23
Views
83
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Death Receptor-Induced Activation of Initiator Caspase 8 Is Antagonized by Serine/Threonine Kinase PAK4

&
Pages 7838-7848 | Received 23 Dec 2002, Accepted 30 Jul 2003, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Haleh Sadat Tavakkol Afshari, Masoud Homayouni Tabrizi, Touran Ardalan, Neda Jalili Anoushirvani & Roya Mahdizadeh. (2022) Anethum Graveolens Essential Oil Nanoemulsions (AGEO-NE) as an Exclusive Apoptotic Inducer in Human Lung Adenocarcinoma (A549) Cells. Nutrition and Cancer 74:4, pages 1411-1419.
Read now
Hanxun Wang, Peilu Song, Yinli Gao, Lanlan Shen, Hanqin Xu, Jian Wang & Maosheng Cheng. (2021) Drug discovery targeting p21-activated kinase 4 (PAK4): a patent review. Expert Opinion on Therapeutic Patents 31:11, pages 977-987.
Read now
Chetan K Rane & Audrey Minden. (2014) P21 activated kinases. Small GTPases 5:1.
Read now
Audrey Minden. (2012) PAK4–6 in cancer and neuronal development. Cellular Logistics 2:2, pages 95-104.
Read now

Articles from other publishers (79)

Wei‐En Yang, Yi‐Tzu Chen, Chun‐Wen Su, Mu‐Kuan Chen, Chia‐Ming Yeh, Yen‐Lin Chen, Meng‐Ying Tsai, Shun‐Fa Yang & Chiao‐Wen Lin. (2023) Hispolon induces apoptosis in oral squamous cell carcinoma cells through JNK / HO ‐1 pathway activation . Journal of Cellular and Molecular Medicine 27:9, pages 1250-1260.
Crossref
Hiroshi Ueda. (2023) Prothymosin α Plays Role as a Brain Guardian through Ecto-F1 ATPase-P2Y12 Complex and TLR4/MD2. Cells 12:3, pages 496.
Crossref
Dalia H. El-Kashef & Haitham M. Sewilam. (2023) Empagliflozin mitigates methotrexate-induced hepatotoxicity: Targeting ASK-1/JNK/Caspase-3 pathway. International Immunopharmacology 114, pages 109494.
Crossref
Md. Mozibullah & Md. Junaid. (2023) Biological role of the PAK4 signaling pathway: A prospective therapeutic target for multivarious cancers. Arabian Journal of Chemistry 16:1, pages 104438.
Crossref
Jeremy M. Kelm, Hariprasad Aruri, Prasanth R. Nyalapatla & Navnath S. Gavande. 2023. Fused Pyrimidine-Based Drug Discovery. Fused Pyrimidine-Based Drug Discovery 165 191 .
Yixi Yuan, Hongyan Zhang, Danni Li, Ying Li, Fengzhan Lin, Yanzhi Wang, Hui Song, Xu Liu, Feng Li & Jian Zhang. (2022) PAK4 in cancer development: Emerging player and therapeutic opportunities. Cancer Letters 545, pages 215813.
Crossref
Xiaodong Li & Feng Li. (2022) p21-Activated Kinase: Role in Gastrointestinal Cancer and Beyond. Cancers 14:19, pages 4736.
Crossref
Xinbo Yu, Changwei Huang, Jiyuan Liu, Xinyu Shi & Xiaodong Li. (2022) The significance of PAK4 in signaling and clinicopathology: A review. Open Life Sciences 17:1, pages 586-598.
Crossref
Andrew Wu & Xiaoyan Jiang. (2021) p21-Activated kinases as promising therapeutic targets in hematological malignancies. Leukemia 36:2, pages 315-326.
Crossref
Yiling Wang & Audrey Minden. (2021) The Use of Nanomedicine to Target Signaling by the PAK Kinases for Disease Treatment. Cells 10:12, pages 3565.
Crossref
Mohankumar Amirthalingam, Sundararaj Palanisamy & Shinkichi Tawata. (2021) p21-Activated kinase 1 (PAK1) in aging and longevity: An overview. Ageing Research Reviews 71, pages 101443.
Crossref
Azza Naїja, Maysaloun Merhi, Varghese Inchakalody, Queenie Fernandes, Sarra Mestiri, Kirti S. Prabhu, Shahab Uddin & Said Dermime. (2021) The role of PAK4 in the immune system and its potential implication in cancer immunotherapy. Cellular Immunology 367, pages 104408.
Crossref
Gabriela M. Wright, Nick T. Gimbrone, Bhaswati Sarcar, Trent R. Percy, Edna R. Gordián, Fumi Kinose, Natália J. Sumi, Uwe Rix & W. Douglas Cress. (2021) CDK4/6 inhibition synergizes with inhibition of P21-Activated Kinases (PAKs) in lung cancer cell lines. PLOS ONE 16:6, pages e0252927.
Crossref
Zlata Vershinin, Michal Feldman & Dan Levy. (2020) PAK4 methylation by the methyltransferase SETD6 attenuates cell adhesion. Scientific Reports 10:1.
Crossref
Susanne Nichterwitz, Jik Nijssen, Helena Storvall, Christoph Schweingruber, Laura Helen Comley, Ilary Allodi, Mirjam van der Lee, Qiaolin Deng, Rickard Sandberg & Eva Hedlund. (2020) LCM-seq reveals unique transcriptional adaptation mechanisms of resistant neurons and identifies protective pathways in spinal muscular atrophy. Genome Research 30:8, pages 1083-1096.
Crossref
Silin Huang, Ying Zhu, Chunfei Wang, Xiaxi Li, Xiaobing Cui, Sufang Tu, Lijuan You, JingWen Fu, Zemin Chen, Wei Hu & Wei Gong. (2020) PAK5 facilitates the proliferation, invasion and migration in colorectal cancer cells. Cancer Medicine 9:13, pages 4777-4790.
Crossref
Meihua Wang, Qianqian Gao, Yufang Chen, Ziyan Li, Lingping Yue & Yun Cao. (2019) PAK4, a target of miR-9-5p, promotes cell proliferation and inhibits apoptosis in colorectal cancer. Cellular & Molecular Biology Letters 24:1.
Crossref
Pei-Lu Song, Gang Wang, Yuan Su, Han-Xun Wang, Jian Wang, Feng Li & Mao-Sheng Cheng. (2019) Strategy and validation of a structure-based method for the discovery of selective inhibitors of PAK isoforms and the evaluation of their anti-cancer activity. Bioorganic Chemistry 91, pages 103168.
Crossref
Dalia H. El-Kashef & Ahmed R. El-Sheakh. (2019) Hepatoprotective effect of celecoxib against tamoxifen-induced liver injury via inhibiting ASK-1/JNK pathway in female rats. Life Sciences 231, pages 116573.
Crossref
Xiao-Hong Li, Xue-Ming Zhou, Xiao-Juan Li, Yue-Yun Liu, Qun Liu, Xiao-Ling Guo, Li-Qiang Yang & Jia-Xu Chen. (2019) Effects of Xiaoyaosan on the Hippocampal Gene Expression Profile in Rats Subjected to Chronic Immobilization Stress. Frontiers in Psychiatry 10.
Crossref
Judit Castillo, Jaco C. Knol, Cindy M. Korver, Sander R. Piersma, Thang V. Pham, Richard R. de Goeij-de Haas, Ans M.M. van Pelt, Connie R. Jimenez & Bastiaan J.H. Jansen. (2019) Human Testis Phosphoproteome Reveals Kinases as Potential Targets in Spermatogenesis and Testicular Cancer. Molecular & Cellular Proteomics 18, pages S132-S144.
Crossref
So-Yoon Won, Jung-Jin Park, Eun-Young Shin & Eung-Gook Kim. (2019) PAK4 signaling in health and disease: defining the PAK4–CREB axis. Experimental & Molecular Medicine 51:2, pages 1-9.
Crossref
Chetan K. Rane & Audrey Minden. (2019) P21 activated kinase signaling in cancer. Seminars in Cancer Biology 54, pages 40-49.
Crossref
Chau‑Chyun SheuWei‑An ChangMing‑Ju TsaiSsu‑Hui LiaoInn‑Wen ChongPo‑Lin Kuo. (2019) Bioinformatic analysis of next‑generation sequencing data to identify dysregulated genes in fibroblasts of idiopathic pulmonary fibrosis. International Journal of Molecular Medicine.
Crossref
Chetan K. Rane, Misaal Patel, Li Cai, William Senapedis, Erkan Baloglu & Audrey Minden. (2018) Decrypting the PAK4 transcriptome profile in mammary tumor forming cells using Next Generation Sequencing. Genomics 110:4, pages 248-256.
Crossref
Shriniwas S. Basaiyye, Pravin K. Naoghare, Sanjeev Kanojiya, Amit Bafana, Patrizio Arrigo, Kannan Krishnamurthi & Saravanadevi Sivanesan. (2018) Molecular mechanism of apoptosis induction in Jurkat E6-1 cells by Tribulus terrestris alkaloids extract. Journal of Traditional and Complementary Medicine 8:3, pages 410-419.
Crossref
Nour S Erekat. (2018) Cerebellar Upregulation of Cell Surface Death Receptor–Mediated Apoptotic Factors in Harmaline-Induced Tremor: An Immunohistochemistry Study. Journal of Cell Death 11, pages 117906601880909.
Crossref
Akira Takaguri, Takashi Kubo, Masaya Mori & Kumi Satoh. (2017) The protective role of YAP1 on ER stress-induced cell death in vascular smooth muscle cells. European Journal of Pharmacology 815, pages 470-477.
Crossref
E. A. Generalov, N. T. Levashova, A. E. Sidorova, P. M. Chumakov & L. V. Yakovenko. (2017) An autowave model of the bifurcation behavior of transformed cells in response to polysaccharide. Biophysics 62:5, pages 717-721.
Crossref
Xiang Li, Jiabin Li & Feng Li. (2017) P21 activated kinase 4 binds translation elongation factor eEF1A1 to promote gastric cancer cell migration and invasion. Oncology Reports 37:5, pages 2857-2864.
Crossref
Li-Fang He, Hong-Wu Xu, Min Chen, Zhi-Rong Xian, Xiao-Fen Wen, Min-Na Chen, Cai-Wen Du, Wen-He Huang, Jun-Dong Wu & Guo-Jun Zhang. (2016) Activated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling. Oncotarget 8:11, pages 17573-17585.
Crossref
Kiruthikah Thillai, Hoyin Lam, Debashis Sarker & Claire M. Wells. (2016) Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer?. Oncotarget 8:8, pages 14173-14191.
Crossref
Chetan Rane, William Senapedis, Erkan Baloglu, Yosef Landesman, Marsha Crochiere, Soumyasri Das-Gupta & Audrey Minden. (2017) A novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth. Scientific Reports 7:1.
Crossref
Muraleedharan Parvathy, Sreeharshan Sreeja, Rakesh Kumar & Madhavan Radhakrishna Pillai. (2016) Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells. BMC Cancer 16:S1.
Crossref
Yang-Guang Shao. (2016) Group II p21-activated kinases as therapeutic targets in gastrointestinal cancer. World Journal of Gastroenterology 22:3, pages 1224.
Crossref
Jennifer E. Kung & Natalia Jura. (2016) Structural Basis for the Non-catalytic Functions of Protein Kinases. Structure 24:1, pages 7-24.
Crossref
Katharine M H Tomalty, Mariah H Meek, Molly R Stephens, Gonzalo Rincón, Nann A Fangue, Bernie P May & Melinda R Baerwald. (2015) Transcriptional Response to Acute Thermal Exposure in Juvenile Chinook Salmon Determined by RNAseq. G3 Genes|Genomes|Genetics 5:7, pages 1335-1349.
Crossref
Byung Hak Ha, Elizabeth M. Morse, Benjamin E. Turk & Titus J. Boggon. (2015) Signaling, Regulation, and Specificity of the Type II p21-activated Kinases. Journal of Biological Chemistry 290:21, pages 12975-12983.
Crossref
Neha Singla & D. K. Dhawan. (2014) Zinc down regulates Apaf-1-dependent Bax/Bcl-2 mediated caspases activation during aluminium induced neurotoxicity. BioMetals 28:1, pages 61-73.
Crossref
Wannapa Sornjai, Kornpat Khungwanmaythawee, Saovaros Svasti, Suthat Fucharoen, Phitchayapak Wintachai, Sutee Yoksan, Sukathida Ubol, Nitwara Wikan & Duncan R. Smith. (2014) Dengue virus infection of erythroid precursor cells is modulated by both thalassemia trait status and virus adaptation. Virology 471-473, pages 61-71.
Crossref
Nikhil Tyagi, Arun Bhardwaj, Ajay P. Singh, Steven McClellan, James E. Carter & Seema Singh. (2014) p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway. Oncotarget 5:18, pages 8778-8789.
Crossref
Na Shen, Fei Yan, Jiuxia Pang, Lai-Chu Wu, Aref Al-Kali, Mark R. Litzow & Shujun Liu. (2014) A nucleolin-DNMT1 regulatory axis in acute myeloid leukemogenesis. Oncotarget 5:14, pages 5494-5509.
Crossref
C Wang, Y Li, H Zhang, F Liu, Z Cheng, D Wang, G Wang, H Xu, Y Zhao, L Cao & F Li. (2013) Oncogenic PAK4 regulates Smad2/3 axis involving gastric tumorigenesis. Oncogene 33:26, pages 3473-3484.
Crossref
Sheran H. W. Law & Thomas D. Sargent. (2014) The Serine-Threonine Protein Kinase PAK4 Is Dispensable in Zebrafish: Identification of a Morpholino-Generated Pseudophenotype. PLoS ONE 9:6, pages e100268.
Crossref
Jaewon Lim, Yoon Suk Kim, Sung Hoon Kim, Yoonjung Cho, Min Ho Lee, Byung Chul Jung, Dongju Jung & Ki-Jong Rhee. (2013) Triglyceride enhances susceptibility to TNF-α-induced cell death in THP-1 cells. Genes & Genomics 36:1, pages 87-93.
Crossref
Maria Radu, Galina Semenova, Rachelle Kosoff & Jonathan Chernoff. (2013) PAK signalling during the development and progression of cancer. Nature Reviews Cancer 14:1, pages 13-25.
Crossref
Helen King, Nicole S. Nicholas & Claire M. Wells. 2014. 347 387 .
Amin Moghaddas Gholami, Hannes Hahne, Zhixiang Wu, Florian Johann Auer, Chen Meng, Mathias Wilhelm & Bernhard Kuster. (2013) Global Proteome Analysis of the NCI-60 Cell Line Panel. Cell Reports 4:3, pages 609-620.
Crossref
L E Wong, N Chen, V Karantza & A Minden. (2013) The Pak4 protein kinase is required for oncogenic transformation of MDA-MB-231 breast cancer cells. Oncogenesis 2:6, pages e50-e50.
Crossref
Anna E. Dart & Claire M. Wells. (2013) P21-activated kinase 4 – Not just one of the PAK. European Journal of Cell Biology 92:4-5, pages 129-138.
Crossref
Audrey Minden. (2012) The Pak4 Protein Kinase in Breast Cancer. ISRN Oncology 2012, pages 1-5.
Crossref
Tanya Nekrasova & Audrey Minden. (2011) Role for p21-activated kinase PAK4 in development of the mammalian heart. Transgenic Research 21:4, pages 797-811.
Crossref
Meng Gong, Minjie Xia, Jing Zhang, Jiao Gu, Xuyang Liu & Jingqiu Cheng. (2011) A novel anti-lymphoma protein RE26 from Rozites emodensis (Berk.) Moser. Applied Microbiology and Biotechnology 93:3, pages 1097-1108.
Crossref
Perry M. Chan & Ed Manser. 2012. Protein Phosphorylation in Health and Disease. Protein Phosphorylation in Health and Disease 171 187 .
Kohsuke TakedaIsao NaguroHideki NishitohAtsushi MatsuzawaHidenori Ichijo. (2011) Apoptosis Signaling Kinases: From Stress Response to Health Outcomes. Antioxidants & Redox Signaling 15:3, pages 719-761.
Crossref
Tanya Nekrasova & Audrey Minden. (2011) PAK4 is required for regulation of the cell-cycle regulatory protein p21, and for control of cell-cycle progression. Journal of Cellular Biochemistry 112:7, pages 1795-1806.
Crossref
. (2011) Notice of Retraction. Carcinogenesis 32:5, pages 765-771.
Crossref
Yanmei Tian, Liang Lei & Audrey Minden. (2011) A key role for Pak4 in proliferation and differentiation of neural progenitor cells. Developmental Biology 353:2, pages 206-216.
Crossref
Y Liu, N Chen, X Cui, X Zheng, L Deng, S Price, V Karantza & A Minden. (2010) The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis. Oncogene 29:44, pages 5883-5894.
Crossref
Simona Baldassa, Alessandra Maria Calogero, Graziano Colombo, Renata Zippel & Nerina Gnesutta. (2010) N-terminal interaction domain implicates PAK4 in translational regulation and reveals novel cellular localization signals. Journal of Cellular Physiology 224:3, pages 722-733.
Crossref
Lisa Epstein Wong, Albert B. Reynolds, Nadishani T. Dissanayaka & Audrey Minden. (2010) p120-catenin is a binding partner and substrate for Group B Pak kinases. Journal of Cellular Biochemistry 110:5, pages 1244-1254.
Crossref
Brion W. Murray, Chuangxing Guo, Joseph Piraino, John K. Westwick, Cathy Zhang, Jane Lamerdin, Eleanor Dagostino, Daniel Knighton, Cho-Ming Loi, Michael Zager, Eugenia Kraynov, Ian Popoff, James G. Christensen, Ricardo Martinez, Susan E. Kephart, Joseph Marakovits, Shannon Karlicek, Simon Bergqvist & Tod Smeal. (2010) Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proceedings of the National Academy of Sciences 107:20, pages 9446-9451.
Crossref
Eva Maria Galan Moya, Armelle Le Guelte & Julie Gavard. (2009) PAKing up to the endothelium. Cellular Signalling 21:12, pages 1727-1737.
Crossref
Yanmei Tian, Liang Lei, Marta Cammarano, Tanya Nekrasova & Audrey Minden. (2009) Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation. Mechanisms of Development 126:8-9, pages 710-720.
Crossref
P R Molli, D Q Li, B W Murray, S K Rayala & R Kumar. (2009) PAK signaling in oncogenesis. Oncogene 28:28, pages 2545-2555.
Crossref
Anupam Kumar, Poonam R. Molli, Suresh B. Pakala, Tri M. Bui Nguyen, Suresh K. Rayala & Rakesh Kumar. (2009) PAK thread from amoeba to mammals. Journal of Cellular Biochemistry 107:4, pages 579-585.
Crossref
Hongran ChoiWonbong LimJi-Eun KimInae KimJinan JeongYoungjong KoJongwoon SongSunyeol YouDoman KimMisook KimByung-Kuk KimOkjoon Kim. (2009) Cell Death and Intracellular Distribution of Hematoporphyrin in a KB Cell Line. Photomedicine and Laser Surgery 27:3, pages 453-460.
Crossref
Tanya Nekrasova, Michelle L. Jobes, Jenhao H. Ting, George C. Wagner & Audrey Minden. (2008) Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion. Developmental Biology 322:1, pages 95-108.
Crossref
Ramneet Kaur, Xin Yuan, Michael L. Lu & Steven P. Balk. (2008) Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins. The Prostate 68:14, pages 1510-1516.
Crossref
Jeyanthy Eswaran, Meera Soundararajan, Rakesh Kumar & Stefan Knapp. (2008) UnPAKing the class differences among p21-activated kinases. Trends in Biochemical Sciences 33:8, pages 394-403.
Crossref
Yingying Liu, Hang Xiao, Yanmei Tian, Tanya Nekrasova, Xingpei Hao, Hong Jin Lee, Nanjoo Suh, Chung S. Yang & Audrey Minden. (2008) The Pak4 Protein Kinase Plays a Key Role in Cell Survival and Tumorigenesis in Athymic Mice. Molecular Cancer Research 6:7, pages 1215-1224.
Crossref
Luis E. Arias-Romero & Jonathan Chernoff. (2008) A tale of two Paks. Biology of the Cell 100:2, pages 97-108.
Crossref
Ulrike E.E. Rennefahrt, Sean W. Deacon, Sirlester A. Parker, Karthik Devarajan, Alexander Beeser, Jonathan Chernoff, Stefan Knapp, Benjamin E. Turk & Jeffrey R. Peterson. (2007) Specificity Profiling of Pak Kinases Allows Identification of Novel Phosphorylation Sites. Journal of Biological Chemistry 282:21, pages 15667-15678.
Crossref
Brinda Ravikumar, Zdenek Berger, Coralie Vacher, Cahir J. O'Kane & David C. Rubinsztein. (2006) Rapamycin pre-treatment protects against apoptosis. Human Molecular Genetics 15:7, pages 1209-1216.
Crossref
Xiaofan Li & Audrey Minden. (2005) PAK4 Functions in Tumor Necrosis Factor (TNF) α-induced Survival Pathways by Facilitating TRADD Binding to the TNF Receptor. Journal of Biological Chemistry 280:50, pages 41192-41200.
Crossref
Shenghao Jin, Ya Zhuo, Weining Guo & Jeffrey Field. (2005) p21-activated Kinase 1 (Pak1)-dependent Phosphorylation of Raf-1 Regulates Its Mitochondrial Localization, Phosphorylation of BAD, and Bcl-2 Association. Journal of Biological Chemistry 280:26, pages 24698-24705.
Crossref
Dechao Li, Eisaku Ueta, Tsuyoshi Kimura, Tetsuya Yamamoto & Tokio Osaki. (2004) Reactive oxygen species (ROS) control the expression of Bcl-2 family proteins by regulating their phosphorylation and ubiquitination. Cancer Science 95:8, pages 644-650.
Crossref
Anupama E Gururaj, Suresh K Rayala & Rakesh Kumar. (2004) p21-activated kinase signaling in breast cancer. Breast Cancer Research 7:1.
Crossref
Brigitte C. Widemann. (2004) Merlin PAKs a Punch. The Cancer Journal 10:1, pages 8-11.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.