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Molecular and Cellular Biology Volume 23, 2003 - Issue 19
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Mammalian Genetic Models with Minimal or Complex Phenotypes

Role of Plk2 (Snk) in Mouse Development and Cell Proliferation

Sheng Ma1 Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts02138
,
Jean Charron2 Centre de Recherche en Cancérologie de l'Université Laval, L'Hôtel-Dieu de Québec, CHUQ, Québec, CanadaG1R 2J6
&
Raymond L. Erikson1 Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts02138Correspondence[email protected]
Pages 6936-6943 | Received 29 May 2003, Accepted 16 Jun 2003, Published online: 27 Mar 2023

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Crossref
C Helmke, S Becker & K Strebhardt. (2015) The role of Plk3 in oncogenesis. Oncogene 35:2, pages 135-147.
Crossref
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Crossref
Jung-Eun Park, Tae-Sung Kim, Lingjun Meng, Jeong K. Bang, Bo Y. Kim & Kyung S. Lee. (2015) Putting a bit into the polo-box domain of polo-like kinase 1. Journal of Analytical Science and Technology 6:1.
Crossref
Monika S. Kowalczyk, Itay Tirosh, Dirk Heckl, Tata Nageswara Rao, Atray Dixit, Brian J. Haas, Rebekka K. Schneider, Amy J. Wagers, Benjamin L. Ebert & Aviv Regev. (2015) Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells. Genome Research 25:12, pages 1860-1872.
Crossref
Kyung S. Lee, Terrence R. BurkeJrJr, Jung-Eun Park, Jeong K. Bang & Eunhye Lee. (2015) Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy. Trends in Pharmacological Sciences 36:12, pages 858-877.
Crossref
Neil D. Palmisiano & Margaret T. Kasner. (2015) Polo-like kinase and its inhibitors: Ready for the match to start?. American Journal of Hematology 90:11, pages 1071-1076.
Crossref
Karineh Kazazian, Olga Brashavitskaya, Francis S. W. Zih, David Berger-Richardson, Roland S. Z. Xu, Karina Pacholczyk, Jennifer Macmillan & Carol J. Swallow. (2015) Polo-Like Kinases in Colorectal Cancer: Potential for Targeted Therapy. Current Colorectal Cancer Reports 11:4, pages 187-199.
Crossref
Ju Hee Kim, Bonsu Ku, Kyung S. Lee & Seung Jun Kim. (2015) Structural analysis of the polo-box domain of human Polo-like kinase 2. Proteins: Structure, Function, and Bioinformatics 83:7, pages 1201-1208.
Crossref
Xiaoqi Liu. (2015) Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment. Translational Oncology 8:3, pages 185-195.
Crossref
LI YING LIU, WEI WANG, LING YU ZHAO, BO GUO, JUAN YANG, XIAO GE ZHAO, TU SHENG SONG, CHEN HUANG & JI RU XU. (2015) Silencing of polo-like kinase 2 increases cell proliferation and decreases apoptosis in SGC-7901 gastric cancer cells. Molecular Medicine Reports 11:4, pages 3033-3038.
Crossref
Sihem Zitouni, Catarina Nabais, Swadhin Chandra Jana, Adán Guerrero & Mónica Bettencourt-Dias. (2014) Polo-like kinases: structural variations lead to multiple functions. Nature Reviews Molecular Cell Biology 15:7, pages 433-452.
Crossref
Hyungshin Yim & Raymond L. Erikson. (2014) Plk1-targeted therapies in TP53- or RAS-mutated cancer. Mutation Research/Reviews in Mutation Research 761, pages 31-39.
Crossref
Elizabeth VillegasElena B. KabotyanskiAmy N. ShoreChad J. CreightonThomas F. WestbrookJeffrey M. Rosen. (2014) Plk2 regulates mitotic spindle orientation and mammary gland development. Development 141:7, pages 1562-1571.
Crossref
Su-Yeon Lee, Chuljoon Jang & Kyung-Ah Lee. (2014) Polo-Like Kinases (Plks), a Key Regulator of Cell Cycle and New Potential Target for Cancer Therapy. Development & Reproduciton 18:1, pages 65-71.
Crossref
Jeanette Schwarz, Stefanie Schmidt, Olga Will, Tomas Koudelka, Kaja Köhler, Melanie Boss, Björn Rabe, Andreas Tholey, Jürgen Scheller, Dirk Schmidt-Arras, Michael Schwake, Stefan Rose-John & Athena Chalaris. (2014) Polo-like Kinase 2, a Novel ADAM17 Signaling Component, Regulates Tumor Necrosis Factor α Ectodomain Shedding. Journal of Biological Chemistry 289:5, pages 3080-3093.
Crossref
M. Bergeron, R. Motter, P. Tanaka, D. Fauss, M. Babcock, S.-s. Chiou, S. Nelson, F. San Pablo & J.P. Anderson. (2014) In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 α-synuclein phosphorylation in mouse brain. Neuroscience 256, pages 72-82.
Crossref
Xinglu Huang, Fan Zhang, Xiaolian Sun, Ki-Young Choi, Gang Niu, Guofeng Zhang, Jinxia Guo, Seulki Lee & Xiaoyuan Chen. (2014) The genotype-dependent influence of functionalized multiwalled carbon nanotubes on fetal development. Biomaterials 35:2, pages 856-865.
Crossref
Danielle L. Aubele, Roy K. Hom, Marc Adler, Robert A. GalemmoJr.Jr., Simeon Bowers, Anh P. Truong, Hu Pan, Paul Beroza, R. Jeffrey Neitz, Nanhua Yao, May Lin, George Tonn, Heather Zhang, Michael P. Bova, Zhao Ren, Danny Tam, Lany Ruslim, Jeanne Baker, Linnea Diep, Kent Fitzgerald, Jennifer Hoffman, Ruth Motter, Donald Fauss, Pearl Tanaka, Michael Dappen, Jacek Jagodzinski, Wayman Chan, Andrei W. Konradi, Lee Latimer, Yong L. Zhu, Hing L. Sham, John P. Anderson, Marcelle Bergeron & Dean R. Artis. (2013) Selective and Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors That Reduce α-Synuclein Phosphorylation in Rat Brain. ChemMedChem 8:8, pages 1295-1313.
Crossref
Frank Louwen & Juping Yuan. (2013) Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy. Oncotarget 4:7, pages 958-971.
Crossref
Kent Fitzgerald, Marcelle Bergeron, Christopher Willits, Simeon Bowers, Danielle L. Aubele, Erich Goldbach, George Tonn, Daniel Ness & Andrew Olaharski. (2013) Pharmacological inhibition of Polo Like Kinase 2 (PLK2) does not cause chromosomal damage or result in the formation of micronuclei. Toxicology and Applied Pharmacology 269:1, pages 1-7.
Crossref
Jing Lu, Shengchang Xin, Huan Meng, Matt Veldman, David Schoenfeld, Chao Che, Ruibin Yan, Hanbing Zhong, Song Li & Shuo Lin. (2013) A Novel Anti-Tumor Inhibitor Identified by Virtual Screen with PLK1 Structure and Zebrafish Assay. PLoS ONE 8:4, pages e53317.
Crossref
Yusuke Mita, Tomomi Noguchi-Yachide, Minoru Ishikawa & Yuichi Hashimoto. (2013) Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton. Bioorganic & Medicinal Chemistry 21:3, pages 608-617.
Crossref
Jijing Luo & Xiaoqi Liu. (2012) Polo-like kinase 1, on the rise from cell cycle regulation to prostate cancer development. Protein & Cell 3:3, pages 182-197.
Crossref
Onur Cizmecioglu, Annekatrin Krause, Ramona Bahtz, Lena Ehret, Nisar Malek & Ingrid Hoffmann. (2012) Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4). Journal of Cell Science 125:4, pages 981-992.
Crossref
Tao Shen, Yan Li, Liqing Yang, Xiaojun Xu, Feng Liang, Shuang Liang, Gen Ba, Feng Xue & Qin Fu. (2012) Upregulation of Polo-like kinase 2 gene expression by GATA-1 acetylation in human osteosarcoma MG-63 cells. The International Journal of Biochemistry & Cell Biology 44:2, pages 423-429.
Crossref
PW Jordan, J Karppinen & MA Handel. (2012) Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes. Journal of Cell Science.
Crossref
Leonidas Benetatos, Aggeliki Dasoula, Eleftheria Hatzimichael, Nelofer Syed, Maria Voukelatou, George Dranitsaris, Konstantinos L. Bourantas & Tim Crook. (2011) Polo-like kinase 2 (SNK/PLK2) is a novel epigenetically regulated gene in acute myeloid leukemia and myelodysplastic syndromes: genetic and epigenetic interactions. Annals of Hematology 90:9, pages 1037-1045.
Crossref
Marcos Malumbres. (2011) Physiological Relevance of Cell Cycle Kinases. Physiological Reviews 91:3, pages 973-1007.
Crossref
Nelofer Syed, Helen M. Coley, Jalid Sehouli, Dominique Koensgen, Alexander Mustea, Peter Szlosarek, Iain McNeish, Sarah P. Blagden, Peter Schmid, David P. Lovell, Eleftheria Hatzimichael & Tim Crook. (2011) Polo-like Kinase Plk2 Is an Epigenetic Determinant of Chemosensitivity and Clinical Outcomes in Ovarian Cancer. Cancer Research 71:9, pages 3317-3327.
Crossref
Kea Joo Lee, Yeunkum Lee, Aaron Rozeboom, Ji-Yun Lee, Noriko Udagawa, Hyang-Sook Hoe & Daniel T.S. Pak. (2011) Requirement for Plk2 in Orchestrated Ras and Rap Signaling, Homeostatic Structural Plasticity, and Memory. Neuron 69:5, pages 957-973.
Crossref
Mokdad Mezna, George Kontopidis & Campbell McInnes. 2011. Protein Kinases as Drug Targets. Protein Kinases as Drug Targets 229 270 .
Klaus Strebhardt. (2010) Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy. Nature Reviews Drug Discovery 9:8, pages 643-660.
Crossref
Hua Sui, Xiao-guang Lu, Li-bin Zhan, Wan-zhen Jiang, Xin Qi, Xiao-yang Gong & Xin-ping Niu. (2010) Decreased expression of spine-associated Rap guanosine triphosphatase-activating protein (SPAR) in glutamate-treated primary hippocampal neurons. Journal of Clinical Neuroscience 17:8, pages 1042-1046.
Crossref
Tara R. Rheault, Kelly H. Donaldson, Jennifer G. Badiang-Alberti, Ronda G. Davis-Ward, C. Webb Andrews, Ramesh Bambal, Jeffrey R. Jackson & Mui Cheung. (2010) Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: Potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties. Bioorganic & Medicinal Chemistry Letters 20:15, pages 4587-4592.
Crossref
Jung-Eun Park, Nak-Kyun Soung, Yoshikazu Johmura, Young H. Kang, Chenzhong Liao, Kyung H. Lee, Chi Hoon Park, Marc C. Nicklaus & Kyung S. Lee. (2010) Polo-box domain: a versatile mediator of polo-like kinase function. Cellular and Molecular Life Sciences 67:12, pages 1957-1970.
Crossref
Zdenek Andrysik, William Z. Bernstein, Li Deng, David L. Myer, Ya-Qin Li, Jay A. Tischfield, Peter J. Stambrook & El Mustapha Bahassi. (2010) The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus. Nucleic Acids Research 38:9, pages 2931-2943.
Crossref
Yan Degenhardt & Thomas Lampkin. (2010) Targeting Polo-like Kinase in Cancer Therapy. Clinical Cancer Research 16:2, pages 384-389.
Crossref
Martial K. Mbefo, Katerina E. Paleologou, Ahmed Boucharaba, Abid Oueslati, Heinrich Schell, Margot Fournier, Diana Olschewski, Guowei Yin, Markus Zweckstetter, Eliezer Masliah, Philipp J. Kahle, Harald Hirling & Hilal A. Lashuel. (2010) Phosphorylation of Synucleins by Members of the Polo-like Kinase Family. Journal of Biological Chemistry 285:4, pages 2807-2822.
Crossref
Stephen J. Smerdon & Michael B. Yaffe. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 539 550 .
Wolfgang Reindl, Martin Gräber, Klaus Strebhardt & Thorsten Berg. (2009) Development of high-throughput assays based on fluorescence polarization for inhibitors of the polo-box domains of polo-like kinases 2 and 3. Analytical Biochemistry 395:2, pages 189-194.
Crossref
Takumi Matsumoto, Ping-yuan Wang, Wenzhe Ma, Ho Joong Sung, Satoaki Matoba & Paul M. Hwang. (2009) Polo-like kinases mediate cell survival in mitochondrial dysfunction. Proceedings of the National Academy of Sciences 106:34, pages 14542-14546.
Crossref
Wolfgang Reindl, Juping Yuan, Andrea Krämer, Klaus Strebhardt  & Thorsten Berg. (2009) A Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis. ChemBioChem 10:7, pages 1145-1148.
Crossref
Dorothea Rudolph, Martin Steegmaier, Matthias Hoffmann, Matthias Grauert, Anke Baum, Jens Quant, Christian Haslinger, Pilar Garin-Chesa & Günther R. Adolf. (2009) BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity. Clinical Cancer Research 15:9, pages 3094-3102.
Crossref
Keith R. Shockley, Oxana P. Lazarenko, Piotr J. Czernik, Clifford J. Rosen, Gary A. Churchill & Beata Lecka-Czernik. (2009) PPARγ2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells. Journal of Cellular Biochemistry 106:2, pages 232-246.
Crossref
Yali Yang, Jingxiang Bai, Rulong Shen, Sharron A.N. Brown, Elena Komissarova, Ying Huang, Ning Jiang, Gregory F. Alberts, Max Costa, Luo Lu, Jeffrey A. Winkles & Wei Dai. (2008) Polo-like Kinase 3 Functions as a Tumor Suppressor and Is a Negative Regulator of Hypoxia-Inducible Factor-1α under Hypoxic Conditions. Cancer Research 68:11, pages 4077-4085.
Crossref
Barbara C.M. van de Weerdt, Dene R. Littler, Rob Klompmaker, Angelina Huseinovic, Alex Fish, Anastassis Perrakis & René H. Medema. (2008) Polo-box domains confer target specificity to the Polo-like kinase family. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1783:6, pages 1015-1022.
Crossref
Daniel P. Seeburg, Monica Feliu-Mojer, Johanna Gaiottino, Daniel T.S. Pak & Morgan Sheng. (2008) Critical Role of CDK5 and Polo-like Kinase 2 in Homeostatic Synaptic Plasticity during Elevated Activity. Neuron 58:4, pages 571-583.
Crossref
Svetlana I. Novikova, Fang He, Jie Bai, Nicholas J. Cutrufello, Michael S. Lidow & Ashiwel S. Undieh. (2008) Maternal Cocaine Administration in Mice Alters DNA Methylation and Gene Expression in Hippocampal Neurons of Neonatal and Prepubertal Offspring. PLoS ONE 3:4, pages e1919.
Crossref
Jernej Kristl, Petra Slanc, Metka Krašna, Aleš Berlec, Matjaž Jeras & Borut Štrukelj. (2007) Calcipotriol Affects Keratinocyte Proliferation by Decreasing Expression of Early Growth Response-1 and Polo-like Kinase-2. Pharmaceutical Research 25:3, pages 521-529.
Crossref
Yuichi NishiEric RogersScott M. RobertsonRueyling Lin. (2008) Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6 . Development 135:4, pages 687-697.
Crossref
Michael Kothe, Darcy Kohls, Simon Low, Rocco Coli, Glen R. Rennie, Frederic Feru, Cyrille Kuhn & Yuan-Hua Ding. (2007) Selectivity-determining Residues in Plk1. Chemical Biology & Drug Design 70:6, pages 540-546.
Crossref
Travis L. Schmit & Nihal Ahmad. (2007) Regulation of mitosis via mitotic kinases: new opportunities for cancer management. Molecular Cancer Therapeutics 6:7, pages 1920-1931.
Crossref
Kristin L.M. Boylan, Mary A. Gosse, Sarah E. Staggs, Siegfried Janz, Suzanne Grindle, Geoffrey S. Kansas & Brian G. Van Ness. (2007) A Transgenic Mouse Model of Plasma Cell Malignancy Shows Phenotypic, Cytogenetic, and Gene Expression Heterogeneity Similar to Human Multiple Myeloma. Cancer Research 67:9, pages 4069-4078.
Crossref
Sean M. O'Donnell, Geoffrey H. Holm, Janene M. Pierce, Bing Tian, Melissa J. Watson, Ravi S. Chari, Dean W. Ballard, Allan R. Brasier & Terence S. Dermody. (2006) Identification of an NF-κB-Dependent Gene Network in Cells Infected by Mammalian Reovirus. Journal of Virology 80:3, pages 1077-1086.
Crossref
Nelofer Syed, Paul Smith, Alexandra Sullivan, Lindsay C. Spender, Martin Dyer, Lorraine Karran, Jenny O'Nions, Martin Allday, Ingrid Hoffmann, Dorothy Crawford, Beverley Griffin, Paul J. Farrell & Tim Crook. (2006) Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies . Blood 107:1, pages 250-256.
Crossref
Adam G. Eldridge, Alexander V. Loktev, David V. Hansen, Emmy W. Verschuren, Julie D.R. Reimann & Peter K. Jackson. (2006) The Evi5 Oncogene Regulates Cyclin Accumulation by Stabilizing the Anaphase-Promoting Complex Inhibitor Emi1. Cell 124:2, pages 367-380.
Crossref
Satomi Yogosawa, Shigetsugu Hatakeyama, Keiichi I. Nakayama, Hiroyuki Miyoshi, Shinichi Kohsaka & Chihiro Akazawa. (2005) Ubiquitylation and Degradation of Serum-inducible Kinase by hVPS18, a RING-H2 Type Ubiquitin Ligase. Journal of Biological Chemistry 280:50, pages 41619-41627.
Crossref
Robert Habedanck, York-Dieter Stierhof, Christopher J. Wilkinson & Erich A. Nigg. (2005) The Polo kinase Plk4 functions in centriole duplication. Nature Cell Biology 7:11, pages 1140-1146.
Crossref
Shannon Reagan-Shaw & Nihal Ahmad. (2005) Polo-like kinase (Plk) 1 as a target for prostate cancer management. IUBMB Life (International Union of Biochemistry and Molecular Biology: Life) 57:10, pages 677-682.
Crossref
Zebo Huang & Alan Tunnacliffe. (2005) Gene induction by desiccation stress in human cell cultures. FEBS Letters 579:22, pages 4973-4977.
Crossref
Erica D. Watson & James C. Cross. (2005) Development of Structures and Transport Functions in the Mouse Placenta. Physiology 20:3, pages 180-193.
Crossref
Elizabeth J. Ryu, James M. Angelastro & Lloyd A. Greene. (2005) Analysis of gene expression changes in a cellular model of Parkinson disease. Neurobiology of Disease 18:1, pages 54-74.
Crossref
Daniel P Seeburg, Daniel Pak & Morgan Sheng. (2005) Polo-like kinases in the nervous system. Oncogene 24:2, pages 292-298.
Crossref
Frank Eckerdt, Juping Yuan & Klaus Strebhardt. (2005) Polo-like kinases and oncogenesis. Oncogene 24:2, pages 267-276.
Crossref
Jeffrey A Winkles & Gregory F Alberts. (2005) Differential regulation of polo-like kinase 1, 2, 3, and 4 gene expression in mammalian cells and tissues. Oncogene 24:2, pages 260-266.
Crossref
Wilma L. Lingle, Kara Lukasiewicz & Jeffrey L. Salisbury. 2005. Genome Instability in Cancer Development. Genome Instability in Cancer Development 393 421 .
Silke Warnke, Stefan Kemmler, Rebecca S Hames, Hsiao-Lun Tsai, Urs Hoffmann-Rohrer, Andrew M Fry & Ingrid Hoffmann. (2004) Polo-like Kinase-2 Is Required for Centriole Duplication in Mammalian Cells. Current Biology 14:13, pages 1200-1207.
Crossref
Francis A. Barr, Herman H. W. Silljé & Erich A. Nigg. (2004) Polo-like kinases and the orchestration of cell division. Nature Reviews Molecular Cell Biology 5:6, pages 429-441.
Crossref

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