter Kolesar, Radka Chaloupkova, Jiri Damborsky, Patrick Sung, Xiaolan Zhao, Michael Lisby & Lumir Krejci. (2010) Rad52 SUMOylation affects the efficiency of the DNA repair. Nucleic Acids Research 38:14, pages 4708-4721.
Crossref
Ana Traven, Tricia L. Lo, Trevor Lithgow & Jörg Heierhorst. (2010) The Yeast PUF Protein Puf5 Has Pop2-Independent Roles in Response to DNA Replication Stress. PLoS ONE 5:5, pages e10651.
Crossref
Michèle Riesen & Alan Morgan. (2009) Calorie restriction reduces rDNA recombination independently of rDNA silencing. Aging Cell 8:6, pages 624-632.
Crossref
Austen R.D. Ganley, Satoru Ide, Kimiko Saka & Takehiko Kobayashi. (2009) The Effect of Replication Initiation on Gene Amplification in the rDNA and Its Relationship to Aging. Molecular Cell 35:5, pages 683-693.
Crossref
Takehiko Kobayashi. (2008) A new role of the rDNA and nucleolus in the nucleus—rDNA instability maintains genome integrity. BioEssays 30:3, pages 267-272.
Crossref
Chonghua Li, John E. Mueller, Megan Elfline & Mary Bryk. (2008) Linker histone H1 represses recombination at the ribosomal DNA locus in the budding yeast Saccharomyces cerevisiae. Molecular Microbiology 67:4, pages 906-919.
Crossref
Jordi Torres-Rosell, Ivana Sunjevaric, Giacomo De Piccoli, Meik Sacher, Nadine Eckert-Boulet, Robert Reid, Stefan Jentsch, Rodney Rothstein, Luis Aragón & Michael Lisby. (2007) The Smc5–Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus. Nature Cell Biology 9:8, pages 923-931.
Crossref
Yanping Li, Athena W. Lin, Xiaojing Zhang, Yanqing Wang, Xiaoling Wang & David W. Goodrich. (2007) Cancer Cells and Normal Cells Differ in Their Requirements for Thoc1 . Cancer Research 67:14, pages 6657-6664.
Crossref
Seanna J McTaggart, Jeffry L Dudycha, Angela Omilian & Teresa J Crease. (2007) Rates of Recombination in the Ribosomal DNA of Apomictically Propagated Daphnia obtusa Lines . Genetics 175:1, pages 311-320.
Crossref
Deborah Blake, Brian Luke, Pamela Kanellis, Paul Jorgensen, Theo Goh, Sonya Penfold, Bobby-Joe Breitkreutz, Daniel Durocher, Matthias Peter & Mike Tyers. (2006) The F-Box Protein Dia2 Overcomes Replication Impedance to Promote Genome Stability in Saccharomyces cerevisiae . Genetics 174:4, pages 1709-1727.
Crossref
Sabrina Grenetier, Céline Bouchoux & Valérie Goguel. (2006) CTD kinase I is required for the integrity of the rDNA tandem array. Nucleic Acids Research 34:17, pages 4996-5006.
Crossref
Shankar Prasad Das & Pratima Sinha. (2005) The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging. Biochemical and Biophysical Research Communications 337:1, pages 167-172.
Crossref
Colin S. Gillespie, Carole J. Proctor, Richard J. Boys, Daryl P. Shanley, Darren J. Wilkinson & Thomas B.L. Kirkwood. (2004) A mathematical model of ageing in yeast. Journal of Theoretical Biology 229:2, pages 189-196.
Crossref
Takehiko Kobayashi, Takashi Horiuchi, Prasad Tongaonkar, Loan Vu & Masayasu Nomura. (2004) SIR2 Regulates Recombination between Different rDNA Repeats, but Not Recombination within Individual rRNA Genes in Yeast. Cell 117:4, pages 441-453.
Crossref
Naomi Serizawa, Takashi Horiuchi & Takehiko Kobayashi. (2004) Transcription-mediated hyper-recombination in HOT1. Genes to Cells 9:4, pages 305-315.
Crossref
Alaric A. Falcón & John P. Aris. (2003) Plasmid Accumulation Reduces Life Span in Saccharomyces cerevisiae. Journal of Biological Chemistry 278:43, pages 41607-41617.
Crossref
Yasushi Takeuchi, Takashi Horiuchi & Takehiko Kobayashi. (2003) Transcription-dependent recombination and the role of fork collision in yeast rDNA. Genes & Development 17:12, pages 1497-1506.
Crossref
Laura N. RuscheAnn L. KirchmaierJasper Rine. (2003) The Establishment, Inheritance, and Function of Silenced Chromatin in Saccharomyces cerevisiae . Annual Review of Biochemistry 72:1, pages 481-516.
Crossref
Sarit Cohen, Keren Yacobi & Daniel Segal. (2003) Extrachromosomal Circular DNA of Tandemly Repeated Genomic Sequences in Drosophila . Genome Research 13:6a, pages 1133-1145.
Crossref
Jessica A Downs, Effie Kosmidou, Alan Morgan & Stephen P Jackson. (2003) Suppression of Homologous Recombination by the Saccharomyces cerevisiae Linker Histone. Molecular Cell 11:6, pages 1685-1692.
Crossref
S. Michal Jazwinski. 2003. Aging of Organisms. Aging of Organisms 1 30 .
. (2002) Anti-Aging Medicine LiteratureWatch. Journal of Anti-Aging Medicine 5:2, pages 211-230.
Crossref
Richard D. KolodnerChristopher D. PutnamKyungjae Myung. (2002) Maintenance of Genome Stability in Saccharomyces cerevisiae . Science 297:5581, pages 552-557.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.