3
Views
50
CrossRef citations to date
0
Altmetric
Cell Growth and Development

p27Kip1 Inhibition of GRB2-SOS Formation Can Regulate Ras Activation

, &
Pages 3735-3752 | Received 04 Dec 2002, Accepted 12 Mar 2003, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Savitha S. Sharma & W. Jackson Pledger. (2016) The non-canonical functions of p27Kip1 in normal and tumor biology. Cell Cycle 15:9, pages 1189-1201.
Read now
Gustavo Baldassarre & Barbara Belletti. (2016) Meet me in the cytoplasm: A role for p27Kip1 in the control of H-Ras. Small GTPases 7:2, pages 71-75.
Read now
André Bernards & Jeffrey Settleman. (2007) GEFs in growth factor signaling. Growth Factors 25:5, pages 355-361.
Read now
Shiri Kfir, Marcelo Ehrlich, Ayelet Goldshmid, Xuedong Liu, Yoel Kloog & Yoav I. Henis. (2005) Pathway- and Expression Level-Dependent Effects of Oncogenic N-Ras: p27Kip1 Mislocalization by the Ral-GEF Pathway and Erk-Mediated Interference with Smad Signaling. Molecular and Cellular Biology 25:18, pages 8239-8250.
Read now

Articles from other publishers (45)

Brian B Luczak, Benjamin T James & Hani Z Girgis. (2019) A survey and evaluations of histogram-based statistics in alignment-free sequence comparison. Briefings in Bioinformatics 20:4, pages 1222-1237.
Crossref
Rami Alrezk, Fady Hannah-Shmouni & Constantine A Stratakis. (2017) MEN4 and CDKN1B mutations: the latest of the MEN syndromes. Endocrine-Related Cancer 24:10, pages T195-T208.
Crossref
Mariateresa FulcinitiJoaquin Martinez-LopezWilliam SenapedisStefania OlivaRajya Lakshmi BandiNicola AmodioYan XuRaphael SzalatAnnamaria GullaMehmet K. SamurAldo RoccaroMaria LinaresMichele CeaErkan BalogluChristian ArguetaYosef LandesmanSharon ShachamSiyuan LiuMonica Schenone, Shiaw-Lin WuBarry KargerRao Prabhala, Kenneth C. AndersonNikhil C. Munshi. (2017) Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma. Blood 129:16, pages 2233-2245.
Crossref
Rosa-Maria Ferraiuolo, Janice Tubman, Indrajit Sinha, Caroline Hamm & Lisa Ann Porter. (2017) The cyclin-like protein, SPY1, regulates the ERα and ERK1/2 pathways promoting tamoxifen resistance. Oncotarget 8:14, pages 23337-23352.
Crossref
Ilenia Pellizzari, Linda Fabris, Stefania Berton, Ilenia Segatto, Francesca Citron, Sara D’Andrea, Martina Cusan, Sara Benevol, Tiziana Perin, Samuele Massarut, Vincenzo Canzonieri, Monica Schiappacassi, Barbara Belletti & Gustavo Baldassarre. (2016) p27kip1 expression limits H-Ras-driven transformation and tumorigenesis by both canonical and non-canonical mechanisms. Oncotarget 7:40, pages 64560-64574.
Crossref
Umamaheswari A, Sandeep S, Hema K, Pradeep N, Suchitra MM & Rajeswari J. (2016) Molecular docking and dynamic studies of human growth factor receptorbound protein (Grb) 2 insights to identify novel inhibitors. Journal of Clinical and Scientific Research 5:4, pages 252-258.
Crossref
F. Bocaneti, G. Altamura, A. Corteggio, M. Martano, F. Roperto, E. Velescu & G. Borzacchiello. (2013) Expression of platelet derived growth factor β receptor, its activation and downstream signals in bovine cutaneous fibropapillomas. Research in Veterinary Science 94:3, pages 596-601.
Crossref
Bin ZhangMin LiTinisha McDonaldTessa L. HolyoakeRandall T. MoonDario Campana, Leonard Shultz & Ravi Bhatia. (2013) Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt–β-catenin signaling. Blood 121:10, pages 1824-1838.
Crossref
Caleb B. McDonald, Jimmy El Hokayem, Nawal Zafar, Jordan E. Balke, Vikas Bhat, David C. Mikles, Brian J. Deegan, Kenneth L. Seldeen & Amjad Farooq. (2013) Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner. Journal of Molecular Recognition 26:2, pages 92-103.
Crossref
Gennaro Altamura, Annunziata Corteggio, Lubna Nasir, Zheng Qiang Yuan, Franco Roperto & Giuseppe Borzacchiello. (2013) Analysis of Activated Platelet-Derived Growth Factor β Receptor and Ras-MAP Kinase Pathway in Equine Sarcoid Fibroblasts . BioMed Research International 2013, pages 1-12.
Crossref
Bo DiaoYing LiuYi ZhangQin LiuWen-Jie LuGuoZheng Xu. (2012) Functional Network Analysis with the Subcellular Location and Gene Ontology Information in Human Allergic Asthma. Genetic Testing and Molecular Biomarkers 16:11, pages 1287-1292.
Crossref
Ellen Hukkelhoven, Yuhui Liu, Nancy Yeh, Daniel Ciznadija, Stacy W. Blain & Andrew Koff. (2012) Tyrosine Phosphorylation of the p21 Cyclin-dependent Kinase Inhibitor Facilitates the Development of Proneural Glioma. Journal of Biological Chemistry 287:46, pages 38523-38530.
Crossref
Caleb B. McDonald, Vikas Bhat, David C. Mikles, Brian J. Deegan, Kenneth L. Seldeen & Amjad Farooq. (2012) Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner. FEBS Journal 279:12, pages 2156-2173.
Crossref
Venkatesh Arulalapperumal, Sugunadevi Sakkiah, Sundarapandian Thangapandian, Yun-O Lee, Chandrasekaran Meganathan, Swan Hwang & Keun-Woo Lee. (2012) Ligand Based Pharmacophore Identification and Molecular Docking Studies for Grb2 Inhibitors. Bulletin of the Korean Chemical Society 33:5, pages 1707-1714.
Crossref
Pei-Shan Wang, Jing Wang, Yi Zheng & Catherine J. Pallen. (2012) Loss of Protein-tyrosine Phosphatase α (PTPα) Increases Proliferation and Delays Maturation of Oligodendrocyte Progenitor Cells. Journal of Biological Chemistry 287:15, pages 12529-12540.
Crossref
Caleb B. McDonald, Jordan E. Balke, Vikas Bhat, David C. Mikles, Brian J. Deegan, Kenneth L. Seldeen & Amjad Farooq. (2012) Multivalent Binding and Facilitated Diffusion Account for the Formation of the Grb2–Sos1 Signaling Complex in a Cooperative Manner. Biochemistry 51:10, pages 2122-2135.
Crossref
Annunziata Corteggio, Ornella Di Geronimo, Sante Roperto, Franco Roperto & Giuseppe Borzacchiello. (2012) Activated platelet-derived growth factor β receptor and Ras–mitogen-activated protein kinase pathway in natural bovine urinary bladder carcinomas. The Veterinary Journal 191:3, pages 393-395.
Crossref
José J. FusterHerminia González-NavarroAngela VinuéPedro Molina-SànchezMaria J. Andrés-ManzanoKeiichi I. NakayamaKeiko NakayamaAntonio Díez-JuanAntonio BernadCristina RodríguezJosé Martínez-GonzálezVicente Andrés. (2011) Deficient p27 Phosphorylation at Serine 10 Increases Macrophage Foam Cell Formation and Aggravates Atherosclerosis Through a Proliferation-Independent Mechanism. Arteriosclerosis, Thrombosis, and Vascular Biology 31:11, pages 2455-2463.
Crossref
Stéphane Pierre, Anne-Sophie bats & Xavier Coumoul. (2011) Understanding SOS (Son of Sevenless). Biochemical Pharmacology 82:9, pages 1049-1056.
Crossref
Caleb B. McDonald, Kenneth L. Seldeen, Brian J. Deegan, Vikas Bhat & Amjad Farooq. (2011) Binding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms. Journal of Molecular Recognition 24:4, pages 585-596.
Crossref
José J. Fuster, José M. González, María D. Edo, Rosa Viana, Patricia Boya, Javier Cervera, Marcel Verges, José Rivera & Vicente Andrés. (2010) Tumor suppressor p27 Kip1 undergoes endolysosomal degradation through its interaction with sorting nexin 6 . The FASEB Journal 24:8, pages 2998-3009.
Crossref
Jinyi Liu, Dongyun Zhang, Xiaoyi Mi, Qing Xia, Yonghui Yu, Zhenghong Zuo, Wei Guo, Xuewei Zhao, Jia Cao, Qing Yang, Angela Zhu, Wancai Yang, Xianglin Shi, Jingxia Li & Chuanshu Huang. (2010) p27 Suppresses Arsenite-induced Hsp27/Hsp70 Expression through Inhibiting JNK2/c-Jun- and HSF-1-dependent Pathways. Journal of Biological Chemistry 285:34, pages 26058-26065.
Crossref
J. J. Fuster, P. Fernandez, H. Gonzalez-Navarro, C. Silvestre, Y. N. A. Nabah & V. Andres. (2009) Control of cell proliferation in atherosclerosis: insights from animal models and human studies. Cardiovascular Research 86:2, pages 254-264.
Crossref
S Chu, T McDonald & R Bhatia. (2010) Role of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors. Leukemia 24:4, pages 779-787.
Crossref
Adolfo Pedroza-Saavedra, Eric W-F Lam, Fernando Esquivel-Guadarrama & Lourdes Gutierrez-Xicotencatl. (2010) The human papillomavirus type 16 E5 oncoprotein synergizes with EGF-receptor signaling to enhance cell cycle progression and the down-regulation of p27Kip1. Virology 400:1, pages 44-52.
Crossref
Caleb B. McDonald, Kenneth L. Seldeen, Brian J. Deegan, Vikas Bhat & Amjad Farooq. (2010) Assembly of the Sos1–Grb2–Gab1 ternary signaling complex is under allosteric control. Archives of Biochemistry and Biophysics 494:2, pages 216-225.
Crossref
Sara Molatore & Natalia S. Pellegata. 2010. Neuroendocrinology - Pathological Situations and Diseases. Neuroendocrinology - Pathological Situations and Diseases 295 320 .
Caleb B. McDonald, Kenneth L. Seldeen, Brian J. Deegan & Amjad Farooq. (2009) SH3 Domains of Grb2 Adaptor Bind to PXψPXR Motifs Within the Sos1 Nucleotide Exchange Factor in a Discriminate Manner. Biochemistry 48:19, pages 4074-4085.
Crossref
Sunita K. Agarwal, Carmen M. Mateo & Stephen J. Marx. (2009) Rare Germline Mutations in Cyclin-Dependent Kinase Inhibitor Genes in Multiple Endocrine Neoplasia Type 1 and Related States. The Journal of Clinical Endocrinology & Metabolism 94:5, pages 1826-1834.
Crossref
Caleb B. McDonald, Kenneth L. Seldeen, Brian J. Deegan & Amjad Farooq. (2008) Structural basis of the differential binding of the SH3 domains of Grb2 adaptor to the guanine nucleotide exchange factor Sos1. Archives of Biochemistry and Biophysics 479:1, pages 52-62.
Crossref
Abde M. Abukhdeir & Ben Ho Park. (2008) p21 and p27: roles in carcinogenesis and drug resistance. Expert Reviews in Molecular Medicine 10.
Crossref
Caleb B. McDonald, Kenneth L. Seldeen, Brian J. Deegan, Marc S. Lewis & Amjad Farooq. (2008) Grb2 adaptor undergoes conformational change upon dimerization. Archives of Biochemistry and Biophysics 475:1, pages 25-35.
Crossref
Yuhui Liu, Nancy Yeh, Xin-Hua Zhu, Margaret Leversha, Carlos Cordon-Cardo, Ronald Ghossein, Bhuvanesh Singh, Eric Holland & Andrew Koff. (2007) Somatic cell type specific gene transfer reveals a tumor-promoting function for p21Waf1/Cip1. The EMBO Journal 26:22, pages 4683-4693.
Crossref
Lucas P. Nacusi & Robert J. Sheaff. (2007) Deregulation of Cell Cycle Machinery in Pancreatic Cancer. Pancreatology 7:4, pages 373-377.
Crossref
Matthias Grimmler, Yuefeng Wang, Thomas Mund, Zoran Cilenšek, Eva-Maria Keidel, M. Brett Waddell, Heidelinde Jäkel, Michael Kullmann, Richard W. Kriwacki & Ludger Hengst. (2007) Cdk-Inhibitory Activity and Stability of p27 Are Directly Regulated by Oncogenic Tyrosine Kinases. Cell 128:2, pages 269-280.
Crossref
Elita Avota, Harry Harms & Sibylle Schneider-Schaulies. (2006) Measles virus induces expression of SIP110, a constitutively membrane clustered lipid phosphatase, which inhibits T cell proliferation. Cellular Microbiology 8:11, pages 1826-1839.
Crossref
Ruiying Zhao & Mong-Hong Lee. 2006. Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents. Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents 29 53 .
Xiaohua Huang, Erika Wagner, Renate Dumdey, Andreas Peth, Matthias Berse, Wolfgang Dubiel & Christoph Berndt. (2006) Phosphorylation by COP9 Signalosome-Associated CK2 Promotes Degradation of p27 during the G1 Cell Cycle Phase. Israel Journal of Chemistry 46:2, pages 231-238.
Crossref
Christian KardinalMarc DangersAngelika KardinalAlexandra KochDominique Tobias BrandtTeruko TamuraKarl Welte. (2006) Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4. Blood 107:3, pages 1133-1140.
Crossref
Andrew Koff. (2006) How to decrease p27Kip1 levels during tumor development. Cancer Cell 9:2, pages 75-76.
Crossref
Stephanie J. Moeller & Robert J. Sheaff. 2006. Cell Cycle Regulation. Cell Cycle Regulation 1 29 .
David R. Shaffer, Agnes Viale, Ryota Ishiwata, Margaret Leversha, Semra Olgac, Katia Manova, Jaya Satagopan, Howard Scher & Andrew Koff. (2004) Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate. Proceedings of the National Academy of Sciences 102:1, pages 210-215.
Crossref
Arnaud Besson, Mark Gurian-West, Anja Schmidt, Alan Hall & James M. Roberts. (2004) p27 Kip1 modulates cell migration through the regulation of RhoA activation . Genes & Development 18:8, pages 862-876.
Crossref
James S. Foster, Romaine I. Fernando, Noriko Ishida, Keiichi I. Nakayama & Jay Wimalasena. (2003) Estrogens Down-regulate p27 in Breast Cancer Cells through Skp2 and through Nuclear Export Mediated by the ERK Pathway. Journal of Biological Chemistry 278:42, pages 41355-41366.
Crossref
Angel Alkarain & Joyce Slingerland. (2003) Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer. Breast Cancer Research 6:1.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.