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Molecular and Cellular Biology Volume 23, 2003 - Issue 15
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Cell Growth and Development

Rb and N-ras Function Together To Control Differentiation in the Mouse

Chiaki Takahashi1 Department of Medical Oncology and Medicine, Dana-Farber Cancer Institute and Harvard Medical School
,
Roderick T. Bronson2 Department of Pathology, Tufts University Schools of Medicine and Veterinary Medicine, Boston, Massachusetts02111;3 Rodent Histopathology Core
,
Merav Socolovsky4 Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts02142
,
Bernardo Contreras1 Department of Medical Oncology and Medicine, Dana-Farber Cancer Institute and Harvard Medical School
,
Kwang Youl Lee1 Department of Medical Oncology and Medicine, Dana-Farber Cancer Institute and Harvard Medical School
,
Tyler Jacks5 Department of Biology and Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts02139
,
Makoto Noda6 Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto606-8501, Japan
,
Raju Kucherlapati7 Harvard-Partners Center for Genetics and Genomics, Harvard Medical School, Boston, Massachusetts02115
&
Mark E. Ewen1 Department of Medical Oncology and Medicine, Dana-Farber Cancer Institute and Harvard Medical SchoolCorrespondence[email protected]
 show all
Pages 5256-5268 | Received 08 Nov 2002, Accepted 30 Apr 2003, Published online: 27 Mar 2023

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Chongwen Xu, Xin Sun, Sida Qin, Huangzhen Wang, Zhiwei Zheng, Shaohua Xu, Gang Luo, Peng Liu, Jian Liu, Ning Du, Yunfeng Zhang, Dapeng Liu & Hong Ren. (2015) Let-7a regulates mammosphere formation capacity through Ras/NF-κB and Ras/MAPK/ERK pathway in breast cancer stem cells. Cell Cycle 14:11, pages 1686-1697.
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Manabu Taura, Mary Ann Suico, Kosuke Koyama, Kensei Komatsu, Rui Miyakita, Chizuru Matsumoto, Eriko Kudo, Ryusho Kariya, Hiroki Goto, Shunsuke Kitajima, Chiaki Takahashi, Tsuyoshi Shuto, Mitsuyoshi Nakao, Seiji Okada & Hirofumi Kai. (2012) Rb/E2F1 Regulates the Innate Immune Receptor Toll-Like Receptor 3 in Epithelial Cells. Molecular and Cellular Biology 32:8, pages 1581-1590.
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Francesca De Santa, Sonia Albini, Eleonora Mezzaroma, Livio Baron, Armando Felsani & Maurizia Caruso. (2007) pRb-Dependent Cyclin D3 Protein Stabilization Is Required for Myogenic Differentiation. Molecular and Cellular Biology 27:20, pages 7248-7265.
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Poppy P. Fotiadou, Chiaki Takahashi, Hasan N. Rajabi & Mark E. Ewen. (2007) Wild-Type NRas and KRas Perform Distinct Functions during Transformation. Molecular and Cellular Biology 27:19, pages 6742-6755.
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Nam-Sung Moon, Luisa Di Stefano & Nicholas Dyson. (2006) A Gradient of Epidermal Growth Factor Receptor Signaling Determines the Sensitivity of rbf1 Mutant Cells to E2F-Dependent Apoptosis. Molecular and Cellular Biology 26:20, pages 7601-7615.
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Huifang Sun, Yanjie Chang, Brett Schweers, Michael A. Dyer, Xiaojing Zhang, Simon W. Hayward & David W. Goodrich. (2006) An E2F Binding-Deficient Rb1 Protein Partially Rescues Developmental Defects Associated with Rb1 Nullizygosity. Molecular and Cellular Biology 26:4, pages 1527-1537.
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Chiaki Takahashi, Bernardo Contreras, Roderick T. Bronson, Massimo Loda & Mark E. Ewen. (2004) Genetic Interaction between Rb and K-ras in the Control of Differentiation and Tumor Suppression. Molecular and Cellular Biology 24:23, pages 10406-10415.
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V M Ho, B E Schaffer, A N Karnezis, K S Park & J Sage. (2009) The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras. Oncogene 28:10, pages 1393-1399.
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S X Skapek, Y-R Pan & E Y-H P Lee. (2006) Regulation of cell lineage specification by the retinoblastoma tumor suppressor. Oncogene 25:38, pages 5268-5276.
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D W Goodrich. (2006) The retinoblastoma tumor-suppressor gene, the exception that proves the rule. Oncogene 25:38, pages 5233-5243.
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Qin Yan, Jin-Ping Liu & David Wan-Cheng Li. (2006) Apoptosis in lens development and pathology. Differentiation 74:5, pages 195-211.
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Chiaki Takahashi, Bernardo Contreras, Tsuyoshi Iwanaga, Yujiro Takegami, Anke Bakker, Roderick T Bronson, Makoto Noda, Massimo Loda, Jennifer L Hunt & Mark E Ewen. (2005) Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor. Nature Genetics 38:1, pages 118-123.
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Lucia Latella & Pier Lorenzo Puri. 2006. Rb and Tumorigenesis. Rb and Tumorigenesis 106 117 .
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Liang Zhu. (2005) Tumour suppressor retinoblastoma protein Rb: A transcriptional regulator. European Journal of Cancer 41:16, pages 2415-2427.
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Mark E. Ewen. (2005) Functions of the retinoblastoma protein that contribute to tumor suppression. Drug Discovery Today: Disease Mechanisms 2:2, pages 185-190.
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Johanna Mantela, Zhe Jiang, Jukka Ylikoski, Bernd Fritzsch, Eldad Zacksenhaus & Ulla Pirvola. (2005) The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear. Development 132:10, pages 2377-2388.
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Maria A Ciemerych & Peter Sicinski. (2005) Cell cycle in mouse development. Oncogene 24:17, pages 2877-2898.
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Sladjana Gagrica, Stefanie Hauser, Ingrid Kolfschoten, Lisa Osterloh, Reuven Agami & Stefan Gaubatz. (2004) Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein. The EMBO Journal 23:23, pages 4627-4638.
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Michael S. Huh, Maura H. Parker, Anthony Scimè, Robin Parks & Michael A. Rudnicki. (2004) Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation. Journal of Cell Biology 166:6, pages 865-876.
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