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Gene Expression

The Splicing Factor U2AF Small Subunit Is Functionally Conserved between Fission Yeast and Humans

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Pages 4229-4240 | Received 20 Nov 2003, Accepted 25 Feb 2004, Published online: 27 Mar 2023

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Olga Herdt, Stefan Reich, Jan Medenbach, Bernd Timmermann, Didrik Olofsson, Marco Preußner & Florian Heyd. (2020) The zinc finger domains in U2AF26 and U2AF35 have diverse functionalities including a role in controlling translation. RNA Biology 17:6, pages 843-856.
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Tongbin Wu & Xiang-Dong Fu. (2015) Genomic functions of U2AF in constitutive and regulated splicing. RNA Biology 12:5, pages 479-485.
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Vinod Sridharan, Joseph Heimiller & Ravinder Singh. (2011) Genomic mRNA Profiling Reveals Compensatory Mechanisms for the Requirement of the Essential Splicing Factor U2AF. Molecular and Cellular Biology 31:4, pages 652-661.
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Vinod Sridharan & Ravinder Singh. (2007) A Conditional Role of U2AF in Splicing of Introns with Unconventional Polypyrimidine Tracts. Molecular and Cellular Biology 27:20, pages 7334-7344.
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Articles from other publishers (35)

Claudio Sette & Maria Paola Paronetto. (2022) Somatic Mutations in Core Spliceosome Components Promote Tumorigenesis and Generate an Exploitable Vulnerability in Human Cancer. Cancers 14:7, pages 1827.
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Brian A. Wadugu, Sridhar Nonavinkere Srivatsan, Amanda Heard, Michael O. Alberti, Matthew Ndonwi, Jie Liu, Sarah Grieb, Joseph Bradley, Jin Shao, Tanzir Ahmed, Cara L. Shirai, Ajay Khanna, Dennis L. Fei, Christopher A. Miller, Timothy A. Graubert & Matthew J. Walter. (2021) U2af1 is a haplo-essential gene required for hematopoietic cancer cell survival in mice. Journal of Clinical Investigation 131:21.
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Peter S. Choi & Andrei Thomas-Tikhonenko. (2021) RNA-binding proteins of COSMIC importance in cancer. Journal of Clinical Investigation 131:18.
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Ana Guijarro-Hernández & José Luis Vizmanos. (2021) A Broad Overview of Signaling in Ph-Negative Classic Myeloproliferative Neoplasms. Cancers 13:5, pages 984.
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Laurynas Vilys, Inga Peciuliene, Egle Jakubauskiene, Ruta Zinkeviciute, Yuichi Makino & Arvydas Kanopka. (2021) U2AF - Hypoxia-induced fas alternative splicing regulator. Experimental Cell Research 399:1, pages 112444.
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Xuhua Xia. (2020) RNA-Seq approach for accurate characterization of splicing efficiency of yeast introns. Methods 176, pages 25-33.
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Anna E. Marneth & Ann Mullally. (2020) The Molecular Genetics of Myeloproliferative Neoplasms. Cold Spring Harbor Perspectives in Medicine 10:2, pages a034876.
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Mohammad S. Esfahani, Luke J. Lee, Young-Jun Jeon, Ryan A. Flynn, Henning Stehr, Angela B. Hui, Noriko Ishisoko, Eric Kildebeck, Aaron M. Newman, Scott V. Bratman, Matthew H. Porteus, Howard Y. Chang, Ash A. Alizadeh & Maximilian Diehn. (2019) Functional significance of U2AF1 S34F mutations in lung adenocarcinomas. Nature Communications 10:1.
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Xiaoxue Wang, Xiaomeng Song & Xiaojing Yan. (2019) Effect of RNA splicing machinery gene mutations on prognosis of patients with MDS. Medicine 98:21, pages e15743.
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Geetha Melangath, Titash Sen, Rakesh Kumar, Pushpinder Bawa, Subha Srinivasan & Usha Vijayraghavan. (2017) Functions for fission yeast splicing factors SpSlu7 and SpPrp18 in alternative splice-site choice and stress-specific regulated splicing. PLOS ONE 12:12, pages e0188159.
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Olga Herdt, Alexander Neumann, Bernd Timmermann & Florian Heyd. (2017) The cancer-associated U2AF35 470A>G (Q157R) mutation creates an in-frame alternative 5′ splice site that impacts splicing regulation in Q157R patients. RNA 23:12, pages 1796-1806.
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Benjamin Jung Fair & Jeffrey A. Pleiss. (2016) The power of fission: yeast as a tool for understanding complex splicing. Current Genetics 63:3, pages 375-380.
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Jana Kralovicova & Igor Vorechovsky. (2017) Alternative splicing of U2AF1 reveals a shared repression mechanism for duplicated exons . Nucleic Acids Research 45:1, pages 417-434.
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Daniela Eckert, Nicole Andrée, Aleh Razanau, Susanne Zock-Emmenthal, Martin Lützelberger, Susann Plath, Henning Schmidt, Angel Guerra-Moreno, Luca Cozzuto, José Ayté & Norbert F. Käufer. (2016) Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation. PLOS Genetics 12:1, pages e1005768.
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Youlian Pan, Therese Ouellet, Sieu Phan, Alain Tchagang, Francois Fauteux & Dan Tulpan. (2015) Digitization of trait representation in microarray data analysis of wheat infected by fusarium graminearum. Digitization of trait representation in microarray data analysis of wheat infected by fusarium graminearum.
Hisashi Yoshida, Sam-Yong Park, Takashi Oda, Taeko Akiyoshi, Mamoru Sato, Mikako Shirouzu, Kengo Tsuda, Kanako Kuwasako, Satoru Unzai, Yutaka Muto, Takeshi Urano & Eiji Obayashi. (2015) A novel 3′ splice site recognition by the two zinc fingers in the U2AF small subunit. Genes & Development 29:15, pages 1649-1660.
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T Okeyo-Owuor, B S White, R Chatrikhi, D R Mohan, S Kim, M Griffith, L Ding, S Ketkar-Kulkarni, J Hundal, K M Laird, C L Kielkopf, T J Ley, M J Walter & T A Graubert. (2014) U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing. Leukemia 29:4, pages 909-917.
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Janine O. Ilagan, Aravind Ramakrishnan, Brian Hayes, Michele E. Murphy, Ahmad S. Zebari, Philip Bradley & Robert K. Bradley. (2015) U2AF1 mutations alter splice site recognition in hematological malignancies . Genome Research 25:1, pages 14-26.
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Laura Mojardín, Javier Botet, Luis Quintales, Sergio Moreno & Margarita Salas. (2013) New Insights into the RNA-Based Mechanism of Action of the Anticancer Drug 5′-Fluorouracil in Eukaryotic Cells. PLoS ONE 8:11, pages e78172.
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Franck Martin. (2012) Fifteen years of the yeast three-hybrid system: RNA–protein interactions under investigation. Methods 58:4, pages 367-375.
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Hidenobu Uchida, Eri Ikeuchi, Tomohito Yamasaki & Takeshi Ohama. (2012) THE ROLE OF ZINC FINGER PROTEIN IN RNAi INTERFERENCE IN A UNICELLULAR GREEN ALGA CHLAMYDOMONAS REINHARDTII (CHLOROPHYCEAE) . Journal of Phycology 48:5, pages 1299-1303.
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Kristine Potter, Nicole Cremona, Sham Sunder & Jo Ann Wise. (2012) A dominant role for meiosis-specific 3′ RNA processing in controlling expression of a fission yeast cyclin gene. RNA 18:7, pages 1408-1420.
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Timothy A Graubert, Dong Shen, Li Ding, Theresa Okeyo-Owuor, Cara L Lunn, Jin Shao, Kilannin Krysiak, Christopher C Harris, Daniel C Koboldt, David E Larson, Michael D McLellan, David J Dooling, Rachel M Abbott, Robert S Fulton, Heather Schmidt, Joelle Kalicki-Veizer, Michelle O'Laughlin, Marcus Grillot, Jack Baty, Sharon Heath, John L Frater, Talat Nasim, Daniel C Link, Michael H Tomasson, Peter Westervelt, John F DiPersio, Elaine R Mardis, Timothy J Ley, Richard K Wilson & Matthew J Walter. (2011) Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nature Genetics 44:1, pages 53-57.
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Pinchao Ma & Xuhua Xia. (2011) Factors Affecting Splicing Strength of Yeast Genes. Comparative and Functional Genomics 2011, pages 1-13.
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Long Ma & H. Robert Horvitz. (2009) Mutations in the Caenorhabditis elegans U2AF Large Subunit UAF-1 Alter the Choice of a 3′ Splice Site In Vivo. PLoS Genetics 5:11, pages e1000708.
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Zhaohua TangAmy TsurumiSarah AlaeiChristopher WilsonCathleen ChiuJessica OyaBenson Ngo. (2007) Dsk1p kinase phosphorylates SR proteins and regulates their cellular localization in fission yeast. Biochemical Journal 405:1, pages 21-30.
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Noriko Haraguchi, Tomoko Andoh, David Frendewey & Tokio Tani. (2007) Mutations in the SF1-U2AF59-U2AF23 Complex Cause Exon Skipping in Schizosaccharomyces pombe. Journal of Biological Chemistry 282:4, pages 2221-2228.
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Bing-Bing Wang & Volker Brendel. (2006) Molecular Characterization and Phylogeny of U2AF35 Homologs in Plants. Plant Physiology 140:2, pages 624-636.
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Valerie Wood. 2006. Comparative Genomics. Comparative Genomics 233 285 .
Nicole Averbeck, Sham Sunder, Nicole Sample, Jo Ann Wise & Janet Leatherwood. (2005) Negative Control Contributes to an Extensive Program of Meiotic Splicing in Fission Yeast. Molecular Cell 18:4, pages 491-498.
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Kristy L. Henscheid, David S. Shin, S. Craig Cary & J. Andrew Berglund. (2005) The splicing factor U2AF65 is functionally conserved in the thermotolerant deep-sea worm Alvinella pompejana. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1727:3, pages 197-207.
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Christopher J. Webb, Sujata Lakhe-Reddy, Charles M. Romfo & Jo Ann Wise. (2005) Analysis of Mutant Phenotypes and Splicing Defects Demonstrates Functional Collaboration between the Large and Small Subunits of the Essential Splicing Factor U2AF In Vivo. Molecular Biology of the Cell 16:2, pages 584-596.
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Christopher J. Webb, Charles M. Romfo, Willem J. van Heeckeren & Jo Ann Wise. (2005) Exonic splicing enhancers in fission yeast: functional conservation demonstrates an early evolutionary origin. Genes & Development 19:2, pages 242-254.
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Hideki Yashiroda & Keiji Tanaka. (2004) Hub1 is an essential ubiquitin-like protein without functioning as a typical modifier in fission yeast. Genes to Cells 9:12, pages 1189-1197.
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