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Transcriptional Regulation

Estrogen Receptor-Dependent Proteasomal Degradation of the Glucocorticoid Receptor Is Coupled to an Increase in Mdm2 Protein Expression

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Pages 5867-5881 | Received 19 Mar 2003, Accepted 27 May 2003, Published online: 27 Mar 2023

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Andreas G. Moraitis, Thaddeus Block, Dat Nguyen & Joseph K. Belanoff. (2017) The role of glucocorticoid receptors in metabolic syndrome and psychiatric illness. The Journal of Steroid Biochemistry and Molecular Biology 165, pages 114-120.
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Eva Kassi, Narjes Nasiri-Ansari, Eliana Spilioti, Vassiliki Kalotychou, Panagiota E. Apostolou, Paraskevi Moutsatsou & Athanasios G. Papavassiliou. (2016) Vitamin D interferes with glucocorticoid responsiveness in human peripheral blood mononuclear target cells. Cellular and Molecular Life Sciences 73:22, pages 4341-4354.
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P Zhang, S Elabd, S Hammer, V Solozobova, H Yan, F Bartel, S Inoue, T Henrich, J Wittbrodt, F Loosli, G Davidson & C Blattner. (2015) TRIM25 has a dual function in the p53/Mdm2 circuit. Oncogene 34:46, pages 5729-5738.
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Crossref
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Crossref
M. A. Orlovsky. (2012) Allelic polymorphism of glucocorticoid receptor NR3C1 (GR): from molecular biology to clinical implications. Biopolymers and Cell 28:5, pages 338-351.
Crossref
Stian Knappskog, Jone Trovik, Janusz Marcickiewicz, Solveig Tingulstad, Annetine C. Staff, Pål Romundstad, Kristian Hveem, Lars Vatten, Helga B. Salvesen & Per E. Lønning. (2012) SNP285C modulates oestrogen receptor/Sp1 binding to the MDM2 promoter and reduces the risk of endometrial but not prostatic cancer. European Journal of Cancer 48:13, pages 1988-1996.
Crossref
Laura N. VandenbergTheo ColbornTyrone B. HayesJerrold J. HeindelDavid R. JacobsJr.Jr., Duk-Hee LeeToshi ShiodaAna M. SotoFrederick S. vom SaalWade V. WelshonsR. Thomas Zoeller & John Peterson Myers. (2012) Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses. Endocrine Reviews 33:3, pages 378-455.
Crossref
Javier Cotignola, Joanne F. Chou, Pampa Roy, Nandita Mitra, Klaus Busam, Allan C. Halpern & Irene Orlow. (2012) Investigation of the Effect of MDM2 SNP309 and TP53 Arg72Pro Polymorphisms on the Age of Onset of Cutaneous Melanoma. Journal of Investigative Dermatology 132:5, pages 1471-1478.
Crossref
Gitte Vrelits Sørensen, Deirdre P Cronin-Fenton, Henrik Toft Sørensen, Sinna Pilgaard Ulrichsen, Lars Pedersen & Timothy L Lash. (2012) Use of glucocorticoids and risk of breast cancer: a Danish population-based case-control study. Breast Cancer Research 14:1.
Crossref
Frank Essmann & Klaus Schulze-Osthoff. (2012) Translational approaches targeting the p53 pathway for anti-cancer therapy. British Journal of Pharmacology 165:2, pages 328-344.
Crossref
Xavier Dezitter, Bernadette Masselot, Meryem Tardivel, Claude Mereau-Richard, Pierre Formstecher & Thierry Idziorek. (2011) Macromolecular synthesis inhibitors perturb glucocorticoid receptor trafficking. The Journal of Steroid Biochemistry and Molecular Biology 126:3-5, pages 104-112.
Crossref
Hongping Yu, Yu-jing Huang, Zhensheng Liu, Li-E Wang, Guojun Li, Erich M. Sturgis, David G. Johnson & Qingyi Wei. (2011) Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck . Molecular Carcinogenesis 50:9, pages 697-706.
Crossref
Xiaoman Wo, Dong Han, Haiming Sun, Yang Liu, Xiangning Meng, Jing Bai, Feng Chen, Yang Yu, Yan Jin & Songbin Fu. (2011) MDM2 SNP309 contributes to tumor susceptibility: A meta-analysis. Journal of Genetics and Genomics.
Crossref
Roberto Stella, Giancarlo Biancotto, Morten Krogh, Roberto Angeletti, Giandomenico Pozza, Maria Catia Sorgato, Peter James & Igino Andrighetto. (2011) Protein Expression Changes in Skeletal Muscle in Response to Growth Promoter Abuse in Beef Cattle. Journal of Proteome Research 10:6, pages 2744-2757.
Crossref
Angelika Brekman, Kathryn E Singh, Alla Polotskaia, Nandini Kundu & Jill Bargonetti. (2011) A p53-independent role of Mdm2 in estrogen-mediated activation of breast cancer cell proliferation. Breast Cancer Research 13:1.
Crossref
Laura Davies, Elissavet Paraskevopoulou, Malihah Sadeq, Christiana Symeou, Constantia Pantelidou, Constantinos Demonacos & Marija Krstic-Demonacos. (2011) Regulation of Glucocorticoid Receptor Activity by a Stress Responsive Transcriptional Cofactor. Molecular Endocrinology 25:1, pages 58-71.
Crossref
Pia Bagamasbad & Robert J. Denver. (2011) Mechanisms and significance of nuclear receptor auto- and cross-regulation. General and Comparative Endocrinology 170:1, pages 3-17.
Crossref
Hui Wan Chua, Daniel Ng, Serena Choo, San San Lum, Huihua Li, Li Ying Soh, Kanaga Sabapathy & Adeline Seow. (2010) Effect of MDM2 SNP309 and p53 codon 72 polymorphisms on lung cancer risk and survival among non-smoking Chinese women in Singapore. BMC Cancer 10:1.
Crossref
Sara Proietti, Alessandra Cucina, Fabrizio D’Anselmi, Simona Dinicola, Alessia Pasqualato, Elisabetta Lisi & Mariano Bizzarri. (2010) Melatonin and vitamin D3 synergistically down-regulate Akt and MDM2 leading to TGFβ-1-dependent growth inhibition of breast cancer cells. Journal of Pineal Research, pages no-no.
Crossref
Chia-Li Kao, Han-Shui Hsu, Hsin-Wu Chen & Tzu-Hao Cheng. (2009) Rapamycin increases the p53/MDM2 protein ratio and p53-dependent apoptosis by translational inhibition of mdm2 in cancer cells. Cancer Letters 286:2, pages 250-259.
Crossref
Chunyan Zhao, Milica Putnik, Jan-Åke Gustafsson & Karin Dahlman-Wright. (2009) Microarray analysis of altered gene expression in ERβ-overexpressing HEK293 cells. Endocrine 36:2, pages 224-232.
Crossref
Yong Zhang, Donald Y.M. Leung, Steven K. Nordeen & Elena Goleva. (2009) Estrogen Inhibits Glucocorticoid Action via Protein Phosphatase 5 (PP5)-mediated Glucocorticoid Receptor Dephosphorylation. Journal of Biological Chemistry 284:36, pages 24542-24552.
Crossref
Zaowen Chen, Yunfu Lin, Eveline Barbieri, Sue Burlingame, John Hicks, Andrew Ludwig & Jason M. Shohet. (2009) Mdm2 Deficiency Suppresses MYCN-Driven Neuroblastoma Tumorigenesis In Vivo. Neoplasia 11:8, pages 753-762.
Crossref
Larissa Belova, Bertha Delgado, Masha Kocherginsky, Amal Melhem, Olufunmilayo I. Olopade & Suzanne D. Conzen. (2008) Glucocorticoid receptor expression in breast cancer associates with older patient age. Breast Cancer Research and Treatment 116:3, pages 441-447.
Crossref
L. CarraroS. FerraressoB. CardazzoC. Romualdi, C. MontesissaF. Gottardo, T. PatarnelloM. CastagnaroL. Bargelloni. (2009) Expression profiling of skeletal muscle in young bulls treated with steroidal growth promoters. Physiological Genomics 38:2, pages 138-148.
Crossref
Izabela Zawlik, Daisuke Kita, Salvatore Vaccarella, Michel Mittelbronn, Silvia Franceschi & Hiroko Ohgaki. (2009) Common Polymorphisms in the MDM2 and TP53 Genes and the Relationship between TP53 Mutations and Patient Outcomes in Glioblastomas . Brain Pathology 19:2, pages 188-194.
Crossref
Lakshmi Gopinathan, Daniel B. Hannon, Jeffrey M. Peters & John P. Vanden Heuvel. (2009) Regulation of Peroxisome Proliferator–Activated Receptor-α by MDM2. Toxicological Sciences 108:1, pages 48-58.
Crossref
Leonardo Machado Crema, Deusa Vendite, Ana Paula Horn, Luisa Amalia Diehl, Ana Paula Aguiar, Edelvan Nunes, Lúcia Vinade, Fernanda Urruth Fontella, Christianne Salbego & Carla Dalmaz. (2008) Effects of Chronic Restraint Stress and Estradiol Replacement on Glutamate Release and Uptake in the Spinal Cord from Ovariectomized Female Rats. Neurochemical Research 34:3, pages 499-507.
Crossref
Johan Högberg, Ilona Silins & Ulla Stenius. 2009. Molecular, Clinical and Environmental Toxicology. Molecular, Clinical and Environmental Toxicology 181 208 .
Fiona EM Paulin, Mary O'Neill, Gillian McGregor, Andrew Cassidy, Alison Ashfield, Clinton W Ali, Alastair J Munro, Lee Baker, Colin A Purdie, David P Lane & Alastair M Thompson. (2008) MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism. BMC Cancer 8:1.
Crossref
Joerg Bittenbring, Frédérique Parisot, Alain Wabo, Monika Mueller, Lynn Kerschenmeyer, Markus Kreuz, Lorenz Truemper, Olfert Landt, Alain Menzel, Michael Pfreundschuh & Klaus Roemer. (2008) MDM2 gene SNP309 T/G and p53gene SNP72 G/C do not influence diffuse large B-cell non-Hodgkin lymphoma onset or survival in central European Caucasians. BMC Cancer 8:1.
Crossref
H. Karimi Kinyamu, Jennifer B. Collins, Sherry F. Grissom, Pratibha B. Hebbar & Trevor K. Archer. (2008) Genome wide transcriptional profiling in breast cancer cells reveals distinct changes in hormone receptor target genes and chromatin modifying enzymes after proteasome inhibition. Molecular Carcinogenesis 47:11, pages 845-885.
Crossref
Y. Morishima, A. M. Wang, Z. Yu, W. B. Pratt, Y. Osawa & A. P. Lieberman. (2008) CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins. Human Molecular Genetics 17:24, pages 3942-3952.
Crossref
José A. Rodríguez-Navarro, Rosa M. Solano, María J. Casarejos, Ana Gomez, Juan Perucho, Justo García de Yébenes & María A. Mena. (2008) Gender differences and estrogen effects in parkin null mice. Journal of Neurochemistry 106:5, pages 2143-2157.
Crossref
A B D'Assoro, R Busby, I D Acu, C Quatraro, M M Reinholz, D J Farrugia, M A Schroeder, C Allen, F Stivala, E Galanis & J L Salisbury. (2008) Impaired p53 function leads to centrosome amplification, acquired ERα phenotypic heterogeneity and distant metastases in breast cancer MCF-7 xenografts. Oncogene 27:28, pages 3901-3911.
Crossref
San San Lum, Hui Wan Chua, Huihua Li, Wen-Feng Li, Nanyan Rao, Jin Wei, Zhiming Shao & Kanaga Sabapathy. (2008) MDM2 SNP309 G allele increases risk but the T allele is associated with earlier onset age of sporadic breast cancers in the Chinese population. Carcinogenesis 29:4, pages 754-761.
Crossref
Stafford L. Lightman, Crispin C. Wiles, Helen C. Atkinson, David E. Henley, Georgina M. Russell, Jack A. Leendertz, Mervyn A. McKenna, Francesca Spiga, Susan A. Wood & Becky L. Conway-Campbell. (2008) The significance of glucocorticoid pulsatility. European Journal of Pharmacology 583:2-3, pages 255-262.
Crossref
E L Milliken, K L Lozada, E Johnson, M D Landis, D D Seachrist, I Whitten, A L M Sutton, F W Abdul-Karim & R A Keri. (2007) Ovarian hyperstimulation induces centrosome amplification and aneuploid mammary tumors independently of alterations in p53 in a transgenic mouse model of breast cancer. Oncogene 27:12, pages 1759-1766.
Crossref
Lakshmi Gopinathan, Daniel B. Hannon, Russell W. Smith, Jeffrey M. Peters & John P. Vanden Heuvel. (2008) Regulation of Peroxisome Proliferator-Activated Receptors by E6-Associated Protein. PPAR Research 2008, pages 1-8.
Crossref
Paraskevi Moutsatsou & Athanasios G. Papavassiliou. (2007) Breast Carcinoma: The glucocorticoid receptor signalling in breast cancer. Journal of Cellular and Molecular Medicine 12:1, pages 145-163.
Crossref
Marjet D. Heitzer, Irene M. Wolf, Edwin R. Sanchez, Selma F. Witchel & Donald B. DeFranco. (2007) Glucocorticoid receptor physiology. Reviews in Endocrine and Metabolic Disorders 8:4, pages 321-330.
Crossref
Becky L. Conway-Campbell, Mervyn A. McKenna, Crispin C. Wiles, Helen C. Atkinson, E. Ron de Kloet & Stafford L. Lightman. (2007) Proteasome-Dependent Down-Regulation of Activated Nuclear Hippocampal Glucocorticoid Receptors Determines Dynamic Responses to Corticosterone. Endocrinology 148:11, pages 5470-5477.
Crossref
Aejaz Sayeed, Santhi D. Konduri, Wensheng Liu, Sanjay Bansal, Fengzhi Li & Gokul M. Das. (2007) Estrogen Receptor α Inhibits p53-Mediated Transcriptional Repression: Implications for the Regulation of Apoptosis. Cancer Research 67:16, pages 7746-7755.
Crossref
Vanessa Duong, Nathalie Boulle, Sylvain Daujat, Jérôme Chauvet, Sandrine Bonnet, Henry Neel & Vincent Cavaillès. (2007) Differential Regulation of Estrogen Receptor α Turnover and Transactivation by Mdm2 and Stress-Inducing Agents. Cancer Research 67:11, pages 5513-5521.
Crossref
Chunyan Zhao, Jason Matthews, Michel Tujague, Jinghong Wan, Anders Ström, Gudrun Toresson, Eric W-F. Lam, Guojun Cheng, Jan-Åke Gustafsson & Karin Dahlman-Wright. (2007) Estrogen Receptor β2 Negatively Regulates the Transactivation of Estrogen Receptor α in Human Breast Cancer Cells. Cancer Research 67:8, pages 3955-3962.
Crossref
Dong Fu & Basil D. Roufogalis. (2007) Actin disruption inhibits endosomal traffic of P-glycoprotein-EGFP and resistance to daunorubicin accumulation. American Journal of Physiology-Cell Physiology 292:4, pages C1543-C1552.
Crossref
Wenwei Hu, Zhaohui Feng, Lan Ma, John Wagner, J. Jeremy Rice, Gustavo Stolovitzky & Arnold J. Levine. (2007) A Single Nucleotide Polymorphism in the MDM2 Gene Disrupts the Oscillation of p53 and MDM2 Levels in Cells . Cancer Research 67:6, pages 2757-2765.
Crossref
Pratibha B. Hebbar & Trevor K. Archer. (2007) Chromatin-dependent Cooperativity between Site-specific Transcription Factors in Vivo. Journal of Biological Chemistry 282:11, pages 8284-8291.
Crossref
Christine S. Walsh, Carl W. Miller, Beth Y. Karlan & H. Phillip Koeffler. (2007) Association between a functional single nucleotide polymorphism in the MDM2 gene and sporadic endometrial cancer risk. Gynecologic Oncology 104:3, pages 660-664.
Crossref
G L Bond & A J Levine. (2007) A single nucleotide polymorphism in the p53 pathway interacts with gender, environmental stresses and tumor genetics to influence cancer in humans. Oncogene 26:9, pages 1317-1323.
Crossref
Gretchen A. LaRusch, Mark W. Jackson, James D. Dunbar, Robert S. Warren, David B. Donner & Lindsey D. Mayo. (2007) Nutlin3 Blocks Vascular Endothelial Growth Factor Induction by Preventing the Interaction between Hypoxia Inducible Factor 1α and Hdm2. Cancer Research 67:2, pages 450-454.
Crossref
Dong-Hai Xiong, Hui Shen, Lan-Juan Zhao, Peng Xiao, Tie-Lin Yang, Yan Guo, Wei Wang, Yan-Fang Guo, Yong-Jun Liu, Robert R Recker & Hong-Wen Deng. (2006) Robust and Comprehensive Analysis of 20 Osteoporosis Candidate Genes by Very High-Density Single-Nucleotide Polymorphism Screen Among 405 White Nuclear Families Identified Significant Association and Gene-Gene Interaction. Journal of Bone and Mineral Research 21:11, pages 1678-1695.
Crossref
Selma F Witchel & Donald B DeFranco. (2006) Mechanisms of Disease: regulation of glucocorticoid and receptor levels—impact on the metabolic syndrome. Nature Clinical Practice Endocrinology & Metabolism 2:11, pages 621-631.
Crossref
S.D.M. Malouitre, S. Barker, J.R. Puddefoot, J. Jalili, H.R. Glover & G.P. Vinson. (2006) Regulation of hepatic steroid receptors and enzymes by the 3β-hydroxysteroid dehydrogenase inhibitor trilostane. The Journal of Steroid Biochemistry and Molecular Biology 101:2-3, pages 97-105.
Crossref
A J Levine, W Hu & Z Feng. (2006) The P53 pathway: what questions remain to be explored?. Cell Death & Differentiation 13:6, pages 1027-1036.
Crossref
Gareth L. Bond, Kim M. Hirshfield, Tomas Kirchhoff, Gabriella Alexe, Elisabeth E. Bond, Harlan Robins, Frank Bartel, Helge Taubert, Peter Wuerl, William Hait, Deborah Toppmeyer, Kenneth Offit & Arnold J. Levine. (2006) MDM2 SNP309 Accelerates Tumor Formation in a Gender-Specific and Hormone-Dependent Manner. Cancer Research 66:10, pages 5104-5110.
Crossref
E Claire Dees & Robert Z Orlowski. (2006) Targeting the ubiquitin–proteasome pathway in breast cancer therapy. Future Oncology 2:1, pages 121-135.
Crossref
Mathilde Calligé & Hélène Richard-Foy. (2006) Ligand-Induced Estrogen Receptor α Degradation by the Proteasome: New Actors?. Nuclear Receptor Signaling 4:1, pages nrs.04004.
Crossref
M. D Heitzer & D. B. DeFranco. (2006) Mechanism of Action of Hic-5/Androgen Receptor Activator 55, a LIM Domain-Containing Nuclear Receptor Coactivator. Molecular Endocrinology 20:1, pages 56-64.
Crossref
Zhuo Zhang, Hui Wang, Mao Li, Elizabeth R Rayburn, Sudhir Agrawal & Ruiwen Zhang. (2005) Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway. Oncogene 24:48, pages 7238-7247.
Crossref
Mao Li, Zhuo Zhang, Donald L. Hill, Xinbin Chen, Hui Wang & Ruiwen Zhang. (2005) Genistein, a Dietary Isoflavone, Down-Regulates the MDM2 Oncogene at Both Transcriptional and Posttranslational Levels. Cancer Research 65:18, pages 8200-8208.
Crossref
Ayesha Ismail & Zafar Nawaz. (2005) Nuclear hormone receptor degradation and gene transcription: An update. IUBMB Life (International Union of Biochemistry and Molecular Biology: Life) 57:7, pages 483-490.
Crossref
Xinjia Wang & Donald B. DeFranco. (2005) Alternative Effects of the Ubiquitin-Proteasome Pathway on Glucocorticoid Receptor Down-Regulation and Transactivation Are Mediated by CHIP, an E3 Ligase. Molecular Endocrinology 19:6, pages 1474-1482.
Crossref
W. R. HARMSTON, P. TADDAYON, K. KOLMAN & N. CHANDAR. (2005) EFFECT OF OVEREXPRESSION OF ESTROGEN RECEPTORS IN OSTEOBLASTS. In Vitro Cellular & Developmental Biology - Animal 41:8, pages 264.
Crossref
Gerd Pääjärvi, Matti Viluksela, Raimo Pohjanvirta, Ulla Stenius & Johan Högberg. (2005) TCDD activates Mdm2 and attenuates the p53 response to DNA damaging agents. Carcinogenesis 26:1, pages 201-208.
Crossref
L.I. Serova, S. Maharjan & E.L. Sabban. (2005) Estrogen modifies stress response of catecholamine biosynthetic enzyme genes and cardiovascular system in ovariectomized female rats. Neuroscience 132:2, pages 249-259.
Crossref
Tuyen Hoang, Ingvild S. Fenne, Carol Cook, Bente Børud, Marit Bakke, Ernst Asbjørn Lien & Gunnar Mellgren. (2004) cAMP-dependent Protein Kinase Regulates Ubiquitin-Proteasome-mediated Degradation and Subcellular Localization of the Nuclear Receptor Coactivator GRIP1. Journal of Biological Chemistry 279:47, pages 49120-49130.
Crossref
NAIMA ISMAILI & MICHAEL J. GARABEDIAN. (2004) Modulation of Glucocorticoid Receptor Function via Phosphorylation. Annals of the New York Academy of Sciences 1024:1, pages 86-101.
Crossref
SAGAR SENGUPTA & BOHDAN WASYLYK. (2004) Physiological and Pathological Consequences of the Interactions of the p53 Tumor Suppressor with the Glucocorticoid, Androgen, and Estrogen Receptors. Annals of the New York Academy of Sciences 1024:1, pages 54-71.
Crossref
Yetao Jin, Shelya X. Zeng, Hunjoo Lee & Hua Lu. (2004) MDM2 Mediates p300/CREB-binding Protein-associated Factor Ubiquitination and Degradation. Journal of Biological Chemistry 279:19, pages 20035-20043.
Crossref
Zafar Nawaz & Bert W. O’Malley. (2004) Urban Renewal in the Nucleus: Is Protein Turnover by Proteasomes Absolutely Required for Nuclear Receptor-Regulated Transcription?. Molecular Endocrinology 18:3, pages 493-499.
Crossref
H.Karimi Kinyamu & Trevor K. Archer. (2004) Modifying chromatin to permit steroid hormone receptor-dependent transcription. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1677:1-3, pages 30-45.
Crossref
Turk Rhen, Sherry Grissom, Cynthia Afshari & John A. Cidlowski. (2003) Dexamethasone blocks the rapid biological effects of 17β‐estradiol in the rat uterus without antagonizing its global genomic actions. The FASEB Journal 17:13, pages 1849-1870.
Crossref

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