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Molecular and Cellular Biology Volume 22, 2002 - Issue 22
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Mammalian Genetic Models with Minimal or Complex Phenotypes

Heat Shock Transcription Factor 2 Is Not Essential for Embryonic Development, Fertility, or Adult Cognitive and Psychomotor Function in Mice

D. Randy McMillan1 Departments of Internal Medicine;2 Pediatrics
,
Elisabeth Christians1 Departments of Internal Medicine
,
Michael Forster3 Department of Pharmacology, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas76107
,
XianZhong Xiao1 Departments of Internal Medicine
,
Patrice Connell1 Departments of Internal Medicine
,
Jean-Christophe Plumier4 Stroke & Neurovascular Regulation Unit, Harvard Medical School Massachusetts General Hospital at Charlestown, Charlestown, Massachussetts02129
,
XiaoXia Zuo1 Departments of Internal Medicine
,
James Richardson5 Pathology
,
Sylvia Morgan1 Departments of Internal Medicine
&
Ivor J. Benjamin1 Departments of Internal Medicine;6 Division of Cell and Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas75235Correspondence[email protected]
 show all
Pages 8005-8014 | Received 25 Jun 2002, Accepted 20 Aug 2002, Published online: 28 Mar 2023

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Saffet Ozturk. (2023) Genetic variants underlying spermatogenic arrests in men with non-obstructive azoospermia. Cell Cycle 22:9, pages 1021-1061.
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Florent Le Masson, Zak Razak, Mo Kaigo, Christophe Audouard, Colette Charry, Howard Cooke, J. Timothy Westwood & Elisabeth S. Christians. (2011) Identification of Heat Shock Factor 1 Molecular and Cellular Targets during Embryonic and Adult Female Meiosis. Molecular and Cellular Biology 31:16, pages 3410-3423.
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Yanzhong Hu & Nahid F. Mivechi. (2006) Association and Regulation of Heat Shock Transcription Factor 4b with both Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and Dual-Specificity Tyrosine Phosphatase DUSP26. Molecular and Cellular Biology 26:8, pages 3282-3294.
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Ashish Nagarsekar, Jeffrey D. Hasday & Ishwar S. Singh. (2005) CXC Chemokines: A New Family of Heat-Shock Proteins?. Immunological Investigations 34:3, pages 381-398.
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Articles from other publishers (59)

Yasuko Tokunaga, Ken-Ichiro Otsuyama, Shigeru Kakuta & Naoki Hayashida. (2022) Heat Shock Transcription Factor 2 Is Significantly Involved in Neurodegenerative Diseases, Inflammatory Bowel Disease, Cancer, Male Infertility, and Fetal Alcohol Spectrum Disorder: The Novel Mechanisms of Several Severe Diseases. International Journal of Molecular Sciences 23:22, pages 13763.
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Nishi Gupta, Saumya Sarkar, Poonam Mehta, Satya Narayan Sankhwar & Singh Rajender. (2022) Polymorphisms in the HSF2 , LRRC6 , MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility . Andrologia 54:9.
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Agathe Duchateau, Aurélie de Thonel, Rachid El Fatimy, Véronique Dubreuil & Valérie Mezger. (2020) The “HSF connection”: Pleiotropic regulation and activities of Heat Shock Factors shape pathophysiological brain development. Neuroscience Letters 725, pages 134895.
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Jenny Joutsen & Lea Sistonen. (2019) Tailoring of Proteostasis Networks with Heat Shock Factors. Cold Spring Harbor Perspectives in Biology 11:4, pages a034066.
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D. Haouzi, I. Boumela, K. Chebli & S. Hamamah. (2018) Global, Survival, and Apoptotic Transcriptome during Mouse and Human Early Embryonic Development. BioMed Research International 2018, pages 1-16.
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Hao Deng, Wen Zheng & Zhi Song. (2018) The genetics and molecular biology of fever-associated seizures or epilepsy. Expert Reviews in Molecular Medicine 20.
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Xiongjie Jin, Binnur Eroglu, Demetrius Moskophidis & Nahid F. Mivechi. 2018. Chaperones. Chaperones 1 22 .
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Kaixiang Cao, Clayton K. Collings, Stacy A. Marshall, Marc A. Morgan, Emily J. Rendleman, Lu Wang, Christie C. Sze, Tianjiao Sun, Elizabeth T. Bartom & Ali Shilatifard. (2017) SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression. Genes & Development 31:8, pages 787-801.
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Elisabeth S. Christians. 2017. The Role of Heat Shock Proteins in Reproductive System Development and Function. The Role of Heat Shock Proteins in Reproductive System Development and Function 1 27 .
Ashish Kumar & M.K. Thakur. (2016) Binding of transcription factors to Presenilin 1 and 2 promoter cis-acting elements varies during the development of mouse cerebral cortex. Neuroscience Letters 628, pages 98-104.
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Ahmed G. Nomir, Yuto Takeuchi, Junji Fujikawa, Ashraf A. El Sharaby, Satoshi Wakisaka & Makoto Abe. (2016) Fate mapping of Trps1 daughter cells during cardiac development using novel Trps1-Cre mice. genesis 54:7, pages 379-388.
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Dig B. Mahat, H. Hans Salamanca, Fabiana M. Duarte, Charles G. Danko & John T. Lis. (2016) Mammalian Heat Shock Response and Mechanisms Underlying Its Genome-wide Transcriptional Regulation. Molecular Cell 62:1, pages 63-78.
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Chengkai Dai & Stephen Byers Sampson. (2016) HSF1: Guardian of Proteostasis in Cancer. Trends in Cell Biology 26:1, pages 17-28.
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Koji Shiraishi. 2016. Heat Shock Factor. Heat Shock Factor 147 164 .
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Viktoria Ortner, Alfred Ludwig, Elisabeth Riegel, Sarah Dunzinger & Thomas Czerny. (2014) An artificial HSE promoter for efficient and selective detection of heat shock pathway activity. Cell Stress and Chaperones 20:2, pages 277-288.
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Sudhish Sharma, Rachana Mishra, Brandon L. Walker, Savitha Deshmukh, Manuela Zampino, Jay Patel, Mani Anamalai, David Simpson, Ishwar S. Singh, Shalesh Kaushal & Sunjay Kaushal. (2014) Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death. Cell Stress and Chaperones 20:1, pages 185-201.
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Elizabeth E. Puscheck, Awoniyi O. Awonuga, Yu Yang, Zhongliang Jiang & Daniel A. Rappolee. 2015. Cell Signaling During Mammalian Early Embryo Development. Cell Signaling During Mammalian Early Embryo Development 77 128 .
Anson Pierce, Natalia Podlutskaya, Jonathan J. Halloran, Stacy A. Hussong, Pei-Yi Lin, Raquel Burbank, Matthew J. Hart & Veronica Galvan. (2013) Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease. Journal of Neurochemistry 124:6, pages 880-893.
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Sylvain Lecomte, Léa Reverdy, Catherine Le Quément, Florent Le Masson, Axelle Amon, Pascale Le Goff, Denis Michel, Elisabeth Christians & Yves Le Dréan. (2013) Unraveling Complex Interplay between Heat Shock Factor 1 and 2 Splicing Isoforms. PLoS ONE 8:2, pages e56085.
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Lisha Mou, Yadong Wang, Honggang Li, Yi Huang, Tao Jiang, Weiren Huang, Zesong Li, Jing Chen, Jun Xie, Yuchen Liu, Zhimao Jiang, Xianxin Li, Jiongxian Ye, Zhiming Cai & Yaoting Gui. (2012) A dominant-negative mutation of HSF2 associated with idiopathic azoospermia. Human Genetics 132:2, pages 159-165.
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Chengkai Dai, Siyuan Dai & Junyue Cao. (2012) Proteotoxic stress of cancer: Implication of the heat-shock response in oncogenesis. Journal of Cellular Physiology 227:8, pages 2982-2987.
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Toyohide Shinkawa, Ke Tan, Mitsuaki Fujimoto, Naoki Hayashida, Kaoru Yamamoto, Eiichi Takaki, Ryosuke Takii, Ramachandran Prakasam, Sachiye Inouye, Valerie Mezger & Akira Nakai. (2011) Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation. Molecular Biology of the Cell 22:19, pages 3571-3583.
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Florent Le Masson & Elisabeth Christians. (2010) HSFs and regulation of Hsp70.1 (Hspa1b) in oocytes and preimplantation embryos: new insights brought by transgenic and knockout mouse models. Cell Stress and Chaperones 16:3, pages 275-285.
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Xiongjie Jin, Binnur Eroglu, Demetrius Moskophidis & Nahid F. Mivechi. 2011. Molecular Chaperones. Molecular Chaperones 1 20 .
Andrew T. N. Tebbenkamp & David R. Borchelt. (2010) Analysis of Chaperone mRNA Expression in the Adult Mouse Brain by Meta Analysis of the Allen Brain Atlas. PLoS ONE 5:10, pages e13675.
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Ryma Abane & Valérie Mezger. (2010) Roles of heat shock factors in gametogenesis and development. FEBS Journal 277:20, pages 4150-4172.
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Johanna K. Björk & Lea Sistonen. (2010) Regulation of the members of the mammalian heat shock factor family. FEBS Journal 277:20, pages 4126-4139.
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S Lecomte, F Desmots, F Le Masson, P Le Goff, D Michel, E S Christians & Y Le Dréan. (2010) Roles of heat shock factor 1 and 2 in response to proteasome inhibition: consequence on p53 stability. Oncogene 29:29, pages 4216-4224.
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Christiane Richter-LandsbergKate Reed Herbert, Afshin Samali & Adrienne Gorman. 2009. Heat Shock Proteins in Neural Cells. Heat Shock Proteins in Neural Cells 25 37 .
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Donald C. Wilkerson, Lynea A. Murphy & Kevin D. Sarge. (2008) Interaction of HSF1 and HSF2 with the Hspa1b Promoter in Mouse Epididymal Spermatozoa1. Biology of Reproduction 79:2, pages 283-288.
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Hiroshi Kajiya, Masahiro Ito, Hayato Ohshima, Shin-ichi Kenmotsu, William L. Ries, Ivor J. Benjamin & Sakamuri V. Reddy. (2006) RANK ligand expression in heat shock factor-2 deficient mouse bone marrow stromal/preosteoblast cells. Journal of Cellular Biochemistry 97:6, pages 1362-1369.
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