Advanced search
Publication Cover
Molecular and Cellular Biology Volume 23, 2003 - Issue 1
Submit an article Journal homepage
156
Views
391
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Hypoxia-Inducible Factor 1α Is Essential for Cell Cycle Arrest during Hypoxia

Nobuhito GodaMolecular Biology Section, Division of Biology, University of California, San Diego, La Jolla, California92093
,
Heather E. RyanMolecular Biology Section, Division of Biology, University of California, San Diego, La Jolla, California92093
,
Bahram KhadiviMolecular Biology Section, Division of Biology, University of California, San Diego, La Jolla, California92093
,
Wayne McNultyMolecular Biology Section, Division of Biology, University of California, San Diego, La Jolla, California92093
,
Robert C. RickertMolecular Biology Section, Division of Biology, University of California, San Diego, La Jolla, California92093
&
Randall S. JohnsonMolecular Biology Section, Division of Biology, University of California, San Diego, La Jolla, California92093Correspondence[email protected]
Pages 359-369 | Received 12 Jun 2002, Accepted 30 Sep 2002, Published online: 27 Mar 2023

Citations (391)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (17)

Drashti Desai & Pravin Shende. (2022) Cyclodextrin-based gefitinib nanobubbles for synergistic apoptosis in lung cancer. Materials Technology 37:11, pages 1665-1676.
Read now
Ali Asghar Kiani, Hossein Elyasi, Shadiyeh Ghoreyshi, Negar Nouri, Ali Safarzadeh & Amirhossein Nafari. (2021) Study on hypoxia-inducible factor and its roles in immune system. Immunological Medicine 44:4, pages 223-236.
Read now
Michal W. Luczak, Casey Krawic & Anatoly Zhitkovich. (2021) NAD+ metabolism controls growth inhibition by HIF1 in normoxia and determines differential sensitivity of normal and cancer cells. Cell Cycle 20:18, pages 1812-1827.
Read now
Noel A. Warfel. (2017) Targeting CDK4/6 to oppose hypoxia-mediated therapeutic resistance. Cell Cycle 16:13, pages 1241-1242.
Read now
Fan Wang, Haoxiang Zhang, Naihan Xu, Nunu Huang, Caiming Tian, Anlin Ye, Guangnan Hu, Jie He & Yaou Zhang. (2016) A novel hypoxia-induced miR-147a regulates cell proliferation through a positive feedback loop of stabilizing HIF-1α. Cancer Biology & Therapy 17:8, pages 790-798.
Read now
Sandra Schick, Kolja Becker, Sudhir Thakurela, David Fournier, Mareike Hildegard Hampel, Stefan Legewie & Vijay K. Tiwari. (2016) Identifying Novel Transcriptional Regulators with Circadian Expression. Molecular and Cellular Biology 36:4, pages 545-558.
Read now
Maryam Esfahani, Fatemeh Karimi, Saeid Afshar, Somayeh niknazar, Sareh Sohrabi & Rezvan Najafi. (2015) Prolyl hydroxylase inhibitors act as agents to enhance the efficiency of cell therapy. Expert Opinion on Biological Therapy 15:12, pages 1739-1755.
Read now
Shuang Li, Qingzhu Wei, Qin Li, Bin Zhang & Qiang Xiao. (2015) Down-regulating HIF-1α by lentivirus-mediated shRNA for therapy of triple negative breast cancer. Cancer Biology & Therapy 16:6, pages 866-875.
Read now
Noel A Warfel, Nathan G Dolloff, David T Dicker, Jozef Malysz & Wafik S. El-Deiry. (2013) CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth. Cell Cycle 12:23, pages 3689-3701.
Read now
Tanushri Sengupta, Gathi Abraham, Yanfei Xu, Bruce E. Clurman & Alex C. Minella. (2011) Hypoxia-Inducible Factor 1 Is Activated by Dysregulated Cyclin E during Mammary Epithelial Morphogenesis. Molecular and Cellular Biology 31:18, pages 3885-3895.
Read now
Peter Ebbesen, Erik O. Pettersen, Thomas A. Gorr, Gerhard Jobst, Kaye Williams, Jochen Kieninger, Roland H. Wenger, Silvia Pastorekova, Ludwig Dubois, Philippe Lambin, Brad G. Wouters, Twan Van Den Beucken, Claudiu T. Supuran, Lorenz Poellinger, Peter Ratcliffe, Arvydas Kanopka, Agnes Görlach, Max Gasmann, Adrian L. Harris, Patrick Maxwell & Andrea Scozzafava. (2009) Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies. Journal of Enzyme Inhibition and Medicinal Chemistry 24:sup1, pages 1-39.
Read now
Gina F Lungu, George Stoica & Paul KY Wong. (2008) Down-regulation of Jab1, HIF-1α, and VEGF by Moloney murine leukemia virus-ts1 infection: A possible cause of neurodegeneration. Journal of Neurovirology 14:3, pages 239-251.
Read now
Jung-whan Kim, Ping Gao, Yen-Chun Liu, Gregg L. Semenza & Chi V. Dang. (2007) Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1. Molecular and Cellular Biology 27:21, pages 7381-7393.
Read now
Wei Li, Amira Sanki, Rooshdiya Z. Karim, John F. Thompson, C. Soon Lee, Liqing Zhuang, Stanley W. McCarthy & Richard A. Scolyer. (2006) The role of cell cycle regulatory proteins in the pathogenesis of melanoma. Pathology 38:4, pages 287-301.
Read now
Fiona A. Mack, Jagruti H. Patel, Mangatt P. Biju, Volker H. Haase & M. Celeste Simon. (2005) Decreased Growth of Vhl−− Fibrosarcomas Is Associated with Elevated Levels of Cyclin Kinase Inhibitors p21 and p27. Molecular and Cellular Biology 25:11, pages 4565-4578.
Read now
Mi-Jung Lee, Jee-Youn Kim, Kyoungho Suk & Jae-Hoon Park. (2004) Identification of the Hypoxia-Inducible Factor 1α-Responsive HGTD-P Gene as a Mediator in the Mitochondrial Apoptotic Pathway. Molecular and Cellular Biology 24:9, pages 3918-3927.
Read now
Lawrence B. Gardner, Feng Li, Xuejie Yang & Chi V. Dang. (2003) Anoxic Fibroblasts Activate a Replication Checkpoint That Is Bypassed By E1a. Molecular and Cellular Biology 23:24, pages 9032-9045.
Read now

Articles from other publishers (374)

Victor E. Reyes. (2023) Helicobacter pylori and Its Role in Gastric Cancer. Microorganisms 11:5, pages 1312.
Crossref
Haodong Yu, Ya He, Jinying Zhang, Ziyi Zhang & Xuezhen Zhang. (2023) Hepatic transcriptome analysis reveals the metabolic strategies of largemouth bass (Micropterus salmoides) under different dissolved oxygen condition. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 45, pages 101032.
Crossref
Bonita H. Powell, Andrey Turchinovich, Yongchun Wang, Olesia Gololobova, Dominik Buschmann, Martha A. Zeiger, Christopher B. Umbricht & Kenneth W. Witwer. (2023) miR-210 Expression Is Strongly Hypoxia-Induced in Anaplastic Thyroid Cancer Cell Lines and Is Associated with Extracellular Vesicles and Argonaute-2. International Journal of Molecular Sciences 24:5, pages 4507.
Crossref
Jun Muto, Shinji Fukuda, Kenji Watanabe, Xiuju Dai, Teruko Tsuda, Takeshi Kiyoi, Kenji Kameda, Ryosuke Kawakami, Hideki Mori, Ken Shiraishi, Masamoto Murakami, Takeshi Imamura, Shigeki Higashiyama, Yasuhiro Fujisawa, Yoichi Mizukami & Koji Sayama. (2023) Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21. Communications Biology 6:1.
Crossref
Rabiatul Basria S. M. N. Mydin, Alam Mahboob, Srimala Sreekantan, Khairul Arifah Saharudin, Ekhlas Qaid Qazem, Roshasnorlyza Hazan & Mustafa Fadzil Farid Wajidi. (2023) Mechano‐cytoskeleton remodeling mechanism and molecular docking studies on nanosurface technology: Titania nanotube arrays. Biotechnology and Applied Biochemistry.
Crossref
Mehtap Kilic Eren. 2023. Hypoxia in Cancer: Significance and Impact on Cancer Therapy. Hypoxia in Cancer: Significance and Impact on Cancer Therapy 89 117 .
Neha Masarkar, Suman Kumar Ray, Pragati Raghuwanshi, Ashish K. Yadav & Sukhes Mukherjee. 2023. Hypoxia in Cancer: Significance and Impact on Cancer Therapy. Hypoxia in Cancer: Significance and Impact on Cancer Therapy 275 295 .
Ali Rafat, Khadijeh Dizaji Asl, Zeinab Mazloumi, Bahram Samadirad, Fereidoun Ashrafianbonab, Raheleh Farahzadi & Hojjatollah Nozad Charoudeh. (2022) Bone marrow CD34 positive cells may be suitable for collection after death. Transfusion and Apheresis Science 61:6, pages 103452.
Crossref
Kshitiz, Junaid Afzal, Yasir Suhail, Hao Chang, Maimon E. Hubbi, Archer Hamidzadeh, Ruchi Goyal, Yamin Liu, Peng Sun, Stefania Nicoli, Chi V. Dang & Andre Levchenko. (2022) Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells. Cell Systems 13:12, pages 1048-1064.e7.
Crossref
Ting Liu, Min Yan, Fen Liu, Yuyan Ma & Yan Fang. (2022) The role of p53‐MDM2 signaling in missed abortion and possible pathogenesis . Journal of Obstetrics and Gynaecology Research 48:11, pages 2686-2696.
Crossref
Ana Karen Torres-Soria, Yair Romero, Yalbi I. Balderas-Martínez, Rafael Velázquez-Cruz, Luz Maria Torres-Espíndola, Angel Camarena, Edgar Flores-Soto, Héctor Solís-Chagoyán, Víctor Ruiz, Ángeles Carlos-Reyes, Citlaltepetl Salinas-Lara, Erika Rubí Luis-García, Jaime Chávez, Manuel Castillejos-López & Arnoldo Aquino-Gálvez. (2022) Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary Fibrosis. Cells 11:19, pages 2938.
Crossref
Ruining Liu, Victoria Muliadi, Wenjun Mou, Hanxiong Li, Juan Yuan, Johan Holmberg, Benedict J. Chambers, Nadeem Ullah, Jakob Wurth, Mohammad Alzrigat, Susanne Schlisio, Berit Carow, Lars Gunnar Larsson & Martin E. Rottenberg. (2022) HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection. Nature Communications 13:1.
Crossref
Jinwei Zhang, Xiaoqian Wu, Jideng Ma, Keren Long, Jing Sun, Mingzhou Li & Liangpeng Ge. (2022) Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells. Frontiers in Immunology 13.
Crossref
Liang Qin, Yoon-Mi Chung, Michael Berk, Bryan Naelitz, Ziqi Zhu, Eric Klein, Abhishek A. Chakraborty & Nima Sharifi. (2022) Hypoxia-Reoxygenation Couples 3βHSD1 Enzyme and Cofactor Upregulation to Facilitate Androgen Biosynthesis and Hormone Therapy Resistance in Prostate Cancer. Cancer Research 82:13, pages 2417-2430.
Crossref
Dong Young Kang, Nipin Sp, Se Won Bae & Kyoung-Jin Jang. (2022) Methylsulfonylmethane relieves cobalt chloride-induced hypoxic toxicity in C2C12 myoblasts. Life Sciences 301, pages 120619.
Crossref
Jingyao Hu, Xinyu Li, Liang Yang & Hangyu Li. (2022) Hypoxia, a key factor in the immune microenvironment. Biomedicine & Pharmacotherapy 151, pages 113068.
Crossref
Kuo-Sheng Hung, Shiow-Yi Chen, Pang-Hung Hsu, Bo-An Lin, Chin-Hua Hu, Cing-Han Yang, Tun-Wen Pai, Wen-Shyong Tzou & Hsin-Yu Chung. (2022) Comparative Transcriptome Analysis of Organ-Specific Adaptive Responses to Hypoxia Provides Insights to Human Diseases. Genes 13:6, pages 1096.
Crossref
Irene Garcés-Lázaro, Rebecca Kotzur, Adelheid Cerwenka & Ofer Mandelboim. (2022) NK Cells Under Hypoxia: The Two Faces of Vascularization in Tumor and Pregnancy. Frontiers in Immunology 13.
Crossref
Carlos H. V. Nascimento-Filho, Alexandra T. Glinos, Yeejin Jang, Eny M. Goloni-Bertollo, Rogerio M. Castilho & Cristiane H. Squarize. (2022) From Tissue Physoxia to Cancer Hypoxia, Cost-Effective Methods to Study Tissue-Specific O2 Levels in Cellular Biology. International Journal of Molecular Sciences 23:10, pages 5633.
Crossref
Aritri Dutta, Parijat Sarkar, Sandeep Shrivastava & Amitabha Chattopadhyay. (2022) Effect of Hypoxia on the Function of the Human Serotonin 1A Receptor . ACS Chemical Neuroscience 13:9, pages 1456-1466.
Crossref
Pooya Farhangnia, Ali-Akbar Delbandi, Nazanin Aghamohammadi, Amir Reza Safdarian & Mahzad Akbarpour. 2022. Handbook of Cancer and Immunology. Handbook of Cancer and Immunology 1 50 .
Mark J. de Keijzer, Daniel J. de Klerk, Lianne R. de Haan, Robert T. van Kooten, Leonardo P. Franchi, Lionel M. Dias, Tony G. Kleijn, Diederick J. van Doorn & Michal Heger. 2022. Photodynamic Therapy. Photodynamic Therapy 285 403 .
Yida Jiang, Li-Juan Duan & Guo-Hua Fong. (2021) Oxygen-sensing mechanisms in development and tissue repair. Development 148:23.
Crossref
Irma Telarovic, Roland H. Wenger & Martin Pruschy. (2021) Interfering with Tumor Hypoxia for Radiotherapy Optimization. Journal of Experimental & Clinical Cancer Research 40:1.
Crossref
Jungeun Lim, Hyeri Choi, Jungho Ahn & Noo Li Jeon. (2021) 3D High‐Content Culturing and Drug Screening Platform to Study Vascularized Hepatocellular Carcinoma in Hypoxic Condition. Advanced NanoBiomed Research 1:12.
Crossref
Barbara Canciani, Valentina Rafaela Herrera Millar, Margherita Pallaoro, Lucia Aidos, Federica Cirillo, Luigi Anastasia, Giuseppe Maria Peretti, Silvia Clotilde Modina, Laura Mangiavini & Alessia Di Giancamillo. (2021) Testing Hypoxia in Pig Meniscal Culture: Biological Role of the Vascular-Related Factors in the Differentiation and Viability of Neonatal Meniscus. International Journal of Molecular Sciences 22:22, pages 12465.
Crossref
Nicole A. Seebacher, Maria Krchniakova, Alexandra E. Stacy, Jan Skoda & Patric J. Jansson. (2021) Tumour Microenvironment Stress Promotes the Development of Drug Resistance. Antioxidants 10:11, pages 1801.
Crossref
Prabhash Kumar Jha, Aatira Vijay, Amit Prabhakar, Tathagata Chatterjee, Velu Nair, Nitin Bajaj, Bhuvnesh Kumar, Manish Sharma & Mohammad Zahid Ashraf. (2021) Transcriptome Profiling Reveals the Endogenous Sponging Role of LINC00659 and UST-AS1 in High-Altitude Induced Thrombosis. Thrombosis and Haemostasis 121:11, pages 1497-1511.
Crossref
Yuan Huang, Junying Fan, Yi Li, Shaozhi Fu, Yue Chen & Jingbo Wu. (2021) Imaging of Tumor Hypoxia With Radionuclide-Labeled Tracers for PET. Frontiers in Oncology 11.
Crossref
Andria Rakotomalala, Alexandre Escande, Alessandro Furlan, Samuel Meignan & Eric Lartigau. (2021) Hypoxia in Solid Tumors: How Low Oxygenation Impacts the “Six Rs” of Radiotherapy. Frontiers in Endocrinology 12.
Crossref
Mohsen Rashid, Leila Rostami Zadeh, Behzad Baradaran, Ommoleila Molavi, Zeinab Ghesmati, Mehdi Sabzichi & Fatemeh Ramezani. (2021) Up-down regulation of HIF-1α in cancer progression. Gene 798, pages 145796.
Crossref
Daniel Otero-Albiol & Amancio Carnero. (2021) Cellular senescence or stemness: hypoxia flips the coin. Journal of Experimental & Clinical Cancer Research 40:1.
Crossref
Joanna M Wierońska, Paulina Cieślik & Leszek Kalinowski. (2021) Nitric Oxide-Dependent Pathways as Critical Factors in the Consequences and Recovery after Brain Ischemic Hypoxia. Biomolecules 11:8, pages 1097.
Crossref
Rajnish Kumar Singh, Yonggang Pei, Dipayan Bose, Zachary L Lamplugh, Kunfeng Sun, Yan Yuan, Paul Lieberman, Jianxin You & Erle S Robertson. (2021) KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia. eLife 10.
Crossref
Wanyan Wang, Jiayan Cui, Hui Ma, Weiqiang Lu & Jin Huang. (2021) Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine. Frontiers in Oncology 11.
Crossref
Элеонора Николаевна Трушина. (2021) APOPTOSIS OF BRAIN NEURONS IN ISCHEMIA. APOPTOSIS OF BRAIN NEURONS IN ISCHEMIA.
Milos Gojkovic, Pedro P. Cunha, Gabriella S. Darmasaputra, Laura Barbieri, Helene Rundqvist, Pedro Veliça & Randall S. Johnson. (2021) Oxygen-Mediated Suppression of CD8+ T Cell Proliferation by Macrophages: Role of Pharmacological Inhibitors of HIF Degradation. Frontiers in Immunology 12.
Crossref
Jimena Druker, James W. Wilson, Fraser Child, Dilem Shakir, Temitope Fasanya & Sonia Rocha. (2021) Role of Hypoxia in the Control of the Cell Cycle. International Journal of Molecular Sciences 22:9, pages 4874.
Crossref
Jorge Andrade, Chenyue Shi, Ana S. H. Costa, Jeongwoon Choi, Jaeryung Kim, Anuradha Doddaballapur, Toshiya Sugino, Yu Ting Ong, Marco Castro, Barbara Zimmermann, Manuel Kaulich, Stefan Guenther, Kerstin Wilhelm, Yoshiaki Kubota, Thomas Braun, Gou Young Koh, Ana Rita Grosso, Christian Frezza & Michael Potente. (2021) Control of endothelial quiescence by FOXO-regulated metabolites. Nature Cell Biology 23:4, pages 413-423.
Crossref
Mariyah Pressley, Jill A. Gallaher, Joel S. Brown, Michal R. Tomaszewski, Punit Borad, Mehdi Damaghi, Robert J. Gillies & Christopher J. Whelan. (2021) Cycling hypoxia selects for constitutive HIF stabilization. Scientific Reports 11:1.
Crossref
Apostolos Menegakis, Rob Klompmaker, Claire Vennin, Aina Arbusà, Maartje Damen, Bram van den Broek, Daniel Zips, Jacco van Rheenen, Lenno Krenning & René H. Medema. (2021) Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence. Cells 10:3, pages 610.
Crossref
Yuling Chen & Timo Gaber. (2021) Hypoxia/HIF Modulates Immune Responses. Biomedicines 9:3, pages 260.
Crossref
Philipp Markolin, Natalie Davidson, Christian K. Hirt, Christophe D. Chabbert, Nicola Zamboni, Gerald Schwank, Wilhelm Krek & Gunnar Rätsch. (2021) Identification of HIF-dependent alternative splicing in gastrointestinal cancers and characterization of a long, coding isoform of SLC35A3. Genomics 113:2, pages 515-529.
Crossref
Tuyelee Das, Uttpal Anand, Swaroop Kumar Pandey, Charles R. AshbyJrJr, Yehuda G. Assaraf, Zhe-Sheng Chen & Abhijit Dey. (2021) Therapeutic strategies to overcome taxane resistance in cancer. Drug Resistance Updates 55, pages 100754.
Crossref
Asieh Emami Nejad, Simin Najafgholian, Alireza Rostami, Alireza Sistani, Samaneh Shojaeifar, Mojgan Esparvarinha, Reza Nedaeinia, Shaghayegh Haghjooy Javanmard, Marjan Taherian, Mojtaba Ahmadlou, Rasoul Salehi, Bahman Sadeghi & Mostafa Manian. (2021) The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment. Cancer Cell International 21:1.
Crossref
Siyao Li, Lu Wen, Xiaoru Hu, Qingqing Wei & Zheng Dong. (2021) HIF in Nephrotoxicity during Cisplatin Chemotherapy: Regulation, Function and Therapeutic Potential. Cancers 13:2, pages 180.
Crossref
Stig Linder. 2021. Clinical Bioenergetics. Clinical Bioenergetics 547 564 .
Abhishek A. Chakraborty. (2020) Coalescing lessons from oxygen sensing, tumor metabolism, and epigenetics to target VHL loss in kidney cancer. Seminars in Cancer Biology 67, pages 34-42.
Crossref
Wen-Ning Xu, Run-Ze Yang, Huo-Liang Zheng, Lei-Sheng Jiang & Sheng-Dan Jiang. (2020) NDUFA4L2 Regulated by HIF-1α Promotes Metastasis and Epithelial–Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production. Frontiers in Cell and Developmental Biology 8.
Crossref
Windsor Wen-Jin Chao, Yu-Kuang Chen, Howard Wen-Haur Chao, Wynn Hwai-Tzong Pan & Hsiao-Ming Chao. (2020) Fortified S-Allyl L-Cysteine: Animal Safety, Effect on Retinal Ischemia, and Role of Wnt in the Underlying Therapeutic Mechanism. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-12.
Crossref
Kinga A. Kocemba-Pilarczyk, Sonia Trojan, Barbara Ostrowska, Małgorzata Lasota, Paulina Dudzik, Dorota Kusior & Marta Kot. (2020) Influence of metformin on HIF-1 pathway in multiple myeloma. Pharmacological Reports 72:5, pages 1407-1417.
Crossref
Marina Andrade-Tomaz, Izadora de Souza, Clarissa Ribeiro Reily Rocha & Luciana Rodrigues Gomes. (2020) The Role of Chaperone-Mediated Autophagy in Cell Cycle Control and Its Implications in Cancer. Cells 9:9, pages 2140.
Crossref
Syam Prakash Somasekharan, Fan Zhang, Neetu Saxena, Jia Ni Huang, I-Chih Kuo, Caitlin Low, Robert Bell, Hans Adomat, Nikolay Stoynov, Leonard Foster, Martin Gleave & Poul H Sorensen. (2020) G3BP1-linked mRNA partitioning supports selective protein synthesis in response to oxidative stress. Nucleic Acids Research 48:12, pages 6855-6873.
Crossref
Akira Wagatsuma, Masayuki Arakawa, Hanano Matsumoto, Ryoichi Matsuda, Takayuki Hoshino & Kunihiko Mabuchi. (2020) Cobalt chloride, a chemical hypoxia-mimicking agent, suppresses myoblast differentiation by downregulating myogenin expression. Molecular and Cellular Biochemistry 470:1-2, pages 199-214.
Crossref
Tamar Sofer, Ruitong Li, Roby Joehanes, Honghuang Lin, Adam C. Gower, Heming Wang, Nuzulul Kurniansyah, Brian E. Cade, Jiwon Lee, Stephanie Williams, Reena Mehra, Sanjay R. Patel, Stuart F. Quan, Yongmei Liu, Jerome I. Rotter, Stephen S. Rich, Avrum Spira, Daniel Levy, Sina A. Gharib, Susan Redline & Daniel J. Gottlieb. (2020) Low oxygen saturation during sleep reduces CD1D and RAB20 expressions that are reversed by CPAP therapy. EBioMedicine 56, pages 102803.
Crossref
Bárbara Acosta‐Iborra, Maria Tiana, Laura Maeso‐Alonso, Rosana Hernández‐Sierra, Gonzalo Herranz, Andrea Santamaria, Carlos Rey, Raquel Luna, Laura Puente‐Santamaria, Margarita M. Marques, Maria C. Marin, Luis del Peso & Benilde Jiménez. (2020) Hypoxia compensates cell cycle arrest with progenitor differentiation during angiogenesis. The FASEB Journal 34:5, pages 6654-6674.
Crossref
Lucia C. Leal-Esteban & Lluis Fajas. (2020) Cell cycle regulators in cancer cell metabolism. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866:5, pages 165715.
Crossref
Alyssa Vito, Nader El-Sayes & Karen Mossman. (2020) Hypoxia-Driven Immune Escape in the Tumor Microenvironment. Cells 9:4, pages 992.
Crossref
Vijay Simha Baddela, Arpna Sharma, Marten Michaelis & Jens Vanselow. (2020) HIF1 driven transcriptional activity regulates steroidogenesis and proliferation of bovine granulosa cells. Scientific Reports 10:1.
Crossref
Yinnan Mu, Wanru Li, Bin Wu, Jiong Chen & Xinhua Chen. (2020) Transcriptome analysis reveals new insights into immune response to hypoxia challenge of large yellow croaker (Larimichthys crocea). Fish & Shellfish Immunology 98, pages 738-747.
Crossref
Yinrui Lei, Tao Chen, Yeyi Li, Man Shang, Yan Zhang, Yuepeng Jin, Qiujing Yu, Fang Guo & Ting Wang. (2020) O-GlcNAcylation of PFKFB3 is required for tumor cell proliferation under hypoxia. Oncogenesis 9:2.
Crossref
Yiming Wang, Song Chen, Zuoqin Yan & Ming Pei. (2019) A prospect of cell immortalization combined with matrix microenvironmental optimization strategy for tissue engineering and regeneration. Cell & Bioscience 9:1.
Crossref
Esha Madan, Taylor M Parker, Christopher J Pelham, Antonio M Palma, Maria L Peixoto, Masaki Nagane, Aliya Chandaria, Ana R Tomás, Rita Canas-Marques, Vanessa Henriques, Antonio Galzerano, Joaquim Cabral-Teixeira, Karuppaiyah Selvendiran, Periannan Kuppusamy, Carlos Carvalho, Antonio Beltran, Eduardo Moreno, Uttam K Pati & Rajan Gogna. (2019) HIF-transcribed p53 chaperones HIF-1α. Nucleic Acids Research 47:19, pages 10212-10234.
Crossref
Keywan Mortezaee, Wrya Parwaie, Elahe Motevaseli, Hanifeh Mirtavoos-Mahyari, Ahmed Eleojo Musa, Dheyauldeen Shabeeb, Farid Esmaely, Masoud Najafi & Bagher Farhood. (2019) Targets for improving tumor response to radiotherapy. International Immunopharmacology 76, pages 105847.
Crossref
Nikhil Gupta, Jung Eun Park, Wilford Tse, Jee Keem Low, Oi Lian Kon, Neil McCarthy & Siu Kwan Sze. (2019) ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer. Oncotarget 10:57, pages 5970-5982.
Crossref
V. A. Kobliakov. (2019) The Mechanisms of Regulation of Aerobic Glycolysis (Warburg Effect) by Oncoproteins in Carcinogenesis. Biochemistry (Moscow) 84:10, pages 1117-1128.
Crossref
Rajnish Kumar Singh, Zachary L. Lamplugh, Fengchao Lang, Yan Yuan, Paul Lieberman, Jianxin You & Erle S. Robertson. (2019) KSHV-encoded LANA protects the cellular replication machinery from hypoxia induced degradation. PLOS Pathogens 15:9, pages e1008025.
Crossref
Camilla HalvarssonEmma RörbyPernilla EliassonStefan LangShamit SonejiJan-Ingvar Jönsson. (2019) Putative Role of Nuclear Factor-Kappa B But Not Hypoxia-Inducible Factor-1α in Hypoxia-Dependent Regulation of Oxidative Stress in Hematopoietic Stem and Progenitor Cells. Antioxidants & Redox Signaling 31:3, pages 211-226.
Crossref
Shengli Xu, Jianxin Huo, Yuhan Huang, Melissa Aw, Shuwen Chen, Shiya Mak, Lian Yee Yip, Ying Swan Ho, Sze Wai Ng, Andy Hee-Meng Tan, Alison Lee, Xijun Ou & Kong-Peng Lam. (2019) von Hippel-Lindau Protein Maintains Metabolic Balance to Regulate the Survival of Naive B Lymphocytes. iScience 17, pages 379-392.
Crossref
Manuel Valenzuela-Valderrama, Paulina Cerda-Opazo, Steffen Backert, María Fernanda González, Nicolás Carrasco-Véliz, Carla Jorquera-Cordero, Sergio Wehinger, Jimena Canales, Denisse Bravo & Andrew F. G. Quest. (2019) The Helicobacter pylori Urease Virulence Factor Is Required for the Induction of Hypoxia-Induced Factor-1α in Gastric Cells. Cancers 11:6, pages 799.
Crossref
Apoorv Gupta, Sugadev Ragumani, Yogendra Kumar Sharma, Yasmin Ahmad & Pankaj Khurana. (2019) Analysis of Hypoxiamir-Gene Regulatory Network Identifies Critical MiRNAs Influencing Cell-Cycle Regulation Under Hypoxic Conditions. MicroRNA 8:3, pages 223-236.
Crossref
Lifei Meng, Xuhui Yang, Xiao Xie & Mingsong Wang. (2019) Mitochondrial NDUFA4L2 protein promotes the vitality of lung cancer cells by repressing oxidative stress. Thoracic Cancer 10:4, pages 676-685.
Crossref
Jung Eun Park, Shun Wilford Tse, Guo Xue, Christina Assisi, Aida Serra Maqueda, Gallart Palau Xavier Ramon, Jee Keem Low, Oi Lian Kon, Chor Yong Tay, James P. Tam & Siu Kwan Sze. (2019) Pulsed SILAC-based proteomic analysis unveils hypoxia- and serum starvation-induced de novo protein synthesis with PHD finger protein 14 (PHF14) as a hypoxia sensitive epigenetic regulator in cell cycle progression . Oncotarget 10:22, pages 2136-2150.
Crossref
Philip Brennecke, Dace Rasina, Oscar Aubi, Katja Herzog, Johannes Landskron, Bastien Cautain, Francisca Vicente, Jordi Quintana, Jordi Mestres, Bahne Stechmann, Bernhard Ellinger, Jose Brea, Jacek L. Kolanowski, Radosław Pilarski, Mar Orzaez, Antonio Pineda-Lucena, Luca Laraia, Faranak Nami, Piotr Zielenkiewicz, Kamil Paruch, Espen Hansen, Jens P. von Kries, Martin Neuenschwander, Edgar Specker, Petr Bartunek, Sarka Simova, Zbigniew Leśnikowski, Stefan Krauss, Lari Lehtiö, Ursula Bilitewski, Mark Brönstrup, Kjetil Taskén, Aigars Jirgensons, Heiko Lickert, Mads H. Clausen, Jeanette H. Andersen, Maria J. Vicent, Olga Genilloud, Aurora Martinez, Marc Nazaré, Wolfgang Fecke & Philip Gribbon. (2019) EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology. SLAS Discovery 24:3, pages 398-413.
Crossref
Eloy Moreno Roig, Arjan Groot, Ala Yaromina, Tessa Hendrickx, Lydie Barbeau, Lorena Giuranno, Glenn Dams, Jonathan Ient, Veronica Olivo Pimentel, Marike van Gisbergen, Ludwig Dubois & Marc Vooijs. (2019) HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells. Cells 8:1, pages 45.
Crossref
Xu Hui, Hisham Al-Ward, Fahmi Shaher, Chun-Yang Liu & Ning Liu. (2019) The Role of miR-210 in the Biological System: A Current Overview. Human Heredity 84:6, pages 233-239.
Crossref
Ola Didrik Saugstad, Ju-Lee Oei, Satyan Lakshminrusimha & Maximo Vento. (2018) Oxygen therapy of the newborn from molecular understanding to clinical practice. Pediatric Research 85:1, pages 20-29.
Crossref
Anastasios Kouroumalis, Eleni Mavrogonatou, Olga D. Savvidou, Panayiotis J. Papagelopoulos, Harris Pratsinis & Dimitris Kletsas. (2019) Major traits of the senescent phenotype of nucleus pulposus intervertebral disc cells persist under the specific microenvironmental conditions of the tissue. Mechanisms of Ageing and Development 177, pages 118-127.
Crossref
Michelle Lampl. 2019. Early Life Origins of Ageing and Longevity. Early Life Origins of Ageing and Longevity 23 34 .
Elizabeth Bowler & Michael R. Ladomery. 2019. Redox-Mediated Signal Transduction. Redox-Mediated Signal Transduction 109 133 .
Afsane Bahrami, Stephen L. Atkin, Muhammed Majeed & Amirhossein Sahebkar. (2018) Effects of curcumin on hypoxia-inducible factor as a new therapeutic target. Pharmacological Research 137, pages 159-169.
Crossref
Martin Schläpfer. (2018) Ist Sauerstoffmangel immer nur schädlich?. Praxis 107:21, pages 1155-1159.
Crossref
Joaquín Araos, Jonathan P. Sleeman & Boyan K. Garvalov. (2018) The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies. Clinical & Experimental Metastasis 35:7, pages 563-599.
Crossref
Klara Janjić, Christoph Kurzmann, Andreas Moritz & Hermann Agis. (2018) Core circadian clock gene expression in human dental pulp‐derived cells in response to L‐mimosine, hypoxia and echinomycin. European Journal of Oral Sciences 126:4, pages 263-271.
Crossref
Binoy Appukuttan, Yuefang Ma, Andrew Stempel, Liam M Ashander, Devy Deliyanti, Jennifer L Wilkinson‐Berka & Justine R Smith. (2018) Effect of NADPH oxidase 1 and 4 blockade in activated human retinal endothelial cells. Clinical & Experimental Ophthalmology 46:6, pages 652-660.
Crossref
Javier Garcia-Bermudez, Lou Baudrier, Konnor La, Xiphias Ge Zhu, Justine Fidelin, Vladislav O. Sviderskiy, Thales Papagiannakopoulos, Henrik Molina, Matija Snuderl, Caroline A. Lewis, Richard L. Possemato & Kıvanç Birsoy. (2018) Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. Nature Cell Biology 20:7, pages 775-781.
Crossref
Wooyoung Jeong, Seoungo Jung, Fuller W. Bazer & Jinyoung Kim. (2018) Hypoxia-dependent accumulation of hypoxia-inducible factor-1 alpha induces transient cell cycle arrest in porcine trophectoderm cells. Theriogenology 115, pages 9-15.
Crossref
Krishna Sundar Twayana & Palaniyandi Ravanan. (2018) Eukaryotic cell survival mechanisms: Disease relevance and therapeutic intervention. Life Sciences 205, pages 73-90.
Crossref
Maria Fragiadaki & Martin P. Zeidler. (2018) Ankyrin repeat and single KH domain 1 (ANKHD1) drives renal cancer cell proliferation via binding to and altering a subset of miRNAs. Journal of Biological Chemistry 293:25, pages 9570-9579.
Crossref
Laura Saenz del Burgo, Jesús Ciriza, Albert Espona-Noguera, Xavi Illa, Enric Cabruja, Gorka Orive, Rosa María Hernández, Rosa Villa, Jose Luis Pedraz & Mar Alvarez. (2018) 3D Printed porous polyamide macrocapsule combined with alginate microcapsules for safer cell-based therapies. Scientific Reports 8:1.
Crossref
Qiang Guo, Fei Lan, Xu Yan, Zhu Xiao, Yuelei Wu & Qin Zhang. (2018) Hypoxia exposure induced cisplatin resistance partially via activating p53 and hypoxia inducible facor‑1α in non‑small cell lung cancer A549 cells. Oncology Letters.
Crossref
Ewelina Krzywinska & Christian Stockmann. (2018) Hypoxia, Metabolism and Immune Cell Function. Biomedicines 6:2, pages 56.
Crossref
David Macias, Andrew S Cowburn, Hortensia Torres-Torrelo, Patricia Ortega-Sáenz, José López-Barneo & Randall S Johnson. (2018) HIF-2α is essential for carotid body development and function. eLife 7.
Crossref
Sho Ikeda, Akihiro Kitadate, Fumito Abe, Naoto Takahashi & Hiroyuki Tagawa. (2018) Hypoxia-inducible KDM3A addiction in multiple myeloma. Blood Advances 2:4, pages 323-334.
Crossref
Zhou Wang, Lingman Ma, Mengqi Su, Yiran Zhou, Ke Mao, Chengqin Li, Guangyong Peng, Changlin Zhou, Baiyong Shen & Jie Dou. (2018) Baicalin induces cellular senescence in human colon cancer cells via upregulation of DEPP and the activation of Ras/Raf/MEK/ERK signaling. Cell Death & Disease 9:2.
Crossref
Mengyu He, Shuying Ma, Qing Cai, Yan Wu, Chengjie Shao, Hui Kong, Hong Wang, Xiaoning Zeng & Weiping Xie. (2018) Hypoxia induces the dysfunction of human endothelial colony-forming cells via HIF-1α signaling. Respiratory Physiology & Neurobiology 247, pages 87-95.
Crossref
Jolene Caifeng Ho, Lissa Nurrul Abdullah, Qing You Pang, Sudhakar Jha, Edward Kai-Hua Chow, Henry Yang, Hiroyuki Kato, Lorenz Poellinger, Jun Ueda & Kian Leong Lee. (2017) Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway. PLOS ONE 12:11, pages e0188051.
Crossref
Xiaoya Ma, Huabing Zhang, Xiang Xue & Yatrik M. Shah. (2017) Hypoxia-inducible factor 2α (HIF-2α) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity. Journal of Biological Chemistry 292:41, pages 17046-17056.
Crossref
Sophie Van Welden, Andrew C. Selfridge & Pieter Hindryckx. (2017) Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD. Nature Reviews Gastroenterology & Hepatology 14:10, pages 596-611.
Crossref
Yanqing Huang, Daniel Lin & Cullen M. Taniguchi. (2017) Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe?. Science China Life Sciences 60:10, pages 1114-1124.
Crossref
Michal W. Luczak & Anatoly Zhitkovich. (2017) Nickel-induced HIF-1α promotes growth arrest and senescence in normal human cells but lacks toxic effects in transformed cells. Toxicology and Applied Pharmacology 331, pages 94-100.
Crossref
Junlian Gu, Yang Li, Jun Zeng, Bo Wang, Kun Ji, Yufeng Tang & Qing Sun. (2017) Knockdown of HIF-1α by siRNA-expressing plasmid delivered by attenuated Salmonella enhances the antitumor effects of cisplatin on prostate cancer. Scientific Reports 7:1.
Crossref
Jia Ma, Serge Evrard, Iker Badiola, Geraldine Siegfried & Abdel-Majid Khatib. (2017) Regulation of the proprotein convertases expression and activity during regenerative angiogenesis: Role of hypoxia-inducible factor (HIF). European Journal of Cell Biology 96:5, pages 457-468.
Crossref
Natalie Burrows & Patrick Henry Maxwell. (2017) Hypoxia and B cells. Experimental Cell Research 356:2, pages 197-203.
Crossref
Jiří Řehulka, Narendran Annadurai, Ivo Frydrych, Pawel Znojek, Petr Džubák, Peter Northcote, John H. Miller, Marián Hajdúch & Viswanath Das. (2017) Cellular effects of the microtubule-targeting agent peloruside A in hypoxia-conditioned colorectal carcinoma cells. Biochimica et Biophysica Acta (BBA) - General Subjects 1861:7, pages 1833-1843.
Crossref
Hanxiang Chen, Qishu Zhang, Lijun Qiao, Xueli Fan, Weifang Zhang, Weiming Zhao & Jason J. Chen. (2017) Cdc6 contributes to abrogating the G1 checkpoint under hypoxic conditions in HPV E7 expressing cells. Scientific Reports 7:1.
Crossref
Benjamin W. Dean, Thalia J. Rashid & Michael G. Jonz. (2017) Mitogenic action of hypoxia upon cutaneous neuroepithelial cells in developing zebrafish. Developmental Neurobiology 77:6, pages 789-801.
Crossref
Giovanni Minervini, Raffaele Lopreiato, Raissa Bortolotto, Antonella Falconieri, Geppo Sartori & Silvio C. E. Tosatto. (2017) Novel interactions of the von Hippel-Lindau (pVHL) tumor suppressor with the CDKN1 family of cell cycle inhibitors. Scientific Reports 7:1.
Crossref
Ioanna SandvigIvana GadjanskiMarija Vlaski-LafargeLeonora BuzanskaDarija LoncaricAna SarnowskaLaura RodriguezAxel SandvigZoran Ivanovic. (2017) Strategies to Enhance Implantation and Survival of Stem Cells After Their Injection in Ischemic Neural Tissue. Stem Cells and Development 26:8, pages 554-565.
Crossref
Sho Ikeda, Akihiro Kitadate, Fumito Abe, Hirobumi Saitoh, Yoshihiro Michishita, Yoshiaki Hatano, Yoshinari Kawabata, Atsushi Kitabayashi, Kazuaki Teshima, Masaaki Kume, Naoto Takahashi & Hiroyuki Tagawa. (2017) Hypoxia-inducible microRNA-210 regulates the DIMT1-IRF4 oncogenic axis in multiple myeloma. Cancer Science 108:4, pages 641-652.
Crossref
Jimena Canales, Manuel Valenzuela, Jimena Bravo, Paulina Cerda-Opazo, Carla Jorquera, Héctor Toledo, Denisse Bravo & Andrew F. G. Quest. (2017) Helicobacter pylori Induced Phosphatidylinositol-3-OH Kinase/mTOR Activation Increases Hypoxia Inducible Factor-1α to Promote Loss of Cyclin D1 and G0/G1 Cell Cycle Arrest in Human Gastric Cells. Frontiers in Cellular and Infection Microbiology 7.
Crossref
Jonathan C. Jun, Aman Rathore, Haris Younas, Daniele Gilkes & Vsevolod Y. Polotsky. (2017) Hypoxia-Inducible Factors and Cancer. Current Sleep Medicine Reports 3:1, pages 1-10.
Crossref
Georg Fluegen, Alvaro Avivar-Valderas, Yarong Wang, Michael R. Padgen, James K. Williams, Ana Rita Nobre, Veronica Calvo, Julie F. Cheung, Jose Javier Bravo-Cordero, David Entenberg, James Castracane, Vladislav Verkhusha, Patricia J. Keely, John Condeelis & Julio A. Aguirre-Ghiso. (2017) Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments. Nature Cell Biology 19:2, pages 120-132.
Crossref
A. M. V. N. Prathyusha, Godi Raghu & Pallaval Veera Bramhachari. 2017. Role of Transcription Factors in Gastrointestinal Malignancies. Role of Transcription Factors in Gastrointestinal Malignancies 73 89 .
Inho Choi, Saipriya Lammata, Neha Merchant & Dongkyoo Park. 2017. Role of Transcription Factors in Gastrointestinal Malignancies. Role of Transcription Factors in Gastrointestinal Malignancies 465 478 .
Sasidhar Eda, Ramakrishna Vadde & Rajeswari Jinka. 2017. Role of Transcription Factors in Gastrointestinal Malignancies. Role of Transcription Factors in Gastrointestinal Malignancies 131 159 .
Martyna Krzykawska-Serda, Richard C. Miller, Martyna Elas, Boris Epel, Eugene D. Barth, Mathew Maggio & Howard J. Halpern. 2017. Oxygen Transport to Tissue XXXIX. Oxygen Transport to Tissue XXXIX 319 325 .
Ivan Menendez-Montes, Beatriz Escobar, Beatriz Palacios, Manuel Jose Gómez, Jose Luis Izquierdo-Garcia, Lorena Flores, Luis Jesus Jiménez-Borreguero, Julian Aragones, Jesus Ruiz-Cabello, Miguel Torres & Silvia Martin-Puig. (2016) Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation. Developmental Cell 39:6, pages 724-739.
Crossref
Stephanie L. Ham, Ramila Joshi, Gary D. Luker & Hossein Tavana. (2016) Engineered Breast Cancer Cell Spheroids Reproduce Biologic Properties of Solid Tumors. Advanced Healthcare Materials 5:21, pages 2788-2798.
Crossref
Dorota Przybylska, Dorota Janiszewska, Aleksandra Goździk, Anna Bielak-Zmijewska, Piotr Sunderland, Ewa Sikora & Grażyna Mosieniak. (2016) NOX4 downregulation leads to senescence of human vascular smooth muscle cells. Oncotarget 7:41, pages 66429-66443.
Crossref
Gang Yang, Guangbing Xiong, Zhe Cao, Suli Zheng, Lei You, Taiping Zhang & Yupei Zhao. (2016) miR-497 expression, function and clinical application in cancer. Oncotarget 7:34, pages 55900-55911.
Crossref
Paola Ulivi, Giorgia Marisi & Alessandro Passardi. (2016) Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer. Oncotarget 7:29, pages 46678-46691.
Crossref
Deirdre Scully, Eleanor Keane, Emily Batt, Priyadarssini Karunakaran, Debra F. Higgins & Nobue Itasaki. (2016) Hypoxia promotes production of neural crest cells in the embryonic head. Development 143:10, pages 1742-1752.
Crossref
Alain de Bruin, Peter W. A. Cornelissen, Bettina C. Kirchmaier, Michal Mokry, Elhadi Iich, Ella Nirmala, Kuo-Hsuan Liang, Anna M. D. Végh, Koen T. Scholman, Marian J. Groot Koerkamp, Frank C. Holstege, Edwin Cuppen, Stefan Schulte-Merker & Walbert J. Bakker. (2016) Genome-wide analysis reveals NRP1 as a direct HIF1α-E2F7 target in the regulation of motorneuron guidance in vivo . Nucleic Acids Research 44:8, pages 3549-3566.
Crossref
Qiyuan Zhou, Tianji Chen, Wei Zhang, Melike Bozkanat, Yongchao Li, Lei Xiao, Richard B. van Breemen, John W. Christman, Jacob I. Sznajder & Guofei Zhou. (2016) Suppression of von Hippel-Lindau Protein in Fibroblasts Protects against Bleomycin-Induced Pulmonary Fibrosis. American Journal of Respiratory Cell and Molecular Biology 54:5, pages 728-739.
Crossref
Basudev Chowdhury, Elizabeth G. Porter, Jane C. Stewart, Christina R. Ferreira, Matthew J. Schipma & Emily C. Dykhuizen. (2016) PBRM1 Regulates the Expression of Genes Involved in Metabolism and Cell Adhesion in Renal Clear Cell Carcinoma. PLOS ONE 11:4, pages e0153718.
Crossref
Ming-Chih Lai, Chiao-May Chang & H. Sunny Sun. (2016) Hypoxia Induces Autophagy through Translational Up-Regulation of Lysosomal Proteins in Human Colon Cancer Cells. PLOS ONE 11:4, pages e0153627.
Crossref
Rosalie Richards, Michael D. Jenkinson, Brian J. Haylock & Violaine See. (2016) Cell cycle progression in glioblastoma cells is unaffected by pathophysiological levels of hypoxia. PeerJ 4, pages e1755.
Crossref
Hye-Lan Lee, Hye Yeong Lee, Yeomin Yun, Jinsoo Oh, Lihua Che, Minhyung Lee & Yoon Ha. (2016) Hypoxia-specific, VEGF-expressing neural stem cell therapy for safe and effective treatment of neuropathic pain. Journal of Controlled Release 226, pages 21-34.
Crossref
Hannah X. Chu & Nicole M. Jones. (2015) Changes in Hypoxia-Inducible Factor-1 (HIF-1) and Regulatory Prolyl Hydroxylase (PHD) Enzymes Following Hypoxic–Ischemic Injury in the Neonatal Rat. Neurochemical Research 41:3, pages 515-522.
Crossref
IGOR BRYUKHOVETSKIY, ANDREY BRYUKHOVETSKIY, YURI KHOTIMCHENKO & POLINA MISCHENKO. (2016) Novel cellular and post-genomic technologies in the treatment of glioblastoma multiforme (Review). Oncology Reports 35:2, pages 639-648.
Crossref
Elena Riboldi & Antonio Sica. 2016. The Innate Immune Response to Noninfectious Stressors. The Innate Immune Response to Noninfectious Stressors 81 106 .
Naomi Dirckx & Christa Maes. 2016. Cartilage. Cartilage 143 168 .
Ingrid Thurlings & Alain de Bruin. 2016. Cell Cycle Oscillators. Cell Cycle Oscillators 71 88 .
Maimon E. Hubbi & Gregg L. Semenza. (2015) Regulation of cell proliferation by hypoxia-inducible factors. American Journal of Physiology-Cell Physiology 309:12, pages C775-C782.
Crossref
Lynda M. McEvoy, Sharon A. O’Toole, Cathy D. Spillane, Cara M. Martin, Michael F. Gallagher, Britta Stordal, Gordon Blackshields, Orla Sheils & John J. O’Leary. (2015) Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer. BMC Cancer 15:1.
Crossref
Zongwei Wang, Charlotta Dabrosin, Xin Yin, Mark M. Fuster, Alexandra Arreola, W. Kimryn Rathmell, Daniele Generali, Ganji P. Nagaraju, Bassel El-Rayes, Domenico Ribatti, Yi Charlie Chen, Kanya Honoki, Hiromasa Fujii, Alexandros G. Georgakilas, Somaira Nowsheen, Amedeo Amedei, Elena Niccolai, Amr Amin, S. Salman Ashraf, Bill Helferich, Xujuan Yang, Gunjan Guha, Dipita Bhakta, Maria Rosa Ciriolo, Katia Aquilano, Sophie Chen, Dorota Halicka, Sulma I. Mohammed, Asfar S. Azmi, Alan Bilsland, W. Nicol Keith & Lasse D. Jensen. (2015) Broad targeting of angiogenesis for cancer prevention and therapy. Seminars in Cancer Biology 35, pages S224-S243.
Crossref
S. Sathya, S. Sudhagar & B.S. Lakshmi. (2015) Estrogen suppresses breast cancer proliferation through GPER / p38 MAPK axis during hypoxia. Molecular and Cellular Endocrinology 417, pages 200-210.
Crossref
Pinelopi P. KapitsinouVolker H. Haase. (2015) Molecular mechanisms of ischemic preconditioning in the kidney. American Journal of Physiology-Renal Physiology 309:10, pages F821-F834.
Crossref
Anja KonzackMirza JakupovicKateryna KubaichukAgnes GörlachFrank DombrowskiIlkka MiinalainenRaija SormunenThomas Kietzmann. (2015) Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis. Antioxidants & Redox Signaling 23:14, pages 1059-1075.
Crossref
Yogesh Saini, Steven P. Proper, Peter Dornbos, Krista K. Greenwood, Anna K. Kopec, Scott G. Lynn, Elizabeth Grier, Lyle D. Burgoon, Timothy R. Zacharewski, Russell S. Thomas, Jack R. Harkema & John J. LaPres. (2015) Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice. PLOS ONE 10:9, pages e0139270.
Crossref
Paula A. Bousquet, Joe Alexander Sandvik, Magnus Ø. Arntzen, Nina F. Jeppesen Edin, Stine Christoffersen, Ute Krengel, Erik O. Pettersen & Bernd Thiede. (2015) Hypoxia Strongly Affects Mitochondrial Ribosomal Proteins and Translocases, as Shown by Quantitative Proteomics of HeLa Cells. International Journal of Proteomics 2015, pages 1-9.
Crossref
Nanduri R. Prabhakar & Gregg L. Semenza. (2015) Oxygen Sensing and Homeostasis. Physiology 30:5, pages 340-348.
Crossref
Silvia Peppicelli, Francesca Bianchini & Lido Calorini. (2015) Metabolic reprogramming as a continuous changing behavior of tumor cells. Tumor Biology 36:8, pages 5759-5762.
Crossref
Joanna Kalucka, Gunnar Schley, Adela Georgescu, Bernd Klanke, Susanne Rössler, Jasmin Baumgartl, Joachim Velden, Kerstin Amann, Carsten Willam, Randall S. Johnson, Kai-Uwe Eckardt & Alexander Weidemann. (2015) Kidney injury is independent of endothelial HIF-1α. Journal of Molecular Medicine 93:8, pages 891-904.
Crossref
Kirti Bhatt, Qingqing Wei, Navjotsingh Pabla, Guie Dong, Qing-Sheng Mi, Mingyu Liang, Changlin Mei & Zheng Dong. (2015) MicroRNA-687 Induced by Hypoxia-Inducible Factor-1 Targets Phosphatase and Tensin Homolog in Renal Ischemia-Reperfusion Injury. Journal of the American Society of Nephrology 26:7, pages 1588-1596.
Crossref
Jurstine Daruwalla, Khaled Greish, Cathy Malcontenti-Wilson, Vijayaragavan Muralidharan, Hiroshi Maeda & Chris Christophi. (2015) Styrene maleic acid copolymer–pirarubicin induces tumor-selective oxidative stress and decreases tumor hypoxia as possible treatment of colorectal cancer liver metastases. Surgery 158:1, pages 236-247.
Crossref
Mark A. J. Chaplain & Gibin G. Powathil. (2015) Multiscale Modelling of Cancer Progression and Treatment Control: The Role of Intracellular Heterogeneities in Chemotherapy Treatment. Biophysical Reviews and Letters 10:02, pages 97-114.
Crossref
Richa S. Rathod, Amrita A. Khaire, Anvita A. Kale & Sadhana R. Joshi. (2015) Maternal omega‐3 fatty acid supplementation to a vitamin B 12 deficient diet normalizes angiogenic markers in the pup brain at birth . International Journal of Developmental Neuroscience 43:1, pages 43-49.
Crossref
Bastien Cautain, Nuria de Pedro, Christian Schulz, Javier Pascual, Thiciana da S. Sousa, Jesús Martin, Ignacio Pérez-Victoria, Francisco Asensio, Ignacio González, Gerald F. Bills, Fernando Reyes, Olga Genilloud & Francisca Vicente. (2015) Identification of the Lipodepsipeptide MDN-0066, a Novel Inhibitor of VHL/HIF Pathway Produced by a New Pseudomonas Species. PLOS ONE 10:5, pages e0125221.
Crossref
Nobutaka Doi, Ryohei Ogawa, Zheng-Guo Cui, Akihiro Morii, Akihiko Watanabe, Shinji Kanayama, Yuko Yoneda & Takashi Kondo. (2015) The acquired radioresistance in HeLa cells under conditions mimicking hypoxia was attenuated by a decreased expression of HIF subunit genes induced by RNA interference. Experimental Cell Research 333:2, pages 249-260.
Crossref
Matthias Brock, Thomas J. Haider, Johannes Vogel, Max Gassmann, Rudolf Speich, Michelle Trenkmann, Silvia Ulrich, Malcolm Kohler & Lars C. Huber. (2015) The hypoxia-induced microRNA-130a controls pulmonary smooth muscle cell proliferation by directly targeting CDKN1A. The International Journal of Biochemistry & Cell Biology 61, pages 129-137.
Crossref
Viswanath Das, Jana Štěpánková, Marián Hajdúch & John H. Miller. (2015) Role of tumor hypoxia in acquisition of resistance to microtubule-stabilizing drugs. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1855:2, pages 172-182.
Crossref
Gibin G. Powathil, Maciej Swat & Mark A.J. Chaplain. (2015) Systems oncology: Towards patient-specific treatment regimes informed by multiscale mathematical modelling. Seminars in Cancer Biology 30, pages 13-20.
Crossref
A Mühleisen, M Giaisi, R Köhler, P H Krammer & M Li-Weber. (2014) Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression. Cell Death & Disease 5:12, pages e1575-e1575.
Crossref
Anne-Theres Henze, Boyan K. Garvalov, Sascha Seidel, Angel M. Cuesta, Mathias Ritter, Alina Filatova, Franziska Foss, Higinio Dopeso, Clara L. Essmann, Patrick H. Maxwell, Guido Reifenberger, Peter Carmeliet, Amparo Acker-Palmer & Till Acker. (2014) Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. Nature Communications 5:1.
Crossref
Boyan K. Garvalov, Franziska Foss, Anne-Theres Henze, Ioanna Bethani, Sabine Gräf-Höchst, Devendra Singh, Alina Filatova, Higinio Dopeso, Sascha Seidel, Miriam Damm, Amparo Acker-Palmer & Till Acker. (2014) PHD3 regulates EGFR internalization and signalling in tumours. Nature Communications 5:1.
Crossref
Biagio Ricciuti, Carmen Mecca, Lucio Crinò, Sara Baglivo, Matteo Cenci & Giulio Metro. (2014) Non-coding RNAs in lung cancer. Oncoscience 1:11, pages 674-705.
Crossref
Donald J. Scholten, Christine M. Timmer, Jacqueline D. Peacock, Dominic W. Pelle, Bart O. Williams & Matthew R. Steensma. (2014) Down Regulation of Wnt Signaling Mitigates Hypoxia-Induced Chemoresistance in Human Osteosarcoma Cells. PLoS ONE 9:10, pages e111431.
Crossref
HAO DING, SONG CHEN, JUN-HUI YIN, XUE-TAO XIE, ZHEN-HONG ZHU, YOU-SHUI GAO & CHANG-QING ZHANG. (2014) Continuous hypoxia regulates the osteogenic potential of mesenchymal stem cells in a time-dependent manner. Molecular Medicine Reports 10:4, pages 2184-2190.
Crossref
Asis Palazon, Ananda W. Goldrath, Victor Nizet & Randall S. Johnson. (2014) HIF Transcription Factors, Inflammation, and Immunity. Immunity 41:4, pages 518-528.
Crossref
Jin Lan, Yajun Xue, Huairui Chen, Sanhu Zhao, Zhijian Wu, Jun Fang, Cong Han & Meiqing Lou. (2014) Hypoxia-induced miR-497 decreases glioma cell sensitivity to TMZ by inhibiting apoptosis. FEBS Letters 588:18, pages 3333-3339.
Crossref
Toru Mitsumori, Yumi Nozaki, Ichiro Kawashima, Takeo Yamamoto, Yuki Shobu, Kei Nakajima, Soji Morishita, Norio Komatsu & Keita Kirito. (2014) Hypoxia inhibits JAK2V617F activation via suppression of SHP-2 function in myeloproliferative neoplasm cells. Experimental Hematology 42:9, pages 783-792.e1.
Crossref
Brian Ortmann, Jimena Druker & Sonia Rocha. (2014) Cell cycle progression in response to oxygen levels. Cellular and Molecular Life Sciences 71:18, pages 3569-3582.
Crossref
Maimon E. HubbiDaniele M. Gilkes, Hongxia Hu Kshitiz, Ishrat Ahmed & Gregg L. Semenza. (2014) Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression. Proceedings of the National Academy of Sciences 111:32.
Crossref
Linda Pilgaard, Joachim Høg Mortensen, Michael Henriksen, Pia Olesen, Preben Sørensen, Rene Laursen, Mogens Vyberg, Ralf Agger, Vladimir Zachar, Torben Moos & Meg Duroux. (2014) Cripto-1 Expression in Glioblastoma Multiforme. Brain Pathology 24:4, pages 360-370.
Crossref
Petr Y. BaranovBudd A. TuckerMichael J. Young. (2014) Low-Oxygen Culture Conditions Extend the Multipotent Properties of Human Retinal Progenitor Cells. Tissue Engineering Part A 20:9-10, pages 1465-1475.
Crossref
A Casazza, G Di Conza, M Wenes, V Finisguerra, S Deschoemaeker & M Mazzone. (2013) Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment. Oncogene 33:14, pages 1743-1754.
Crossref
Bingqing Huang, Juying Qian, Jianying Ma, Zheyong Huang, Yunli Shen, Xueying Chen, Aijun Sun, Junbo Ge & Haozhu Chen. (2014) Myocardial transfection of hypoxia-inducible factor-1α and co-transplantation of mesenchymal stem cells enhance cardiac repair in rats with experimental myocardial infarction. Stem Cell Research & Therapy 5:1.
Crossref
Kartik Gupta, Esha Madan, Muzzammil Sayyid, Hugo Arias-Pulido, Eduardo Moreno, Periannan Kuppusamy & Rajan Gogna. (2013) Oxygen regulates molecular mechanisms of cancer progression and metastasis. Cancer and Metastasis Reviews 33:1, pages 183-215.
Crossref
S Raz, D Sheban, N Gonen, M Stark, B Berman & Y G Assaraf. (2014) Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest. Cell Death & Disease 5:2, pages e1067-e1067.
Crossref
B. Bedessem & A. Stéphanou. (2014) A mathematical model of HiF-1-mediated response to hypoxia on the G1/S transition. Mathematical Biosciences 248, pages 31-39.
Crossref
Zhiqiang Chang, Lifeng Huo, Yimin Wu & Pei Zhang. (2014) HIF-1 α had Pivotal Effects on Downregulation of miR-210 Decreasing Viability and Inducing Apoptosis in Hypoxic Chondrocytes . The Scientific World Journal 2014, pages 1-9.
Crossref
Aurélien Lathuilière, Steffen Cosson, Matthias P. Lutolf, Bernard L. Schneider & Patrick Aebischer. (2014) A high-capacity cell macroencapsulation system supporting the long-term survival of genetically engineered allogeneic cells. Biomaterials 35:2, pages 779-791.
Crossref
Haejin Yoon, Seung-Hyun Shin, Dong Hoon Shin, Yang-Sook Chun & Jong-Wan Park. (2014) Differential roles of Sirt1 in HIF-1α and HIF-2α mediated hypoxic responses. Biochemical and Biophysical Research Communications 444:1, pages 36-43.
Crossref
Pauline Gravelle, Christine Jean, Julien Familiades, Emilie Decaup, Amandine Blanc, Christine Bezombes-Cagnac, Camille Laurent, Ariel Savina, Jean-Jacques Fournié & Guy Laurent. (2014) Cell Growth in Aggregates Determines Gene Expression, Proliferation, Survival, Chemoresistance, and Sensitivity to Immune Effectors in Follicular Lymphoma. The American Journal of Pathology 184:1, pages 282-295.
Crossref
Gibin Powathil & Mark A. J. Chaplain. 2014. Mathematical Oncology 2013. Mathematical Oncology 2013 237 263 .
You Mie Lee, Sun-Hee Lee, Kheun Byeol Lee, Minh Phuong Nguyen, Min-Young Lee, Gyu Hwan Park & Mi Jeong Kwon. (2013) Silencing of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs Stimulates Hyperplastic Phenotypes through Activation of Epidermal Growth Factor Receptor and Hypoxia-Inducible Factor-2α. PLoS ONE 8:12, pages e84520.
Crossref
Carme Camps, Adrian L. Harris & Jiannis Ragoussis. 2013. MicroRNAs in Medicine. MicroRNAs in Medicine 267 285 .
J Zhou & Y Liu. (2013) Effects of genistein and estrogen on the genioglossus in rats exposed to chronic intermittent hypoxia may be HIF-1α dependent. Oral Diseases 19:7, pages 702-711.
Crossref
Marius Ilie, Véronique Hofman, Joséphine Zangari, Johanna Chiche, Jérôme Mouroux, Nathalie M. Mazure, Jacques Pouysségur, Patrick Brest & Paul Hofman. (2013) Response of CAIX and CAXII to in vitro re-oxygenation and clinical significance of the combined expression in NSCLC patients. Lung Cancer 82:1, pages 16-23.
Crossref
You-Shui Gao, Hao Ding, Xue-Tao Xie & Chang-Qing Zhang. (2013) Osteogenic induction protects rat bone marrow–derived mesenchymal stem cells against hypoxia-induced apoptosis in vitro. Journal of Surgical Research 184:2, pages 873-879.
Crossref
Jiangting Hu, Ern Yu Tan, Leticia Campo, Russell Leek, Zainina Seman, Helen Turley, Domenico Delia, Alfredo Cesario, Kevin Gatter & Francesco Pezzella. (2013) TRAP1 is Involved in Cell Cycle Regulated by Retinoblastoma Susceptibility Gene (RB1) in Early Hypoxia and has Variable Expression Patterns in Human Tumors. Journal of Cancer Research Updates 2:3, pages 194-210.
Crossref

Displaying 200 of 391 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.