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Molecular and Cellular Biology Volume 23, 2003 - Issue 16
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DNA Dynamics and Chromosome Structure

Autophosphorylation of the Catalytic Subunit of the DNA-Dependent Protein Kinase Is Required for Efficient End Processing during DNA Double-Strand Break Repair

Qi Ding1 College of Veterinary Medicine and Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan48824
,
Yeturu V. R. Reddy2 Lineberger Comprehensive Cancer Center
,
Wei Wang1 College of Veterinary Medicine and Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan48824
,
Timothy Woods1 College of Veterinary Medicine and Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan48824
,
Pauline Douglas3 Departments of Biochemistry and Molecular Biology and Biological Sciences, University of Calgary, Calgary, Alberta, CanadaT2N 1N4
,
Dale A. Ramsden2 Lineberger Comprehensive Cancer Center;4 Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
,
Susan P. Lees-Miller3 Departments of Biochemistry and Molecular Biology and Biological Sciences, University of Calgary, Calgary, Alberta, CanadaT2N 1N4
&
Katheryn Meek1 College of Veterinary Medicine and Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan48824Correspondence[email protected]
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Pages 5836-5848 | Received 17 Oct 2002, Accepted 14 May 2003, Published online: 27 Mar 2023

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Crossref
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Crossref
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Pauline Douglas, Ruiqiong Ye, Laura Trinkle-Mulcahy, Jessica A. NealVeerle De Wever, Nick A. MorriceKatheryn MeekSusan P. Lees-Miller. (2014) Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis. Bioscience Reports 34:3.
Crossref
Swetha Inturi, Neera Tewari-Singh, Chapla Agarwal, Carl W. White & Rajesh Agarwal. (2014) Activation of DNA damage repair pathways in response to nitrogen mustard-induced DNA damage and toxicity in skin keratinocytes. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 763-764, pages 53-63.
Crossref
Anthony J. Davis, Benjamin P.C. Chen & David J. Chen. (2014) DNA-PK: A dynamic enzyme in a versatile DSB repair pathway. DNA Repair 17, pages 21-29.
Crossref
Gabrielle J. Grundy, Hayley A. Moulding, Keith W. Caldecott & Stuart L. Rulten. (2014) One ring to bring them all—The role of Ku in mammalian non-homologous end joining. DNA Repair 17, pages 30-38.
Crossref
Sarvan Kumar Radhakrishnan, Nicholas Jette & Susan P. Lees-Miller. (2014) Non-homologous end joining: Emerging themes and unanswered questions. DNA Repair 17, pages 2-8.
Crossref
Catherine J. Pears & Nicholas D. Lakin. (2014) Emerging models for DNA repair: Dictyostelium discoideum as a model for nonhomologous end-joining. DNA Repair 17, pages 121-131.
Crossref
Yu-Fen Lin, Hatsumi Nagasawa, John B. Little, Takamitsu A. Kato, Hung-Ying Shih, Xian-Jin Xie, Paul F. Wilson Jr.John R. Brogan, Akihiro Kurimasa, David J. Chen, Joel S. Bedford & Benjamin P. C. Chen. (2014) Differential Radiosensitivity Phenotypes of DNA-PKcs Mutations Affecting NHEJ and HRR Systems following Irradiation with Gamma-Rays or Very Low Fluences of Alpha Particles. PLoS ONE 9:4, pages e93579.
Crossref
Konstantin Akopiants, Susovan Mohapatra, Vijay Menon, Tong Zhou, Kristoffer Valerie & Lawrence F. Povirk. (2014) Tracking the processing of damaged DNA double-strand break ends by ligation-mediated PCR: increased persistence of 3′-phosphoglycolate termini in SCAN1 cells. Nucleic Acids Research 42:5, pages 3125-3137.
Crossref
Yi Zhou, Pierre Caron, Gaëlle Legube & Tanya T. Paull. (2014) Quantitation of DNA double-strand break resection intermediates in human cells. Nucleic Acids Research 42:3, pages e19-e19.
Crossref
Salim Abdisalaam, Anthony J. Davis, David J. Chen & George Alexandrakis. (2014) Scanning fluorescence correlation spectroscopy techniques to quantify the kinetics of DNA double strand break repair proteins after γ-irradiation and bleomycin treatment. Nucleic Acids Research 42:1, pages e5-e5.
Crossref
Yi Zhou & Tanya T. Paull. (2013) DNA-dependent Protein Kinase Regulates DNA End Resection in Concert with Mre11-Rad50-Nbs1 (MRN) and Ataxia Telangiectasia-mutated (ATM). Journal of Biological Chemistry 288:52, pages 37112-37125.
Crossref
Matthew L Hirsch, Chengwen Li, Isabella Bellon, Chaoying Yin, Sai Chavala, Marina Pryadkina, Isabelle Richard & Richard Jude Samulski. (2013) Oversized AAV Transductifon Is Mediated via a DNA-PKcs-independent, Rad51C-dependent Repair Pathway. Molecular Therapy 21:12, pages 2205-2216.
Crossref
Donald S. KirkpatrickDaisy J. BustosTaner DoganJocelyn ChanLilian PhuAmy YoungLori S. FriedmanMarcia BelvinQinghua Song, Corey E. Bakalarski & Klaus P. Hoeflich. (2013) Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition. Proceedings of the National Academy of Sciences 110:48, pages 19426-19431.
Crossref
M Evert, M Frau, M L Tomasi, G Latte, M M Simile, M A Seddaiu, A Zimmermann, S Ladu, T Staniscia, S Brozzetti, G Solinas, F Dombrowski, F Feo, R M Pascale & D F Calvisi. (2013) Deregulation of DNA-dependent protein kinase catalytic subunit contributes to human hepatocarcinogenesis development and has a putative prognostic value. British Journal of Cancer 109:10, pages 2654-2664.
Crossref
Candelaria Bracalente, Irene L. Ibañez, Beatriz Molinari, Mónica Palmieri, Andrés Kreiner, Alejandro Valda, Jorge Davidson & Hebe Durán. (2013) Induction and Persistence of Large γH2AX Foci by High Linear Energy Transfer Radiation in DNA-Dependent protein kinase–Deficient Cells. International Journal of Radiation Oncology*Biology*Physics 87:4, pages 785-794.
Crossref
Andréia Maria da Silva Fonseca, Jaqueline de Azevedo Silva, João Alexandre Trés Pancotto, Eduardo Antônio Donadi, Ludovica Segat, Sergio Crovella & Paula Sandrin-Garcia. (2013) Polymorphisms in STK17A gene are associated with systemic lupus erythematosus and its clinical manifestations. Gene 527:2, pages 435-439.
Crossref
Lisa Woodbine, Jessica A. Neal, Nanda-Kumar Sasi, Mayuko Shimada, Karen Deem, Helen Coleman, William B. Dobyns, Tomoo Ogi, Katheryn Meek, E. Graham Davies & Penny A. Jeggo. (2013) PRKDC mutations in a SCID patient with profound neurological abnormalities. Journal of Clinical Investigation 123:7, pages 2969-2980.
Crossref
Chen Wang & Susan P. Lees-Miller. (2013) Detection and Repair of Ionizing Radiation-Induced DNA Double Strand Breaks: New Developments in Nonhomologous End Joining. International Journal of Radiation Oncology*Biology*Physics 86:3, pages 440-449.
Crossref
Junya Unno, Masatoshi Takagi, Jinhua Piao, Masataka Sugimoto, Fumiko Honda, Daisuke Maeda, Mitsuko Masutani, Tohru Kiyono, Fumiaki Watanabe, Tomohiro Morio, Hirobumi Teraoka & Shuki Mizutani. (2013) Artemis-dependent DNA double-strand break formation at stalled replication forks. Cancer Science 104:6, pages 703-710.
Crossref
Susovan Mohapatra, Steven M. Yannone, Suk-Hee Lee, Robert A. Hromas, Konstantin Akopiants, Vijay Menon, Dale A. Ramsden & Lawrence F. Povirk. (2013) Trimming of damaged 3′ overhangs of DNA double-strand breaks by the Metnase and Artemis endonucleases. DNA Repair 12:6, pages 422-432.
Crossref
N Jiang, Y Shen, X Fei, K Sheng, P Sun, Y Qiu, J Larner, L Cao, X Kong & J Mi. (2013) Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells. Cell Death & Disease 4:5, pages e647-e647.
Crossref
Fengxiang Wei, Judy Yan, Damu Tang, Xiaozeng Lin, Lizhi He, Yanyun Xie, Lijian Tao & Shaojuan Wang. (2013) Inhibition of ERK activation enhances the repair of double-stranded breaks via non-homologous end joining by increasing DNA-PKcs activation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1833:1, pages 90-100.
Crossref
E. Aaron Runkle, Hongtao Zhang, Zheng Cai, Zhiqiang Zhu, Barry L. Karger, Shiaw-Lin Wu, Donald M. O'Rourke, Zhaocai Zhou, Qiang Wang & Mark I. Greene. (2012) Reversion of the ErbB malignant phenotype and the DNA damage response. Experimental and Molecular Pathology 93:3, pages 324-333.
Crossref
Xiaonan Sun, Chunying Yang, Hai Liu, Qi Wang, Shi-Xiu Wu, Xia Li, Tian Xie, Kathryn L. Brinkman, Bin S. Teh, E. Brian Butler, Bo Xu & Shu Zheng. (2012) Identification and Characterization of a Small Inhibitory Peptide That Can Target DNA-PKcs Autophosphorylation and Increase Tumor Radiosensitivity. International Journal of Radiation Oncology*Biology*Physics 84:5, pages 1212-1219.
Crossref
Shruti Malu, Vidyasagar Malshetty, Dailia Francis & Patricia Cortes. (2012) Role of non-homologous end joining in V(D)J recombination. Immunologic Research 54:1-3, pages 233-246.
Crossref
Arne Kousholt, Tobias Menzel & Claus Sørensen. (2012) Pathways for Genome Integrity in G2 Phase of the Cell Cycle. Biomolecules 2:4, pages 579-607.
Crossref
Larry H. Thompson. (2012) Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography. Mutation Research/Reviews in Mutation Research 751:2, pages 158-246.
Crossref
Mahmoud Toulany, Kyung-Jong Lee, Kazi R. Fattah, Yu-Fen Lin, Brigit Fehrenbacher, Martin Schaller, Benjamin P. Chen, David J. Chen & H. Peter Rodemann. (2012) Akt Promotes Post-Irradiation Survival of Human Tumor Cells through Initiation, Progression, and Termination of DNA-PKcs–Dependent DNA Double-Strand Break Repair. Molecular Cancer Research 10:7, pages 945-957.
Crossref
K. Meek, S. P. Lees-Miller & M. Modesti. (2011) N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku. Nucleic Acids Research 40:7, pages 2964-2973.
Crossref
Amol S. Hosing, Nicholas C.K. Valerie, Jaroslaw Dziegielewski, David L. Brautigan & James M. Larner. (2012) PP6 Regulatory Subunit R1 Is Bidentate Anchor for Targeting Protein Phosphatase-6 to DNA-dependent Protein Kinase. Journal of Biological Chemistry 287:12, pages 9230-9239.
Crossref
Maria Quanz, Aurélie Herbette, Mano Sayarath, Leanne de Koning, Thierry Dubois, Jian-Sheng Sun & Marie Dutreix. (2012) Heat Shock Protein 90α (Hsp90α) Is Phosphorylated in Response to DNA Damage and Accumulates in Repair Foci. Journal of Biological Chemistry 287:12, pages 8803-8815.
Crossref
Sara N. Andres, Alexandra Vergnes, Dejan Ristic, Claire Wyman, Mauro Modesti & Murray Junop. (2012) A human XRCC4–XLF complex bridges DNA. Nucleic Acids Research 40:4, pages 1868-1878.
Crossref
S. Roy, S. N. Andres, A. Vergnes, J. A. Neal, Y. Xu, Y. Yu, S. P. Lees-Miller, M. Junop, M. Modesti & K. Meek. (2012) XRCC4's interaction with XLF is required for coding (but not signal) end joining. Nucleic Acids Research 40:4, pages 1684-1694.
Crossref
Michael Weinfeld & Susan P. Lees-Miller. 2012. DNA Repair in Cancer Therapy. DNA Repair in Cancer Therapy 161 189 .
Y Shen, Y Wang, K Sheng, X Fei, Q Guo, J Larner, X Kong, Y Qiu & J Mi. (2011) Serine/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma. Cell Death & Disease 2:12, pages e241-e241.
Crossref
Shivani Ponnala, Krishna Kumar Veeravalli, Chandramu Chetty, Dzung H. Dinh & Jasti S. Rao. (2011) Regulation of DNA Repair Mechanism in Human Glioma Xenograft Cells both In Vitro and In Vivo in Nude Mice. PLoS ONE 6:10, pages e26191.
Crossref
Edward A. Nam, Runxiang Zhao & David Cortez. (2011) Analysis of Mutations That Dissociate G2 and Essential S Phase Functions of Human Ataxia Telangiectasia-mutated and Rad3-related (ATR) Protein Kinase. Journal of Biological Chemistry 286:43, pages 37320-37327.
Crossref
Edward A. Nam, Runxiang Zhao, Gloria G. Glick, Carol E. Bansbach, David B. Friedman & David Cortez. (2011) Thr-1989 Phosphorylation Is a Marker of Active Ataxia Telangiectasia-mutated and Rad3-related (ATR) Kinase. Journal of Biological Chemistry 286:33, pages 28707-28714.
Crossref
Edward P. Morris, Angel Rivera-Calzada, Paula C. A. da Fonseca, Oscar Llorca, Laurence H. Pearl & Laura Spagnolo. (2011) Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies. Nucleic Acids Research 39:13, pages 5757-5767.
Crossref
Shizhou Liu, Bunsyo Shiotani, Mayurika Lahiri, Alexandre Maréchal, Alice Tse, Charles Chung Yun Leung, J.N. Mark Glover, Xiaohong H. Yang & Lee Zou. (2011) ATR Autophosphorylation as a Molecular Switch for Checkpoint Activation. Molecular Cell 43:2, pages 192-202.
Crossref
Saleh Ihmaid, Jasim Al-Rawi, Christopher Bradley, Michael J. Angove, Murray N. Robertson & Rachel L. Clark. (2011) Synthesis, structural elucidation, DNA-PK inhibition, homology modelling and anti-platelet activity of morpholino-substituted-1,3-naphth-oxazines. Bioorganic & Medicinal Chemistry 19:13, pages 3983-3994.
Crossref
Jessica A. Neal & Katheryn Meek. (2011) Choosing the right path: Does DNA-PK help make the decision?. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 711:1-2, pages 73-86.
Crossref
Shichuan Zhang, Hirohiko Yajima, HoangDinh Huynh, Junke Zheng, Elsa Callen, Hua-Tang Chen, Nancy Wong, Samuel Bunting, Yu-Fen Lin, Mengxia Li, Kyung-Jone Lee, Michael Story, Eric Gapud, Barry P. Sleckman, André Nussenzweig, Cheng Cheng Zhang, David J. Chen & Benjamin P.C. Chen. (2011) Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. Journal of Cell Biology 193:2, pages 295-305.
Crossref
Kyung-Jong Lee, Yu-Fen Lin, Han-Yi Chou, Hirohiko Yajima, Kazi R. Fattah, Sheng-Chung Lee & Benjamin P.C. Chen. (2011) Involvement of DNA-dependent Protein Kinase in Normal Cell Cycle Progression through Mitosis. Journal of Biological Chemistry 286:14, pages 12796-12802.
Crossref
Hatsumi Nagasawa, John B. Little, Yu-Fen Lin, Sairei So, Akihiro Kurimasa, Yuanlin Peng, John R. Brogan, David J. Chen, Joel S. Bedford & Benjamin P. C. Chen. (2011) Differential Role of DNA-PKcs Phosphorylations and Kinase Activity in Radiosensitivity and Chromosomal Instability. Radiation Research 175:1, pages 83-89.
Crossref
Olga Momčilović, Christopher Navara & Gerald Schatten. 2011. Cell Cycle in Development. Cell Cycle in Development 415 458 .
Young-Kook Choi, Kevin Nash, Barry J. Byrne, Nicholas Muzyczka & Sihong Song. (2010) The Effect of DNA-Dependent Protein Kinase on Adeno-Associated Virus Replication. PLoS ONE 5:12, pages e15073.
Crossref
Tracey A. Dobbs, John A. Tainer & Susan P. Lees-Miller. (2010) A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. DNA Repair 9:12, pages 1307-1314.
Crossref
B B Olsen, O-G Issinger & B Guerra. (2010) Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells. Oncogene 29:45, pages 6016-6026.
Crossref
Hatsumi Nagasawa, John R. Brogan, Yuanlin Peng, John B. Little & Joel S. Bedford. (2010) Some unsolved problems and unresolved issues in radiation cytogenetics: A review and new data on roles of homologous recombination and non-homologous end joining. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 701:1, pages 12-22.
Crossref
A Tomashevski, D R Webster, P Grammas, M Gorospe & I I Kruman. (2010) Cyclin-C-dependent cell-cycle entry is required for activation of non-homologous end joining DNA repair in postmitotic neurons. Cell Death & Differentiation 17:7, pages 1189-1198.
Crossref
Tomasz Poplawski & Janusz Blasiak. (2009) BCR/ABL downregulates DNA-PKCS-dependent and upregulates backup non-homologous end joining in leukemic cells. Molecular Biology Reports 37:5, pages 2309-2315.
Crossref
Steven A. Roberts, Natasha Strande, Martin D. Burkhalter, Christina Strom, Jody M. Havener, Paul Hasty & Dale A. Ramsden. (2010) Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends. Nature 464:7292, pages 1214-1217.
Crossref
Sébastien Soubeyrand, Louise Pope & Robert J.G. Haché. (2010) Topoisomerase IIα-dependent induction of a persistent DNA damage response in response to transient etoposide exposure. Molecular Oncology 4:1, pages 38-51.
Crossref
Cynthia L. Hendrickson, Shubhadeep Purkayastha, Elzbieta Pastwa, Ronald D. Neumann & Thomas A. Winters. (2010) Coincident In Vitro Analysis of DNA-PK-Dependent and -Independent Nonhomologous End Joining . Journal of Nucleic Acids 2010, pages 1-11.
Crossref
Takashi Ochi, Bancinyane Lynn Sibanda, Qian Wu, Dimitri Y. Chirgadze, Victor M. Bolanos-Garcia & Tom L. Blundell. (2010) Structural Biology of DNA Repair: Spatial Organisation of the Multicomponent Complexes of Nonhomologous End Joining. Journal of Nucleic Acids 2010, pages 1-19.
Crossref
Michal Hammel, Yaping Yu, Brandi L. Mahaney, Brandon Cai, Ruiqiong Ye, Barry M. Phipps, Robert P. Rambo, Greg L. Hura, Martin Pelikan, Sairei So, Ramin M. Abolfath, David J. Chen, Susan P. Lees-Miller & John A. Tainer. (2010) Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex. Journal of Biological Chemistry 285:2, pages 1414-1423.
Crossref
Mahmoud Toulany, Rainer Kehlbach, H. Peter Rodemann & Hossein Mozdarani. (2010) Radiocontrast media affect radiation-induced DNA damage repair in vitro and in vivo by affecting Akt signalling. Radiotherapy and Oncology 94:1, pages 110-116.
Crossref
Xiaoping Cui & Michael R. Lieber. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 2165 2170 .
Mirjam van der Burg, Jacques JM van Dongen & Dik C van Gent. (2009) DNA-PKcs deficiency in human: long predicted, finally found. Current Opinion in Allergy & Clinical Immunology 9:6, pages 503-509.
Crossref
Eli S. Williams, Rebekah Klingler, Brian Ponnaiya, Tanja Hardt, Evelin Schrock, Susan P. Lees-Miller, Katheryn Meek, Robert L. Ullrich & Susan M. Bailey. (2009) Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence. Cancer Research 69:5, pages 2100-2107.
Crossref
Jun Mi, Jaroslaw Dziegielewski, Elzbieta Bolesta, David L. Brautigan & James M. Larner. (2009) Activation of DNA-PK by Ionizing Radiation Is Mediated by Protein Phosphatase 6. PLoS ONE 4:2, pages e4395.
Crossref
Brandi L. Mahaney, Katheryn MeekSusan P. Lees-Miller. (2009) Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochemical Journal 417:3, pages 639-650.
Crossref
Ken-ichi YANO, Keiko MOROTOMI-YANO, Noritaka ADACHI & Hidenori AKIYAMA. (2009) Molecular Mechanism of Protein Assembly on DNA Double-strand Breaks in the Non-homologous End-joining Pathway. Journal of Radiation Research 50:2, pages 97-108.
Crossref
Sarah S. Durkin, Xin Guo, Kimberly A. Fryrear, Valia T. Mihaylova, Saurabh K. Gupta, S. Mehdi Belgnaoui, Abdelali Haoudi, Gary M. Kupfer & O. John Semmes. (2008) HTLV-1 Tax Oncoprotein Subverts the Cellular DNA Damage Response via Binding to DNA-dependent Protein Kinase. Journal of Biological Chemistry 283:52, pages 36311-36320.
Crossref
Robert Hromas, Justin Wray, Suk-Hee Lee, Leah Martinez, Jacqueline Farrington, Lori Kwan Corwin, Heather Ramsey, Jac A. Nickoloff & Elizabeth A. Williamson. (2008) The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining. DNA Repair 7:12, pages 1927-1937.
Crossref
Jennifer BlickwedehlManjula AgarwalChanghyun Seong, Raj K. PanditaThomas Melendy, Patrick Sung, Tej K. PanditaNaveen Bangia. (2008) Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability. Proceedings of the National Academy of Sciences 105:42, pages 16165-16170.
Crossref
Joyce C.Y. Cheung, Brenda Salerno & Les A. Hanakahi. (2008) Evidence for an inositol hexakisphosphate-dependent role for Ku in mammalian nonhomologous end joining that is independent of its role in the DNA-dependent protein kinase. Nucleic Acids Research 36:17, pages 5713-5726.
Crossref
Mahmoud Toulany, Rainer Kehlbach, Urszula Florczak, Ali Sak, Shaomeng Wang, Jianyong Chen, Markus Lobrich & H. Peter Rodemann. (2008) Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair. Molecular Cancer Therapeutics 7:7, pages 1772-1781.
Crossref
Katherine S. Pawelczak & John J. Turchi. (2008) A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining. Nucleic Acids Research 36:12, pages 4022-4031.
Crossref
Dewight R. Williams, Kyung-Jong Lee, Jian Shi, David J. Chen & Phoebe L. Stewart. (2008) Cryo-EM Structure of the DNA-Dependent Protein Kinase Catalytic Subunit at Subnanometer Resolution Reveals α Helices and Insight into DNA Binding. Structure 16:3, pages 468-477.
Crossref
Alexander E. Ochem, Hocine Rechreche, Doris Skopac & Arturo Falaschi. (2008) Stimulation of the DNA unwinding activity of human DNA helicase II/Ku by phosphorylation. Archives of Biochemistry and Biophysics 470:1, pages 1-7.
Crossref
Eric Weterings & David J Chen. (2008) The endless tale of non-homologous end-joining. Cell Research 18:1, pages 114-124.
Crossref
Meena Shrivastav, Leyma P De Haro & Jac A Nickoloff. (2007) Regulation of DNA double-strand break repair pathway choice. Cell Research 18:1, pages 134-147.
Crossref
Katheryn Meek, Van Dang & Susan P. Lees-Miller. 2008. 33 58 .
D C van Gent & M van der Burg. (2007) Non-homologous end-joining, a sticky affair. Oncogene 26:56, pages 7731-7740.
Crossref
David J. Chen & Chaitanya S. Nirodi. (2007) The Epidermal Growth Factor Receptor: A Role in Repair of Radiation-Induced DNA Damage. Clinical Cancer Research 13:22, pages 6555-6560.
Crossref
Peï-Yu Wu, Philippe Frit, Laurent Malivert, Patrick Revy, Denis Biard, Bernard Salles & Patrick Calsou. (2007) Interplay between Cernunnos-XLF and Nonhomologous End-joining Proteins at DNA Ends in the Cell. Journal of Biological Chemistry 282:44, pages 31937-31943.
Crossref
Xiaoping Cui & Katheryn Meek. (2007) Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathway. Proceedings of the National Academy of Sciences 104:43, pages 17046-17051.
Crossref
Eric Weterings & David J. Chen. (2007) DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?. Journal of Cell Biology 179:2, pages 183-186.
Crossref
Barbara Corneo, Rebecca L. Wendland, Ludovic Deriano, Xiaoping Cui, Isaac A. Klein, Serre-Yu Wong, Suzzette Arnal, Abigail J. Holub, Geoffrey R. Weller, Bette A. Pancake, Sundeep Shah, Vicky L. Brandt, Katheryn Meek & David B. Roth. (2007) Rag mutations reveal robust alternative end joining. Nature 449:7161, pages 483-486.
Crossref
Melissa S. Bentle, Kathryn E. Reinicke, Ying Dong, Erik A. Bey & David A. Boothman. (2007) Nonhomologous End Joining Is Essential for Cellular Resistance to the Novel Antitumor Agent, β-Lapachone. Cancer Research 67:14, pages 6936-6945.
Crossref
Lawrence F. Povirk, Rui-Zhe Zhou, Dale A. Ramsden, Susan P. Lees-Miller & Kristoffer Valerie. (2007) Phosphorylation in the serine/threonine 2609–2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts. Nucleic Acids Research 35:12, pages 3869-3878.
Crossref
Chun J. Tsai, Sunny A. Kim & Gilbert Chu. (2007) Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends. Proceedings of the National Academy of Sciences 104:19, pages 7851-7856.
Crossref
Ugo Déry & Jean-Yves Masson. (2007) Twists and turns in the function of DNA damage signaling and repair proteins by post-translational modifications. DNA Repair 6:5, pages 561-577.
Crossref
Naoya Uematsu, Eric Weterings, Ken-ichi Yano, Keiko Morotomi-Yano, Burkhard Jakob, Gisela Taucher-Scholz, Pierre-Olivier Mari, Dik C. van Gent, Benjamin P.C. Chen & David J. Chen. (2007) Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. The Journal of Cell Biology 177:2, pages 219-229.
Crossref
Joe Budman, Sunny A. Kim & Gilbert Chu. (2007) Processing of DNA for Nonhomologous End-joining Is Controlled by Kinase Activity and XRCC4/Ligase IV. Journal of Biological Chemistry 282:16, pages 11950-11959.
Crossref
Benjamin P.C. Chen, Naoya Uematsu, Junya Kobayashi, Yaniv Lerenthal, Andrea Krempler, Hirohiko Yajima, Markus Löbrich, Yosef Shiloh & David J. Chen. (2007) Ataxia Telangiectasia Mutated (ATM) Is Essential for DNA-PKcs Phosphorylations at the Thr-2609 Cluster upon DNA Double Strand Break. Journal of Biological Chemistry 282:9, pages 6582-6587.
Crossref
Lori S. Hart, David Ornelles & Constantinos Koumenis. (2007) The Adenoviral E4orf6 Protein Induces Atypical Apoptosis in Response to DNA Damage. Journal of Biological Chemistry 282:9, pages 6061-6067.
Crossref
M. Jeyakumar, Xue-feng Liu, Hediye Erdjument-Bromage, Paul Tempst & Milan K. Bagchi. (2007) Phosphorylation of Thyroid Hormone Receptor-associated Nuclear Receptor Corepressor Holocomplex by the DNA-dependent Protein Kinase Enhances Its Histone Deacetylase Activity. Journal of Biological Chemistry 282:13, pages 9312-9322.
Crossref
Tsutomu Shimura, Melvenia M. Martin, Michael J. Torres, Cory Gu, Janice M. Pluth, Maria A. DiBernardi, Jeffrey S. McDonald & Mirit I. Aladjem. (2007) DNA-PK Is Involved in Repairing a Transient Surge of DNA Breaks Induced by Deceleration of DNA Replication. Journal of Molecular Biology 367:3, pages 665-680.
Crossref
David Murray & Alexander J. McEwan. (2007) Radiobiology of Systemic Radiation Therapy. Cancer Biotherapy and Radiopharmaceuticals 22:1, pages 1-23.
Crossref
Lawrence F. Povirk. 2007. Apoptosis, Senescence, and Cancer. Apoptosis, Senescence, and Cancer 265 278 .
Pierre-Olivier Mari, Bogdan I. FloreaStephan P. PersengievNicole S. VerkaikHennie T. BrüggenwirthMauro ModestiGiuseppina Giglia-MariKarel Bezstarosti, Jeroen A. A. Demmers, Theo M. Luider, Adriaan B. Houtsmuller & Dik C. van Gent. (2006) Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proceedings of the National Academy of Sciences 103:49, pages 18597-18602.
Crossref
Doris Niewolik, Ulrich Pannicke, Haihui Lu, Yunmei Ma, Ling-Chi Vicky Wang, Peter Kulesza, Ebrahim Zandi, Michael R. Lieber & Klaus Schwarz. (2006) DNA-PKcs Dependence of Artemis Endonucleolytic Activity, Differences between Hairpins and 5′ or 3′ Overhangs. Journal of Biological Chemistry 281:45, pages 33900-33909.
Crossref
Lawrence F. Povirk. (2006) Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks. DNA Repair 5:9-10, pages 1199-1212.
Crossref
Aaron A Goodarzi, Yaping Yu, Enriqueta Riballo, Pauline Douglas, Sarah A Walker, Ruiqiong Ye, Christine Härer, Caterina Marchetti, Nick Morrice, Penny A Jeggo & Susan P Lees-Miller. (2006) DNA-PK autophosphorylation facilitates Artemis endonuclease activity. The EMBO Journal 25:16, pages 3880-3889.
Crossref
Sergei V Kozlov, Mark E Graham, Cheng Peng, Philip Chen, Phillip J Robinson & Martin F Lavin. (2006) Involvement of novel autophosphorylation sites in ATM activation. The EMBO Journal 25:15, pages 3504-3514.
Crossref
Barbara Bertocci, Annie De Smet, Jean-Claude Weill & Claude-Agnès Reynaud. (2006) Nonoverlapping Functions of DNA Polymerases Mu, Lambda, and Terminal Deoxynucleotidyltransferase during Immunoglobulin V(D)J Recombination In Vivo. Immunity 25:1, pages 31-41.
Crossref
Xiaofeng Jiang, Yingli Sun, Shujuan Chen, Kanaklata Roy & Brendan D. Price. (2006) The FATC Domains of PIKK Proteins Are Functionally Equivalent and Participate in the Tip60-dependent Activation of DNA-PKcs and ATM. Journal of Biological Chemistry 281:23, pages 15741-15746.
Crossref
William S. Dynan, Yoshihiko Takeda & Shuyi Li. (2006) Modifying the function of DNA repair nanomachines for therapeutic benefit. Nanomedicine: Nanotechnology, Biology and Medicine 2:2, pages 74-81.
Crossref
B. Salles, P. Calsou, P. Frit & C. Muller. (2006) The DNA repair complex DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy. Pathologie Biologie 54:4, pages 185-193.
Crossref
Laura Spagnolo, Angel Rivera-Calzada, Laurence H. Pearl & Oscar Llorca. (2006) Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair. Molecular Cell 22:4, pages 511-519.
Crossref
Bipasha Mukherjee, Chase Kessinger, Junya Kobayashi, Benjamin P.C. Chen, David J. Chen, Aloke Chatterjee & Sandeep Burma. (2006) DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells. DNA Repair 5:5, pages 575-590.
Crossref
Christopher M. Sturgeon, Zachary A. Knight, Kevan M. Shokat & Michel Roberge. (2006) Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage. Molecular Cancer Therapeutics 5:4, pages 885-892.
Crossref
J. Valentin. (2016) Chapters 6 and 7. Annals of the ICRP 35:4, pages 93-140.
Crossref
J. Valentin. (2016) Chapter 3. Annals of the ICRP 35:4, pages 41-60.
Crossref
Ian G. Cowell, Barbara W. Durkacz & Michael J. Tilby. (2005) Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated. Biochemical Pharmacology 71:1-2, pages 13-20.
Crossref

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