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Youwei Xin, Yali Hou, Jingnan Zhang, Tingting Ding, Zhiyu Guan, Dongyan Zhang, Dan Wang, Siqi Jia, Siqi Li & Xiujuan Zhao. (2022) Metabolomics analysis of the effects of quercetin on Cd-induced hepatotoxicityin rats. Free Radical Research 56:2, pages 185-195.
Read now
Read now
Stephanie E. King, Eric Nilsson, Daniel Beck & Michael K. Skinner. (2019) Adipocyte epigenetic alterations and potential therapeutic targets in transgenerationally inherited lean and obese phenotypes following ancestral exposures. Adipocyte 8:1, pages 362-378.
Read now
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Valentina Sepe, Eleonora Distrutti, Stefano Fiorucci & Angela Zampella. (2015) Farnesoid X receptor modulators (2011 – 2014): a patent review. Expert Opinion on Therapeutic Patents 25:8, pages 885-896.
Read now
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Cheng Wang, Fengxiao Zhang, Lin Wang, Yanqing Zhang, Xiangrao Li, Kun Huang, Meng Du, Fangmei Liu, Shizheng Huang, Youfei Guan, Dan Huang & Kai Huang. (2013) Poly(ADP-Ribose) Polymerase 1 Promotes Oxidative-Stress-Induced Liver Cell Death via Suppressing Farnesoid X Receptor α. Molecular and Cellular Biology 33:22, pages 4492-4503.
Read now
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S. Stahl, M. R. Davies, D. I. Cook & M. J. Graham. (2008) Nuclear hormone receptor-dependent regulation of hepatic transporters and their role in the adaptive response in cholestasis. Xenobiotica 38:7-8, pages 725-777.
Read now
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Shi-Ying Cai & James L Boyer. (2006) FXR: a target for cholestatic syndromes?. Expert Opinion on Therapeutic Targets 10:3, pages 409-421.
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Thierry Claudel, Ekkehard Sturm, Folkert Kuipers & Bart Staels. (2004) The farnesoid X receptor: a novel drug target?. Expert Opinion on Investigational Drugs 13:9, pages 1135-1148.
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Sander Houten & Johan Auwerx. (2004) The enterohepatic nuclear receptors are major regulators of the enterohepatic circulation of bile salts. Annals of Medicine 36:7, pages 482-491.
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Articles from other publishers (124)
Kritika Karri & David J. Waxman. (2023) TCDD dysregulation of lncRNA expression, liver zonation and intercellular communication across the liver lobule. Toxicology and Applied Pharmacology 471, pages 116550.
Crossref
Crossref
Danmei Yu, Zhou Lu, Ruyu Wang, Yusen Xiang, Hongtao Li, Jiani Lu, Lijun Zhang, Hongzhuan Chen, Weihua Li, Xin Luan & Lili Chen. (2023) FXR agonists for colorectal and liver cancers, as a stand-alone or in combination therapy. Biochemical Pharmacology 212, pages 115570.
Crossref
Crossref
Yanlin Guo, Guixiang Xie & Xiaoyan Zhang. (2023) Role of FXR in Renal Physiology and Kidney Diseases. International Journal of Molecular Sciences 24:3, pages 2408.
Crossref
Crossref
Sen Lin, Sutian Wang, Peng Wang, Cuiming Tang, Zhenjiang Wang, Lian Chen, Guoqing Luo, Hong Chen, Yuntao Liu, Bin Feng, De Wu, Douglas G. Burrin & Zhengfeng Fang. (2023) Bile acids and their receptors in regulation of gut health and diseases. Progress in Lipid Research 89, pages 101210.
Crossref
Crossref
Magdalena Rausch, Sophia L. Samodelov, Michele Visentin & Gerd A. Kullak-Ublick. (2022) The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity. International Journal of Molecular Sciences 23:22, pages 13967.
Crossref
Crossref
Dong Liu, Yanglin Ji, Qian Cheng, Yamin Zhu, Haibo Zhang, Yatu Guo, Xiupeng Cao & Hao Wang. (2022) Dietary astaxanthin-rich extract ameliorates atherosclerosis/retinopathy and restructures gut microbiome in apolipoprotein E-deficient mice fed on a high-fat diet. Food & Function 13:20, pages 10461-10475.
Crossref
Crossref
Weinan Zhou & Sayeepriyadarshini Anakk. (2022) Enterohepatic and non-canonical roles of farnesoid X receptor in controlling lipid and glucose metabolism. Molecular and Cellular Endocrinology 549, pages 111616.
Crossref
Crossref
Pengfei Zhao, Shicheng Fan, Yue Gao, Min Huang & Huichang Bi. (2022) Nuclear Receptor-Mediated Hepatomegaly and Liver Regeneration: An Update. Drug Metabolism and Disposition 50:5, pages 636-645.
Crossref
Crossref
Si-yu Tian, Shu-ming Chen, Cheng-xi Pan & Yong Li. (2022) FXR: structures, biology, and drug development for NASH and fibrosis diseases. Acta Pharmacologica Sinica 43:5, pages 1120-1132.
Crossref
Crossref
Ankang Peng, Shunzhi Liu, Lu Fang, Zixing Zhu, Yuan Zhou, Shanshan Yue, Zejiang Ma, Xiaoang Liu, Shilin Xue, Yingkun Qiu & Rong Qi. (2022) Inonotus obliquus and its bioactive compounds alleviate non-alcoholic fatty liver disease via regulating FXR/SHP/SREBP-1c axis. European Journal of Pharmacology 921, pages 174841.
Crossref
Crossref
Xiongfei Huang, Mingjie Fan & Wendong Huang. (2022) Pleiotropic roles of FXR in liver and colorectal cancers. Molecular and Cellular Endocrinology 543, pages 111543.
Crossref
Crossref
若岚 朱. (2022) The Pathogenesis and Treatment Progress of NAFLD Targeted by SREBP-1 Related Path-way. Advances in Clinical Medicine 12:05, pages 4210-4220.
Crossref
Crossref
James L. Thorne & Giorgia Cioccoloni. 2022. Nuclear Receptors in Human Health and Disease. Nuclear Receptors in Human Health and Disease
83
105
.
Yuanying Fang, Lamees Hegazy, Brian N. Finck & Bahaa Elgendy. (2021) Recent Advances in the Medicinal Chemistry of Farnesoid X Receptor. Journal of Medicinal Chemistry 64:24, pages 17545-17571.
Crossref
Crossref
Philipp Königshofer, Ksenia Brusilovskaya, Oleksandr Petrenko, Benedikt Silvester Hofer, Philipp Schwabl, Michael Trauner & Thomas Reiberger. (2021) Nuclear receptors in liver fibrosis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1867:12, pages 166235.
Crossref
Crossref
Kemp M. Anderson & Christopher P. Gayer. (2021) The Pathophysiology of Farnesoid X Receptor (FXR) in the GI Tract: Inflammation, Barrier Function and Innate Immunity. Cells 10:11, pages 3206.
Crossref
Crossref
Anna Mukha, Eric Kalkhoven & Saskia W.C. van Mil. (2021) Splice variants of metabolic nuclear receptors: Relevance for metabolic disease and therapeutic targeting. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1867:10, pages 166183.
Crossref
Crossref
Monique D. Appelman, Suzanne W. van der Veen & Saskia W. C. van Mil. (2021) Post-Translational Modifications of FXR; Implications for Cholestasis and Obesity-Related Disorders. Frontiers in Endocrinology 12.
Crossref
Crossref
Josué Orozco-Aguilar, Felipe Simon & Claudio Cabello-Verrugio. (2021) Redox-Dependent Effects in the Physiopathological Role of Bile Acids. Oxidative Medicine and Cellular Longevity 2021, pages 1-15.
Crossref
Crossref
Katrin Panzitt & Martin Wagner. (2021) FXR in liver physiology: Multiple faces to regulate liver metabolism. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1867:7, pages 166133.
Crossref
Crossref
Donald J. AbrahamPeter T.W. Cheng, Ellen Kick & Ranjan Mukherjee. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery
1
117
.
Sayeepriyadarshini Anakk & Angela E. Dean. (2020) Fxr-alpha Skips Alternatively in Liver Metabolism. Gastroenterology 159:5, pages 1655-1657.
Crossref
Crossref
Michael Weinberger, Filipa C. Simões, Roger Patient, Tatjana Sauka-Spengler & Paul R. Riley. (2020) Functional Heterogeneity within the Developing Zebrafish Epicardium. Developmental Cell 52:5, pages 574-590.e6.
Crossref
Crossref
Thierry Claudel & Michael Trauner. 2020. The Liver. The Liver
299
312
.
Maribel Méndez-Tepepa, Dafne Zepeda-Pérez, Leticia Nicolás-Toledo, Lourdes Arteaga-Casteñeda, Gabriel Gutiérrez-Ospina & Estela Cuevas-Romero. (2020) Inferring lanosterol functions in the female rabbit reproductive tract based on the immunolocalization of lanosterol 14-demethylase and farnesoid beta-receptor. Acta Histochemica 122:2, pages 151472.
Crossref
Crossref
Yuji Shiozaki, Audrey L. Keenan & Makoto Miyazaki. 2020. Lipid Signaling and Metabolism. Lipid Signaling and Metabolism
413
426
.
Tanja Šarenac & Momir Mikov. (2019) Cervical Cancer, Different Treatments and Importance of Bile Acids as Therapeutic Agents in This Disease. Frontiers in Pharmacology 10.
Crossref
Crossref
William M. Pandak & Genta Kakiyama. (2019) The acidic pathway of bile acid synthesis: Not just an alternative pathway. Liver Research 3:2, pages 88-98.
Crossref
Crossref
Shuqi Pu, Xiaojie Wu, Xiaoying Yang, Yunzhan Zhang, Yunkai Dai, Yueling Zhang, Xiaoting Wu, Yan Liu, Xiaona Cui, Haiyong Jin, Jianhong Cao, Ruliu Li, Jiazhong Cai, Qizhi Cao, Ling Hu & Yong Gao. (2019) The Therapeutic Role of Xenobiotic Nuclear Receptors Against Metabolic Syndrome. Current Drug Metabolism 20:1, pages 15-22.
Crossref
Crossref
Dong-Ju Shin & Li Wang. 2019. Bile Acids and Their Receptors. Bile Acids and Their Receptors
51
72
.
Tim van Zutphen, Anna Bertolini, Hilde D. de Vries, Vincent W. Bloks, Jan Freark de Boer, Johan W. Jonker & Folkert Kuipers. 2019. Bile Acids and Their Receptors. Bile Acids and Their Receptors
207
234
.
Manon Garcia, Laura Thirouard, Lauriane Sedès, Mélusine Monrose, Hélène Holota, Françoise Caira, David Volle & Claude Beaudoin. (2018) Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases. International Journal of Molecular Sciences 19:11, pages 3630.
Crossref
Crossref
Verena Hiebl, Angela Ladurner, Simone Latkolik & Verena M. Dirsch. (2018) Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR. Biotechnology Advances 36:6, pages 1657-1698.
Crossref
Crossref
P. Holy, A. Kloudova & P. Soucek. (2018) Importance of genetic background of oxysterol signaling in cancer. Biochimie 153, pages 109-138.
Crossref
Crossref
R Malivindi, M Santoro, D De Rose, S Panza, S Gervasi, V Rago & S Aquila. (2018) Activated-farnesoid X receptor (FXR) expressed in human sperm alters its fertilising ability. Reproduction 156:3, pages 249-259.
Crossref
Crossref
Matteo Tardelli, Thierry Claudel, Francesca Bruschi & Michael Trauner. (2018) Nuclear Receptor Regulation of Aquaglyceroporins in Metabolic Organs. International Journal of Molecular Sciences 19:6, pages 1777.
Crossref
Crossref
Jennifer Walshe, Neil A. Richardson, Najla Khaled Al Abdulsalam, Sally-Anne Stephenson & Damien G. Harkin. (2018) A potential role for Eph receptor signalling during migration of corneal endothelial cells. Experimental Eye Research 170, pages 92-100.
Crossref
Crossref
Kim Frisch & Aage Kristian Olsen Alstrup. (2018) On the Evolution of Bile Salts and the Farnesoid X Receptor in Vertebrates. Physiological and Biochemical Zoology 91:2, pages 797-813.
Crossref
Crossref
Vittoria Massafra & Saskia W.C. van Mil. (2018) Farnesoid X receptor: A “homeostat” for hepatic nutrient metabolism. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:1, pages 45-59.
Crossref
Crossref
Carolyn M. Klinge. 2018. Principles of Endocrinology and Hormone Action. Principles of Endocrinology and Hormone Action
187
232
.
Hong Wang, Zhou Zhao, Jiyu Zhou, Yitong Guo, Guangji Wang, Haiping Hao & Xiaowei Xu. (2017) A novel intestinal-restricted FXR agonist. Bioorganic & Medicinal Chemistry Letters 27:15, pages 3386-3390.
Crossref
Crossref
Frédéric G. Brunet, Thibault Lorin, Laure Bernard, Zofia Haftek-Terreau, Delphine Galiana, Manfred Schartl & Jean-Nicolas Volff. 2017. Evolutionary Biology: Self/Nonself Evolution, Species and Complex Traits Evolution, Methods and Concepts. Evolutionary Biology: Self/Nonself Evolution, Species and Complex Traits Evolution, Methods and Concepts
369
396
.
Laura E. Downing, Daniel Edgar, Patricia A. Ellison & Marie-Louise Ricketts. (2017) Mechanistic insight into nuclear receptor-mediated regulation of bile acid metabolism and lipid homeostasis by grape seed procyanidin extract (GSPE). Cell Biochemistry and Function 35:1, pages 12-32.
Crossref
Crossref
J. JUŘICA, G. DOVRTĚLOVÁ, K. NOSKOVÁ & O. ZENDULKA. (2016) Bile Acids, Nuclear Receptors and Cytochrome P450. Physiological Research, pages S427-S440.
Crossref
Crossref
Chang Yeob Han, Tae Hyun Kim, Ja Hyun Koo & Sang Geon Kim. (2016) Farnesoid X receptor as a regulator of fuel consumption and mitochondrial function. Archives of Pharmacal Research 39:8, pages 1062-1074.
Crossref
Crossref
Natalia Gomez-Ospina, Carol J. Potter, Rui Xiao, Kandamurugu Manickam, Mi-Sun Kim, Kang Ho Kim, Benjamin L. Shneider, Jennifer L. Picarsic, Theodora A. Jacobson, Jing Zhang, Weimin He, Pengfei Liu, A. S. Knisely, Milton J. Finegold, Donna M. Muzny, Eric Boerwinkle, James R. Lupski, Sharon E. Plon, Richard A. Gibbs, Christine M. Eng, Yaping Yang, Gabriel C. Washington, Matthew H. Porteus, William E. Berquist, Neeraja Kambham, Ravinder J. Singh, Fan Xia, Gregory M. Enns & David D. Moore. (2016) Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis. Nature Communications 7:1.
Crossref
Crossref
Carolyn M. Klinge. 2018. Diabetes. Epidemiology, Genetics, Pathogenesis, Diagnosis, Prevention, and Treatment. Diabetes. Epidemiology, Genetics, Pathogenesis, Diagnosis, Prevention, and Treatment
1
47
.
Lusi Ye, Ying Jiang & Xiaoxia Zuo. (2015) Farnesoid-X-receptor expression in monocrotaline-induced pulmonary arterial hypertension and right heart failure. Biochemical and Biophysical Research Communications 467:1, pages 164-170.
Crossref
Crossref
Fabio R. Santori. (2015) Nuclear hormone receptors put immunity on sterols. European Journal of Immunology 45:10, pages 2730-2741.
Crossref
Crossref
Lili Ding, Li Yang, Zhengtao Wang & Wendong Huang. (2015) Bile acid nuclear receptor FXR and digestive system diseases. Acta Pharmaceutica Sinica B 5:2, pages 135-144.
Crossref
Crossref
Ana Ana MariaMoreno-Ramos Oscar AndréasNeena B. Haider. (2016) Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases. Journal of Experimental Neuroscience 9s2, pages JEN.S25480.
Crossref
Crossref
Yang Jiao, Yan Lu & Xiao-ying Li. (2014) Farnesoid X receptor: a master regulator of hepatic triglyceride and glucose homeostasis. Acta Pharmacologica Sinica 36:1, pages 44-50.
Crossref
Crossref
Firdose Begum Shaik, Durbaka V. R. Prasad & Venkata Ramireddy Narala. (2014) Role of farnesoid X receptor in inflammation and resolution. Inflammation Research 64:1, pages 9-20.
Crossref
Crossref
Salvatore Modica, Marica Cariello, Annalisa Morgano, Isabelle Gross, Maria Carmela Vegliante, Stefania Murzilli, Lorena Salvatore, Jean-Noel Freund, Carlo Sabbà & Antonio Moschetta. (2014) Transcriptional Regulation of the Intestinal Nuclear Bile Acid Farnesoid X Receptor (FXR) by the caudal-related Homeobox 2 (CDX2). Journal of Biological Chemistry 289:41, pages 28421-28432.
Crossref
Crossref
Arely Anaya-Hernández, Maribel Méndez-Tepepa, Hernández-Aragón Laura G.Pablo Pacheco, Margarita Martínez-Gómez, Francisco Castelán & Estela Cuevas. (2014) Farnesoid X receptor immunolocalization in reproductive tissues of adult female rabbits. Acta Histochemica 116:6, pages 1068-1074.
Crossref
Crossref
Nidhi Singh, Manisha Yadav, Abhishek Kumar Singh, Harish Kumar, Shailendra Kumar Dhar Dwivedi, Jay Sharan Mishra, Anagha Gurjar, Amit Manhas, Sharat Chandra, Prem Narayan Yadav, Kumaravelu Jagavelu, Mohammad Imran Siddiqi, Arun Kumar Trivedi, Naibedya Chattopadhyay & Sabyasachi Sanyal. (2014) Synthetic FXR Agonist GW4064 Is a Modulator of Multiple G Protein–Coupled Receptors. Molecular Endocrinology 28:5, pages 659-673.
Crossref
Crossref
Lin Ding, Shuguang Pang, Yongmei Sun, Yuling Tian, Li Yu & Ningning Dang. (2014) Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes. International Journal of Endocrinology 2014, pages 1-13.
Crossref
Crossref
Frank G. Schaap, Michael Trauner & Peter L. M. Jansen. (2013) Bile acid receptors as targets for drug development. Nature Reviews Gastroenterology & Hepatology 11:1, pages 55-67.
Crossref
Crossref
Simona D’Amore, Giuseppe Palasciano & Antonio Moschetta. 2014. A Systems Biology Approach to Study Metabolic Syndrome. A Systems Biology Approach to Study Metabolic Syndrome
27
61
.
Stephen P.H. Alexander, Helen E. Benson, Elena Faccenda, Adam J. Pawson, Joanna L. Sharman, Michael Spedding, John A. Peters & Anthony J. Harmar. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Nuclear Hormone Receptors. British Journal of Pharmacology 170:8, pages 1652-1675.
Crossref
Crossref
Xiulong Song, Yuan Chen, Leila Valanejad, Rajani Kaimal, Bingfang Yan, Matthew Stoner & Ruitang Deng. (2013) Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor. Journal of Lipid Research 54:11, pages 3030-3044.
Crossref
Crossref
Stefania Catalano, Salvatore Panza, Rocco Malivindi, Cinzia Giordano, Ines Barone, Gianluca Bossi, Marilena Lanzino, Rosa Sirianni, Loredana Mauro, Diego Sisci, Daniela Bonofiglio & Sebastiano Andò. (2013)
Inhibition of leydig tumor growth by farnesoid X receptor activation: The
in vitro
and
in vivo
basis for a novel therapeutic strategy
. International Journal of Cancer 132:10, pages 2237-2247.
Crossref
Crossref
Michele Vacca, Chiara Degirolamo, Vittoria Massafra, Lorenzo Polimeno, Renato Mariani-Costantini, Giuseppe Palasciano & Antonio Moschetta. (2013) Nuclear receptors in regenerating liver and hepatocellular carcinoma. Molecular and Cellular Endocrinology 368:1-2, pages 108-119.
Crossref
Crossref
Yuan Chen, Xiulong Song, Leila Valanejad, Alexander Vasilenko, Vijay More, Xi Qiu, Weikang Chen, Yurong Lai, Angela Slitt, Matthew Stoner, Bingfang Yan & Ruitang Deng. (2013) Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma. Hepatology 57:4, pages 1530-1541.
Crossref
Crossref
A. Mencarelli, S. Cipriani, B. Renga, C. D’Amore, G. Palladino, E. Distrutti, F. Baldelli & S. Fiorucci. (2013) FXR activation improves myocardial fatty acid metabolism in a rodent model of obesity-driven cardiotoxicity. Nutrition, Metabolism and Cardiovascular Diseases 23:2, pages 94-101.
Crossref
Crossref
Riko Ichikawa, Tetsuro Takayama, Kazuaki Yoneno, Nobuhiko Kamada, Mina T. Kitazume, Hajime Higuchi, Katsuyoshi Matsuoka, Mitsuhiro Watanabe, Hiroshi Itoh, Takanori Kanai, Tadakazu Hisamatsu & Toshifumi Hibi. (2012) Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway. Immunology 136:2, pages 153-162.
Crossref
Crossref
Daniel MerkDieter Steinhilber & Manfred Schubert-Zsilavecz. (2012) Medicinal chemistry of farnesoid X receptor ligands: from agonists and antagonists to modulators. Future Medicinal Chemistry 4:8, pages 1015-1036.
Crossref
Crossref
Sejung Maeng, Jung Hwan Lee, Gil Jung Kim, Sung Hun Kim, Hak Cheol Kwon, Yun Kyung Shin & Young Chang Sohn. (2012) Molecular and expression analysis of the farnesoid X receptor in the urochordate Halocynthia roretzi. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 161:3, pages 189-196.
Crossref
Crossref
João Soeiro Teodoro, Anabela Pinto Rolo & Carlos Marques Palmeira. (2011) Hepatic FXR: key regulator of whole-body energy metabolism. Trends in Endocrinology & Metabolism 22:11, pages 458-466.
Crossref
Crossref
Michele Vacca, Chiara Degirolamo, Renato Mariani‐Costantini, Giuseppe Palasciano & Antonio Moschetta. (2011) Lipid‐sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome. WIREs Systems Biology and Medicine 3:5, pages 562-587.
Crossref
Crossref
Thierry Claudel, Gernot Zollner, Martin Wagner & Michael Trauner. (2011) Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1812:8, pages 867-878.
Crossref
Crossref
Wahiba Berrabah, Pierrette Aumercier, Philippe Lefebvre & Bart Staels. (2011) Control of nuclear receptor activities in metabolism by post-translational modifications. FEBS Letters 585:11, pages 1640-1650.
Crossref
Crossref
Thijs W.H. Pols, Lilia G. Noriega, Mitsunori Nomura, Johan Auwerx & Kristina Schoonjans. (2011) The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation. Journal of Hepatology 54:6, pages 1263-1272.
Crossref
Crossref
Antimo Gioiello, Antonio Macchiarulo, Andrea Carotti, Paolo Filipponi, Gabriele Costantino, Giovanni Rizzo, Luciano Adorini & Roberto Pellicciari. (2011) Extending SAR of bile acids as FXR ligands: Discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine. Bioorganic & Medicinal Chemistry 19:8, pages 2650-2658.
Crossref
Crossref
J Y Lee, K T Lee, J K Lee, K H Lee, K-T Jang, J S Heo, S H Choi, YIl Kim & J C Rhee. (2011) Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion. British Journal of Cancer 104:6, pages 1027-1037.
Crossref
Crossref
Tadeja Rezen, Damjana Rozman, Jean-Marc Pascussi & Katalin Monostory. (2011) Interplay between cholesterol and drug metabolism. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1814:1, pages 146-160.
Crossref
Crossref
Donald J. AbrahamPeter T.W. Cheng, Ellen Kick & Ranjan Mukherjee. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery
77
188
.
Deanna L. Howarth, Lee R. Hagey, Sheran H.W. Law, Ni Ai, Matthew D. Krasowski, Sean Ekins, John T. Moore, Erin M. Kollitz, David E. Hinton & Seth W. Kullman. (2010) Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro. Aquatic Toxicology 98:3, pages 245-255.
Crossref
Crossref
Joseph T. LundquistIVIV, Douglas C. Harnish, Callain Y. Kim, John F. Mehlmann, Rayomand J. Unwalla, Kristin M. Phipps, Matthew L. Crawley, Thomas Commons, Daniel M. Green, Weixin Xu, Wah-Tung Hum, Julius E. Eta, Irene Feingold, Vikram Patel, Mark J. Evans, KehDih Lai, Lisa Borges-Marcucci, Paige E. Mahaney & Jay E. Wrobel. (2010) Improvement of Physiochemical Properties of the Tetrahydroazepinoindole Series of Farnesoid X Receptor (FXR) Agonists: Beneficial Modulation of Lipids in Primates. Journal of Medicinal Chemistry 53:4, pages 1774-1787.
Crossref
Crossref
Salvatore Modica, Raffaella M. Gadaleta & Antonio Moschetta. (2010) Deciphering the nuclear bile acid receptor FXR paradigm. Nuclear Receptor Signaling 8:1, pages nrs.08005.
Crossref
Crossref
Andrea Mencarelli & Stefano Fiorucci. (2010) FXR an emerging therapeutic target for the treatment of atherosclerosis. Journal of Cellular and Molecular Medicine 14:1-2, pages 79-92.
Crossref
Crossref
Daniel J Fairbanks. 2001. eLS. eLS.
Alexander R. Moise, Susana Alvarez, Marta Domínguez, Rosana Alvarez, Marcin Golczak, Glenn P. Lobo, Johannes von Lintig, Angel R. de Lera & Krzysztof Palczewski. (2009) Activation of Retinoic Acid Receptors by Dihydroretinoids. Molecular Pharmacology 76:6, pages 1228-1237.
Crossref
Crossref
. (2009) Liver X and farnesoid X. British Journal of Pharmacology 158, pages S159-S159.
Crossref
Crossref
. (2009) NUCLEAR RECEPTORS. British Journal of Pharmacology 158, pages S157-S167.
Crossref
Crossref
Stefano Fiorucci & Franco Baldelli. (2009) Farnesoid X receptor agonists in biliary tract disease. Current Opinion in Gastroenterology 25:3, pages 252-259.
Crossref
Crossref
Peter P. Toth. (2009) Novel Therapies for Increasing Serum Levels of HDL. Endocrinology and Metabolism Clinics of North America 38:1, pages 151-170.
Crossref
Crossref
Philippe Lefebvre, Bertrand Cariou, Fleur Lien, Folkert Kuipers & Bart Staels. (2009) Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation. Physiological Reviews 89:1, pages 147-191.
Crossref
Crossref
Yan-Dong Wang, Wei-Dong Chen, David D Moore & Wendong Huang. (2008) FXR: a metabolic regulator and cell protector. Cell Research 18:11, pages 1087-1095.
Crossref
Crossref
Jen-Chieh Chuang, Ji-Young Cha, James C. Garmey, Raghavendra G. Mirmira & Joyce J. Joyce J.. (2008) Research Resource: Nuclear Hormone Receptor Expression in the Endocrine Pancreas. Molecular Endocrinology 22:10, pages 2353-2363.
Crossref
Crossref
Jyrki J. Eloranta & Gerd A. Kullak-Ublick. (2008) The Role of FXR in Disorders of Bile Acid Homeostasis. Physiology 23:5, pages 286-295.
Crossref
Crossref
Charles Thomas, Roberto Pellicciari, Mark Pruzanski, Johan Auwerx & Kristina Schoonjans. (2008) Targeting bile-acid signalling for metabolic diseases. Nature Reviews Drug Discovery 7:8, pages 678-693.
Crossref
Crossref
Shikha S Sundaram, Kevin E Bove, Mark A Lovell & Ronald J Sokol. (2008) Mechanisms of Disease: inborn errors of bile acid synthesis. Nature Clinical Practice Gastroenterology & Hepatology 5:8, pages 456-468.
Crossref
Crossref
Erica J. Reschly, Ni Ai, Sean Ekins, William J. Welsh, Lee R. Hagey, Alan F. Hofmann & Matthew D. Krasowski. (2008) Evolution of the bile salt nuclear receptor FXR in vertebrates*. Journal of Lipid Research 49:7, pages 1577-1587.
Crossref
Crossref
Daniel B. Magner & Adam Antebi. (2008) Caenorhabditis elegans nuclear receptors: insights into life traits. Trends in Endocrinology & Metabolism 19:5, pages 153-160.
Crossref
Crossref
Koji Nagao & Teruyoshi Yanagita. (2008) Bioactive lipids in metabolic syndrome. Progress in Lipid Research 47:2, pages 127-146.
Crossref
Crossref
K.G. Ramawat, M. Marthur, S. Dass & S. Suthar. 2008. Bioactive Molecules and Medicinal Plants. Bioactive Molecules and Medicinal Plants
101
121
.
Shannon M. Reilly & Chih-Hao Lee. 2008. Atherosclerosis and Oxidant Stress. Atherosclerosis and Oxidant Stress
96
122
.
Shi-Ying Cai, Liangshi Xiong, Charles G. Wray, Nazzareno Ballatori & James L. Boyer. (2007) The farnesoid X receptor FXRα/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 293:3, pages R1400-R1409.
Crossref
Crossref
Stefano Fiorucci, Gianni Rizzo, Annibale Donini, Eleonora Distrutti & Luca Santucci. (2007) Targeting farnesoid X receptor for liver and metabolic disorders. Trends in Molecular Medicine 13:7, pages 298-309.
Crossref
Crossref
Sander M. Houten, David H. Volle, Carolyn L. Cummins, David J. Mangelsdorf & Johan Auwerx. (2007) In Vivo Imaging of Farnesoid X Receptor Activity Reveals the Ileum as the Primary Bile Acid Signaling Tissue. Molecular Endocrinology 21:6, pages 1312-1323.
Crossref
Crossref
David D. Moore, Shigeaki Kato, Wen Xie, David J. Mangelsdorf, Daniel R. Schmidt, Rui Xiao & Steven A. Kliewer. (2006) International Union of Pharmacology. LXII. The NR1H and NR1I Receptors: Constitutive Androstane Receptor, Pregnene X Receptor, Farnesoid X Receptor α, Farnesoid X Receptor β, Liver X Receptor α, Liver X Receptor β, and Vitamin D Receptor. Pharmacological Reviews 58:4, pages 742-759.
Crossref
Crossref
Pierre Germain, Bart Staels, Catherine Dacquet, Michael Spedding & Vincent Laudet. (2006) Overview of Nomenclature of Nuclear Receptors. Pharmacological Reviews 58:4, pages 685-704.
Crossref
Crossref
Karen E. Swales, Márta Korbonits, Robert Carpenter, Desmond T. Walsh, Timothy D. Warner & David Bishop-Bailey. (2006) The Farnesoid X Receptor Is Expressed in Breast Cancer and Regulates Apoptosis and Aromatase Expression. Cancer Research 66:20, pages 10120-10126.
Crossref
Crossref
Florence Y. Lee, Hans Lee, Melissa L. Hubbert, Peter A. Edwards & Yanqiao Zhang. (2006) FXR, a multipurpose nuclear receptor. Trends in Biochemical Sciences 31:10, pages 572-580.
Crossref
Crossref
Shuguang Wang, KehDih Lai, Franklin J. Moy, Anitha Bhat, Helen B. Hartman & Mark J. Evans. (2006) The Nuclear Hormone Receptor Farnesoid X Receptor (FXR) Is Activated by Androsterone. Endocrinology 147:9, pages 4025-4033.
Crossref
Crossref
Amber K. Goetz, Wenjun Bao, Hongzu Ren, Judith E. Schmid, Douglas B. Tully, Carmen Wood, John C. Rockett, Michael G. Narotsky, Guobin Sun, Guy R. Lambert, Sheau-Fung Thai, Douglas C. Wolf, Stephen Nesnow & David J. Dix. (2006) Gene expression profiling in the liver of CD-1 mice to characterize the hepatotoxicity of triazole fungicides. Toxicology and Applied Pharmacology 215:3, pages 274-284.
Crossref
Crossref
Angie L. Bookout, Yangsik Jeong, Michael Downes, Ruth T. Yu, Ronald M. Evans & David J. Mangelsdorf. (2006) Anatomical Profiling of Nuclear Receptor Expression Reveals a Hierarchical Transcriptional Network. Cell 126:4, pages 789-799.
Crossref
Crossref
Ruitang Deng, Dongfang Yang, Jian Yang & Bingfang Yan. (2006)
Oxysterol 22(
R
)-Hydroxycholesterol Induces the Expression of the Bile Salt Export Pump through Nuclear Receptor Farsenoid X Receptor but Not Liver X Receptor
. Journal of Pharmacology and Experimental Therapeutics 317:1, pages 317-325.
Crossref
Crossref
Kotoko Nakata, Yoshitomo Tanaka, Tatsuya Nakano, Tatsuhiko Adachi, Hiroshi Tanaka, Tsuguchika Kaminuma & Toshihisa Ishikawa. (2006) Nuclear Receptor-Mediated Transcriptional Regulation in Phase I, II, and III Xenobiotic Metabolizing Systems. Drug Metabolism and Pharmacokinetics 21:6, pages 437-457.
Crossref
Crossref
Nada Y. KalaanyDavid J. Mangelsdorf. (2006) LXRS AND FXR: The Yin and Yang of Cholesterol and Fat Metabolism. Annual Review of Physiology 68:1, pages 159-191.
Crossref
Crossref
Thierry ClaudelBart StaelsFolkert Kuipers. (2005) The Farnesoid X Receptor. Arteriosclerosis, Thrombosis, and Vascular Biology 25:10, pages 2020-2030.
Crossref
Crossref
Martin O'BrienSier-Ching ChanthaAlain RahierDaniel P. Matton. (2005)
Lipid Signaling in Plants. Cloning and Expression Analysis of the Obtusifoliol 14
α
-Demethylase from
Solanum chacoense
Bitt., a Pollination- and Fertilization-Induced Gene with Both Obtusifoliol and Lanosterol Demethylase Activity
. Plant Physiology 139:2, pages 734-749.
Crossref
Crossref
Roberto Pellicciari, Gabriele Costantino & Stefano Fiorucci. (2005) Farnesoid X Receptor: From Structure to Potential Clinical Applications. Journal of Medicinal Chemistry 48:17, pages 5383-5403.
Crossref
Crossref
Martin Wagner & Michael Trauner. (2005) Transcriptional regulation of hepatobiliary transport systems in health and disease: Implications for a rationale approach to the treatment of intrahepatic cholestasis. Annals of Hepatology 4:2, pages 77-99.
Crossref
Crossref
Daniel S. Ory. (2004) Nuclear Receptor Signaling in the Control of Cholesterol Homeostasis. Circulation Research 95:7, pages 660-670.
Crossref
Crossref
Michael Trauner & James L. Boyer. (2004) Cholestatic syndromes. Current Opinion in Gastroenterology 20:3, pages 220-230.
Crossref
Crossref
Zhengdong Zhang, Paula E. Burch, Austin J. Cooney, Rainer B. Lanz, Fred A. Pereira, Jiaqian Wu, Richard A. Gibbs, George Weinstock & David A. Wheeler. (2004) Genomic Analysis of the Nuclear Receptor Family: New Insights Into Structure, Regulation, and Evolution From the Rat Genome. Genome Research 14:4, pages 580-590.
Crossref
Crossref
David Bishop-Bailey, Desmond T. Walsh & Timothy D. Warner. (2004) Expression and activation of the farnesoid X receptor in the vasculature. Proceedings of the National Academy of Sciences 101:10, pages 3668-3673.
Crossref
Crossref
Yanqiao Zhang, Lawrence W. Castellani, Christopher J. Sinal, Frank J. Gonzalez & Peter A. Edwards. (2004) Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR. Genes & Development 18:2, pages 157-169.
Crossref
Crossref
Kyung-Hyun Cho, Ji-Young Park, Jang-Il Han & Tae-Sook Jeong. (2003) Ligand-binding domain of farnesoid X receptor (FXR) had the highest sensitivity and activity among FXR variants in a fluorescence-based assay. Lipids 38:11, pages 1149-1156.
Crossref
Crossref
Li-Zhi Mi, Srikripa Devarakonda, Joel M. Harp, Qing Han, Roberto Pellicciari, Timothy M. Willson, Sepideh Khorasanizadeh & Fraydoon Rastinejad. (2003) Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR. Molecular Cell 11:4, pages 1093-1100.
Crossref
Crossref
Jodi M Maglich, Ann E Sluder, Tim M Willson & John T Moore. (2003) Beyond the Human Genome. American Journal of PharmacoGenomics 3:5, pages 345-353.
Crossref
Crossref
Marc Robinson-Rechavi & Vincent Laudet. 2003. Nuclear Receptors. Nuclear Receptors
93
118
.