Advanced search
Publication Cover
Molecular and Cellular Biology Volume 23, 2003 - Issue 22
Submit an article Journal homepage
319
Views
1,078
CrossRef citations to date
0
Altmetric
Nucleocytoplasmic Communication

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

Donna D. ZhangDepartment of Biochemistry, University of Missouri—Columbia, Columbia, Missouri65212
&
Mark HanninkDepartment of Biochemistry, University of Missouri—Columbia, Columbia, Missouri65212Correspondence[email protected]
Pages 8137-8151 | Received 06 Jun 2003, Accepted 04 Aug 2003, Published online: 27 Mar 2023

Citations (1078)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (49)

Bo Yin, Yu-Bin Wang, Xiang Li & Xu-Wei Hou. (2022) β‑aminoisobutyric acid ameliorates hypertensive vascular remodeling via activating the AMPK/SIRT1 pathway in VSMCs. Bioengineered 13:6, pages 14382-14401.
Read now
Liyuan Zhou, Changchen Hu, Yujun Li & Binquan Wang. (2022) Sulforaphane alleviates hypoxic vestibular vertigo (HVV) by increasing NO production via upregulating the expression of NRF2. Bioengineered 13:4, pages 10351-10361.
Read now
Jian-hong Qi & Fang-xu Dong. (2021) The relevant targets of anti-oxidative stress: a review. Journal of Drug Targeting 29:7, pages 677-686.
Read now
Javier Toro-Pérez & Ramón Rodrigo. (2021) Contribution of oxidative stress in the mechanisms of postoperative complications and multiple organ dysfunction syndrome. Redox Report 26:1, pages 35-44.
Read now
Xiaoxiao Wang, Hui Fang, Gang Xu, Ying Yang, Ruizhe Xu, Qiang Liu, Xiangyu Xue, Jiaqi Liu & Hezhi Wang. (2020) Resveratrol Prevents Cognitive Impairment in Type 2 Diabetic Mice by Upregulating Nrf2 Expression and Transcriptional Level. Diabetes, Metabolic Syndrome and Obesity 13, pages 1061-1075.
Read now
Te-Fu Tsai, Po-Chun Chen, Yi-Chia Lin, Kuang-Yu Chou, Hung-En Chen, Chao-Yen Ho, Ji-Fan Lin & Thomas I-Sheng Hwang. (2020) Miconazole Contributes to NRF2 Activation by Noncanonical P62-KEAP1 Pathway in Bladder Cancer Cells. Drug Design, Development and Therapy 14, pages 1209-1218.
Read now
Daisuke Yasuda, Tomoyuki Ohe, Kyoko Takahashi, Riyo Imamura, Hirotatsu Kojima, Takayoshi Okabe, Yoshinobu Ichimura, Masaaki Komatsu, Masayuki Yamamoto, Tetsuo Nagano & Tadahiko Mashino. (2020) Inhibitors of the protein–protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line. Free Radical Research 54:11-12, pages 859-871.
Read now
Haishan Zhou, Yan Wang, Qidong You & Zhengyu Jiang. (2020) Recent progress in the development of small molecule Nrf2 activators: a patent review (2017-present). Expert Opinion on Therapeutic Patents 30:3, pages 209-225.
Read now
Michael J. Kerins, Pengfei Liu, Wang Tian, William Mannheim, Donna D. Zhang & Aikseng Ooi. (2019) Genome-Wide CRISPR Screen Reveals Autophagy Disruption as the Convergence Mechanism That Regulates the NRF2 Transcription Factor. Molecular and Cellular Biology 39:13.
Read now
E. W. Cloer, P. F. Siesser, E. M. Cousins, D. Goldfarb, D. D. Mowrey, J. S. Harrison, S. J. Weir, N. V. Dokholyan & M. B. Major. (2018) p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2. Molecular and Cellular Biology 38:22.
Read now
N. T. Moldogazieva, I. M. Mokhosoev, N. B. Feldman & S. V. Lutsenko. (2018) ROS and RNS signalling: adaptive redox switches through oxidative/nitrosative protein modifications. Free Radical Research 52:5, pages 507-543.
Read now
Shun Kageyama, Tetsuya Saito, Miki Obata, Ryo-hei Koide, Yoshinobu Ichimura & Masaaki Komatsu. (2018) Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant. Molecular and Cellular Biology 38:7.
Read now
Hyo Jin Son, Se Hee Han, Ji Ae Lee, Eun Jung Shin & Onyou Hwang. (2017) Potential repositioning of exemestane as a neuroprotective agent for Parkinson’s disease. Free Radical Research 51:6, pages 633-645.
Read now
Shasha Tao, Pengfei Liu, Gang Luo, Montserrat Rojo de la Vega, Heping Chen, Tongde Wu, Joseph Tillotson, Eli Chapman & Donna D. Zhang. (2017) p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex. Molecular and Cellular Biology 37:8.
Read now
Tatsuro Iso, Takafumi Suzuki, Liam Baird & Masayuki Yamamoto. (2016) Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells. Molecular and Cellular Biology 36:24, pages 3100-3112.
Read now
Ji Ae Lee, Hyo Jin Son, Ji Hyun Kim, Ki Duk Park, Nari Shin, Hye Ri Kim, Eun Mee Kim, Dong Jin Kim & Onyou Hwang. (2016) A novel synthetic isothiocyanate ITC-57 displays antioxidant, anti-inflammatory, and neuroprotective properties in a mouse Parkinson’s disease model. Free Radical Research 50:11, pages 1188-1199.
Read now
Sybil Obuobi, Sanzhar Karatayev, Christina Li Lin Chai, Pui Lai Rachel Ee & Peter Mátyus. (2016) The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseases. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup3, pages 194-204.
Read now
Seyed Fazel Nabavi, Alistair J. Barber, Carmela Spagnuolo, Gian Luigi Russo, Maria Daglia, Seyed Mohammad Nabavi & Eduardo Sobarzo-Sánchez. (2016) Nrf2 as molecular target for polyphenols: A novel therapeutic strategy in diabetic retinopathy. Critical Reviews in Clinical Laboratory Sciences 53:5, pages 293-312.
Read now
Ryota Saito, Takafumi Suzuki, Keiichiro Hiramoto, Soichiro Asami, Eriko Naganuma, Hiromi Suda, Tatsuro Iso, Hirotaka Yamamoto, Masanobu Morita, Liam Baird, Yuki Furusawa, Takaaki Negishi, Masakazu Ichinose & Masayuki Yamamoto. (2016) Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response. Molecular and Cellular Biology 36:2, pages 271-284.
Read now
Shasha Yin & Wangsen Cao. (2015) Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation. Molecular and Cellular Biology 35:15, pages 2673-2683.
Read now
Takahiro Shibata. (2015) 15-Deoxy-Δ12,14-prostaglandin J2 as an electrophilic mediator. Bioscience, Biotechnology, and Biochemistry 79:7, pages 1044-1049.
Read now
Claudia Geismann, Alexander Arlt, Susanne Sebens & Heiner Schäfer. (2014) Cytoprotection “gone astray”: Nrf2 and its role in cancer. OncoTargets and Therapy 7, pages 1497-1518.
Read now
Y. Gao, S.-F. Chu, J.-P. Li, W. Zuo, Z.-L. Wen, W.-B. He, J.-Q. Yan & N.-H. Chen. (2014) Do glial cells play an anti-oxidative role in Huntington's disease?. Free Radical Research 48:10, pages 1135-1144.
Read now
Thibaud Metzger, Charlotte Kleiss & Izabela Sumara. (2013) CUL3 and protein kinases: Insights from PLK1/KLHL22 interaction. Cell Cycle 12:14, pages 2291-2296.
Read now
Alexandria Lau, Yi Zheng, Shasha Tao, Huihui Wang, Samantha A. Whitman, Eileen White & Donna D. Zhang. (2013) Arsenic Inhibits Autophagic Flux, Activating the Nrf2-Keap1 Pathway in a p62-Dependent Manner. Molecular and Cellular Biology 33:12, pages 2436-2446.
Read now
Abigail F. Smith & George Loo. (2012) Upregulation of haeme oxygenase-1 by zinc in HCT-116 cells. Free Radical Research 46:9, pages 1099-1107.
Read now
Jianglin Ma, Hong Cai, Tongde Wu, Bijan Sobhian, Yanying Huo, Allen Alcivar, Monal Mehta, Ka Lung Cheung, Shridar Ganesan, Ah-Ng Tony Kong, Donna D. Zhang & Bing Xia. (2012) PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear Accumulation and Function. Molecular and Cellular Biology 32:8, pages 1506-1517.
Read now
Larry G. Higgins & John D. Hayes. (2011) Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents. Drug Metabolism Reviews 43:2, pages 92-137.
Read now
Zheng Sun, Tongde Wu, Fei Zhao, Alexandria Lau, Christina M. Birch & Donna D. Zhang. (2011) KPNA6 (Importin α7)-Mediated Nuclear Import of Keap1 Represses the Nrf2-Dependent Antioxidant Response. Molecular and Cellular Biology 31:9, pages 1800-1811.
Read now
Patricia Rada, Ana I. Rojo, Sudhir Chowdhry, Michael McMahon, John D. Hayes & Antonio Cuadrado. (2011) SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner. Molecular and Cellular Biology 31:6, pages 1121-1133.
Read now
Ashwini Gore, Maitreyi Muralidhar, Michael Graham Espey, Kurt Degenhardt & Lin L. Mantell. (2010) Hyperoxia sensing: From molecular mechanisms to significance in disease. Journal of Immunotoxicology 7:4, pages 239-254.
Read now
Shruti Singh, Sonal Vrishni, Brijesh K. Singh, Irfan Rahman & Poonam Kakkar. (2010) Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases. Free Radical Research 44:11, pages 1267-1288.
Read now
Alexandria Lau, Xiao-Jun Wang, Fei Zhao, Nicole F. Villeneuve, Tongde Wu, Tao Jiang, Zheng Sun, Eileen White & Donna D. Zhang. (2010) A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62. Molecular and Cellular Biology 30:13, pages 3275-3285.
Read now
Jinqing Li, Tomonaga Ichikawa, Joseph S Janicki & Taixing Cui. (2009) Targeting the Nrf2 pathway against cardiovascular disease. Expert Opinion on Therapeutic Targets 13:7, pages 785-794.
Read now
Zheng Sun, Y. Eugene Chin & Donna D. Zhang. (2009) Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response. Molecular and Cellular Biology 29:10, pages 2658-2672.
Read now
Antonio Cuadrado, Paz Moreno-Murciano & José Pedraza-Chaverri. (2009) The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease. Expert Opinion on Therapeutic Targets 13:3, pages 319-329.
Read now
Makoto Kobayashi, Li Li, Noriko Iwamoto, Yaeko Nakajima-Takagi, Hiroshi Kaneko, Yuko Nakayama, Masami Eguchi, Yoshiko Wada, Yoshito Kumagai & Masayuki Yamamoto. (2009) The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds. Molecular and Cellular Biology 29:2, pages 493-502.
Read now
Tae Yamamoto, Takafumi Suzuki, Akira Kobayashi, Junko Wakabayashi, Jon Maher, Hozumi Motohashi & Masayuki Yamamoto. (2008) Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity. Molecular and Cellular Biology 28:8, pages 2758-2770.
Read now
Yukari Zenke-Kawasaki, Yoshihiro Dohi, Yasutake Katoh, Tsuyoshi Ikura, Masae Ikura, Toshimasa Asahara, Fuminori Tokunaga, Kazuhiro Iwai & Kazuhiko Igarashi. (2007) Heme Induces Ubiquitination and Degradation of the Transcription Factor Bach1. Molecular and Cellular Biology 27:19, pages 6962-6971.
Read now
Zheng Sun, Shirley Zhang, Jefferson Y. Chan & Donna D. Zhang. (2007) Keap1 Controls Postinduction Repression of the Nrf2-Mediated Antioxidant Response by Escorting Nuclear Export of Nrf2. Molecular and Cellular Biology 27:18, pages 6334-6349.
Read now
Shih-Ching Lo & Mark Hannink. (2006) CAND1-Mediated Substrate Adaptor Recycling Is Required for Efficient Repression of Nrf2 by Keap1. Molecular and Cellular Biology 26:4, pages 1235-1244.
Read now
Akira Kobayashi, Moon-Il Kang, Yoriko Watai, Kit I. Tong, Takahiro Shibata, Koji Uchida & Masayuki Yamamoto. (2006) Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1. Molecular and Cellular Biology 26:1, pages 221-229.
Read now
Donna D. Zhang. (2006) Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway. Drug Metabolism Reviews 38:4, pages 769-789.
Read now
Paul Nioi, Truyen Nguyen, Philip J. Sherratt & Cecil B. Pickett. (2005) The Carboxy-Terminal Neh3 Domain of Nrf2 Is Required for Transcriptional Activation. Molecular and Cellular Biology 25:24, pages 10895-10906.
Read now
Michaella Velichkova & Tama Hasson. (2005) Keap1 Regulates the Oxidation-Sensitive Shuttling of Nrf2 into and out of the Nucleus via a Crm1-Dependent Nuclear Export Mechanism. Molecular and Cellular Biology 25:11, pages 4501-4513.
Read now
Ruben N. Karapetian, Alexandra G. Evstafieva, Irina S. Abaeva, Nina V. Chichkova, Grigoriy S. Filonov, Yuri P. Rubtsov, Elena A. Sukhacheva, Sergey V. Melnikov, Ulrich Schneider, Erich E. Wanker & Andrey B. Vartapetian. (2005) Nuclear Oncoprotein Prothymosin α Is a Partner of Keap1: Implications for Expression of Oxidative Stress-Protecting Genes. Molecular and Cellular Biology 25:3, pages 1089-1099.
Read now
Donna D. Zhang, Shih-Ching Lo, Janet V. Cross, Dennis J. Templeton & Mark Hannink. (2004) Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex. Molecular and Cellular Biology 24:24, pages 10941-10953.
Read now
Sara B. Cullinan, John D. Gordan, Jianping Jin, J. Wade Harper & J. Alan Diehl. (2004) The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase. Molecular and Cellular Biology 24:19, pages 8477-8486.
Read now
Akira Kobayashi, Moon-Il Kang, Hiromi Okawa, Makiko Ohtsuji, Yukari Zenke, Tomoki Chiba, Kazuhiko Igarashi & Masayuki Yamamoto. (2004) Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2. Molecular and Cellular Biology 24:16, pages 7130-7139.
Read now

Articles from other publishers (1029)

Elisa B. Monteiro, Matheus Ajackson, Milena B. Stockler-Pinto, Fitsum Guebre-Egziabher, Julio B. Daleprane & Christophe O. Soulage. (2023) Sulforaphane exhibits potent renoprotective effects in preclinical models of kidney diseases: A systematic review and meta-analysis. Life Sciences 322, pages 121664.
Crossref
Yusuke Aihara, Bumpei Maeda, Kanna Goto, Koji Takahashi, Mika Nomoto, Shigeo Toh, Wenxiu Ye, Yosuke Toda, Mami Uchida, Eri Asai, Yasuomi Tada, Kenichiro Itami, Ayato Sato, Kei Murakami & Toshinori Kinoshita. (2023) Identification and improvement of isothiocyanate-based inhibitors on stomatal opening to act as drought tolerance-conferring agrochemicals. Nature Communications 14:1.
Crossref
Ramya Modi, Nick McKee, Ning Zhang, Amir Alwali, Samantha Nelson, Aditi Lohar, Raluca Ostafe, Donna D. Zhang & Elizabeth I. Parkinson. (2023) Stapled Peptides as Direct Inhibitors of Nrf2-sMAF Transcription Factors. Journal of Medicinal Chemistry 66:9, pages 6184-6192.
Crossref
Rosanna Di Paola, Salvatore Cuzzocrea, Roberta Fusco & Marika Cordaro. 2023. Recent Developments in Antioxidants from Natural Sources. Recent Developments in Antioxidants from Natural Sources.
Yujiro Maeoka, Ryan J. CorneliusJames A. McCormick. (2023) Cullin 3 and Blood Pressure Regulation: Insights From Familial Hyperkalemic Hypertension. Hypertension 80:5, pages 912-923.
Crossref
Tomoya Kitakaze, Masako Inoue & Hitoshi Ashida. (2023) Aged Garlic Extract Prevents Alcohol‐Induced Cytotoxicity through Induction of Aldehyde Dehydrogenase 2 in the Liver of Mice. Molecular Nutrition & Food Research 67:10.
Crossref
Alessandro Allegra, Giuseppe Murdaca, Giuseppe Mirabile & Sebastiano Gangemi. (2023) Redox Signaling Modulates Activity of Immune Checkpoint Inhibitors in Cancer Patients. Biomedicines 11:5, pages 1325.
Crossref
Gregory A. Shilovsky & Daria V. Dibrova. (2023) Regulation of Cell Proliferation and Nrf2-Mediated Antioxidant Defense: Conservation of Keap1 Cysteines and Nrf2 Binding Site in the Context of the Evolution of KLHL Family. Life 13:4, pages 1045.
Crossref
Diego Alem, Xinrui Yang, Francisca Beato, Bhaswati Sarcar, Alexandra F. Tassielli, Ruifan Dai, Tara L. Hogenson, Margaret A. Park, Kun Jiang, Jianfeng Cai, Yu Yuan, Martin E. Fernandez‐Zapico, Aik Choon Tan, Jason B. Fleming & Hao Xie. (2023) Translational relevance of SOS1 targeting for KRAS ‐mutant colorectal cancer . Molecular Carcinogenesis.
Crossref
Christopher Krewenka, Sandra Rizzi, Chi Huu Nguyen, Marcin Delijewski, Lars Gille, Katrin Staniek, Johanna Catharina Duvigneau, Khaled Radad, Andrea Müllebner, Barbara Kranner & Rudolf Moldzio. (2023) Radical Scavenging Is Not Involved in Thymoquinone-Induced Cell Protection in Neural Oxidative Stress Models. Antioxidants 12:4, pages 858.
Crossref
Klaus Seedorf, Csaba Weber, Cedric Vinson, Sylvie Berger, Laurent-Michel Vuillard, Arpad Kiss, Stephanie Creusot, Olivier Broux, Anne Geant, Catherine Ilic, Karine Lemaitre, Johann Richard, Adel Hammoutene, Julien Mahieux, Virginie Martiny, Didier Durand, Fabien Melchiore, Miklos Nyerges, Valerie Paradis, Nicolas Provost, Valérie Duvivier & Philippe Delerive. (2023) Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice. JHEP Reports 5:4, pages 100651.
Crossref
Jielian Wu, Wenxiu Liu, Shumin Hou, Yanrui Wang, Haihong Fang, Shanshan Luo, Lang Yang & Chungen Wen. (2023) Identification of Nrf2/Keap1 pathway and its transcriptional regulation of antioxidant genes after exposure to microcystins in freshwater mussel Cristaria plicata. Developmental & Comparative Immunology 141, pages 104629.
Crossref
Jialin Feng, Oliver J. Read & Albena T. Dinkova-Kostova. (2023) Nrf2 in TIME: The Emerging Role of Nuclear Factor Erythroid 2-Related Factor 2 in the Tumor Immune Microenvironment. Molecules and Cells 46:3, pages 142-152.
Crossref
Takafumi Suzuki, Jun Takahashi & Masayuki Yamamoto. (2023) Molecular Basis of the KEAP1-NRF2 Signaling Pathway. Molecules and Cells 46:3, pages 133-141.
Crossref
Waseem Chauhan & Rahima Zennadi. (2023) Keap1-Nrf2 Heterodimer: A Therapeutic Target to Ameliorate Sickle Cell Disease. Antioxidants 12:3, pages 740.
Crossref
Somayyeh Ghareghomi, Faezeh Moosavi-Movahedi, Luciano Saso, Mehran Habibi-Rezaei, Ali Khatibi, Jun Hong & Ali A. Moosavi-Movahedi. (2023) Modulation of Nrf2/HO-1 by Natural Compounds in Lung Cancer. Antioxidants 12:3, pages 735.
Crossref
Zoe González-Carnicero, Raquel Hernanz, Marta Martínez-Casales, María Teresa Barrús, Ángela Martín & María Jesús Alonso. (2023) Regulation by Nrf2 of IL-1β-induced inflammatory and oxidative response in VSMC and its relationship with TLR4. Frontiers in Pharmacology 14.
Crossref
Agnieszka Łoboda & Józef Dulak. (2023) Nuclear Factor Erythroid 2-Related Factor 2 and Its Targets in Skeletal Muscle Repair and Regeneration. Antioxidants & Redox Signaling.
Crossref
Albena T. Dinkova-Kostova & Ian M. Copple. (2023) Advances and challenges in therapeutic targeting of NRF2. Trends in Pharmacological Sciences 44:3, pages 137-149.
Crossref
Chunfeng Lu, Yiming Jiang, Wenxuan Xu & Xiaofeng Bao. (2023) Sestrin2: multifaceted functions, molecular basis, and its implications in liver diseases. Cell Death & Disease 14:2.
Crossref
Hyunju Kang & Bohkyung Kim. (2023) Bioactive Compounds as Inhibitors of Inflammation, Oxidative Stress and Metabolic Dysfunctions via Regulation of Cellular Redox Balance and Histone Acetylation State. Foods 12:5, pages 925.
Crossref
Lucas Fornari Laurindo, Mariana Canevari de Maio, Giulia Minniti, Natália de Góes Corrêa, Sandra Maria Barbalho, Karina Quesada, Elen Landgraf Guiguer, Kátia Portero Sloan, Claudia R. P. Detregiachi, Adriano Cressoni Araújo & Ricardo de Alvares Goulart. (2023) Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review. Metabolites 13:2, pages 243.
Crossref
Yunjiang Zhou, Yaxin Chen, Yongwei Shi, Leyin Wu, Yingying Tan, Tao Li, Yigang Chen, Jiazeng Xia & Rong Hu. (2023) FAM117B promotes gastric cancer growth and drug resistance by targeting the KEAP1/NRF2 signaling pathway. Journal of Clinical Investigation 133:3.
Crossref
Pengfei Liu, Annadurai Anandhan, Jinjing Chen, Aryatara Shakya, Matthew Dodson, Aikseng Ooi, Eli Chapman, Eileen White, Joe GN. Garcia & Donna D. Zhang. (2023) Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease. Redox Biology 59, pages 102570.
Crossref
D. Allan ButterfieldDebra Boyd-KimballTanea T. Reed. (2023) CELLULAR STRESS RESPONSE (HORMESIS) IN RESPONSE TO BIOACTIVE NUTRACEUTICALS WITH RELEVANCE TO ALZHEIMER DISEASE. Antioxidants & Redox Signaling.
Crossref
Franziska Linke, James E. C. Johnson, Stefanie Kern, Christopher D. Bennett, Anbarasu Lourdusamy, Daniel Lea, Steven C. Clifford, Catherine L. R. Merry, Snow Stolnik, Morgan R. Alexander, Andrew C. Peet, David J. Scurr, Rian L. Griffiths, Anna M. Grabowska, Ian D. Kerr & Beth Coyle. (2023) Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging. Acta Neuropathologica Communications 11:1.
Crossref
Ivan T. Demchenko, Hagir B. Suliman, Sergey Y. Zhilyaey, Olga S. Alekseeva, Tatyana F. Platonova, Matthew S. Makowski, Claude A. Piantadosi & Heath G. Gasier. (2023) GAT inhibition preserves cerebral blood flow and reduces oxidant damage to mitochondria in rodents exposed to extreme hyperbaric oxygen. Frontiers in Molecular Neuroscience 15.
Crossref
Albena Dinkova-KostovaT.T.. (2023) KEAP1/NRF2 as a druggable target. Arhiv za farmaciju 73:2, pages 89-108.
Crossref
Qi Wang, Dong Lin, Xue-Feng Liu, Fang Dai, Xiao-Jie Jin & Bo Zhou. (2023) Engineering piperlongumine-inspired analogs as Nrf2-dependent neuroprotectors against oxidative damage by an electrophilicity-based strategy. Free Radical Biology and Medicine 194, pages 298-307.
Crossref
Paige E. Jamieson, Franck Carbonero & Jan F. Stevens. (2023) Dietary (poly)phenols mitigate inflammatory bowel disease: Therapeutic targets, mechanisms of action, and clinical observations. Current Research in Food Science 6, pages 100521.
Crossref
Enrique Crisman, Pablo Duarte, Esteban Dauden, Antonio Cuadrado, María Isabel Rodríguez‐Franco, Manuela G. López & Rafael León. (2022) KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential. Medicinal Research Reviews 43:1, pages 237-287.
Crossref
Yanjun Tian, Haiqing Liu, Mengwei Wang, Ruihao Wang, Guandong Yi, Meng Zhang & Ruijiao Chen. (2022) Role of STAT3 and NRF2 in Tumors: Potential Targets for Antitumor Therapy. Molecules 27:24, pages 8768.
Crossref
Sameer Ullah Khan, Sheikh Rayees, Pankaj Sharma & Fayaz Malik. (2022) Targeting redox regulation and autophagy systems in cancer stem cells. Clinical and Experimental Medicine.
Crossref
Matthew Dodson, Aryatara Shakya, Annadurai Anandhan, Jinjing Chen, Joe G.N. Garcia & Donna D. Zhang. (2022) NRF2 and Diabetes: The Good, the Bad, and the Complex. Diabetes 71:12, pages 2463-2476.
Crossref
Farhad Pouremamali, Amir Pouremamali, Mehdi Dadashpour, Narges Soozangar & Farhad Jeddi. (2022) An update of Nrf2 activators and inhibitors in cancer prevention/promotion. Cell Communication and Signaling 20:1.
Crossref
Qianhui Wang, Benson O.A. Botchway, Yong Zhang & Xuehong Liu. (2022) Ellagic acid activates the Keap1-Nrf2-ARE signaling pathway in improving Parkinson’s disease: A review. Biomedicine & Pharmacotherapy 156, pages 113848.
Crossref
Liam Baird, Thomas W. Kensler & Masayuki Yamamoto. (2022) Novel NRF2 ‐activated cancer treatments utilizing synthetic lethality . IUBMB Life 74:12, pages 1209-1231.
Crossref
Vy Ngo & Martin L. Duennwald. (2022) Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease. Antioxidants 11:12, pages 2345.
Crossref
Fengyu Ma, Shangdie Luo, Chunting Lu, Xinrong Jiang, Kexiao Chen, Jianwen Deng, Shuyuan Ma & Zejian Li. (2022) The role of Nrf2 in periodontal disease by regulating lipid peroxidation, inflammation and apoptosis. Frontiers in Endocrinology 13.
Crossref
Rumei Luan, Dongyan Ding & Junling Yang. (2022) The protective effect of natural medicines against excessive inflammation and oxidative stress in acute lung injury by regulating the Nrf2 signaling pathway. Frontiers in Pharmacology 13.
Crossref
Sameer Ullah Khan, Kaneez Fatima, Shariqa Aisha, Baseerat Hamza & Fayaz Malik. (2022) Redox balance and autophagy regulation in cancer progression and their therapeutic perspective. Medical Oncology 40:1.
Crossref
Qianqian Li, George Fadoul, Milos Ikonomovic, Tuo Yang & Feng Zhang. (2022) Sulforaphane promotes white matter plasticity and improves long-term neurological outcomes after ischemic stroke via the Nrf2 pathway. Free Radical Biology and Medicine 193, pages 292-303.
Crossref
Rohini Srivastava, Raquel Fernández-Ginés, José Antonio Encinar, Antonio Cuadrado & Geoff Wells. (2022) The current status and future prospects for therapeutic targeting of KEAP1-NRF2 and β-TrCP-NRF2 interactions in cancer chemoresistance. Free Radical Biology and Medicine 192, pages 246-260.
Crossref
Michalina Kryszczuk & Oksana Kowalczuk. (2022) Significance of NRF2 in physiological and pathological conditions an comprehensive review. Archives of Biochemistry and Biophysics 730, pages 109417.
Crossref
Hanan Saleh, Mohamed Salama & Rehab Mohamed Hussein. (2022) Polyethylene glycol capped gold nanoparticles ameliorate renal ischemia–reperfusion injury in diabetic mice through AMPK-Nrf2 signaling pathway. Environmental Science and Pollution Research 29:51, pages 77884-77907.
Crossref
Jung-Hwan Kim, Heejung Yang & Kee K. Kim. (2022) Camellia japonica Root Extract Increases Antioxidant Genes by Induction of NRF2 in HeLa Cells. Plants 11:21, pages 2914.
Crossref
Alexandra Van Hall-Beauvais, Jesse R Poganik, Kuan-Ting Huang, Saba Parvez, Yi Zhao, Hong-Yu Lin, Xuyu Liu, Marcus John Curtis Long & Yimon Aye. (2022) Z-REX uncovers a bifurcation in function of Keap1 paralogs. eLife 11.
Crossref
Wenlong Zhang, Xiaohe Li, Jiaqian Xu, Ying Wang, Zhengcao Xing, Shuming Hu, Qiuju Fan, Shaoyong Lu, Jinke Cheng, Jianmin Gu & Rong Cai. (2022) The RSL3 Induction of KLK Lung Adenocarcinoma Cell Ferroptosis by Inhibition of USP11 Activity and the NRF2-GSH Axis. Cancers 14:21, pages 5233.
Crossref
Somayyeh Ghareghomi, Mehran Habibi-Rezaei, Marzia Arese, Luciano Saso & Ali Akbar Moosavi-Movahedi. (2022) Nrf2 Modulation in Breast Cancer. Biomedicines 10:10, pages 2668.
Crossref
James J. M. Loan, Rustam Al-Shahi Salman, Barry W. McColl & Giles E. Hardingham. (2022) Activation of Nrf2 to Optimise Immune Responses to Intracerebral Haemorrhage. Biomolecules 12:10, pages 1438.
Crossref
Semira R. Ortiz, Alexander Heinz, Karsten Hiller & Martha S. Field. (2022) Erythritol synthesis is elevated in response to oxidative stress and regulated by the non-oxidative pentose phosphate pathway in A549 cells. Frontiers in Nutrition 9.
Crossref
İzzettin Yazar, Baran Sarıkaya, İsmail Koyuncu, Ataman Gönel, Celal Bozkurt, Serkan Sipahioğlu, Baki Volkan Çetin & Mehmet Akif Altay. (2022) Evaluation of oxidative stress in degenerative rotator cuff tears. Journal of Shoulder and Elbow Surgery 31:10, pages e490-e497.
Crossref
Kit‐Kay Mak, Zhang Shiming, Ola Epemolu, Albena T. Dinkova‐Kostova, Geoffrey Wells, Irina G. Gazaryan, Raghavendra Sakirolla, Zulkefeli Mohd & Mallikarjuna Rao Pichika. (2022) Synthesis and Anti‐Inflammatory Activity of 2‐Amino‐4,5,6,7‐tetrahydrobenzo[ b ]thiophene‐Derived NRF2 Activators . ChemistryOpen 11:10.
Crossref
Federico Manai & Marialaura Amadio. (2022) Dimethyl Fumarate Triggers the Antioxidant Defense System in Human Retinal Endothelial Cells through Nrf2 Activation. Antioxidants 11:10, pages 1924.
Crossref
Brigitta Buttari, Marzia Arese, Rebecca E. Oberley-Deegan, Luciano Saso & Arpita Chatterjee. (2022) NRF2: A crucial regulator for mitochondrial metabolic shift and prostate cancer progression. Frontiers in Physiology 13.
Crossref
Gina Manda, Elena Milanesi, Sermin Genc, Cristina Mariana Niculite, Ionela Victoria Neagoe, Bora Tastan, Elena Mihaela Dragnea & Antonio Cuadrado. (2022) Pros and cons of NRF2 activation as adjunctive therapy in rheumatoid arthritis. Free Radical Biology and Medicine 190, pages 179-201.
Crossref
Jian Dong, Lijun Zhang, Binjia Ruan, Zhongyang Lv, Hongwei Wang, Yongxiang Wang, Qing Jiang & Wangsen Cao. (2022) NRF2 is a critical regulator and therapeutic target of metal implant particle-incurred bone damage. Biomaterials 288, pages 121742.
Crossref
Max B. Sauerland & Michael J. Davies. (2022) Electrophile versus oxidant modification of cysteine residues: Kinetics as a key driver of protein modification. Archives of Biochemistry and Biophysics 727, pages 109344.
Crossref
Hannah C. Feldman, Elisa Merlini, Carlos Guijas, Kristen E. DeMeester, Evert Njomen, Ellen M. Kozina, Minoru Yokoyama, Ekaterina Vinogradova, Holly T. Reardon, Bruno Melillo, Stuart L. Schreiber, Andrea Loreto, Jacqueline L. Blankman & Benjamin F. Cravatt. (2022) Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain. Proceedings of the National Academy of Sciences 119:35.
Crossref
Mohammad Jamaluddin, Aline Haas de Mello, Nisha Tapryal, Tapas K. Hazra, Roberto P. Garofalo & Antonella Casola. (2022) NRF2 Regulates Cystathionine Gamma-Lyase Expression and Activity in Primary Airway Epithelial Cells Infected with Respiratory Syncytial Virus. Antioxidants 11:8, pages 1582.
Crossref
Chirag Vasavda, Risheng Xu, Jason Liew, Ruchita Kothari, Ryan S. Dhindsa, Evan R. Semenza, Bindu D. Paul, Dustin P. Green, Mark F. Sabbagh, Joseph Y. Shin, Wuyang YangAdele M. SnowmanLauren K. AlbacarysAbhay Moghekar, Carlos A. Pardo-Villamizar, Mark LucianoJudy Huang, Chetan Bettegowda, Shawn G. Kwatra, Xinzhong Dong, Michael Lim & Solomon H. Snyder. (2022) Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain. Science Advances 8:31.
Crossref
Sinem Yilmaz, Erdal Bedir & Petek Ballar Kirmizibayrak. (2022) The role of cycloastragenol at the intersection of NRF2/ARE, telomerase, and proteasome activity. Free Radical Biology and Medicine 188, pages 105-116.
Crossref
Tony Heurtaux, David S. Bouvier, Alexandre Benani, Sergio Helgueta Romero, Katrin B. M. Frauenknecht, Michel Mittelbronn & Lasse Sinkkonen. (2022) Normal and Pathological NRF2 Signalling in the Central Nervous System. Antioxidants 11:8, pages 1426.
Crossref
Xiao Hu, Jing Liu, Jun Li, Yuqiong Song, Shengjun Chen, Shaobo Zhou & Xianqing Yang. (2022) Preparation, purification, and identification of novel antioxidant peptides derived from Gracilariopsis lemaneiformis protein hydrolysates. Frontiers in Nutrition 9.
Crossref
Qianqian Wang, Zherui Yang, Jiachen Zhuang, Junhui Zhang, Fei Shen, Peng Yu, Hao Zhong & Fengqin Feng. (2022) Antiaging function of Chinese pond turtle (Chinemys reevesii) peptide through activation of the Nrf2/Keap1 signaling pathway and its structure-activity relationship. Frontiers in Nutrition 9.
Crossref
Jing Li, Bowen Jia, Ying Cheng, Yiting Song, Qianqian Li & Chengliang Luo. (2022) Targeting Molecular Mediators of Ferroptosis and Oxidative Stress for Neurological Disorders. Oxidative Medicine and Cellular Longevity 2022, pages 1-14.
Crossref
Rui Han, Yao Yu, Kanghong Zhao, Jing Wei, Yuhu Hui & Jin-Ming Gao. (2022) Lignans from Eucommia ulmoides Oliver leaves exhibit neuroprotective effects via activation of the PI3K/Akt/GSK-3β/Nrf2 signaling pathways in H2O2-treated PC-12 cells. Phytomedicine 101, pages 154124.
Crossref
Sumi Lee, Dhulfiqar Ali Abed, Mai-Uyen Nguyen, Michael P. Verzi & Longqin Hu. (2022) Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N′-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction. European Journal of Medicinal Chemistry 237, pages 114380.
Crossref
Tianqi Jiang & Yongxiong He. (2022) Recent Advances in the Role of Nuclear Factor Erythroid-2-Related Factor 2 in Spinal Cord Injury: Regulatory Mechanisms and Therapeutic Options. Frontiers in Aging Neuroscience 14.
Crossref
Shunhao Zhang, Sining Duan, Zhuojun Xie, Wanlin Bao, Bo Xu, Wenbin Yang & Lingyun Zhou. (2022) Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress. Frontiers in Pharmacology 13.
Crossref
Xue-Feng Liu, Qi Wang, Jia-Fang Zheng, Zuo-Hu Chai, Fang Dai, Xiao-Jie Jin & Bo Zhou. (2022) Developing dietary curcumin mono-carbonyl piperidinone analogs as Nrf2-dependent cytoprotectors against oxidative damage: Structure-activity relationship and mechanisms. Free Radical Biology and Medicine 186, pages 66-75.
Crossref
Zhao Chen, Lifang Tian, Li Wang, Xiaotao Ma, Fuqian Lei, Xianghui Chen & Rongguo Fu. (2021) TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3β/Nrf2 Pathway. Inflammation 45:3, pages 992-1006.
Crossref
Seyoung Yang, See-Hyoung Park, Sae Woong Oh, Kitae Kwon, Eunbi Yu, Chae Won Lee, Youn Kyoung Son, Changmu Kim, Byoung-Hee Lee, Jae Youl Cho, Youn-Jung Kim & Jongsung Lee. (2022) Antioxidant Activities and Mechanisms of Tomentosin in Human Keratinocytes. Antioxidants 11:5, pages 990.
Crossref
Maryam K. Mohammed & Brian S. Zuckerbraun. 2022. Carbon Monoxide in Drug Discovery. Carbon Monoxide in Drug Discovery 136 159 .
Kenji Kasuno, Junji YodoiMasayuki Iwano. (2022) Urinary Thioredoxin as a Biomarker of Renal Redox Dysregulation and a Companion Diagnostic to Identify Responders to Redox-Modulating Therapeutics. Antioxidants & Redox Signaling 36:13-15, pages 1051-1065.
Crossref
Angela Bonura, Miriam Giacomarra & Giovanna Montana. (2022) The Keap1 signaling in the regulation of HSP90 pathway. Cell Stress and Chaperones 27:3, pages 197-204.
Crossref
Hitesh Kumar, Rachna M. Kumar, Devanjali Bhattacharjee, Preethi Somanna & Vikas Jain. (2022) Role of Nrf2 Signaling Cascade in Breast Cancer: Strategies and Treatment. Frontiers in Pharmacology 13.
Crossref
Jennyffer Souza, Rodrigo Augusto da Silva, Débora da Luz Scheffer, Rafael Penteado, Alexandre Solano, Leonardo Barros, Henning Budde, Andrés Trostchansky & Alexandra Latini. (2022) Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle. Antioxidants 11:5, pages 826.
Crossref
Yu-Chao Li, Yan Wang & Wei Zou. (2022) Exploration on the Mechanism of Ubiquitin Proteasome System in Cerebral Stroke. Frontiers in Aging Neuroscience 14.
Crossref
Vy Ngo, Anne Brickenden, Hansen Liu, Cynthia Yeung, Wing-Yiu Choy & Martin L. Duennwald. (2022) A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90. Disease Models & Mechanisms 15:4.
Crossref
Gili Rosenberg, Sebastian Riquelme, Alice Prince & Roi Avraham. (2022) Immunometabolic crosstalk during bacterial infection. Nature Microbiology 7:4, pages 497-507.
Crossref
Xue‐Yi Wu, Tian Wang, Hui‐Xin Hu, Kan Zhang, Yu Zhao, Bao‐Bing Zhao, Hong‐Xiang Lou, Xiao‐Ning Wang & Tao Shen. (2022) The alleviative effect of flavonol‐type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders . Phytotherapy Research 36:4, pages 1692-1707.
Crossref
Romain Vallion, Kévin Hardonnière, Abderrahmane Bouredji, Marie-Hélène Damiens, Claudine Deloménie, Marc Pallardy, Pierre-Jacques Ferret & Saadia Kerdine-Römer. (2022) The Inflammatory Response in Human Keratinocytes Exposed to Cinnamaldehyde Is Regulated by Nrf2. Antioxidants 11:3, pages 575.
Crossref
Sibo Wang, Hongzhi Wu, Yunhui Zhu, Hongxia Cui, Ji Yang, Mingyuan Lu, Huangzuo Cheng, Lihong Gu, Tieshan Xu & Li Xu. (2022) Effect of Lycopene on the Growth Performance, Antioxidant Enzyme Activity, and Expression of Gene in the Keap1-Nrf2 Signaling Pathway of Arbor Acres Broilers. Frontiers in Veterinary Science 9.
Crossref
Harit Panda, Huaichun Wen, Mikiko Suzuki & Masayuki Yamamoto. (2022) Multifaceted Roles of the KEAP1–NRF2 System in Cancer and Inflammatory Disease Milieu. Antioxidants 11:3, pages 538.
Crossref
Cecilia Zazueta, Alexis Paulina Jimenez-Uribe, José Pedraza-Chaverri & Mabel Buelna-Chontal. (2022) Genetic Variations on Redox Control in Cardiometabolic Diseases: The Role of Nrf2. Antioxidants 11:3, pages 507.
Crossref
Sicong Wang, Giovanna Di Trapani & Kathryn F. Tonissen. (2022) Expanding the armory for treating lymphoma: Targeting redox cellular status through thioredoxin reductase inhibition. Pharmacological Research 177, pages 106134.
Crossref
Cory A. Berger, Collin P. Ward, Sibel I. Karchner, Robert K. Nelson, Christopher M. Reddy, Mark E. Hahn & Ann M. Tarrant. (2022) Nematostella vectensis exhibits an enhanced molecular stress response upon co-exposure to highly weathered oil and surface UV radiation. Marine Environmental Research 175, pages 105569.
Crossref
Jia-Yi Yin, Ya-Ning Han, Meng-Qi Liu, Zan-Hao Piao, Xu Zhang, Yu-Ting Xue & Ying-Hua Zhang. (2022) Structure-guided discovery of antioxidant peptides bounded to the Keap1 receptor as hunter for potential dietary antioxidants. Food Chemistry 373, pages 130999.
Crossref
Jung-Hwan Kim, Dong-Min Kang, Young-Jin Cho, Jin-Won Hyun & Mi-Jeong Ahn. (2022) Medicarpin Increases Antioxidant Genes by Inducing NRF2 Transcriptional Level in HeLa Cells. Antioxidants 11:2, pages 421.
Crossref
Marcos Martinez-Banaclocha. (2022) N-Acetyl-Cysteine: Modulating the Cysteine Redox Proteome in Neurodegenerative Diseases. Antioxidants 11:2, pages 416.
Crossref
Antonio Speciale, Claudia Muscarà, Maria Sofia Molonia, Giovanni Toscano, Francesco Cimino & Antonella Saija. (2022) In Vitro Protective Effects of a Standardized Extract From Cynara Cardunculus L. Leaves Against TNF-α-Induced Intestinal Inflammation. Frontiers in Pharmacology 13.
Crossref
Yan Wang, Guanqin Ma, Xue-Feng Wang, Lei Na, Xing Guo, Jiaqi Zhang, Cong Liu, Cheng Du, Ting Qi, Yuezhi Lin & Xiaojun Wang. (2022) Keap1 recognizes EIAV early accessory protein Rev to promote antiviral defense. PLOS Pathogens 18:2, pages e1009986.
Crossref
Michelle T. Barati & Dawn J. Caster. (2022) The Potential of Nrf2 Activation as a Therapeutic Target in Systemic Lupus Erythematosus. Metabolites 12:2, pages 151.
Crossref
Yuchen Lei, Yuxiang Huang, Xin Wen, Zhangyuan Yin, Zhihai Zhang & Daniel J. Klionsky. (2022) How Cells Deal with the Fluctuating Environment: Autophagy Regulation under Stress in Yeast and Mammalian Systems. Antioxidants 11:2, pages 304.
Crossref
Chengtao Sun, Bing Han, Yufei Zhai, Huan Zhao, Xuan Li, Jun Qian, Xiaolong Hao, Qun Liu, Jiayan Shen & Guoyin Kai. (2022) Dihydrotanshinone I inhibits ovarian tumor growth by activating oxidative stress through Keap1-mediated Nrf2 ubiquitination degradation. Free Radical Biology and Medicine 180, pages 220-235.
Crossref
Yuxin Xiao, Rui Huang, Nan Wang, Yuankun Deng, Bie Tan, Yulong Yin, Ming Qi & Jing Wang. (2022) Ellagic Acid Alleviates Oxidative Stress by Mediating Nrf2 Signaling Pathways and Protects against Paraquat-Induced Intestinal Injury in Piglets. Antioxidants 11:2, pages 252.
Crossref
Pablo Duarte, Patrycja Michalska, Enrique Crisman, Antonio Cuadrado & Rafael León. (2022) Novel Series of Dual NRF2 Inducers and Selective MAO-B Inhibitors for the Treatment of Parkinson’s Disease. Antioxidants 11:2, pages 247.
Crossref
Vy Ngo, Nadun C. Karunatilleke, Anne Brickenden, Wing-Yiu Choy & Martin L. Duennwald. (2022) Oxidative Stress-Induced Misfolding and Inclusion Formation of Nrf2 and Keap1. Antioxidants 11:2, pages 243.
Crossref
Wenlan Li, Kristy Swiderski, Kate T. Murphy & Gordon S. Lynch. (2022) Role for Plant-Derived Antioxidants in Attenuating Cancer Cachexia. Antioxidants 11:2, pages 183.
Crossref
Christian Liedtke, Yulia A. Nevzorova, Tom Luedde, Henning Zimmermann, Daniela Kroy, Pavel Strnad, Marie-Luise Berres, Jürgen Bernhagen, Frank Tacke, Jacob Nattermann, Ulrich Spengler, Tilman Sauerbruch, Alexander Wree, Zeinab Abdullah, René H. Tolba, Jonel Trebicka, Twan Lammers, Christian Trautwein & Ralf Weiskirchen. (2022) Liver Fibrosis—From Mechanisms of Injury to Modulation of Disease. Frontiers in Medicine 8.
Crossref
Heath G. Gasier, Hagir B. Suliman & Claude A. Piantadosi. (2022) The HO-1/CO System and Mitochondrial Quality Control in Skeletal Muscle. Exercise and Sport Sciences Reviews 50:1, pages 49-55.
Crossref
Daisuke Yasuda, Ippei Yoshida, Riyo Imamura, Daiki Katagishi, Kyoko Takahashi, Hirotatsu Kojima, Takayoshi Okabe, Yoshinobu Ichimura, Masaaki Komatsu, Tadahiko Mashino & Tomoyuki Ohe. (2022) Development of p62-Keap1 protein–protein interaction inhibitors as doxorubicin-sensitizers against non-small cell lung cancer. Results in Chemistry 4, pages 100609.
Crossref
Deepthy Jayakumar, Kishore Kumar S. Narasimhan & Kalaiselvi Periandavan. (2022) Triad role of hepcidin, ferroportin, and Nrf2 in cardiac iron metabolism: From health to disease. Journal of Trace Elements in Medicine and Biology 69, pages 126882.
Crossref
Sharadha Dayalan Naidu, Takafumi Suzuki, Dina Dikovskaya, Elena V. Knatko, Maureen Higgins, Miu Sato, Miroslav Novak, José A. Villegas, Terry W. Moore, Masayuki Yamamoto & Albena T. Dinkova-Kostova. (2022) The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2. iScience 25:1, pages 103703.
Crossref
Francesco Visioli, Avery Ingram, Joseph S. Beckman, Kathy R. Magnusson & Tory M. Hagen. (2022) Strategies to protect against age-related mitochondrial decay: Do natural products and their derivatives help?. Free Radical Biology and Medicine 178, pages 330-346.
Crossref
Eiko Sakai, Fatima Farhana, Yu Yamaguchi & Takayuki Tsukuba. 2022. 1 28 .
Ranjana Bhandari & Anurag Kuhad. 2022. Probiotic Research in Therapeutics. Probiotic Research in Therapeutics 117 134 .
Seyed Hossein Shahcheraghi, Fateme Salemi, Niloufar Peirovi, Jamshid Ayatollahi, Waqas Alam, Haroon Khan & Luciano Saso. (2021) Nrf2 Regulation by Curcumin: Molecular Aspects for Therapeutic Prospects. Molecules 27:1, pages 167.
Crossref
Xiaojie Liu, Minnan Zhao, Xue Sun, Zhenzhen Meng, Xiaojing Bai, Yanchao Gong, Limei Xu, Xiaohe Hao, Tingting Yang, Zhao Wei, Xiyu Zhang, Haiyang Guo, Peishan Li, Qiao Liu, Yaoqin Gong, Yufang Shi & Changshun Shao. (2021) Autophagic Flux Unleashes GATA4-NF-κB Axis to Promote Antioxidant Defense-Dependent Survival of Colorectal Cancer Cells under Chronic Acidosis. Oxidative Medicine and Cellular Longevity 2021, pages 1-19.
Crossref
Jacek Rysz, Beata Franczyk, Magdalena Rysz-Górzyńska & Anna Gluba-Brzózka. (2021) Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake. International Journal of Molecular Sciences 23:1, pages 183.
Crossref
Giovanni Giurdanella, Anna Longo, Alfio Distefano, Melania Olivieri, Martina Cristaldi, Alessia Cosentino, Aleksandra Agafonova, Nunzia Caporarello, Gabriella Lupo & Carmelina Daniela Anfuso. (2021) The Anti-Inflammatory Effect of the β1-Adrenergic Receptor Antagonist Metoprolol on High Glucose Treated Human Microvascular Retinal Endothelial Cells. Cells 11:1, pages 51.
Crossref
Jessica D. Rosarda, Kelsey R. Baron, Kayla Nutsch, Gabriel M. Kline, Caroline Stanton, Jeffery W. Kelly, Michael J. Bollong & R. Luke Wiseman. (2021) Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2. ACS Chemical Biology 16:12, pages 2852-2863.
Crossref
Yi-Tian Ying, Jing Yang, Xun Tan, Rui Liu, Ying Zhuang, Jia-Xue Xu & Wei-Jia Ren. (2021) Escherichia coli and Staphylococcus aureus Differentially Regulate Nrf2 Pathway in Bovine Mammary Epithelial Cells: Relation to Distinct Innate Immune Response. Cells 10:12, pages 3426.
Crossref
Silvia Bono, Marco Feligioni & Massimo Corbo. (2021) Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy. Molecular Neurodegeneration 16:1.
Crossref
Yuan-Ye Dang, Hua Luo, Yong-Mei Li, Yang Zhou, Xiu Luo, Shui-Mu Lin, Shou-Ping Liu, Simon Ming-Yuen Lee, Chu-Wen Li & Xiao-Yan Dai. (2021) Curcumin prevents As3+-induced carcinogenesis through regulation of GSK3β/Nrf2. Chinese Medicine 16:1.
Crossref
Shuai Huang, Gen Chen, Jia Sun, Yunjie Chen, Nan Wang, Yetong Dong, Enzhao Shen, Zhicheng Hu, Wenjie Gong, Litai Jin & Weitao Cong. (2021) Histone deacetylase 3 inhibition alleviates type 2 diabetes mellitus-induced endothelial dysfunction via Nrf2. Cell Communication and Signaling 19:1.
Crossref
Rui-Feng Fan, Kou-Kou Tang, Zhen-Yong Wang & Lin Wang. (2021) Persistent activation of Nrf2 promotes a vicious cycle of oxidative stress and autophagy inhibition in cadmium-induced kidney injury. Toxicology 464, pages 152999.
Crossref
Robin Schumann, Eileen Bischoff, Severina Klaus, Sophie Möhring, Julia Flock, Sandro Keller, Kim Remans, Markus Ganter & Marcel Deponte. (2021) Protein abundance and folding rather than the redox state of Kelch13 determine the artemisinin susceptibility of Plasmodium falciparum. Redox Biology 48, pages 102177.
Crossref
Chiao-Yun Lin, Chen-Bin Chang, Ren-Chin Wu, Angel Chao, Yun-Shien Lee, Chi-Neu Tsai, Chih-Hao Chen, Chih-Feng Yen & Chia-Lung Tsai. (2021) Glucose Activates Lysine-Specific Demethylase 1 through the KEAP1/p62 Pathway. Antioxidants 10:12, pages 1898.
Crossref
Wei Lei, Valentin M. Kliebe & Xin Chen. (2021) An Investigation into the Impact of a Glutaminase Inhibitor, Compound 968, on Nrf2 Signaling. Future Pharmacology 1:1, pages 41-47.
Crossref
Nadine Hellmuth, Camilla Brat, Omar Awad, Sven George, Astrid Kahnt, Tom Bauer, Hai Phong Huynh Phuoc, Dieter Steinhilber, Carlo Angioni, Mohamed Hassan, Katharina J. Hock, Georg Manolikakes, Kai Zacharowski, Jessica Roos & Thorsten J. Maier. (2021) Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids. Frontiers in Pharmacology 12.
Crossref
Rokeya Akter, Habibur Rahman, Tapan Behl, Mohammad Arifur Rahman Chowdhury, Mohammad Manirujjaman, Israt Jahan Bulbul, Shimaa E. Elshenaw, Delia Mirela Tit & Simona Bungau. (2021) Prospective Role of Polyphenolic Compounds in the Treatment of Neurodegenerative Diseases. CNS & Neurological Disorders - Drug Targets 20:5, pages 430-450.
Crossref
Marina DiotalleviFaseeha AyazThomas NicolMark J. Crabtree. (2021) Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine. Biochemical Society Transactions 49:5, pages 2189-2198.
Crossref
Jared Sivinski, Donna D. Zhang & Eli Chapman. (2021) Targeting NRF2 to treat cancer. Seminars in Cancer Biology 76, pages 61-73.
Crossref
Cody J. Schmidlin, Aryatara Shakya, Matthew Dodson, Eli Chapman & Donna D. Zhang. (2021) The intricacies of NRF2 regulation in cancer. Seminars in Cancer Biology 76, pages 110-119.
Crossref
Bashayer R. Al-Mubarak, Karen F.S. Bell, Sudhir Chowdhry, Paul J. Meakin, Paul S. Baxter, Sean McKay, Owen Dando, Michael L.J. Ashford, Irina Gazaryan, John D. Hayes & Giles E. Hardingham. (2021) Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress. Redox Biology 47, pages 102158.
Crossref
Ravichandran Jayasuriya, Umapathy Dhamodharan, Daoud Ali, Kumar Ganesan, Baojun Xu & Kunka Mohanram Ramkumar. (2021) Targeting Nrf2/Keap1 signaling pathway by bioactive natural agents: Possible therapeutic strategy to combat liver disease. Phytomedicine 92, pages 153755.
Crossref
Qing-Qing Xu, Pang Chui Shaw, Zhen Hu, Wen Yang, Siu-Po Ip, Yan-Fang Xian & Zhi-Xiu Lin. (2021) Comparison of the chemical constituents and anti-Alzheimer’s disease effects of Uncaria rhynchophylla and Uncaria tomentosa. Chinese Medicine 16:1.
Crossref
Hu Liu, Lee J. Johnston, Fenglai Wang & Xi Ma. (2021) Triggers for the Nrf2/ARE Signaling Pathway and Its Nutritional Regulation: Potential Therapeutic Applications of Ulcerative Colitis. International Journal of Molecular Sciences 22:21, pages 11411.
Crossref
Sheng Zhao, Wu Chen, Wei Li, Weimin Yu, Siqi Li, Ting Rao, Yuan Ruan, Xiangjun Zhou, Cong Liu, Yucheng Qi & Fan Cheng. (2021) LncRNA TUG1 attenuates ischaemia‐reperfusion‐induced apoptosis of renal tubular epithelial cells by sponging miR‐144‐3p via targeting Nrf2. Journal of Cellular and Molecular Medicine 25:20, pages 9767-9783.
Crossref
Jie Fu, Miao Xu, Longsheng Xu, Huadong Ni, Baoxia Zhao, Chaobo Ni, Mingde Huang, Jianjun Zhu, Ge Luo & Ming Yao. (2021) Sulforaphane alleviates hyperalgesia and enhances analgesic potency of morphine in rats with cancer-induced bone pain. European Journal of Pharmacology 909, pages 174412.
Crossref
Cláudia Teixeira, Pedro Rodrigues, Paula Serrão, Luís Figueira, Laura Guimarães, Luís Oliva Teles, Helena Peres & António Paulo Carvalho. (2021) Dietary tryptophan supplementation does not affect growth but increases brain serotonin level and modulates the expression of some liver genes in zebrafish (Danio rerio). Fish Physiology and Biochemistry 47:5, pages 1541-1558.
Crossref
Marcella Canton, Ricardo Sánchez-Rodríguez, Iolanda Spera, Francisca C. Venegas, Maria Favia, Antonella Viola & Alessandra Castegna. (2021) Reactive Oxygen Species in Macrophages: Sources and Targets. Frontiers in Immunology 12.
Crossref
Camille Audousset, Toby McGovern & James G. Martin. (2021) Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches – Pulmonary Disease/Asthma. Frontiers in Physiology 12.
Crossref
Jie Fu, Chaobo Ni, Hua‐Dong Ni, Long‐Sheng Xu, Qiu‐Li He, Huan Pan, Dong‐Dong Huang, Yan‐Bao Sun, Ge Luo, Ming‐Juan Liu & Ming Yao. (2021) Spinal Nrf2 translocation may inhibit neuronal NF‐κB activation and alleviate allodynia in a rat model of bone cancer pain. Journal of Neurochemistry 158:5, pages 1110-1130.
Crossref
Pengfei Liu, Matthew Dodson, Hui Li, Cody J. Schmidlin, Aryatara Shakya, Yongyi Wei, Joe G.N. Garcia, Eli Chapman, Pawel R. Kiela, Qing-Yu Zhang, Eileen White, Xinxin Ding, Aikseng Ooi & Donna D. Zhang. (2021) Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism. Molecular Metabolism 51, pages 101243.
Crossref
J. Jiménez-Villegas, L. Ferraiuolo, R.J. Mead, P.J. Shaw, A. Cuadrado & A.I. Rojo. (2021) NRF2 as a therapeutic opportunity to impact in the molecular roadmap of ALS. Free Radical Biology and Medicine 173, pages 125-141.
Crossref
Marta Cykowiak, Violetta Krajka-Kuźniak, Robert Kleszcz, Małgorzata Kucińska, Hanna Szaefer, Hanna Piotrowska-Kempisty, Adam Plewiński, Marek Murias & Wanda Baer-Dubowska. (2021) Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo. Nutrients 13:9, pages 3000.
Crossref
Liang Yuh Chew, Heng Zhang, Jianzheng He & Fengwei Yu. (2021) The Nrf2-Keap1 pathway is activated by steroid hormone signaling to govern neuronal remodeling. Cell Reports 36:5, pages 109466.
Crossref
Yu Hara, Kentaro Nakashima, Ryo Nagasawa, Kota Murohashi, Yoichi Tagami, Ayako Aoki, Koji Okudela & Takeshi Kaneko. (2021) Heme Oxygenase-1 in Patients With Interstitial Lung Disease: A Review of the Clinical Evidence. The American Journal of the Medical Sciences 362:2, pages 122-129.
Crossref
Lulu Chen, Zixiang Chen, Zhuqiu Xu, Weifeng Feng, Xiaonan Yang & Zuoliang Qi. (2021) Polydatin protects Schwann cells from methylglyoxal induced cytotoxicity and promotes crushed sciatic nerves regeneration of diabetic rats. Phytotherapy Research 35:8, pages 4592-4604.
Crossref
Nadun C. Karunatilleke, Courtney S. Fast, Vy Ngo, Anne Brickenden, Martin L. Duennwald, Lars Konermann & Wing-Yiu Choy. (2021) Nrf2, the Major Regulator of the Cellular Oxidative Stress Response, is Partially Disordered. International Journal of Molecular Sciences 22:14, pages 7434.
Crossref
Bingbing Dai, Jithesh J. Augustine, Ya’an Kang, David Roife, Xinqun Li, Jenying Deng, Lin Tan, Leona A. Rusling, John N. Weinstein, Philip L. Lorenzi, Michael P. Kim & Jason B. Fleming. (2021) Compound NSC84167 selectively targets NRF2-activated pancreatic cancer by inhibiting asparagine synthesis pathway. Cell Death & Disease 12:7.
Crossref
Melissa L Wilkinson & Andrew J Gow. (2021) Effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation. Innate Immunity 27:5, pages 353-364.
Crossref
Caren Weinhouse. (2021) The roles of inducible chromatin and transcriptional memory in cellular defense system responses to redox-active pollutants. Free Radical Biology and Medicine 170, pages 85-108.
Crossref
Yingcai Niu, Jing Zhang & Miaoxian Dong. (2021) Nrf2 as a potential target for Parkinson’s disease therapy. Journal of Molecular Medicine 99:7, pages 917-931.
Crossref
Johann Matschke, Safa Larafa & Verena Jendrossek. (2021) Metabolic reprograming of antioxidant defense: a precision medicine perspective for radiotherapy of lung cancer?. Biochemical Society Transactions 49:3, pages 1265-1277.
Crossref
Emiliano PanieriLuciano Saso. (2021) Inhibition of the NRF2/KEAP1 Axis: A Promising Therapeutic Strategy to Alter Redox Balance of Cancer Cells. Antioxidants & Redox Signaling 34:18, pages 1428-1483.
Crossref
Elizabeth M. Repash, Kaitlin M. Pensabene, Peter M. Palenchar & Aimee L. Eggler. (2021) Solving the Problem of Assessing Synergy and Antagonism for Non-Traditional Dosing Curve Compounds Using the DE/ZI Method: Application to Nrf2 Activators. Frontiers in Pharmacology 12.
Crossref
Justin M. Quiles, Mark E. Pepin, Sini Sunny, Sandeep B. Shelar, Anil K. Challa, Brian Dalley, John R. Hoidal, Steven M. Pogwizd, Adam R. Wende & Namakkal S. Rajasekaran. (2021) Identification of Nrf2-responsive microRNA networks as putative mediators of myocardial reductive stress. Scientific Reports 11:1.
Crossref

Displaying 200 of 1078 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.