hpr1Δ Affects Ribosomal DNA Recombination and Cell Life Span in Saccharomyces cerevisiae

REFERENCES

• Aguilera, A., and H. L. Klein. 1988. Genetic control of intrachromosomal recombination in Saccharomyces cerevisiae. I. Isolation and genetic characterization of hyper-recombination mutations. Genetics 119: 779–790.
   PubMed Web of Science ®Google Scholar
• Aguilera, A., and H. L. Klein. 1990. HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene. Mol. Cell. Biol. 10: 1439–1451.
   PubMedGoogle Scholar
• Brachmann, C. B., A. Davies, G. J. Cost, E. Caputo, J. Li, P. Hieter, and J. D. Boeke. 1998. Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14: 115–132.
   PubMed Web of Science ®Google Scholar
• Bryk, M., M. Banerjee, M. Murphy, K. E. Knudsen, D. J. Garfinkel, and M. J. Curcio. 1997. Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast. Genes Dev. 11: 255–269.
   PubMedGoogle Scholar
• Chang, M., D. French-Cornay, H. Y. Fan, H. Klein, C. L. Denis, and J. A. Jaehning. 1999. A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling. Mol. Cell. Biol. 19: 1056–1067.
   PubMedGoogle Scholar
• Chavez, S., and A. Aguilera. 1997. The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability. Genes Dev. 11: 3459–3470.
   PubMed Web of Science ®Google Scholar
• Chavez, S., T. Beilharz, A. G. Rondon, H. Erdjument-Bromage, P. Tempst, J. Q. Svejstrup, T. Lithgow, and A. Aguilera. 2000. A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J. 19: 5824–5834.
   PubMed Web of Science ®Google Scholar
• Christman, M. F., F. S. Dietrich, and G. R. Fink. 1988. Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II. Cell 55: 413–425.
   PubMedGoogle Scholar
• Defossez, P. A., R. Prusty, M. Kaeberlein, S. J. Lin, P. Ferrigno, P. A. Silver, R. L. Keil, and L. Guarente. 1999. Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol. Cell 3: 447–455.
   PubMed Web of Science ®Google Scholar
• Fan, H. Y., K. K. Cheng, and H. L. Klein. 1996. Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1Δ of Saccharomyces cerevisiae. Genetics 142: 749–759.
   PubMedGoogle Scholar
• Fan, H. Y., and H. L. Klein. 1994. Characterization of mutations that suppress the temperature-sensitive growth of the hpr1Δ mutant of Saccharomyces cerevisiae. Genetics 137: 945–956.
   PubMedGoogle Scholar
• Finkel, T., and N. J. Holbrook. 2000. Oxidants, oxidative stress and the biology of ageing. Nature 408: 239–247.
   PubMed Web of Science ®Google Scholar
• Gangloff, S., J. P. McDonald, C. Bendixen, L. Arthur, and R. Rothstein. 1994. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase. Mol. Cell. Biol. 14: 8391–8398.
   PubMed Web of Science ®Google Scholar
• Gangloff, S., H. Zou, and R. Rothstein. 1996. Gene conversion plays the major role in controlling the stability of large tandem repeats in yeast. EMBO J. 15: 1715–1725.
   PubMedGoogle Scholar
• Gottlieb, S., and R. E. Esposito. 1989. A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA. Cell 56: 771–776.
   PubMed Web of Science ®Google Scholar
• Gottschling, D. E., O. M. Aparicio, B. L. Billington, and V. A. Zakian. 1990. Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription. Cell 63: 751–762.
   PubMed Web of Science ®Google Scholar
• Gu, W., S. Malik, M. Ito, C. X. Yuan, J. D. Fondell, X. Zhang, E. Martinez, J. Qin, and R. G. Roeder. 1999. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol. Cell 3: 97–108.
   PubMed Web of Science ®Google Scholar
• Guarente, L. 2000. Sir2 links chromatin silencing, metabolism, and aging. Genes Dev. 14: 1021–1026.
   PubMed Web of Science ®Google Scholar
• Guarente, L., and C. Kenyon. 2000. Genetic pathways that regulate aging in model organisms. Nature 408: 255–262.
   PubMed Web of Science ®Google Scholar
• Guthrie, C., and G. R. Fink. 1995. Guide to yeast genetics and molecular biology. Methods Enzymol. 194: 3–37.
   Google Scholar
• Heo, S. J., K. Tatebayashi, I. Ohsugi, A. Shimamoto, Y. Furuichi, and H. Ikeda. 1999. Bloom’s syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast. Genes Cells 4: 619–625.
   PubMedGoogle Scholar
• Imai, S., C. M. Armstrong, M. Kaeberlein, and L. Guarente. 2000. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403: 795–800.
   PubMed Web of Science ®Google Scholar
• Jazwinski, S. M. 2000. Metabolic control and ageing. Trends Genet. 16: 506–511.
   PubMedGoogle Scholar
• Kaeberlein, M., M. McVey, and L. Guarente. 1999. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13: 2570–2580.
   PubMed Web of Science ®Google Scholar
• Keil, R. L., and A. D. McWilliams. 1993. A gene with specific and global effects on recombination of sequences from tandemly repeated genes in Saccharomyces cerevisiae. Genetics 135: 711–718.
   PubMedGoogle Scholar
• Kennedy, B. K., N. R. Austriaco, Jr., and L. Guarente. 1994. Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span. J. Cell Biol. 127: 1985–1993.
   PubMed Web of Science ®Google Scholar
• Kim, S., A. Benguria, C. Y. Lai, and S. M. Jazwinski. 1999. Modulation of life span by histone deacetylase genes in Saccharomyces cerevisiae. Mol. Biol. Cell 10: 3125–3136.
   PubMedGoogle Scholar
• Kirchman, P. A., S. Kim, C. Y. Lai, and S. M. Jazwinski. 1999. Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. Genetics 152: 179–190.
   PubMed Web of Science ®Google Scholar
• Kobayashi, T., D. J. Heck, M. Nomura, and T. Horiuchi. 1998. Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I. Genes Dev. 12: 3821–3830.
   PubMed Web of Science ®Google Scholar
• Kobayashi, T., and T. Horiuchi. 1996. A yeast gene product, Fob1 protein, required for both replication fork blocking and recombinational hotspot activities. Genes Cells. 1: 465–474.
   PubMed Web of Science ®Google Scholar
• Lin, S. J., P. A. Defossez, and L. Guarente. 2000. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289: 2126–2128.
   PubMed Web of Science ®Google Scholar
• Martin, G. M., and J. Oshima. 2000. Lessons from human progeroid syndromes. Nature 408: 263–266.
   PubMedGoogle Scholar
• Masoro, E. J. 2000. Caloric restriction and aging: an update. Exp. Gerontol. 35: 299–305.
   PubMed Web of Science ®Google Scholar
• McVey, M., M. Kaeberlein, H. A. Tissenbaum, and L. Guarente. 2001. The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. Genetics 157: 1531–1542.
   PubMedGoogle Scholar
• Miller, R. G. 1981. Survival analysis. Wiley, New York, N.Y.
   Google Scholar
• Peto, R., M. C. Pike, P. Armitage, N. E. Breslow, D. R. Cox, S. V. Howard, N. Mantel, K. McPherson, J. Peto, and P. G. Smith. 1977. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br. J. Cancer. 35: 1–39.
   PubMed Web of Science ®Google Scholar
• Piruat, J. I., and A. Aguilera. 1996. Mutations in the yeast SRB2 general transcription factor suppress hpr1-induced recombination and show defects in DNA repair. Genetics 143: 1533–1542.
   PubMedGoogle Scholar
• Piruat, J. I., S. Chavez, and A. Aguilera. 1997. The yeast HRS1 gene is involved in positive and negative regulation of transcription and shows genetic characteristics similar to SIN4 and GAL11. Genetics 147: 1585–1594.
   PubMedGoogle Scholar
• Prado, F., J. I. Piruat, and A. Aguilera. 1997. Recombination between DNA repeats in yeast hpr1Δ cells is linked to transcription elongation. EMBO J. 16: 2826–2835.
   PubMedGoogle Scholar
• Rine, J., and I. Herskowitz. 1987. Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116: 9–22.
   PubMed Web of Science ®Google Scholar
• Rothstein, R. J. 1983. One-step gene disruption in yeast. Methods Enzymol. 101: 202–211.
   PubMed Web of Science ®Google Scholar
• Roy, N., and K. W. Runge. 2000. Two paralogs involved in transcriptional silencing that antagonistically control yeast life span. Curr. Biol. 10: 111–114.
   PubMedGoogle Scholar
• Saffi, J., V. R. Pereira, and J. A. Henriques. 2000. Importance of the Sgs1 helicase activity in DNA repair of Saccharomyces cerevisiae. Curr. Genet. 37: 75–78.
   PubMedGoogle Scholar
• Santos-Rosa, H., and A. Aguilera. 1994. Increase in incidence of chromosome instability and non-conservative recombination between repeats in Saccharomyces cerevisiae hpr1Δ strains. Mol. Gen. Genet. 245: 224–236.
   PubMedGoogle Scholar
• Santos-Rosa, H., and A. Aguilera. 1995. Isolation and genetic analysis of extragenic suppressors of the hyper-deletion phenotype of the Saccharomyces cerevisiae hpr1Δ mutation. Genetics 139: 57–66.
   PubMedGoogle Scholar
• Schneiter, R., C. E. Guerra, M. Lampl, G. Gogg, S. D. Kohlwein, and H. L. Klein. 1999. The Saccharomyces cerevisiae hyperrecombination mutant hpr1Δ is synthetically lethal with two conditional alleles of the acetyl coenzyme A carboxylase gene and causes a defect in nuclear export of polyadenylated RNA. Mol. Cell. Biol. 19: 3415–3422.
   PubMed Web of Science ®Google Scholar
• Sinclair, D. A., and L. Guarente. 1997. Extrachromosomal rDNA circles—a cause of aging in yeast. Cell 91: 1033–1042.
   PubMed Web of Science ®Google Scholar
• Sinclair, D. A., K. Mills, and L. Guarente. 1997. Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science 277: 1313–1316.
   PubMed Web of Science ®Google Scholar
• Smeal, T., J. Claus, B. Kennedy, F. Cole, and L. Guarente. 1996. Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae. Cell 84: 633–642.
   PubMed Web of Science ®Google Scholar
• Smith, J. S., and J. D. Boeke. 1997. An unusual form of transcriptional silencing in yeast ribosomal DNA. Genes Dev. 11: 241–254.
   PubMed Web of Science ®Google Scholar
• Sohal, R. S., and R. Weindruch. 1996. Oxidative stress, caloric restriction, and aging. Science 273: 59–63.
   PubMed Web of Science ®Google Scholar
• Szostak, J. W., and R. Wu. 1980. Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae. Nature 284: 426–430.
   PubMed Web of Science ®Google Scholar
• Tissenbaum, H. A., and L. Guarente. 2001. Increased dosage of a sir-2 gene extends life span in Caenorhabditis elegans. Nature 410: 227–230.
   PubMed Web of Science ®Google Scholar
• Uemura, H., S. Pandit, Y. Jigami, and R. Sternglanz. 1996. Mutations in GCR3, a gene involved in the expression of glycolytic genes in Saccharomyces cerevisiae, suppress the temperature-sensitive growth of hpr1 mutants. Genetics 142: 1095–1103.
   PubMedGoogle Scholar
• Watt, P. M., I. D. Hickson, R. H. Borts, and E. J. Louis. 1996. SGS1, a homologue of the Bloom’s and Werner’s syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae. Genetics 144: 935–945.
   PubMed Web of Science ®Google Scholar
• Watt, P. M., E. J. Louis, R. H. Borts, and I. D. Hickson. 1995. Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation. Cell 81: 253–260.
   PubMed Web of Science ®Google Scholar
• Weindruch, R., and R. Walford. 1988. The retardation of aging and disease by dietary restriction. Charles C Thomas, Publisher, Springfield, Ill.
   Google Scholar