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Gene Expression

Roles for SR Proteins and hnRNP A1 in the Regulation of c-src Exon N1

Nanette Rooke1 Department of Microbiology, Immunology and Molecular Genetics
,
Vadim Markovtsov1 Department of Microbiology, Immunology and Molecular Genetics
,
Esra Cagavi1 Department of Microbiology, Immunology and Molecular Genetics
&
Douglas L. Black1 Department of Microbiology, Immunology and Molecular Genetics;2 Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California90095Correspondence[email protected]
Pages 1874-1884 | Received 16 Aug 2002, Accepted 16 Dec 2002, Published online: 27 Mar 2023

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Kenro UTSUNOMIYA, Kanako OWAKI, Yuushi OKUMURA, Momoko YANO, Takahiro OTO, Eri SUZUKI, Seiko TAMURA, Tomoki ABE, Shohei KOHNO, Ayako OHNO, Katsuya HIRASAKA, Shigetada TESHIMA-KONDOH & Takeshi NIKAWA. (2012) An Intracellular Fragment of Osteoactivin Formed by Ectodomain Shedding Translocated to the Nucleoplasm and Bound to RNA Binding Proteins. Bioscience, Biotechnology, and Biochemistry 76:12, pages 2225-2229.
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David M. Mauger, Carolina Lin & Mariano A. Garcia-Blanco. (2008) hnRNP H and hnRNP F Complex with Fox2 To Silence Fibroblast Growth Factor Receptor 2 Exon IIIc. Molecular and Cellular Biology 28:17, pages 5403-5419.
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Hua-Lin Zhou, Andrew P. Baraniak & Hua Lou. (2007) Role for Fox-1/Fox-2 in Mediating the Neuronal Pathway of Calcitonin/Calcitonin Gene-Related Peptide Alternative RNA Processing. Molecular and Cellular Biology 27:3, pages 830-841.
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J. Barrett Crawford & James G. Patton. (2006) Activation of α-Tropomyosin Exon 2 Is Regulated by the SR Protein 9G8 and Heterogeneous Nuclear Ribonucleoproteins H and F. Molecular and Cellular Biology 26:23, pages 8791-8802.
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Jason G. Underwood, Paul L. Boutz, Joseph D. Dougherty, Peter Stoilov & Douglas L. Black. (2005) Homologues of the Caenorhabditis elegans Fox-1 Protein Are Neuronal Splicing Regulators in Mammals. Molecular and Cellular Biology 25:22, pages 10005-10016.
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Caroline Le Sommer, Michelle Lesimple, Agnès Mereau, Severine Menoret, Marie-Rose Allo & Serge Hardy. (2005) PTB Regulates the Processing of a 3′-Terminal Exon by Repressing both Splicing and Polyadenylation. Molecular and Cellular Biology 25:21, pages 9595-9607.
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Xiang H.-F. Zhang, Thaned Kangsamaksin, Mann S. P. Chao, Joydeep K. Banerjee & Lawrence A. Chasin. (2005) Exon Inclusion Is Dependent on Predictable Exonic Splicing Enhancers. Molecular and Cellular Biology 25:16, pages 7323-7332.
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Somsakul Pop Wongpalee, Ajay Vashisht, Shalini Sharma, Darryl Chui, James A Wohlschlegel & Douglas L Black. (2016) Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing. eLife 5.
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Hana Benhabiles, Jieshuang Jia & Fabrice Lejeune. 2016. Nonsense Mutation Correction in Human Diseases. Nonsense Mutation Correction in Human Diseases 1 76 .
Lindsey Skrdlant & Ren-Jang Lin. 2016. RNA-Protein Complexes and Interactions. RNA-Protein Complexes and Interactions 1 13 .
Muhammad Sohail & Jiuyong Xie. (2015) Diverse regulation of 3′ splice site usage. Cellular and Molecular Life Sciences 72:24, pages 4771-4793.
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Hui Li, Lei Guo, Aixue Huang, Hua Xu, Xuemei Liu, Hongmei Ding, Jie Dong, Jie Li, Chaonan Wang, Xueting Su, Xingfeng Ge, Leqiao Sun, Chenjun Bai, Xuelian Shen, Tao Fang, Zhanghua Li, Yong Zhou, Linsheng Zhan, Shaohua Li, Jianwei Xie & Ningsheng Shao. (2015) Nanoparticle-conjugated aptamer targeting hnRNP A2/B1 can recognize multiple tumor cells and inhibit their proliferation. Biomaterials 63, pages 168-176.
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Alger Fredericks, Kamil Cygan, Brian Brown & William Fairbrother. (2015) RNA-Binding Proteins: Splicing Factors and Disease. Biomolecules 5:2, pages 893-909.
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Yoseph Barash & Jorge Vaquero Garcia. 2014. Spliceosomal Pre-mRNA Splicing. Spliceosomal Pre-mRNA Splicing 411 423 .
Manti Guha & Narayan G. Avadhani. (2013) Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics. Mitochondrion 13:6, pages 577-591.
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Jacques Jean-Philippe, Sean Paz & Massimo Caputi. (2013) hnRNP A1: The Swiss Army Knife of Gene Expression. International Journal of Molecular Sciences 14:9, pages 18999-19024.
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Lorena Zubović, Marco Baralle & Francisco E. Baralle. (2012) Mutually exclusive splicing regulates the Nav 1.6 sodium channel function through a combinatorial mechanism that involves three distinct splicing regulatory elements and their ligands. Nucleic Acids Research 40:13, pages 6255-6269.
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Miguel B. Coelho & Christopher W. J. Smith. 2012. Alternative pre-mRNA Splicing. Alternative pre-mRNA Splicing 93 107 .
Indrani Talukdar, Supriya Sen, Rodolfo Urbano, James Thompson, John R. Yates & Nicholas J. G. Webster. (2011) hnRNP A1 and hnRNP F Modulate the Alternative Splicing of Exon 11 of the Insulin Receptor Gene. PLoS ONE 6:11, pages e27869.
Crossref
Jens Rauch, Kim Moran-Jones, Valerie Albrecht, Thomas Schwarzl, Keith Hunter, Olivier Gires & Walter Kolch. (2011) c-Myc Regulates RNA Splicing of the A-Raf Kinase and Its Activation of the ERK Pathway. Cancer Research 71:13, pages 4664-4674.
Crossref
Eliseos J. Mucaki, Peter Ainsworth & Peter K. Rogan. (2011) Comprehensive prediction of mRNA splicing effects of BRCA1 and BRCA2 variants. Human Mutation 32:7, pages 735-742.
Crossref
Suhyung ChoAmy HoangRahul Sinha, Xiang-Yang Zhong, Xiang-Dong Fu, Adrian R. Krainer & Gourisankar Ghosh. (2011) Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly. Proceedings of the National Academy of Sciences 108:20, pages 8233-8238.
Crossref
Jason L. Burkhead, Martina Ralle, Phillip Wilmarth, Larry David & Svetlana Lutsenko. (2011) Elevated Copper Remodels Hepatic RNA Processing Machinery in the Mouse Model of Wilson's Disease. Journal of Molecular Biology 406:1, pages 44-58.
Crossref
Sergio Barberan-Soler, Pedro Medina, Jeffrey Estella, James Williams & Alan M. Zahler. (2011) Co-regulation of alternative splicing by diverse splicing factors in Caenorhabditis elegans. Nucleic Acids Research 39:2, pages 666-674.
Crossref
Siew Ping Han, Yue Hang Tang & Ross Smith. (2010) Functional diversity of the hnRNPs: past, present and perspectives. Biochemical Journal 430:3, pages 379-392.
Crossref
Xinshu Xiao & Jae‐Hyung Lee. (2010) Systems analysis of alternative splicing and its regulation. WIREs Systems Biology and Medicine 2:5, pages 550-565.
Crossref
Jean-François Fisette, Johanne Toutant, Samuel Dugré-Brisson, Luc Desgroseillers & Benoit Chabot. (2010) hnRNP A1 and hnRNP H can collaborate to modulate 5′ splice site selection. RNA 16:1, pages 228-238.
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Xiangli Niu, Di Luo, Shaopei Gao, Guangjun Ren, Lijuan Chang, Yuke Zhou, Xiaoli Luo, Yuxiang Li, Pei Hou, Wei Tang, Bao-Rong Lu & Yongsheng Liu. (2010) A conserved unusual posttranscriptional processing mediated by short, direct repeated (SDR) sequences in plants. Journal of Genetics and Genomics 37:1, pages 85-99.
Crossref
Kim Moran-Jones, Joan Grindlay, Marc Jones, Ross Smith & Jim C. Norman. (2009) hnRNP A2 Regulates Alternative mRNA Splicing of TP53INP2 to Control Invasive Cell Migration. Cancer Research 69:24, pages 9219-9227.
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Francisco J. Ortega, José M. Moreno-Navarrete, Vicent Ribas, Eduardo Esteve, Jose I. Rodriguez-Hermosa, Bartomeu Ruiz, Belén Peral, Wifredo Ricart, Antonio Zorzano & José M. Fernández-Real. (2009) Subcutaneous Fat Shows Higher Thyroid Hormone Receptor-α1 Gene Expression Than Omental Fat. Obesity 17:12, pages 2134-2141.
Crossref
Ravi K. Singh, Aixa Tapia-Santos, Thomas W. Bebee & Dawn S. Chandler. (2009) Conserved sequences in the final intron of MDM2 are essential for the regulation of alternative splicing of MDM2 in response to stress. Experimental Cell Research 315:19, pages 3419-3432.
Crossref
Yaowu He, Joseph A. Rothnagel, Michael R. Epis, Peter J. Leedman & Ross Smith. (2009) Downstream targets of heterogeneous nuclear ribonucleoprotein A2 mediate cell proliferation. Molecular Carcinogenesis 48:2, pages 167-179.
Crossref
Jennifer C. LongJavier F. Caceres. (2008) The SR protein family of splicing factors: master regulators of gene expression. Biochemical Journal 417:1, pages 15-27.
Crossref
Matthew J. Schellenberg, Dustin B. Ritchie & Andrew M. MacMillan. (2008) Pre-mRNA splicing: a complex picture in higher definition. Trends in Biochemical Sciences 33:6, pages 243-246.
Crossref
Ines Lahmann, Manuela Fabienke, Berenike Henneberg, Oliver Pabst, Franz Vauti, Daniel Minge, Susanne Illenberger, Brigitte M. Jockusch, Martin Korte & Hans-Henning Arnold. (2008) The hnRNP and cytoskeletal protein raver1 contributes to synaptic plasticity. Experimental Cell Research 314:5, pages 1048-1060.
Crossref
Tina Ruggiero, Michele Trabucchi, Marco Ponassi, Giorgio Corte, Ching-Yi Chen, Latifa al-Haj, Khalid SA Khabar, Paola Briata & Roberto Gherzi. (2007) Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling. BMC Molecular Biology 8:1.
Crossref
Qin Li, Ji-Ann Lee & Douglas L. Black. (2007) Neuronal regulation of alternative pre-mRNA splicing. Nature Reviews Neuroscience 8:11, pages 819-831.
Crossref
Sonia Guil & Javier F Cáceres. (2007) The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a. Nature Structural & Molecular Biology 14:7, pages 591-596.
Crossref
Jernej Ule & Robert B. Darnell. 2007. Alternative Splicing in the Postgenomic Era. Alternative Splicing in the Postgenomic Era 148 160 .
Rebeca Martinez-Contreras, Philippe Cloutier, Lulzim Shkreta, Jean-François Fisette, Timothée Revil & Benoit Chabot. 2007. Alternative Splicing in the Postgenomic Era. Alternative Splicing in the Postgenomic Era 123 147 .
Theoni Leoutsakou, Maroulio Talieri & Andreas Scorilas. (2006) Expression analysis and prognostic significance of the SRA1 gene, in ovarian cancer. Biochemical and Biophysical Research Communications 344:2, pages 667-674.
Crossref
Rita Das, Kobina Dufu, Ben Romney, Megan Feldt, Mark Elenko & Robin Reed. (2006) Functional coupling of RNAP II transcription to spliceosome assembly. Genes & Development 20:9, pages 1100-1109.
Crossref
Brian Carpenter, Catriona MacKay, Ayham Alnabulsi, Morven MacKay, Colin Telfer, William T. Melvin & Graeme I. Murray. (2006) The roles of heterogeneous nuclear ribonucleoproteins in tumour development and progression. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1765:2, pages 85-100.
Crossref
Yi Xing & Christopher Lee. (2006) Can RNA selection pressure distort the measurement of Ka/Ks?. Gene 370, pages 1-5.
Crossref
Jernej Ule & Robert B Darnell. (2006) RNA binding proteins and the regulation of neuronal synaptic plasticity. Current Opinion in Neurobiology 16:1, pages 102-110.
Crossref
E Meshorer, B Bryk, D Toiber, J Cohen, E Podoly, A Dori & H Soreq. (2005) SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA. Molecular Psychiatry 10:11, pages 985-997.
Crossref
Hong Chen, William Stuart, Bing Hu, Lisa Nguyen, Ganghua Huang, Thomas L. Clemens & John S. Adams. (2005) Creation of Estrogen Resistance in Vivo by Transgenic Overexpression of the Heterogeneous Nuclear Ribonucleoprotein-Related Estrogen Response Element Binding Protein. Endocrinology 146:10, pages 4266-4273.
Crossref
Julian P. Venables, Cyril F. Bourgeois, Caroline Dalgliesh, Liliane Kister, James Stevenin & David J. Elliott. (2005) Up-regulation of the ubiquitous alternative splicing factor Tra2β causes inclusion of a germ cell-specific exon. Human Molecular Genetics 14:16, pages 2289-2303.
Crossref
Shalini Sharma, Arnold M. Falick & Douglas L. Black. (2005) Polypyrimidine Tract Binding Protein Blocks the 5′ Splice Site-Dependent Assembly of U2AF and the Prespliceosomal E Complex. Molecular Cell 19:4, pages 485-496.
Crossref
Trine Elkjaer Crovato & Jan Egebjerg. (2005) ASF/SF2 and SC35 regulate the glutamate receptor subunit 2 alternative flip/flop splicing. FEBS Letters 579:19, pages 4138-4144.
Crossref
Arianne J. Matlin, Francis Clark & Christopher W. J. Smith. (2005) Understanding alternative splicing: towards a cellular code. Nature Reviews Molecular Cell Biology 6:5, pages 386-398.
Crossref
Kyoungha Han, Gene Yeo, Ping An, Christopher B Burge & Paula J Grabowski. (2005) A Combinatorial Code for Splicing Silencing: UAGG and GGGG Motifs. PLoS Biology 3:5, pages e158.
Crossref
Guang YangShu-Ching HuangJane Y. WuEdward J. BenzJrJr. (2005) An erythroid differentiation–specific splicing switch in protein 4.1R mediated by the interaction of SF2/ASF with an exonic splicing enhancer. Blood 105:5, pages 2146-2153.
Crossref
Jana Královičová, Sophie Houngninou-Molango, Angela Krämer & Igor Vořechovský. (2004) Branch site haplotypes that control alternative splicing. Human Molecular Genetics 13:24, pages 3189-3202.
Crossref
P.J. Grabowski. (2004) A molecular code for splicing silencing: configurations of guanosine-rich motifs. Biochemical Society Transactions 32:6, pages 924-927.
Crossref
Alain Expert-Bezançon, Alain Sureau, Patrice Durosay, Roland Salesse, Herman Groeneveld, Jean Pierre Lecaer & Joëlle Marie. (2004) hnRNP A1 and the SR Proteins ASF/SF2 and SC35 Have Antagonistic Functions in Splicing of β-Tropomyosin Exon 6B. Journal of Biological Chemistry 279:37, pages 38249-38259.
Crossref
Sabrina Salani, Sabrina Lucchiari, Francesco Fortunato, Marco Crimi, Stefania Corti, Federica Locatelli, Patrizia Bossolasco, Nereo Bresolin & Giacomo Pietro Comi. (2004) Developmental and tissue-specific regulation of a novel dysferlin isoform. Muscle & Nerve 30:3, pages 366-374.
Crossref
Kyle Christian, Matti Lang, Patrick Maurel & Françoise Raffalli-Mathieu. (2004) Interaction of Heterogeneous Nuclear Ribonucleoprotein A1 with Cytochrome P450 2A6 mRNA: Implications for Post-Transcriptional Regulation of the CYP2A6 Gene . Molecular Pharmacology 65:6, pages 1405-1414.
Crossref
Zhi-Ming Zheng. (2004) Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression. Journal of Biomedical Science 11:3, pages 278-294.
Crossref
A. Tchourbanov, H.H. Ali & J. Deogun. (2004) Using enhancing signals to improve specificity of ab initio splice site sensors. Using enhancing signals to improve specificity of ab initio splice site sensors.
Cyril F Bourgeois, Fabrice Lejeune & James Stévenin. 2004. 37 88 .
Jonathan Villemaire, Isabelle Dion, Sherif Abou Elela & Benoit Chabot. (2003) Reprogramming Alternative Pre-messenger RNA Splicing through the Use of Protein-binding Antisense Oligonucleotides. Journal of Biological Chemistry 278:50, pages 50031-50039.
Crossref
Douglas L. Black. (2003) Mechanisms of Alternative Pre-Messenger RNA Splicing. Annual Review of Biochemistry 72:1, pages 291-336.
Crossref

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