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Cell Growth and Development

c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-XL

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Pages 7256-7270 | Received 24 Mar 2003, Accepted 11 Jul 2003, Published online: 27 Mar 2023

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Andreas Höglund, Kerstin Strömvall, Yongmei Li, Linus Plym Forshell & Jonas A. Nilsson. (2011) Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition. Cell Cycle 10:20, pages 3598-3607.
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Yu-Zhen Li, Dao-Yuan Lu, Wei-Qi Tan, Jian-Xun Wang & Pei-Feng Li. (2008) p53 Initiates Apoptosis by Transcriptionally Targeting the Antiapoptotic Protein ARC. Molecular and Cellular Biology 28:2, pages 564-574.
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Shala Dezfouli, Antony Bakke, Jie Huang, Anthony Wynshaw-Boris & Peter J. Hurlin. (2006) Inflammatory Disease and Lymphomagenesis Caused by Deletion of the Myc Antagonist Mnt in T Cells. Molecular and Cellular Biology 26:6, pages 2080-2092.
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David J. Adams, Louise van der Weyden, Fanni V. Gergely, Mark J. Arends, Bee Ling Ng, David Tannahill, Roland Kanaar, Andrea Markus, Brian J. Morris & Allan Bradley. (2005) BRCTx Is a Novel, Highly Conserved RAD18-Interacting Protein. Molecular and Cellular Biology 25:2, pages 779-788.
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M. Stacey Ricci, Zhaoyu Jin, Michael Dews, Duonan Yu, Andrei Thomas-Tikhonenko, David T. Dicker & Wafik S. El-Deiry. (2004) Direct Repression of FLIP Expression by c-myc Is a Major Determinant of TRAIL Sensitivity. Molecular and Cellular Biology 24:19, pages 8541-8555.
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Jonas A. Nilsson, Kirsteen H. Maclean, Ulrich B. Keller, Helene Pendeville, Troy A. Baudino & John L. Cleveland. (2004) Mnt Loss Triggers Myc Transcription Targets, Proliferation, Apoptosis, and Transformation. Molecular and Cellular Biology 24:4, pages 1560-1569.
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Yuanle Deng, Sha Li, Meng Wang, Xiaotong Chen, Li Tian, Liqun Wang, Wenyu Yang, Lezhang Chen, Fang He & Wenya Yin. (2020) Flavonoid-rich extracts from okra flowers exert antitumor activity in colorectal cancer through induction of mitochondrial dysfunction-associated apoptosis, senescence and autophagy. Food & Function 11:12, pages 10448-10466.
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Chunhua Huang, Yan Zhang, Hongli Qi, Xintan Xu, Lin Yang & Jianjun Wang. (2020) Myc is involved in Genistein protecting against LPS-induced myocarditis in vitro through mediating MAPK/JNK signaling pathway . Bioscience Reports 40:6.
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Aileen Kim, Philip Stevenson, Ryan D. Cassaday, Lori Soma, Jonathan R. Fromm, Ajay K. Gopal, Stephen D. Smith, Brian Till, Ryan C. Lynch, Chaitra Ujjani, Mazyar Shadman, Edus H. Warren, Manoj Menon, Kenneth Russell & Yolanda D. Tseng. (2020) Impact of Double- or Triple-Hit Pathology on Rates and Durability of Radiation Therapy Response Among Patients With Relapsed or Refractory Large B-Cell Lymphoma. Practical Radiation Oncology 10:1, pages 44-52.
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Dan Xu, Bao Wang, Pan-pan Chen, Yan-zhe Wang, Nai-jun Miao, Fan Yin, Qian Cheng, Zhuan-li Zhou, Hong-yan Xie, Li Zhou, Jun Liu, Xiao-xia Wang, Hong Xue, Wei Zhang & Li-min Lu. (2018) c-Myc promotes tubular cell apoptosis in ischemia-reperfusion-induced renal injury by negatively regulating c-FLIP and enhancing FasL/Fas-mediated apoptosis pathway. Acta Pharmacologica Sinica 40:8, pages 1058-1066.
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Sofia S Pereira, Mariana P Monteiro, Sonir R Antonini & Duarte Pignatelli. (2019) Apoptosis regulation in adrenocortical carcinoma. Endocrine Connections 8:5, pages R91-R104.
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Jia Wang, Zheng Sun, Shihai Yan & Feng Gao. (2019) Effect of miR‑145 on gastric cancer cells. Molecular Medicine Reports.
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Anna Evgen'evna Misyurina, S.K. Kravchenko, V.A. Misyurin, A.M. Kovrigina, A.U. Magomedova, E.A. Baryakh, F.E. Babaeva & A.V. Misyurin. (2019) TP53 Gene Mutations in Tumor Cells of Patients with Aggressive B-Cell Lymphomas. Clinical oncohematology 12:3, pages 263-270.
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Sofia Aakko, Anne Hege Straume, Einar Elvbakken Birkeland, Ping Chen, Xi Qiao, Per Eystein' 'Lønning & Marko J. Kallio. (2019) MYC-Induced miR-203b-3p and miR-203a-3p Control Bcl-xL Expression and Paclitaxel Sensitivity in Tumor Cells. Translational Oncology 12:1, pages 170-179.
Crossref
Man Yu, Ting Liu, Yicheng Chen, Yafang Li & Wenhua Li. (2018) Combination therapy with protein kinase inhibitor H89 and Tetrandrine elicits enhanced synergistic antitumor efficacy. Journal of Experimental & Clinical Cancer Research 37:1.
Crossref
J.A. Jones, F. Karouia, O. Cristea, R.C. Casey, D. Popov & V. Maliev. 2018. Comprehensive Toxicology. Comprehensive Toxicology 183 225 .
Leah Fitzsimmons & Gemma Kelly. (2017) EBV and Apoptosis: The Viral Master Regulator of Cell Fate?. Viruses 9:11, pages 339.
Crossref
Joshua R. Porter, Brian E. Fisher, Laura Baranello, Julia C. Liu, Diane M. Kambach, Zuqin Nie, Woo Seuk Koh, Ji Luo, Jayne M. Stommel, David Levens & Eric Batchelor. (2017) Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response. Molecular Cell 67:6, pages 1013-1025.e9.
Crossref
Zhengfei Shan, Qingzuo Liu, Yuling Li, Jitao Wu, Dekang Sun & Zhenli Gao. (2017) PUMA decreases the growth of prostate cancer PC-3 cells independent of p53. Oncology Letters 13:3, pages 1885-1890.
Crossref
Eva Bauer, Michaela Schlederer, Ruth Scheicher, Jaqueline Horvath, Petra Aigner, Ana-Iris Schiefer, Renate Kain, Heinz Regele, Gregor Hoermann, Günter Steiner, Lukas Kenner, Veronika Sexl, Andreas Villunger, Richard Moriggl & Dagmar Stoiber. (2016) Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice. Oncotarget 7:11, pages 12191-12205.
Crossref
Ferenc Sipos, Gábor Firneisz & Györgyi Műzes. (2016) Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases. World Journal of Gastroenterology 22:35, pages 7938.
Crossref
Theresia R. Kress, Arianna Sabò & Bruno Amati. (2015) MYC: connecting selective transcriptional control to global RNA production. Nature Reviews Cancer 15:10, pages 593-607.
Crossref
Fengmei Cui, Rong Fan, Qiu Chen, Yongming He, Man Song, Zengfu Shang, Shimeng Zhang, Wei Zhu, Jianping Cao, Hua Guan & Ping-Kun Zhou. (2015) The involvement of c-Myc in the DNA double-strand break repair via regulating radiation-induced phosphorylation of ATM and DNA-PKcs activity. Molecular and Cellular Biochemistry 406:1-2, pages 43-51.
Crossref
Chien-An A. Hu, Kirsten White, Salina Torres, Mohammed-Ali Ishak, Laurel Sillerud, Yubin Miao, Zhihe Liu, Zhenglong Wu, Larry Sklar & Marianne Berwick. 2015. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging 161 181 .
Tobias Dechow, Sabine Steidle, Katharina S. Götze, Martina Rudelius, Kerstin Behnke, Konstanze Pechloff, Susanne Kratzat, Lars Bullinger, Falko Fend, Valeria Soberon, Nadya Mitova, Zhoulei Li, Markus Thaler, Jan Bauer, Elke Pietschmann, Corinna Albers, Rebekka Grundler, Marc Schmidt-Supprian, Jürgen Ruland, Christian Peschel, Justus Duyster, Stefan Rose-John, Florian Bassermann & Ulrich Keller. (2014) GP130 activation induces myeloma and collaborates with MYC. Journal of Clinical Investigation 124:12, pages 5263-5274.
Crossref
Chengyao Xie, Yongqi Pan, Fengxia Hao, Yuan Gao, Zan Liu, Xiuwei Zhang, Lingling Xie, Guiyang Jiang, Qingchang Li & Enhua Wang. (2014) C-Myc participates in β-catenin-mediated drug resistance in A549/DDP lung adenocarcinoma cells. APMIS 122:12, pages 1251-1258.
Crossref
Nathiya Muthalagu, Melissa R. Junttila, Katrin E. Wiese, Elmar Wolf, Jennifer Morton, Barbara Bauer, Gerard I. Evan, Martin Eilers & Daniel J. Murphy. (2014) BIM Is the Primary Mediator of MYC-Induced Apoptosis in Multiple Solid Tissues. Cell Reports 8:5, pages 1347-1353.
Crossref
T J Phesse, K B Myant, A M Cole, R A Ridgway, H Pearson, V Muncan, G R van den Brink, K H Vousden, R Sears, L T Vassilev, A R Clarke & O J Sansom. (2014) Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo. Cell Death & Differentiation 21:6, pages 956-966.
Crossref
Concetta Bubici & Salvatore Papa. (2014) JNK signalling in cancer: in need of new, smarter therapeutic targets. British Journal of Pharmacology 171:1, pages 24-37.
Crossref
Gabriel J. Sandoval, Daniel B. Graham, Deepta Bhattacharya, Barry P. Sleckman, Ramnik J. Xavier & Wojciech Swat. (2013) Cutting Edge: Cell-Autonomous Control of IL-7 Response Revealed in a Novel Stage of Precursor B Cells. The Journal of Immunology 190:6, pages 2485-2489.
Crossref
S Catuogno, L Cerchia, G Romano, P Pognonec, G Condorelli & V de Franciscis. (2012) miR-34c may protect lung cancer cells from paclitaxel-induced apoptosis. Oncogene 32:3, pages 341-351.
Crossref
Loning Fu & Nicole M. Kettner. 2013. Chronobiology: Biological Timing in Health and Disease. Chronobiology: Biological Timing in Health and Disease 221 282 .
J-S Kim, B-S Song, K-S Lee, D-H Kim, S-U Kim, Y-K Choo, K-T Chang & D-B Koo. (2012) Tauroursodeoxycholic Acid Enhances the Pre-Implantation Embryo Development by Reducing Apoptosis in Pigs. Reproduction in Domestic Animals 47:5, pages 791-798.
Crossref
Jing Fan, Yun-wei Ou, Chuan-yue Wu, Chun-jiang Yu, Yong-mei Song & Qi-min Zhan. (2012) Migfilin sensitizes cisplatin-induced apoptosis in human glioma cells in vitro. Acta Pharmacologica Sinica 33:10, pages 1301-1310.
Crossref
Juliette Thariat, Antoine Italiano, Fabrice Collin, Antoine Iannessi, Pierre-Yves Marcy, Alexis Lacout, Isabelle Birtwisle-Peyrottes, Antoine Thyss & Jean-Léon Lagrange. (2012) Not all sarcomas developed in irradiated tissue are necessarily radiation-induced – Spectrum of disease and treatment characteristics. Critical Reviews in Oncology/Hematology 83:3, pages 393-406.
Crossref
Yuexia Xie, Jianghong Zhang, Shuang Ye, Mingyuan He, Ruiping Ren, Dexiao Yuan & Chunlin Shao. (2012) SirT1 regulates radiosensitivity of hepatoma cells differently under normoxic and hypoxic conditions. Cancer Science 103:7, pages 1238-1244.
Crossref
Antoine Italiano, Angela Cioffi, Nicolas Penel, Matteo Giaj Levra, Corinne Delcambre, Elsa Kalbacher, Christine Chevreau, François Bertucci, Nicolas Isambert, Jean-Yves Blay, Binh Bui, Cristina Antonescu, David R. D'Adamo, Robert G. Maki & Mary Louise Keohan. (2012) Comparison of doxorubicin and weekly paclitaxel efficacy in metastatic angiosarcomas. Cancer 118:13, pages 3330-3336.
Crossref
André O von Bueren, Christoph Oehler, Tarek Shalaby, Katja von Hoff, Martin Pruschy, Burkhardt Seifert, Nicolas U Gerber, Monika Warmuth-Metz, Duncan Stearns, Charles G Eberhart, Rolf D Kortmann, Stefan Rutkowski & Michael A Grotzer. (2011) c-MYC expression sensitizes medulloblastoma cells to radio- and chemotherapy and has no impact on response in medulloblastoma patients. BMC Cancer 11:1.
Crossref
Andreas Höglund, Lisa M. Nilsson, Somsundar Veppil Muralidharan, Lisa A. Hasvold, Philip Merta, Martina Rudelius, Viktoriya Nikolova, Ulrich Keller & Jonas A. Nilsson. (2011) Therapeutic Implications for the Induced Levels of Chk1 in Myc-Expressing Cancer Cells. Clinical Cancer Research 17:22, pages 7067-7079.
Crossref
Christian SchusterAngelika BergerMaria A. HoelzlEva M. PutzAnna FrenzelOlivia SimmaNadine MoritzAndrea HoelblBoris Kovacic, Michael FreissmuthMathias MüllerAndreas VillungerLeonard MüllauerAna-Iris SchmatzBerthold StreubelEdit Porpaczy, Ulrich Jäger, Dagmar Stoiber & Veronika Sexl. (2011) The cooperating mutation or “second hit” determines the immunologic visibility toward MYC-induced murine lymphomas. Blood 118:17, pages 4635-4645.
Crossref
Wataru Nakajima & Nobuyuki Tanaka. (2011) Noxa induces apoptosis in oncogene-expressing cells through catch-and-release mechanism operating between Puma and Mcl-1. Biochemical and Biophysical Research Communications 413:4, pages 643-648.
Crossref
Theresia R. Kress, Ian G. Cannell, Arjan B. Brenkman, Birgit Samans, Matthias Gaestel, Paul Roepman, Boudewijn M. Burgering, Martin Bushell, Andreas Rosenwald & Martin Eilers. (2011) The MK5/PRAK Kinase and Myc Form a Negative Feedback Loop that Is Disrupted during Colorectal Tumorigenesis. Molecular Cell 41:4, pages 445-457.
Crossref
Jurate Savickiene, Grazina Treigyte, Ceslava Aleksandraviciene & Ruta Navakauskiene. (2010) Low-dose ionizing radiation effects on differentiation of HL-60 cells. Open Life Sciences 5:5, pages 600-612.
Crossref
Jennifer B. Old, Susanne Kratzat, Alexander Hoellein, Steffi Graf, Jonas A. Nilsson, Lisa Nilsson, Keiichi I. Nakayama, Christian Peschel, John L. Cleveland & Ulrich B. Keller. (2010) Skp2 Directs Myc-Mediated Suppression of p27Kip1 yet Has Modest Effects on Myc-Driven Lymphomagenesis. Molecular Cancer Research 8:3, pages 353-362.
Crossref
Kristopher A. SarosiekRaquel MalumbresHovav NechushtanAndrew J. Gentles, Eli Avisar & Izidore S. Lossos. (2010) Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas. Blood 115:3, pages 570-580.
Crossref
J.A. Jones, R.C. Casey & F. Karouia. 2010. Comprehensive Toxicology. Comprehensive Toxicology 181 228 .
André O von Bueren, Tarek Shalaby, Christoph Oehler-Jänne, Lucia Arnold, Duncan Stearns, Charles G Eberhart, Alexandre Arcaro, Martin Pruschy & Michael A Grotzer. (2009) RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells. BMC Cancer 9:1.
Crossref
Jean-Philippe Cosse, Marie Ronvaux, Noëlle Ninane, Martine J. Raes & Carine Michiels. (2009) Hypoxia-Induced Decrease in p53 Protein Level and Increase in c-jun DNA Binding Activity Results in Cancer Cell Resistance to Etoposide. Neoplasia 11:10, pages 976-IN3.
Crossref
Thomas G. Cotter. (2009) Apoptosis and cancer: the genesis of a research field. Nature Reviews Cancer 9:7, pages 501-507.
Crossref
Yunyuan V. Wang, Mathias Leblanc, Mark Wade, Aart G. Jochemsen & Geoffrey M. Wahl. (2009) Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases. Cancer Cell 16:1, pages 33-43.
Crossref
E M Michalak, E S Jansen, L Happo, M S Cragg, L Tai, G K Smyth, A Strasser, J M Adams & C L Scott. (2009) Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis. Cell Death & Differentiation 16:5, pages 684-696.
Crossref
Andreas Höglund, Lisa M. Nilsson, Linus Plym Forshell, Kirsteen H. Maclean & Jonas A. Nilsson. (2009) Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine. Blood 113:18, pages 4281-4288.
Crossref
Crissy Dudgeon, Wei Qiu, Quanhong Sun, Lin Zhang & Jian Yu. 2009. Essentials of Apoptosis. Essentials of Apoptosis 239 260 .
Sefat E. Khuda, William M. Loo, Siegfried Janz, Brian Van Ness & Loren D. Erickson. (2008) Deregulation of c-Myc Confers Distinct Survival Requirements for Memory B Cells, Plasma Cells, and Their Progenitors. The Journal of Immunology 181:11, pages 7537-7549.
Crossref
J Yu & L Zhang. (2009) PUMA, a potent killer with or without p53. Oncogene 27:S1, pages S71-S83.
Crossref
Natalie Meyer & Linda Z. Penn. (2008) Reflecting on 25 years with MYC. Nature Reviews Cancer 8:12, pages 976-990.
Crossref
B Hoffman & D A Liebermann. (2008) Apoptotic signaling by c-MYC. Oncogene 27:50, pages 6462-6472.
Crossref
Steffan T. NawrockiJennifer S. CarewKirsteen H. MacleanJames F. CouragePeng HuangJanet A. HoughtonJohn L. Cleveland, Francis J. GilesDavid J. McConkey. (2008) Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA. Blood 112:7, pages 2917-2926.
Crossref
Maryam Niapour, Yongmao Yu & Stuart A. Berger. (2008) Regulation of Calpain Activity by c-Myc through Calpastatin and Promotion of Transformation in c-Myc-negative Cells by Calpastatin Suppression. Journal of Biological Chemistry 283:31, pages 21371-21381.
Crossref
Yi Ding, Shiqian Shen, Andreia C Lino, Maria A Curotto de Lafaille & Juan J Lafaille. (2008) Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells. Nature Medicine 14:2, pages 162-169.
Crossref
Yunqing Li, Fadila Guessous, Elizabeth B Johnson, Charles G Eberhart, Xiao-Nan Li, Qing Shu, Shongshan Fan, Bachchu Lal, John Laterra, David Schiff & Roger Abounader. (2008) Functional and molecular interactions between the HGF/c-Met pathway and c-Myc in large-cell medulloblastoma. Laboratory Investigation 88:2, pages 98-111.
Crossref
Kirsteen H. Maclean, Frank C. Dorsey, John L. Cleveland & Michael B. Kastan. (2008) Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. Journal of Clinical Investigation 118:1, pages 79-88.
Crossref
Won Je JeonSe Hyun KimMyoung Suk SeoYeni KimUng Gu KangYong-Sung JuhnnYong Sik Kim. (2008) Repeated electroconvulsive seizure induces c-Myc down-regulation and Bad inactivation in the rat frontal cortex. Experimental and Molecular Medicine 40:4, pages 435.
Crossref
T Sumi, N Tsuneyoshi, N Nakatsuji & H Suemori. (2007) Apoptosis and differentiation of human embryonic stem cells induced by sustained activation of c-Myc. Oncogene 26:38, pages 5564-5576.
Crossref
Mariia Yuneva, Nicola Zamboni, Peter Oefner, Ravi Sachidanandam & Yuri Lazebnik. (2007) Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. The Journal of Cell Biology 178:1, pages 93-105.
Crossref
Kirsteen H. Maclean, Michael B. Kastan & John L. Cleveland. (2007) Atm Deficiency Affects Both Apoptosis and Proliferation to Augment Myc-Induced Lymphomagenesis . Molecular Cancer Research 5:7, pages 705-711.
Crossref
Ulrich B Keller, Jennifer B Old, Frank C Dorsey, Jonas A Nilsson, Lisa Nilsson, Kirsteen H MacLean, Linda Chung, Chunying Yang, Charles Spruck, Kelli Boyd, Steven I Reed & John L Cleveland. (2007) Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis. The EMBO Journal 26:10, pages 2562-2574.
Crossref
L M Nilsson, U B Keller, C Yang, J A Nilsson, J L Cleveland & M F Roussel. (2006) Ink4c is dispensable for tumor suppression in Myc-induced B-cell lymphomagenesis. Oncogene 26:20, pages 2833-2839.
Crossref
Hector BiliranJr.Jr., Sanjeev Banerjee, Archana Thakur, Fazlul H. Sarkar, Aliccia Bollig, Fakhara Ahmed, Jiusheng Wu, Yuan Sun & Joshua D. Liao. (2007) c-Myc–Induced Chemosensitization Is Mediated by Suppression of Cyclin D1 Expression and Nuclear Factor-κB Activity in Pancreatic Cancer Cells. Clinical Cancer Research 13:9, pages 2811-2821.
Crossref
Anni I Nieminen, Johanna I Partanen, Annika Hau & Juha Klefstrom. (2007) c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis. The EMBO Journal 26:4, pages 1055-1067.
Crossref
Jagruti H. Patel & Steven B. McMahon. (2007) BCL2 Is a Downstream Effector of MIZ-1 Essential for Blocking c-MYC-induced Apoptosis. Journal of Biological Chemistry 282:1, pages 5-13.
Crossref
Ami Albihn, Jakob Lovén, Johan Ohlsson, Lyda M. Osorio & Marie Henriksson. (2006) c-Myc-dependent etoposide-induced apoptosis involves activation of Bax and caspases, and PKCdelta signaling. Journal of Cellular Biochemistry 98:6, pages 1597-1614.
Crossref
V Labi, M Erlacher, S Kiessling & A Villunger. (2006) BH3-only proteins in cell death initiation, malignant disease and anticancer therapy. Cell Death & Differentiation 13:8, pages 1325-1338.
Crossref
Natalie Meyer, Sam S. Kim & Linda Z. Penn. (2006) The Oscar-worthy role of Myc in apoptosis. Seminars in Cancer Biology 16:4, pages 275-287.
Crossref
Kirsteen H. Maclean & John L. Cleveland. 2010. Childhood Leukemias. Childhood Leukemias 339 361 .
Yuzuru Shiio, Kwang S. Suh, Hookeun Lee, Stuart H. Yuspa, Robert N. Eisenman & Ruedi Aebersold. (2006) Quantitative Proteomic Analysis of Myc-induced Apoptosis. Journal of Biological Chemistry 281:5, pages 2750-2756.
Crossref
Barbara Benassi, Maurizio Fanciulli, Francesco Fiorentino, Alessandro Porrello, Giovanna Chiorino, Massimo Loda, Gabriella Zupi & Annamaria Biroccio. (2006) c-Myc Phosphorylation Is Required for Cellular Response to Oxidative Stress. Molecular Cell 21:4, pages 509-519.
Crossref
Jonas A. Nilsson & John L. Cleveland. 2006. Polyamine Cell Signaling. Polyamine Cell Signaling 249 266 .
Michael Wirtenberger, Kari Hemminki, Asta Försti, Rüdiger Klaes, Rita K. Schmutzler, Ewa Grzybowska, Justo L. Bermejo, Barbara Wappenschmidt, Peter Bugert, Dorota Butkiewicz, Jolanta Pamula, Wioletta Pekala, Helena Zientek, Claus R. Bartram & Barbara Burwinkel. (2005) c-MYC Asn11Ser is associated with increased risk for familial breast cancer. International Journal of Cancer 117:4, pages 638-642.
Crossref
Charles Christopher Henderson, Zhongqiu Zhang, Scott Ryan Manson, Jacob Joseph Riehm, Masaaki Kataoka, Melvin Wayne Flye, Joel Richard Garbow, Ming You & Steven Jay Weintraub. (2005) A moderate reduction of Bcl-xL expression protects against tumorigenesis; however, it also increases susceptibility to tissue injury. Oncogene 24:47, pages 7120-7124.
Crossref
Ulrich Keller, Jonas A Nilsson, Kirsteen H Maclean, Jennifer B Old & John L Cleveland. (2005) Nfkb1 is dispensable for Myc-induced lymphomagenesis. Oncogene 24:41, pages 6231-6240.
Crossref
Michael T. Hemann, Anka Bric, Julie Teruya-Feldstein, Andreas Herbst, Jonas A. Nilsson, Carlos Cordon-Cardo, John L. Cleveland, William P. Tansey & Scott W. Lowe. (2005) Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature 436:7052, pages 807-811.
Crossref
Lakita G. Cavin, Fang Wang, Valentina M. Factor, Swayamjot Kaur, Manickam Venkatraman, Snorri S. Thorgeirsson & Marcello Arsura. (2005) Transforming Growth Factor-α Inhibits the Intrinsic Pathway of c-Myc-Induced Apoptosis through Activation of Nuclear Factor-κB in Murine Hepatocellular Carcinomas. Molecular Cancer Research 3:7, pages 403-412.
Crossref
Jonas A. Nilsson, Ulrich B. Keller, Troy A. Baudino, Chunying Yang, Sara Norton, Jennifer A. Old, Lisa M. Nilsson, Geoffrey Neale, Debora L. Kramer, Carl W. Porter & John L. Cleveland. (2005) Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation. Cancer Cell 7:5, pages 433-444.
Crossref
Ira SKVORTSOVA, Bela-Andre POPPER, Sergej SKVORTSOV, Maria SAURER, Thomas AUER, Robert MOSER, Hans KAMLEITNER, Heinz ZWIERZINA & Peter LUKAS. (2005) Pretreatment with Rituximab Enhances Radiosensitivity of Non-Hodgkin's Lymphoma Cells. Journal of Radiation Research 46:2, pages 241-248.
Crossref
Levi J. Beverly & Anthony J. Capobianco. (2004) Targeting promiscuous signaling pathways in cancer: another Notch in the bedpost. Trends in Molecular Medicine 10:12, pages 591-598.
Crossref
Jonas A. Nilsson, Lisa M. Nilsson, Ulrich Keller, Yoshifumi Yokota, Kelli Boyd & John L. Cleveland. (2004) Id2 Is Dispensable for Myc-Induced Lymphomagenesis. Cancer Research 64:20, pages 7296-7301.
Crossref
David R. Hipfner & Stephen M. Cohen. (2004) Connecting proliferation and apoptosis in development and disease. Nature Reviews Molecular Cell Biology 5:10, pages 805-815.
Crossref
Rozita Bagheri-Yarmand, Amjad H. Talukder, Rui-An Wang, Ratna K. Vadlamudi & Rakesh Kumar. (2004) Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis. Development 131:14, pages 3469-3479.
Crossref
Wan Cheung Cheung, Joong Su Kim, Michael Linden, Liangping Peng, Brian Van Ness, Roberto D. Polakiewicz & Siegfried Janz. (2004) Novel targeted deregulation of c-Myc cooperates with Bcl-XL to cause plasma cell neoplasms in mice. Journal of Clinical Investigation 113:12, pages 1763-1773.
Crossref
Peter J. Hurlin & Shala Dezfouli. 2004. 183 226 .
Jonas A Nilsson & John L Cleveland. (2003) Myc pathways provoking cell suicide and cancer. Oncogene 22:56, pages 9007-9021.
Crossref

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