Molecular and Cellular Biology, Volume 23, Issue 6 (2003)

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Molecular and Cellular Biology, Volume 23, Issue 6 (2003)

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Transcriptional Regulation

Article
The Aryl Hydrocarbon Receptor Mediates Degradation of Estrogen Receptor α through Activation of Proteasomes
Mark Wormke, Matthew Stoner, Bradley Saville, Kelcey Walker, Maen Abdelrahim, Robert Burghardt & Stephen Safe
Pages: 1843-1855
Published online: 27 Mar 2023
AbstractforThe Aryl Hydrocarbon Receptor Mediates Degradation of Estrogen Receptor α through Activation of Proteasomes | Full Text | References | PDF (621.2 KB)
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Article
Human Transcription Elongation Factor NELF: Identification of Novel Subunits and Reconstitution of the Functionally Active Complex
Takashi Narita, Yuki Yamaguchi, Keiichi Yano, Seiji Sugimoto, Sittinan Chanarat, Tadashi Wada, Dong-ki Kim, Jun Hasegawa, Masashi Omori, Naoto Inukai, Masaki Endoh, Tomoko Yamada & Hiroshi Handa
Pages: 1863-1873
Published online: 27 Mar 2023
AbstractforHuman Transcription Elongation Factor NELF: Identification of Novel Subunits and Reconstitution of the Functionally Active Complex | Full Text | References | PDF (570 KB)
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Article
Interleukin-3 Stimulation of mcl-1 Gene Transcription Involves Activation of the PU.1 Transcription Factor through a p38 Mitogen-Activated Protein Kinase-Dependent Pathway
Ju-Ming Wang, Ming-Zong Lai & Hsin-Fang Yang-Yen
Pages: 1896-1909
Published online: 27 Mar 2023
AbstractforInterleukin-3 Stimulation of mcl-1 Gene Transcription Involves Activation of the PU.1 Transcription Factor through a p38 Mitogen-Activated Protein Kinase-Dependent Pathway | Full Text | References | PDF (416.2 KB)
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Article
Regulation of TATA-Binding Protein Binding by the SAGA Complex and the Nhp6 High-Mobility Group Protein
Yaxin Yu, Peter Eriksson, Leena T. Bhoite & David J. Stillman
Pages: 1910-1921
Published online: 27 Mar 2023
AbstractforRegulation of TATA-Binding Protein Binding by the SAGA Complex and the Nhp6 High-Mobility Group Protein | Full Text | References | PDF (582.8 KB)
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Article
Molecular Determinants of Glucocorticoid Receptor Mobility in Living Cells: the Importance of Ligand Affinity
Marcel J. M. Schaaf & John A. Cidlowski
Pages: 1922-1934
Published online: 27 Mar 2023
AbstractforMolecular Determinants of Glucocorticoid Receptor Mobility in Living Cells: the Importance of Ligand Affinity | Full Text | References | PDF (619.5 KB)
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Article
Evidence for DNA Translocation by the ISWI Chromatin-Remodeling Enzyme
Iestyn Whitehouse, Chris Stockdale, Andrew Flaus, Mark D. Szczelkun & Tom Owen-Hughes
Pages: 1935-1945
Published online: 27 Mar 2023
AbstractforEvidence for DNA Translocation by the ISWI Chromatin-Remodeling Enzyme | Full Text | References | PDF (283.5 KB)
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Article
Activation of the Early B-Cell-Specific mb-1 (Ig-α) Gene by Pax-5 Is Dependent on an Unmethylated Ets Binding Site
Holly Maier, Jeff Colbert, Daniel Fitzsimmons, Dawn R. Clark & James Hagman
Pages: 1946-1960
Published online: 27 Mar 2023
AbstractforActivation of the Early B-Cell-Specific mb-1 (Ig-α) Gene by Pax-5 Is Dependent on an Unmethylated Ets Binding Site | Full Text | References | PDF (536.1 KB)
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Article
RNA Polymerase II Accumulation in the Promoter-Proximal Region of the Dihydrofolate Reductase and γ-Actin Genes
Chonghui Cheng & Phillip A. Sharp
Pages: 1961-1967
Published online: 27 Mar 2023
AbstractforRNA Polymerase II Accumulation in the Promoter-Proximal Region of the Dihydrofolate Reductase and γ-Actin Genes | Full Text | References | PDF (210.8 KB)
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Article
Dominant Negative Dimerization of a Mutant Homeodomain Protein in Axenfeld-Rieger Syndrome
Irfan Saadi, Adisa Kuburas, Jamison J. Engle & Andrew F. Russo
Pages: 1968-1982
Published online: 27 Mar 2023
AbstractforDominant Negative Dimerization of a Mutant Homeodomain Protein in Axenfeld-Rieger Syndrome | Full Text | References | PDF (780.1 KB)
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Article
Two Domains of the Progesterone Receptor Interact with the Estrogen Receptor and Are Required for Progesterone Activation of the c-Src/Erk Pathway in Mammalian Cells
Cecilia Ballaré, Markus Uhrig, Thomas Bechtold, Elena Sancho, Marina Di Domenico, Antimo Migliaccio, Ferdinando Auricchio & Miguel Beato
Pages: 1994-2008
Published online: 27 Mar 2023
AbstractforTwo Domains of the Progesterone Receptor Interact with the Estrogen Receptor and Are Required for Progesterone Activation of the c-Src/Erk Pathway in Mammalian Cells | Full Text | References | PDF (685.1 KB)
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Article
Rfm1, a Novel Tethering Factor Required To Recruit the Hst1 Histone Deacetylase for Repression of Middle Sporulation Genes
Ron McCord, Michael Pierce, Jianxin Xie, Sandeep Wonkatal, Carolyn Mickel & Andrew K. Vershon
Pages: 2009-2016
Published online: 27 Mar 2023
AbstractforRfm1, a Novel Tethering Factor Required To Recruit the Hst1 Histone Deacetylase for Repression of Middle Sporulation Genes | Full Text | References | PDF (287.9 KB)
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Article
Principal Role of TRAP/Mediator and SWI/SNF Complexes in Kaposi's Sarcoma-Associated Herpesvirus RTA-Mediated Lytic Reactivation
Yousang Gwack, Hwa Jin Baek, Hiroyuki Nakamura, Sun Hwa Lee, Michael Meisterernst, Robert G. Roeder & Jae U. Jung
Pages: 2055-2067
Published online: 27 Mar 2023
AbstractforPrincipal Role of TRAP/Mediator and SWI/SNF Complexes in Kaposi's Sarcoma-Associated Herpesvirus RTA-Mediated Lytic Reactivation | Full Text | References | PDF (751.7 KB)
  • 81 Views
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Article
Electrostatic Modulation in Steroid Receptor Recruitment of LXXLL and FXXLF Motifs
Bin He & Elizabeth M. Wilson
Pages: 2135-2150
Published online: 27 Mar 2023
AbstractforElectrostatic Modulation in Steroid Receptor Recruitment of LXXLL and FXXLF Motifs | Full Text | References | PDF (1.2 MB)
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Mammalian Genetic Models With Minimal Or Complex Phenotypes

Article
Selective Knockout of Mouse ERG1 B Potassium Channel Eliminates IKr in Adult Ventricular Myocytes and Elicits Episodes of Abrupt Sinus Bradycardia
James P. Lees-Miller, Jiqing Guo, Julie R. Somers, Dan E. Roach, Robert S. Sheldon, Derrick E. Rancourt & Henry J. Duff
Pages: 1856-1862
Published online: 27 Mar 2023
AbstractforSelective Knockout of Mouse ERG1 B Potassium Channel Eliminates IKr in Adult Ventricular Myocytes and Elicits Episodes of Abrupt Sinus Bradycardia | Full Text | References | PDF (180.1 KB)
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Gene Expression

Article
Roles for SR Proteins and hnRNP A1 in the Regulation of c-src Exon N1
Nanette Rooke, Vadim Markovtsov, Esra Cagavi & Douglas L. Black
Pages: 1874-1884
Published online: 27 Mar 2023
AbstractforRoles for SR Proteins and hnRNP A1 in the Regulation of c-src Exon N1 | Full Text | References | PDF (669.1 KB)
  • 21 Views
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Article
Late Cytoplasmic Maturation of the Small Ribosomal Subunit Requires RIO Proteins in Saccharomyces cerevisiae
Emmanuel Vanrobays, Jean-Paul Gelugne, Pierre-Emmanuel Gleizes & Michele Caizergues-Ferrer
Pages: 2083-2095
Published online: 27 Mar 2023
AbstractforLate Cytoplasmic Maturation of the Small Ribosomal Subunit Requires RIO Proteins in Saccharomyces cerevisiae | Full Text | References | PDF (722.6 KB)
  • 15 Views
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Article
Genetic Diversity: Frameshift Mechanisms Alter Coding of a Gene (Epstein-Barr Virus LF3 Gene) That Contains Multiple 102-Base-Pair Direct Sequence Repeats
Shao-An Xue, M. D. Jones, Qi-Long Lu, J. M. Middeldorp & Beverly E. Griffin
Pages: 2192-2201
Published online: 27 Mar 2023
AbstractforGenetic Diversity: Frameshift Mechanisms Alter Coding of a Gene (Epstein-Barr Virus LF3 Gene) That Contains Multiple 102-Base-Pair Direct Sequence Repeats | Full Text | References | PDF (395.5 KB)
  • 46 Views
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Article
mRNA Instability in the Nucleus Due to a Novel Open Reading Frame Element Is a Major Determinant of the Narrow Tissue Specificity of Folate Receptor α
Xuan Zheng, Karen Kelley, Hala Elnakat, Wu Yan, Ted Dorn & Manohar Ratnam
Pages: 2202-2212
Published online: 27 Mar 2023
AbstractformRNA Instability in the Nucleus Due to a Novel Open Reading Frame Element Is a Major Determinant of the Narrow Tissue Specificity of Folate Receptor α | Full Text | References | PDF (473 KB)
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Cell Growth and Development

Article
Human Cytomegalovirus pp71 Stimulates Cell Cycle Progression by Inducing the Proteasome-Dependent Degradation of the Retinoblastoma Family of Tumor Suppressors
Robert F. Kalejta, Jill T. Bechtel & Thomas Shenk
Pages: 1885-1895
Published online: 27 Mar 2023
AbstractforHuman Cytomegalovirus pp71 Stimulates Cell Cycle Progression by Inducing the Proteasome-Dependent Degradation of the Retinoblastoma Family of Tumor Suppressors | Full Text | References | PDF (431.6 KB)
  • 58 Views
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Article
A Raf-1 Mutant That Dissociates MEK/Extracellular Signal-Regulated Kinase Activation from Malignant Transformation and Differentiation but Not Proliferation
Amardeep S. Dhillon, Sharon Meikle, Carole Peyssonnaux, Joan Grindlay, Christian Kaiser, Helge Steen, Peter E. Shaw, Harald Mischak, Alain Eychène & Walter Kolch
Pages: 1983-1993
Published online: 27 Mar 2023
AbstractforA Raf-1 Mutant That Dissociates MEK/Extracellular Signal-Regulated Kinase Activation from Malignant Transformation and Differentiation but Not Proliferation | Full Text | References | PDF (604.7 KB)
  • 10 Views
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Article
Phosphorylation-Dependent Regulation of T-Cell Activation by PAG/Cbp, a Lipid Raft-Associated Transmembrane Adaptor
Dominique Davidson, Marcin Bakinowski, Matthew L. Thomas, Vaclav Horejsi & André Veillette
Pages: 2017-2028
Published online: 27 Mar 2023
AbstractforPhosphorylation-Dependent Regulation of T-Cell Activation by PAG/Cbp, a Lipid Raft-Associated Transmembrane Adaptor | Full Text | References | PDF (425.8 KB)
  • 47 Views
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Article
Tetrameric Oligomerization of IκB Kinase γ (IKKγ) Is Obligatory for IKK Complex Activity and NF-κB Activation
Sebastian Tegethoff, Joachim Behlke & Claus Scheidereit
Pages: 2029-2041
Published online: 27 Mar 2023
AbstractforTetrameric Oligomerization of IκB Kinase γ (IKKγ) Is Obligatory for IKK Complex Activity and NF-κB Activation | Full Text | References | PDF (476.9 KB)
  • 14 Views
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Article
The STE20 Kinase HGK Is Broadly Expressed in Human Tumor Cells and Can Modulate Cellular Transformation, Invasion, and Adhesion
Jocelyn H. Wright, Xueyan Wang, Gerard Manning, Brandon J. LaMere, Phuong Le, Shirley Zhu, Deepak Khatry, Peter M. Flanagan, Sharon D. Buckley, David B. Whyte, Anthony R. Howlett, James R. Bischoff, Kenneth E. Lipson & Bahija Jallal
Pages: 2068-2082
Published online: 27 Mar 2023
AbstractforThe STE20 Kinase HGK Is Broadly Expressed in Human Tumor Cells and Can Modulate Cellular Transformation, Invasion, and Adhesion | Full Text | References | PDF (1 MB)
  • 73 Views
  • 88 CrossRef citations
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Article
Regulation of Insulin Receptor Signaling by the Protein Tyrosine Phosphatase TCPTP
Sandra Galic, Manuela Klingler-Hoffmann, Michelle T. Fodero-Tavoletti, Michelle A. Puryer, Tzu-Ching Meng, Nicholas K. Tonks & Tony Tiganis
Pages: 2096-2108
Published online: 27 Mar 2023
AbstractforRegulation of Insulin Receptor Signaling by the Protein Tyrosine Phosphatase TCPTP | Full Text | References | PDF (744.2 KB)
  • 117 Views
  • 138 CrossRef citations
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Article
A Novel RING Finger Protein, Human Enhancer of Invasion 10, Alters Mitotic Progression through Regulation of Cyclin B Levels
Garabet G. Toby, Wahiba Gherraby, Thomas R. Coleman & Erica A. Golemis
Pages: 2109-2122
Published online: 27 Mar 2023
AbstractforA Novel RING Finger Protein, Human Enhancer of Invasion 10, Alters Mitotic Progression through Regulation of Cyclin B Levels | Full Text | References | PDF (728.8 KB)
  • 55 Views
  • 57 CrossRef citations
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Article
Transcriptional Repressor Functions of Drosophila E2F1 and E2F2 Cooperate To Inhibit Genomic DNA Synthesis in Ovarian Follicle Cells
Pelin Cayirlioglu, William O. Ward, S. Catherine Silver Key & Robert J. Duronio
Pages: 2123-2134
Published online: 27 Mar 2023
AbstractforTranscriptional Repressor Functions of Drosophila E2F1 and E2F2 Cooperate To Inhibit Genomic DNA Synthesis in Ovarian Follicle Cells | Full Text | References | PDF (610.8 KB)
  • 27 Views
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Article
The TRE17 Oncogene Encodes a Component of a Novel Effector Pathway for Rho GTPases Cdc42 and Rac1 and Stimulates Actin Remodeling
Jeffrey M. Masuda-Robens, Sara N. Kutney, Hongwei Qi & Margaret M. Chou
Pages: 2151-2161
Published online: 27 Mar 2023
AbstractforThe TRE17 Oncogene Encodes a Component of a Novel Effector Pathway for Rho GTPases Cdc42 and Rac1 and Stimulates Actin Remodeling | Full Text | References | PDF (849.4 KB)
  • 32 Views
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Article
Cortactin Is a Component of Clathrin-Coated Pits and Participates in Receptor-Mediated Endocytosis
Hong Cao, James D. Orth, Jing Chen, Shaun G. Weller, John E. Heuser & Mark A. McNiven
Pages: 2162-2170
Published online: 27 Mar 2023
AbstractforCortactin Is a Component of Clathrin-Coated Pits and Participates in Receptor-Mediated Endocytosis | Full Text | References | PDF (1.1 MB)
  • 70 Views
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Article
Stabilization of p53 by CP-31398 Inhibits Ubiquitination without Altering Phosphorylation at Serine 15 or 20 or MDM2 Binding
Wenge Wang, Rishu Takimoto, Farzan Rastinejad & Wafik S. El-Deiry
Pages: 2171-2181
Published online: 27 Mar 2023
AbstractforStabilization of p53 by CP-31398 Inhibits Ubiquitination without Altering Phosphorylation at Serine 15 or 20 or MDM2 Binding | Full Text | References | PDF (529.1 KB)
  • 29 Views
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Article
The Phospholipid Transfer Protein Gene Is a Liver X Receptor Target Expressed by Macrophages in Atherosclerotic Lesions
Bryan A. Laffitte, Sean B. Joseph, Mingyi Chen, Antonio Castrillo, Joyce Repa, Damien Wilpitz, David Mangelsdorf & Peter Tontonoz
Pages: 2182-2191
Published online: 27 Mar 2023
AbstractforThe Phospholipid Transfer Protein Gene Is a Liver X Receptor Target Expressed by Macrophages in Atherosclerotic Lesions | Full Text | References | PDF (727.3 KB)
  • 28 Views
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Article
Brain Lipid Binding Protein in Axon-Schwann Cell Interactions and Peripheral Nerve Tumorigenesis
Shyra J. Miller, Hongzhen Li, Tilat A. Rizvi, Yuan Huang, Gunnar Johansson, Jason Bowersock, Amer Sidani, John Vitullo, Kristine Vogel, Linda M. Parysek, Jeffrey E. DeClue & Nancy Ratner
Pages: 2213-2224
Published online: 27 Mar 2023
AbstractforBrain Lipid Binding Protein in Axon-Schwann Cell Interactions and Peripheral Nerve Tumorigenesis | Full Text | References | PDF (971.6 KB)
  • 26 Views
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Nucleocytoplasmic Communication

Article
Intersection of the Kap123p-Mediated Nuclear Import and Ribosome Export Pathways
Y. Sydorskyy, D. J. Dilworth, E. C. Yi, D. R. Goodlett, R. W. Wozniak & J. D. Aitchison
Pages: 2042-2054
Published online: 27 Mar 2023
AbstractforIntersection of the Kap123p-Mediated Nuclear Import and Ribosome Export Pathways | Full Text | References | PDF (531.2 KB)
  • 52 Views
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