68
Views
70
CrossRef citations to date
0
Altmetric
Gene Expression

The Yeast Eukaryotic Initiation Factor 4G (eIF4G) HEAT Domain Interacts with eIF1 and eIF5 and Is Involved in Stringent AUG Selection

, , , , , , & show all
Pages 5431-5445 | Received 18 Mar 2003, Accepted 12 May 2003, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Ora Haimov, Urmila Sehrawat, Ana Tamarkin-Ben Harush, Anat Bahat, Anna Uzonyi, Alexander Will, Hiroyuki Hiraishi, Katsura Asano & Rivka Dikstein. (2018) Dynamic Interaction of Eukaryotic Initiation Factor 4G1 (eIF4G1) with eIF4E and eIF1 Underlies Scanning-Dependent and -Independent Translation. Molecular and Cellular Biology 38:18.
Read now
Chingakham Ranjit Singh, Ryosuke Watanabe, Wasimul Chowdhury, Hiroyuki Hiraishi, Marcelo J. Murai, Yasufumi Yamamoto, David Miles, Yuka Ikeda, Masayo Asano & Katsura Asano. (2012) Sequential Eukaryotic Translation Initiation Factor 5 (eIF5) Binding to the Charged Disordered Segments of eIF4G and eIF2β Stabilizes the 48S Preinitiation Complex and Promotes Its Shift to the Initiation Mode. Molecular and Cellular Biology 32:19, pages 3978-3989.
Read now
Pankaj V. Alone, Chune Cao & Thomas E. Dever. (2008) Translation Initiation Factor 2γ Mutant Alters Start Codon Selection Independent of Met-tRNA Binding . Molecular and Cellular Biology 28:22, pages 6877-6888.
Read now
Klaus H. Nielsen, Leos Valášek, Caroah Sykes, Antonina Jivotovskaya & Alan G. Hinnebusch. (2006) Interaction of the RNP1 Motif in PRT1 with HCR1 Promotes 40S Binding of Eukaryotic Initiation Factor 3 in Yeast. Molecular and Cellular Biology 26:8, pages 2984-2998.
Read now
Antonina V. Jivotovskaya, Leoš Valášek, Alan G. Hinnebusch & Klaus H. Nielsen. (2006) Eukaryotic Translation Initiation Factor 3 (eIF3) and eIF2 Can Promote mRNA Binding to 40S Subunits Independently of eIF4G in Yeast. Molecular and Cellular Biology 26:4, pages 1355-1372.
Read now
Chingakham Ranjit Singh, Cynthia Curtis, Yasufumi Yamamoto, Nathan S. Hall, Dustin S. Kruse, Hui He, Ernest M. Hannig & Katsura Asano. (2005) Eukaryotic Translation Initiation Factor 5 Is Critical for Integrity of the Scanning Preinitiation Complex and Accurate Control of GCN4 Translation. Molecular and Cellular Biology 25:13, pages 5480-5491.
Read now
Leoš Valášek, Klaus H. Nielsen, Fan Zhang, Christie A. Fekete & Alan G. Hinnebusch. (2004) Interactions of Eukaryotic Translation Initiation Factor 3 (eIF3) Subunit NIP1/c with eIF1 and eIF5 Promote Preinitiation Complex Assembly and Regulate Start Codon Selection. Molecular and Cellular Biology 24:21, pages 9437-9455.
Read now
Sandrine Caron, Martine Charon, Elisabeth Cramer, Nahum Sonenberg & Isabelle Dusanter-Fourt. (2004) Selective Modification of Eukaryotic Initiation Factor 4F (eIF4F) at the Onset of Cell Differentiation: Recruitment of eIF4GII and Long-Lasting Phosphorylation of eIF4E. Molecular and Cellular Biology 24:11, pages 4920-4928.
Read now

Articles from other publishers (60)

Richard She, Jingchuan Luo & Jonathan S Weissman. (2023) Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity. Nucleic Acids Research.
Crossref
Rui Xu, Xiangyun Li, Xiaobao Huang, Zhenjia Lin, Ying Xiong, Xiaohong Chen, Coco Chu, Jiande Han & Fang Wang. (2023) Translation-dependent skin hyperplasia is promoted by type 1/17 inflammation in psoriasis. Journal of Dermatological Science 110:1, pages 10-18.
Crossref
Ekaterina D. Shestakova, Victoria V. Smirnova, Ivan N. Shatsky & Ilya M. Terenin. (2023) Specific mechanisms of translation initiation in higher eukaryotes: the eIF4G2 story. RNA 29:3, pages 282-299.
Crossref
Burak Çetin & Seán E O’Leary. (2022) mRNA- and factor-driven dynamic variability controls eIF4F-cap recognition for translation initiation. Nucleic Acids Research 50:14, pages 8240-8261.
Crossref
Urmila Sehrawat, Ora Haimov, Benjamin Weiss, Ana Tamarkin-Ben Harush, Shaked Ashkenazi, Alexander Plotnikov, Tzahi Noiman, Dena Leshkowitz, Gil Stelzer & Rivka Dikstein. (2022) Inhibitors of eIF4G1–eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation. Proceedings of the National Academy of Sciences 119:30.
Crossref
Aishwarya Rana, Nidhi Gupta & Anil Thakur. (2021) Post-transcriptional and translational control of the morphology and virulence in human fungal pathogens. Molecular Aspects of Medicine 81, pages 101017.
Crossref
Mahabub Pasha Mohammad, Anna Smirnova, Stanislava Gunišová & Leoš Shivaya Valášek. (2021) eIF4G is retained on ribosomes elongating and terminating on short upstream ORFs to control reinitiation in yeast. Nucleic Acids Research 49:15, pages 8743-8756.
Crossref
Jonathan Bohlen, Liza Harbrecht, Saioa Blanco, Katharina Clemm von Hohenberg, Kai Fenzl, Günter Kramer, Bernd Bukau & Aurelio A. Teleman. (2020) DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4. Nature Communications 11:1.
Crossref
Jonathan Bohlen, Kai Fenzl, Günter Kramer, Bernd Bukau & Aurelio A. Teleman. (2020) Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells. Molecular Cell 79:4, pages 561-574.e5.
Crossref
Adxebanjo Najeem Adedoja, Timothy McMahan, John Patrick Neal, Siddhartha Hamal Dhakal, Seetharama Jois, Daniel Romo, Ken Hull & Srinivas Garlapati. (2020) Translation initiation factors GleIF4E2 and GleIF4A can interact directly with the components of the pre-initiation complex to facilitate translation initiation in Giardia lamblia. Molecular and Biochemical Parasitology 236, pages 111258.
Crossref
Rishi Kumar Mishra, Ayushi Datey & Tanweer Hussain. (2019) mRNA Recruiting eIF4 Factors Involved in Protein Synthesis and Its Regulation. Biochemistry 59:1, pages 34-46.
Crossref
Shardul D. Kulkarni, Fujun Zhou, Neelam Dabas Sen, Hongen Zhang, Alan G. Hinnebusch & Jon R. Lorsch. (2019) Temperature-dependent regulation of upstream open reading frame translation in S. cerevisiae. BMC Biology 17:1.
Crossref
Nikolay E. Shirokikh & Thomas Preiss. (2018) Translation initiation by cap‐dependent ribosome recruitment: Recent insights and open questions. WIREs RNA 9:4.
Crossref
Neelam Dabas SenFujun ZhouMichael S. Harris, Nicholas T. Ingolia & Alan G. Hinnebusch. (2016) eIF4B stimulates translation of long mRNAs with structured 5′ UTRs and low closed-loop potential but weak dependence on eIF4G. Proceedings of the National Academy of Sciences 113:38, pages 10464-10472.
Crossref
Parimal Kumar, Christopher U.T. Hellen & Tatyana V. Pestova. (2016) Toward the mechanism of eIF4F-mediated ribosomal attachment to mammalian capped mRNAs. Genes & Development 30:13, pages 1573-1588.
Crossref
Thomas E Dever, Terri Goss Kinzy & Graham D Pavitt. (2016) Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae . Genetics 203:1, pages 65-107.
Crossref
Daniel R. Gallie. (2016) Eukaryotic Initiation Factor eIFiso4G1 and eIFiso4G2 Are Isoforms Exhibiting Distinct Functional Differences in Supporting Translation in Arabidopsis. Journal of Biological Chemistry 291:3, pages 1501-1513.
Crossref
Jin Chen, Junhong Choi, Seán E. O'Leary, Arjun Prabhakar, Alexey Petrov, Rosslyn Grosely, Elisabetta Viani Puglisi & Joseph D. Puglisi. (2016) The molecular choreography of protein synthesis: translational control, regulation, and pathways. Quarterly Reviews of Biophysics 49.
Crossref
Daniela Ross & Michael Altmann. 2016. Evolution of the Protein Synthesis Machinery and Its Regulation. Evolution of the Protein Synthesis Machinery and Its Regulation 143 164 .
Joseph Costello, Lydia M Castelli, William Rowe, Christopher J Kershaw, David Talavera, Sarah S Mohammad-Qureshi, Paul F G Sims, Christopher M Grant, Graham D Pavitt, Simon J Hubbard & Mark P Ashe. (2015) Global mRNA selection mechanisms for translation initiation. Genome Biology 16:1.
Crossref
Ora Haimov, Hadar Sinvani & Rivka Dikstein. (2015) Cap-dependent, scanning-free translation initiation mechanisms. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1849:11, pages 1313-1318.
Crossref
Hadar Sinvani, Ora Haimov, Yuri Svitkin, Nahum Sonenberg, Ana Tamarkin-Ben-Harush, Benoit Viollet & Rivka Dikstein. (2015) Translational Tolerance of Mitochondrial Genes to Metabolic Energy Stress Involves TISU and eIF1-eIF4GI Cooperation in Start Codon Selection. Cell Metabolism 21:3, pages 479-492.
Crossref
Daniel R. Gallie. (2014) Insights from a Paradigm Shift: How the Poly(A)-Binding Protein Brings Translating mRNAs Full Circle. New Journal of Science 2014, pages 1-16.
Crossref
Alan G. Hinnebusch. (2014) The Scanning Mechanism of Eukaryotic Translation Initiation. Annual Review of Biochemistry 83:1, pages 779-812.
Crossref
Daniel R Gallie. (2014) The Role of the Poly(A) binding protein in the assembly of the Cap-binding complex during translation initiation in plants. Translation 2:1, pages e29630.
Crossref
Tobias von der Haar & Leoš Shivaya Valášek. 2014. Fungal RNA Biology. Fungal RNA Biology 113 134 .
Rafael E. Luna, Haribabu Arthanari, Hiroyuki Hiraishi, Barak Akabayov, Leiming Tang, Christian Cox, Michelle A. Markus, Lunet E. Luna, Yuka Ikeda, Ryosuke Watanabe, Edward Bedoya, Cathy Yu, Shums Alikhan, Gerhard Wagner & Katsura Asano. (2013) The Interaction between Eukaryotic Initiation Factor 1A and eIF5 Retains eIF1 within Scanning Preinitiation Complexes. Biochemistry 52:52, pages 9510-9518.
Crossref
Ryan M. Patrick & Karen S. Browning. (2012) The eIF4F and eIFiso4F Complexes of Plants: An Evolutionary Perspective. Comparative and Functional Genomics 2012, pages 1-12.
Crossref
Eun-Hee Park, Fan Zhang, Jonas Warringer, Per Sunnerhagen & Alan G Hinnebusch. (2011) Depletion of eIF4G from yeast cells narrows the range of translational efficiencies genome-wide. BMC Genomics 12:1.
Crossref
Lydia M. Castelli, Jennifer Lui, Susan G. Campbell, William Rowe, Leo A. H. Zeef, Leah E. A. Holmes, Nathaniel P. Hoyle, Jonathon Bone, Julian N. Selley, Paul F. G. Sims & Mark P. Ashe. (2011) Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated. Molecular Biology of the Cell 22:18, pages 3379-3393.
Crossref
Julie E. Takacs, Timothy B. Neary, Nicholas T. Ingolia, Adesh K. Saini, Pilar Martin-Marcos, Jerry Pelletier, Alan G. Hinnebusch & Jon R. Lorsch. (2011) Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery. RNA 17:3, pages 439-452.
Crossref
Eun-Hee Park, Sarah E Walker, Joseph M Lee, Stefan Rothenburg, Jon R Lorsch & Alan G Hinnebusch. (2011) Multiple elements in the eIF4G1 N-terminus promote assembly of eIF4G1•PABP mRNPs in vivo . The EMBO Journal 30:2, pages 302-316.
Crossref
Sarah F. Mitchell, Sarah E. Walker, Vaishnavi Rajagopal, Colin Echeverría Aitken & Jon R. Lorsch. 2011. Ribosomes. Ribosomes 155 169 .
Naoki Nemoto, Chingakham Ranjit Singh, Tsuyoshi Udagawa, Suzhi Wang, Elizabeth Thorson, Zachery Winter, Takahiro Ohira, Miki Ii, Leoš Valášek, Susan J. Brown & Katsura Asano. (2010) Yeast 18 S rRNA Is Directly Involved in the Ribosomal Response to Stringent AUG Selection during Translation Initiation. Journal of Biological Chemistry 285:42, pages 32200-32212.
Crossref
Sarah F. Mitchell, Sarah E. Walker, Mikkel A. Algire, Eun-Hee Park, Alan G. Hinnebusch & Jon R. Lorsch. (2010) The 5′-7-Methylguanosine Cap on Eukaryotic mRNAs Serves Both to Stimulate Canonical Translation Initiation and to Block an Alternative Pathway. Molecular Cell 39:6, pages 950-962.
Crossref
Yoshikazu Nakamura, Kei Endo, Hironori Adachi & Akira Ishiguro. 2009. Translational Control in Health and Disease. Translational Control in Health and Disease 369 395 .
Sarah F. Mitchell & Jon R. Lorsch. (2008) Should I Stay or Should I Go? Eukaryotic Translation Initiation Factors 1 and 1A Control Start Codon Recognition. Journal of Biological Chemistry 283:41, pages 27345-27349.
Crossref
Jessica K. Altman, Patrick Yoon, Efstratios Katsoulidis, Barbara Kroczynska, Antonella Sassano, Amanda J. Redig, Heather Glaser, Alison Jordan, Martin S. Tallman, Nissim Hay & Leonidas C. Platanias. (2008) Regulatory Effects of Mammalian Target of Rapamycin-mediated Signals in the Generation of Arsenic Trioxide Responses. Journal of Biological Chemistry 283:4, pages 1992-2001.
Crossref
Katsura Asano & Matthew S. Sachs. (2007) Translation factor control of ribosome conformation during start codon selection. Genes & Development 21:11, pages 1280-1287.
Crossref
Padchanee Sangthong, John Hughes & John E. G. McCarthy. (2007) Distributed control for recruitment, scanning and subunit joining steps of translation initiation. Nucleic Acids Research 35:11, pages 3573-3580.
Crossref
Robert J. C. Gilbert, Yulya Gordiyenko, Tobias von der Haar, Andreas F.-P. SonnenGregor HofmannMaria Nardelli, David I. Stuart & John E. G. McCarthy. (2007) Reconfiguration of yeast 40S ribosomal subunit domains by the translation initiation multifactor complex. Proceedings of the National Academy of Sciences 104:14, pages 5788-5793.
Crossref
Bumjun Lee, Tsuyoshi Udagawa, Chingakham Ranjit Singh & Katsura Asano. 2007. Translation Initiation: Extract Systems and Molecular Genetics. Translation Initiation: Extract Systems and Molecular Genetics 105 137 .
Shin Miyakawa, Akihiro Oguro, Takashi Ohtsu, Hiroaki Imataka, Nahum Sonenberg & Yoshikazu Nakamura. (2006) RNA aptamers to mammalian initiation factor 4G inhibit cap-dependent translation by blocking the formation of initiation factor complexes. RNA 12:10, pages 1825-1834.
Crossref
Zizheng Dong & Jian-Ting Zhang. (2006) Initiation factor eIF3 and regulation of mRNA translation, cell growth, and cancer. Critical Reviews in Oncology/Hematology 59:3, pages 169-180.
Crossref
Aaron K. LeFebvre, Nadejda L. Korneeva, Marjan Trutschl, Urska Cvek, Roy D. Duzan, Christopher A. Bradley, John W.B. Hershey & Robert E. Rhoads. (2006) Translation Initiation Factor eIF4G-1 Binds to eIF3 through the eIF3e Subunit. Journal of Biological Chemistry 281:32, pages 22917-22932.
Crossref
Christoph Bieniossek, Patrick Schütz, Mario Bumann, Andreas Limacher, Isabel Uson & Ulrich Baumann. (2006) The Crystal Structure of the Carboxy-Terminal Domain of Human Translation Initiation Factor eIF5. Journal of Molecular Biology 360:2, pages 457-465.
Crossref
Zhiyi Wei, Yanyan Xue, Hang Xu & Weimin Gong. (2006) Crystal Structure of the C-terminal Domain of S.cerevisiae eIF5. Journal of Molecular Biology 359:1, pages 1-9.
Crossref
Bunpote SiridechadilokChristopher S. FraserRichard J. HallJennifer A. DoudnaEva Nogales. (2005) Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis. Science 310:5753, pages 1513-1515.
Crossref
Romit Majumdar & Umadas Maitra. (2005) Regulation of GTP hydrolysis prior to ribosomal AUG selection during eukaryotic translation initiation. The EMBO Journal 24:21, pages 3737-3746.
Crossref
Christie A Fekete, Drew J Applefield, Stephen A Blakely, Nikolay Shirokikh, Tatyana Pestova, Jon R Lorsch & Alan G Hinnebusch. (2005) The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivo. The EMBO Journal 24:20, pages 3588-3601.
Crossref
Rafael Dhalia, Christian R.S. Reis, Eden R. Freire, Pollyanna O. Rocha, Rodolfo Katz, João R.C. Muniz, Nancy Standart & Osvaldo P. de Melo Neto. (2005) Translation initiation in Leishmania major: characterisation of multiple eIF4F subunit homologues. Molecular and Biochemical Parasitology 140:1, pages 23-41.
Crossref
Rebecca L. Rich & David G. Myszka. (2005) Survey of the year 2003 commercial optical biosensor literature. Journal of Molecular Recognition 18:1, pages 1-39.
Crossref
Ker-Chau Li, Ching-Ti Liu, Wei Sun, Shinsheng Yuan & Tianwei Yu. (2004) A system for enhancing genome-wide coexpression dynamics study. Proceedings of the National Academy of Sciences 101:44, pages 15561-15566.
Crossref
S. Teichert, B. Schönig, S. Richter & B. Tudzynski. (2004) Deletion of the Gibberella fujikuroi glutamine synthetase gene has significant impact on transcriptional control of primary and secondary metabolism. Molecular Microbiology 53:6, pages 1661-1675.
Crossref
Karine Dementhon, Sven J. Saupe & Corinne Clavé. (2004) Characterization of IDI-4, a bZIP transcription factor inducing autophagy and cell death in the fungus Podospora anserina. Molecular Microbiology 53:6, pages 1625-1640.
Crossref
Zhiyi Wei, Ping Zhang, Zhaocai Zhou, Zhongjun Cheng, Mao Wan & Weimin Gong. (2004) Crystal Structure of Human eIF3k, the First Structure of eIF3 Subunits. Journal of Biological Chemistry 279:33, pages 34983-34990.
Crossref
Lee D. KappJon R. Lorsch. (2004) The Molecular Mechanics of Eukaryotic Translation. Annual Review of Biochemistry 73:1, pages 657-704.
Crossref
Marina Ptushkina, Naglis Malys & John E G McCarthy. (2004) eIF4E isoform 2 in Schizosaccharomyces pombe is a novel stress‐response factor . EMBO reports 5:3, pages 311-316.
Crossref
Karine Berthelot, Mark Muldoon, Lukas Rajkowitsch, John Hughes & John E. G. McCarthy. (2004) Dynamics and processivity of 40S ribosome scanning on mRNA in yeast. Molecular Microbiology 51:4, pages 987-1001.
Crossref
John D. Gross, Nathan J. Moerke, Tobias von der Haar, Alexey A. Lugovskoy, Alan B. Sachs, John E.G. McCarthy & Gerhard Wagner. (2003) Ribosome Loading onto the mRNA Cap Is Driven by Conformational Coupling between eIF4G and eIF4E. Cell 115:6, pages 739-750.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.