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Oluwole Alowolodu, Gbemisola Johnson, Lamis Alashwal, Iqbal Addou, Irina V. Zhdanova & Vladimir N. Uversky. (2016) Intrinsic disorder in spondins and some of their interacting partners. Intrinsically Disordered Proteins 4:1.
Read now
Read now
Apostolos I Gogakos, Moira S Cheung, JH Duncan Bassett & Graham R Williams. (2009) Bone signaling pathways and treatment of osteoporosis. Expert Review of Endocrinology & Metabolism 4:6, pages 639-650.
Read now
Read now
Georges Rawadi & Sergio Roman-Roman. (2005) Wnt signalling pathway: a new target for the treatment of osteoporosis. Expert Opinion on Therapeutic Targets 9:5, pages 1063-1077.
Read now
Read now
Minrong Ai, Sheri L. Holmen, Wim Van Hul, Bart O. Williams & Matthew L. Warman. (2005) Reduced Affinity to and Inhibition by DKK1 Form a Common Mechanism by Which High Bone Mass-Associated Missense Mutations in LRP5 Affect Canonical Wnt Signaling. Molecular and Cellular Biology 25:12, pages 4946-4955.
Read now
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Articles from other publishers (130)
Rexhina Vlashi, Xingen Zhang, Mengrui Wu & Guiqian Chen. (2023) Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders. Genes & Diseases 10:4, pages 1291-1317.
Crossref
Crossref
Lawrence H. Winkler. (2023) Human Physiological Limitations to Long-Term Spaceflight and Living in Space. Aerospace Medicine and Human Performance 94:6, pages 444-456.
Crossref
Crossref
Aylin Sepinci Dincel & Niklas Rye Jørgensen. (2022) New Emerging Biomarkers for Bone Disease: Sclerostin and Dickkopf-1 (DKK1). Calcified Tissue International 112:2, pages 243-257.
Crossref
Crossref
Núria Martínez‐Gil, Diana Ovejero, Natalia Garcia‐Giralt, Carlos David Bruque, Leonardo Mellibovsky, Xavier Nogués, Raquel Rabionet, Daniel Grinberg & Susanna Balcells. (2022) Genetic Analysis in a Familial Case With High Bone Mineral Density Suggests Additive Effects at Two Loci. JBMR Plus 6:4.
Crossref
Crossref
Núria Martínez-Gil, Nerea Ugartondo, Daniel Grinberg & Susanna Balcells. (2022) Wnt Pathway Extracellular Components and Their Essential Roles in Bone Homeostasis. Genes 13:1, pages 138.
Crossref
Crossref
Roy B. Choi & Alexander G. Robling. (2021) The Wnt pathway: An important control mechanism in bone's response to mechanical loading. Bone 153, pages 116087.
Crossref
Crossref
Jonathan J Rios, Kristin Denton, Jamie Russell, Julia Kozlitina, Carlos R Ferreira, Amy F Lewanda, Joshua E Mayfield, Eva Moresco, Sara Ludwig, Miao Tang, Xiaohong Li, Stephen Lyon, Anas Khanshour, Nandina Paria, Aysha Khalid, Yang Li, Xudong Xie, Jian Q Feng, Qian Xu, Yongbo Lu, Robert E Hammer, Carol A Wise & Bruce Beutler. (2021) Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice. Journal of Bone and Mineral Research 36:8, pages 1548-1565.
Crossref
Crossref
Gary Davidson. 2021. Pharmacology of the WNT Signaling System. Pharmacology of the WNT Signaling System
45
73
.
Yi Zhang, Guojing Luo & Xijie Yu. (2020) Cellular Communication in Bone Homeostasis and the Related Anti-osteoporotic Drug Development. Current Medicinal Chemistry 27:7, pages 1151-1169.
Crossref
Crossref
Nerea. Alonso & Stuart H. Ralston. 2020. Encyclopedia of Bone Biology. Encyclopedia of Bone Biology
83
91
.
Michael P. Whyte, William H. McAlister, Fan Zhang, Vinieth N. Bijanki, Angela Nenninger, Gary S. Gottesman, Elizabeth L. Lin, Margaret Huskey, Shenghui Duan, Kathryn Dahir & Steven Mumm. (2019) New explanation for autosomal dominant high bone mass: Mutation of low-density lipoprotein receptor-related protein 6. Bone 127, pages 228-243.
Crossref
Crossref
Sheyla González, Denise Oh, Elfren R. Baclagon, Jie J. Zheng & Sophie X. Deng. (2019) Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro. Investigative Opthalmology & Visual Science 60:1, pages 107.
Crossref
Crossref
Alex Darío Cardona-Rincón, Juan Manuel Bello-Gualtero, Juan Carlos Munevar-Niño, Consuelo Romero-Sánchez & Rafael Raúl Valle-Oñate. (2019) Dickkopf 1 protein and its association with joint deterioration in rheumatoid arthritis: Systematic review. Revista Colombiana de Reumatología (English Edition) 26:1, pages 48-57.
Crossref
Crossref
Alex Darío Cardona-Rincón, Juan Manuel Bello-Gualtero, Juan Carlos Munevar-Niño, Consuelo Romero-Sánchez & Rafael Raúl Valle-Oñate. (2019) Proteína Dickkopf 1 y deterioro osteoarticular en artritis reumatoide: revisión sistemática. Revista Colombiana de Reumatología 26:1, pages 48-57.
Crossref
Crossref
Saleha Patel, Alice M. Barkell, Deepti Gupta, Sarah L. Strong, Shaun Bruton, Frederick W. Muskett, Philip W. Addis, Philip S. Renshaw, Patrick M. Slocombe, Carl Doyle, Alison Clargo, Richard J. Taylor, Christine E. Prosser, Alistair J. Henry, Martyn K. Robinson, Lorna C. Waters, Gill Holdsworth & Mark D. Carr. (2018) Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins. Journal of Biological Chemistry 293:31, pages 12149-12166.
Crossref
Crossref
Phillip C. Witcher, Sara E. Miner, Daniel J. Horan, Whitney A. Bullock, Kyung-Eun Lim, Kyung Shin Kang, Alison L. Adaniya, Ryan D. Ross, Gabriela G. Loots & Alexander G. Robling. (2018) Sclerostin neutralization unleashes the osteoanabolic effects of Dkk1 inhibition. JCI Insight 3:11.
Crossref
Crossref
Elham Rismani, Hamzeh Rahimi, Seyed Shahriar Arab, Kayhan Azadmanesh, Morteza Karimipoor & Ladan Teimoori-Toolabi. (2017) Computationally Design of Inhibitory Peptides Against Wnt Signaling Pathway: In Silico Insight on Complex of DKK1 and LRP6. International Journal of Peptide Research and Therapeutics 24:1, pages 49-60.
Crossref
Crossref
Michael H Kagey & Xi He. (2017) Rationale for targeting the Wnt signalling modulator Dickkopf‐1 for oncology. British Journal of Pharmacology 174:24, pages 4637-4650.
Crossref
Crossref
Minna Pekkinen, Giedre Grigelioniene, Leyla Akin, Krati Shah, Kadri Karaer, Selim Kurtoğlu, Alka Ekbote, Zehra Aycan, Elif Sağsak, Sumita Danda, Eva Åström & Outi Mäkitie. (2017)
Novel mutations in the
LRP5
gene in patients with Osteoporosis-pseudoglioma syndrome
. American Journal of Medical Genetics Part A 173:12, pages 3132-3135.
Crossref
Crossref
Won Jai Lee, Jung-Sun Lee, Hyo Min Ahn, Youjin Na, Chae Eun Yang, Ju Hee Lee, JinWoo Hong & Chae-Ok Yun. (2017) Decoy Wnt receptor (sLRP6E1E2)-expressing adenovirus induces anti-fibrotic effect via inhibition of Wnt and TGF-β signaling. Scientific Reports 7:1.
Crossref
Crossref
Tao Yang & Bart O. Williams. (2017) Low-Density Lipoprotein Receptor-Related Proteins in Skeletal Development and Disease. Physiological Reviews 97:3, pages 1211-1228.
Crossref
Crossref
S. RAY, T. EL KHASSAWNA, U. SOMMER, U. THORMANN, N.D. WIJEKOON, K. LIPS, C. HEISS & V. ALT. (2017) Differences in expression of Wnt antagonist Dkk1 in healthy versus pathological bone samples. Journal of Microscopy 265:1, pages 111-120.
Crossref
Crossref
Francesco Bertoldo. 2017. Bone Metastases from Prostate Cancer. Bone Metastases from Prostate Cancer
1
12
.
Sarah Thysen, Frederic Cailotto & Rik Lories. (2016) Osteogenesis induced by frizzled-related protein (FRZB) is linked to the netrin-like domain. Laboratory Investigation 96:5, pages 570-580.
Crossref
Crossref
Maryam K. Mohammed, Connie Shao, Jing Wang, Qiang Wei, Xin Wang, Zachary Collier, Shengli Tang, Hao Liu, Fugui Zhang, Jiayi Huang, Dan Guo, Minpeng Lu, Feng Liu, Jianxiang Liu, Chao Ma, Lewis L. Shi, Aravind Athiviraham, Tong-Chuan He & Michael J. Lee. (2016) Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance. Genes & Diseases 3:1, pages 11-40.
Crossref
Crossref
Michael A. Rudnicki & Bart O. Williams. (2015) Wnt signaling in bone and muscle. Bone 80, pages 60-66.
Crossref
Crossref
Paul J Niziolek, Bryan T MacDonald, Rajendra Kedlaya, Minjie Zhang, Teresita Bellido, Xi He, Matthew L Warman & Alexander G Robling. (2015)
High Bone Mass-Causing Mutant LRP5 Receptors Are Resistant to Endogenous Inhibitors
In Vivo
. Journal of Bone and Mineral Research 30:10, pages 1822-1830.
Crossref
Crossref
Shengnan LiuWei TianJing WangLongfei ChengJian JiaXu Ma. (2014)
Two Single-Nucleotide Polymorphisms in the
DKK1
Gene Are Associated with Developmental Dysplasia of the Hip in the Chinese Han Female Population
. Genetic Testing and Molecular Biomarkers 18:8, pages 557-561.
Crossref
Crossref
Mattia R. Bordoli, Jina Yum, Susanne B. Breitkopf, Jonathan N. Thon, Joseph E. ItalianoJr.Jr., Junyu Xiao, Carolyn Worby, Swee-Kee Wong, Grace Lin, Maja Edenius, Tracy L. Keller, John M. Asara, Jack E. Dixon, Chang-Yeol Yeo & Malcolm Whitman. (2014) A Secreted Tyrosine Kinase Acts in the Extracellular Environment. Cell 158:5, pages 1033-1044.
Crossref
Crossref
Astrid Liedert, Viktoria Röntgen, Thorsten Schinke, Peggy Benisch, Regina Ebert, Franz Jakob, Ludger Klein-Hitpass, Jochen K. Lennerz, Michael Amling & Anita Ignatius. (2014) Osteoblast-Specific Krm2 Overexpression and Lrp5 Deficiency Have Different Effects on Fracture Healing in Mice. PLoS ONE 9:7, pages e103250.
Crossref
Crossref
LiLi Qian, ChangZu Cai, PengFei Yuan, Sun-Young Jeong, XiaoZhou Yang, Venita DeAlmeida, James Ernst, Michael Costa, Stanley N. Cohen & WenSheng Wei. (2014) Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake. Science China Life Sciences 57:5, pages 469-481.
Crossref
Crossref
Patricia Sarrión, Leonardo Mellibovsky, Roser Urreizti, Sergi Civit, Neus Cols, Natàlia García-Giralt, Guy Yoskovitz, Alvaro Aranguren, Jorge Malouf, Silvana Di Gregorio, Luís Del Río, Roberto Güerri, Xavier Nogués, Adolfo Díez-Pérez, Daniel Grinberg & Susana Balcells. (2014) Genetic Analysis of High Bone Mass Cases from the BARCOS Cohort of Spanish Postmenopausal Women. PLoS ONE 9:4, pages e94607.
Crossref
Crossref
A Liedert, T Schinke, A Ignatius & M Amling. (2014) The role of midkine in skeletal remodelling. British Journal of Pharmacology 171:4, pages 870-878.
Crossref
Crossref
Wenbin Wan, Shijin Xia, Bill Kalionis, Lumei Liu & Yaming Li. (2014) The Role of Wnt Signaling in the Development of Alzheimer’s Disease: A Potential Therapeutic Target?. BioMed Research International 2014, pages 1-9.
Crossref
Crossref
Ming-Kang Chang, Ina Kramer, Hansjoerg Keller, Jonathan H Gooi, Corinne Collett, David Jenkins, Seth A Ettenberg, Feng Cong, Christine Halleux & Michaela Kneissel. (2014)
Reversing
LRP
5
-Dependent Osteoporosis and
SOST
Deficiency-Induced Sclerosing Bone Disorders by Altering WNT Signaling Activity
. Journal of Bone and Mineral Research 29:1, pages 29-42.
Crossref
Crossref
Theodora Koromila, Panagiotis Georgoulias, Zoe Dailiana, Evangelia E Ntzani, Stavroula Samara, Chris Chassanidis, Vassiliki Aleporou-Marinou & Panagoula Kollia. (2013) CER1gene variations associated with bone mineral density, bone markers, and early menopause in postmenopausal women. Human Genomics 7:1.
Crossref
Crossref
Sarah L. Dallas, Matthew Prideaux & Lynda F. Bonewald. (2013) The Osteocyte: An Endocrine Cell … and More. Endocrine Reviews 34:5, pages 658-690.
Crossref
Crossref
Eveline Boudin, Igor Fijalkowski, Elke Piters & Wim Van Hul. (2013) The role of extracellular modulators of canonical Wnt signaling in bone metabolism and diseases. Seminars in Arthritis and Rheumatism 43:2, pages 220-240.
Crossref
Crossref
Maurizio Rossini, Davide Gatti & Silvano Adami. (2013) Involvement of WNT/β-catenin Signaling in the Treatment of Osteoporosis. Calcified Tissue International 93:2, pages 121-132.
Crossref
Crossref
Eveline Boudin, Karen Jennes, Fenna de Freitas, David Tegay, Geert Mortier & Wim Van Hul. (2013) No mutations in the serotonin related TPH1 and HTR1B genes in patients with monogenic sclerosing bone disorders. Bone 55:1, pages 52-56.
Crossref
Crossref
Travis A. Burgers & Bart O. Williams. (2013) Regulation of Wnt/β-catenin signaling within and from osteocytes. Bone 54:2, pages 244-249.
Crossref
Crossref
Jung-Min Kim, Jin Seok Choi, Yun-Hee Kim, Seong Hui Jin, Seyoung Lim, Hyun-Jun Jang, Kyong-Tai Kim, Sung Ho Ryu & Pann-Ghill Suh. (2013) An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells. Journal of Cellular Physiology 228:3, pages 617-626.
Crossref
Crossref
Sandra Jastrzebski, Judith Kalinowski, Marina Stolina, Faryal Mirza, Elena Torreggiani, Ivo Kalajzic, Hee Yeon Won, Sun-Kyeong Lee & Joseph Lorenzo. (2013) Changes in bone sclerostin levels in mice after ovariectomy vary independently of changes in serum sclerostin levels. Journal of Bone and Mineral Research 28:3, pages 618-626.
Crossref
Crossref
Gillian Wheater, Mohsen Elshahaly, Stephen P Tuck, Harish K Datta & Jacob M van Laar. (2013) The clinical utility of bone marker measurements in osteoporosis. Journal of Translational Medicine 11:1, pages 201.
Crossref
Crossref
Xiaofeng LiJufang Shan, Woochul ChangIngyu KimJu Bao, Ho-Jin Lee, Xinxin Zhang, Varman T. Samuel, Gerald I. ShulmanDakai LiuJie J. Zheng & Dianqing Wu. (2012) Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism. Proceedings of the National Academy of Sciences 109:28, pages 11402-11407.
Crossref
Crossref
Danjun Ma, Yan Li, Bryan Hackfort, Yingchun Zhao, Jing Xiao, Patrick C. Swanson, Joan Lappe, Peng Xiao, Diane Cullen, Mohammed Akhter, Robert Recker & Gary Guishan Xiao. (2012) Smoke-Induced Signal Molecules in Bone Marrow Cells from Altered Low-Density Lipoprotein Receptor-Related Protein 5 Mice. Journal of Proteome Research 11:7, pages 3548-3560.
Crossref
Crossref
Ju BaoJie J. ZhengDianqing Wu. (2012) The Structural Basis of DKK-Mediated Inhibition of Wnt/LRP Signaling. Science Signaling 5:224.
Crossref
Crossref
Jung-Sun Lee, Man-Wook Hur, Seong Kyung Lee, Won-Il Choi, Young-Guen Kwon & Chae-Ok Yun. (2012) A Novel sLRP6E1E2 Inhibits Canonical Wnt Signaling, Epithelial-to-Mesenchymal Transition, and Induces Mitochondria-Dependent Apoptosis in Lung Cancer. PLoS ONE 7:5, pages e36520.
Crossref
Crossref
Michael Centrella & Thomas L. McCarthy. (2012) Estrogen receptor dependent gene expression by osteoblasts – Direct, indirect, circumspect, and speculative effects. Steroids 77:3, pages 174-184.
Crossref
Crossref
Sara Iozzi, Rosaria Remelli, Barbara Lelli, Daniela Diamanti, Silvia Pileri, Luisa Bracci, Renza Roncarati, Andrea Caricasole & Simonetta Bernocco. (2012) Functional Characterization of a Small-Molecule Inhibitor of the DKK1-LRP6 Interaction. ISRN Molecular Biology 2012, pages 1-9.
Crossref
Crossref
P. Wend, K. Wend, S. A. Krum & G. A. Miranda-Carboni. (2012) The role of WNT10B in physiology and disease. Acta Physiologica 204:1, pages 34-51.
Crossref
Crossref
Je-Yong Choi. (2012) New Avenues in the LRP5-mediated Bone Mass Acquisition. Korean Journal of Bone Metabolism 19:1, pages 1.
Crossref
Crossref
David G. Monroe, Meghan E. McGee-Lawrence, Merry Jo Oursler & Jennifer J. Westendorf. (2012) Update on Wnt signaling in bone cell biology and bone disease. Gene 492:1, pages 1-18.
Crossref
Crossref
Astrid Liedert, Thorsten Schinke, Anita Ignatius & Michael Amling. 2012. Midkine: From Embryogenesis to Pathogenesis and Therapy. Midkine: From Embryogenesis to Pathogenesis and Therapy
211
221
.
Shuo Chen, Doryen Bubeck, Bryan T. MacDonald, Wen-Xue Liang, Jian-Hua Mao, Tomas Malinauskas, Oscar Llorca, A. Radu Aricescu, Christian Siebold, Xi He & E. Yvonne Jones. (2011) Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling. Developmental Cell 21:5, pages 848-861.
Crossref
Crossref
Victoria E. Ahn, Matthew Ling-Hon Chu, Hee-Jung Choi, Denise Tran, Arie Abo & William I. Weis. (2011) Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6. Developmental Cell 21:5, pages 862-873.
Crossref
Crossref
Paul J. Niziolek, Takeisha L. Farmer, Yajun Cui, Charles H. Turner, Matthew L. Warman & Alexander G. Robling. (2011) High-bone-mass-producing mutations in the Wnt signaling pathway result in distinct skeletal phenotypes. Bone 49:5, pages 1010-1019.
Crossref
Crossref
Ling Juan Qiao, Kyung Lhi Kang & Jung Sun Heo. (2011) Simvastatin promotes osteogenic differentiation of mouse embryonic stem cells via canonical Wnt/β-catenin signaling. Molecules and Cells 32:5, pages 437-444.
Crossref
Crossref
Alessandra Pangrazio, Eveline Boudin, Elke Piters, Giuseppe Damante, Nadia Lo Iacono, Angela Valentina D'Elia, Paolo Vezzoni, Wim Van Hul, Anna Villa & Cristina Sobacchi. (2011) Identification of the first deletion in the LRP5 gene in a patient with Autosomal Dominant Osteopetrosis type I. Bone 49:3, pages 568-571.
Crossref
Crossref
Zhousheng Xiao, Mark Dallas, Ni Qiu, Daniel Nicolella, Li Cao, Mark Johnson, Lynda Bonewald & L. Darryl Quarles. (2011)
Conditional deletion of
Pkd1
in osteocytes disrupts skeletal mechanosensing in mice
. The FASEB Journal 25:7, pages 2418-2432.
Crossref
Crossref
Yajun Cui, Paul J Niziolek, Bryan T MacDonald, Cassandra R Zylstra, Natalia Alenina, Daniel R Robinson, Zhendong Zhong, Susann Matthes, Christina M Jacobsen, Ronald A Conlon, Robert Brommage, Qingyun Liu, Faika Mseeh, David R Powell, Qi M Yang, Brian Zambrowicz, Han Gerrits, Jan A Gossen, Xi He, Michael Bader, Bart O Williams, Matthew L Warman & Alexander G Robling. (2011) Lrp5 functions in bone to regulate bone mass. Nature Medicine 17:6, pages 684-691.
Crossref
Crossref
Thomas L. McCarthy, Caleb B. Kallen & Michael Centrella. (2011) β-Catenin independent cross-control between the estradiol and Wnt pathways in osteoblasts. Gene 479:1-2, pages 16-28.
Crossref
Crossref
Rene Olivares-Navarrete, Sharon L. Hyzy, Daphne L. Hutton, Ginger R. Dunn, Christoph Appert, Barbara D. Boyan & Zvi Schwartz. (2011) Role of non-canonical Wnt signaling in osteoblast maturation on microstructured titanium surfaces. Acta Biomaterialia 7:6, pages 2740-2750.
Crossref
Crossref
Jianglei Chen, Chia-Chen Liu, Qianqian Li, Christian Nowak, Guojun Bu & Jianjun Wang. (2011) Two Structural and Functional Domains of MESD Required for Proper Folding and Trafficking of LRP5/6. Structure 19:3, pages 313-323.
Crossref
Crossref
Christian Köhler, Janet K. Lighthouse, Tobias Werther, Olav M. Andersen, Annette Diehl, Peter Schmieder, Jianguang Du, Bernadette C. Holdener & Hartmut Oschkinat. (2011) The Structure of MESD45–184 Brings Light into the Mechanism of LDLR Family Folding. Structure 19:3, pages 337-348.
Crossref
Crossref
Alexandra Filipovich, Rajesh K. Gandhirajan, Iris Gehrke, Simon J. Poll-Wolbeck & Karl-Anton Kreuzer. (2010) Evidence for non-functional Dickkopf-1 (DKK-1) signaling in chronic lymphocytic leukemia (CLL). European Journal of Haematology 85:4, pages 309-313.
Crossref
Crossref
Andrew S. Manolides, Diane M. Cullen & Mohammed P. Akhter. (2010) Effects of glucocorticoid treatment on bone strength. Journal of Bone and Mineral Metabolism 28:5, pages 532-539.
Crossref
Crossref
Seth A. Ettenberg, Olga Charlat, Michael P. Daley, Shanming Liu, Karen J. Vincent, Darrin D. Stuart, Alwin G. Schuller, Jing Yuan, Beatriz Ospina, John Green, Qunyan Yu, Renee Walsh, Sharon Li, Rita Schmitz, Holger Heine, Sanela Bilic, Lance Ostrom, Rebecca Mosher, K. Felix Hartlepp, Zhenping Zhu, Stephen Fawell, Yung-Mae Yao, David Stover, Peter M. Finan, Jeffery A. Porter, William R. Sellers, Ingo M. Klagge & Feng Cong. (2010) Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies. Proceedings of the National Academy of Sciences 107:35, pages 15473-15478.
Crossref
Crossref
Konstantinos Nikopoulos, Hanka Venselaar, Rob W.J. Collin, Rosa Riveiro-Alvarez, F. Nienke Boonstra, Johanna M.M. Hooymans, Arijit Mukhopadhyay, Deborah Shears, Marleen van Bers, Ilse J. de Wijs, Anthonie J. van Essen, Rolf H. Sijmons, Mauk A.D. Tilanus, C. Erik van Nouhuys, Carmen Ayuso, Lies H. Hoefsloot & Frans P.M. Cremers. (2010) Overview of the mutation spectrum in familial exudative vitreoretinopathy and Norrie disease with identification of 21 novel variants in FZD4, LRP5, and NDP. Human Mutation 31:6, pages 656-666.
Crossref
Crossref
Weimin Qiu, Yuhui Hu, Tom E. Andersen, Abbas Jafari, Na Li, Wei Chen & Moustapha Kassem. (2010) Tumor Necrosis Factor Receptor Superfamily Member 19 (TNFRSF19) Regulates Differentiation Fate of Human Mesenchymal (Stromal) Stem Cells through Canonical Wnt Signaling and C/EBP. Journal of Biological Chemistry 285:19, pages 14438-14449.
Crossref
Crossref
Elke Piters, Wendy Balemans, Torben Leo Nielsen, Marianne Andersen, Eveline Boudin, Kim Brixen & Wim Van Hul. (2010) Common Genetic Variation in the DKK1 Gene is Associated with Hip Axis Length but not with Bone Mineral Density and Bone Turnover Markers in Young Adult Men: Results from the Odense Androgen Study. Calcified Tissue International 86:4, pages 271-281.
Crossref
Crossref
Thomas L. McCarthy & Michael Centrella. (2010) Novel Links among Wnt and TGF-β Signaling and Runx2. Molecular Endocrinology 24:3, pages 587-597.
Crossref
Crossref
Wei Yao, Zhiqiang Cheng, Mohammad Shahnazari, Wewei Dai, Mark L Johnson & Nancy E Lane. (2010) Overexpression of secreted frizzled-related protein 1 inhibits bone formation and attenuates parathyroid hormone bone anabolic effects. Journal of Bone and Mineral Research 25:2, pages 190-199.
Crossref
Crossref
Julia Billiard, John A. Robinson, Ramesh A. Bhat, Bheem M. Bhat, Richard J. Murrills & Peter V.N. Bodine. 2010. Bone Cancer. Bone Cancer
47
58
.
Kim-Hien T. Dao & H. M. Jamieson Catriona. 2010. Hematopoietic Stem Cell Biology. Hematopoietic Stem Cell Biology
213
243
.
Richard J. Murrills, Jeanne J. Matteo, Bheem M. Bhat, Valerie E. Coleburn, Kristina M. Allen, Wei Chen, Veronique Damagnez, Ramesh A. Bhat, Frederick J. Bex & Peter V.N. Bodine. (2009) A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V). Journal of Cellular Biochemistry 108:5, pages 1066-1075.
Crossref
Crossref
Frances Milat & Kong Wah Ng. (2009) Is Wnt signalling the final common pathway leading to bone formation?. Molecular and Cellular Endocrinology 310:1-2, pages 52-62.
Crossref
Crossref
Minke E. Binnerts, Nenad Tomasevic, Jessica M. Bright, John Leung, Victoria E. Ahn, Kyung-Ah Kim, Xiaoming Zhan, Shouchun Liu, Shirlee Yonkovich, Jason Williams, Mei Zhou, Delphine Gros, Melissa Dixon, Wouter Korver, William I. Weis & Arie Abo. (2009) The First Propeller Domain of LRP6 Regulates Sensitivity to DKK1. Molecular Biology of the Cell 20:15, pages 3552-3560.
Crossref
Crossref
Chia-Chen Liu, Chelsea Pearson & Guojun Bu. (2009) Cooperative Folding and Ligand-binding Properties of LRP6 β-Propeller Domains. Journal of Biological Chemistry 284:22, pages 15299-15307.
Crossref
Crossref
Takuo Kubota, Toshimi Michigami & Keiichi Ozono. (2009) Wnt signaling in bone metabolism. Journal of Bone and Mineral Metabolism 27:3, pages 265-271.
Crossref
Crossref
Peyman Björklund, Jessica Svedlund, Anna-Karin Olsson, Göran Åkerström & Gunnar Westin. (2009) The Internally Truncated LRP5 Receptor Presents a Therapeutic Target in Breast Cancer. PLoS ONE 4:1, pages e4243.
Crossref
Crossref
Toru Ishibe, Tetsuya Goto, Kentaro Kawata, Shigeru Kobayashi & Tetsu Takahashi. (2009) The Expression of Apolipoprotein E in Osteoblastic Cells on Titanium. The Journal of the Kyushu Dental Society 63:2, pages 78-86.
Crossref
Crossref
Takuo Kubota, Toshimi Michigami, Naoko Sakaguchi, Chikara Kokubu, Akira Suzuki, Noriyuki Namba, Norio Sakai, Shigeo Nakajima, Kenji Imai & Keiichi Ozono. (2008) Lrp6 Hypomorphic Mutation Affects Bone Mass Through Bone Resorption in Mice and Impairs Interaction With Mesd. Journal of Bone and Mineral Research 23:10, pages 1661-1671.
Crossref
Crossref
Harry C. Blair, Mone Zaidi, Christopher L.-H. Huang & Li Sun. (2008) The Developmental Basis of Skeletal Cell Differentiation and the Molecular Basis of Major Skeletal Defects. Biological Reviews.
Crossref
Crossref
Ke Wang, Yazhou Zhang, Xiaofeng Li, Lijun Chen, He Wang, Jianguo Wu, Jie Zheng & Dianqing Wu. (2008) Characterization of the Kremen-binding Site on Dkk1 and Elucidation of the Role of Kremen in Dkk-mediated Wnt Antagonism. Journal of Biological Chemistry 283:34, pages 23371-23375.
Crossref
Crossref
Lijun Chen, Ke Wang, Youming Shao, Jin Huang, Xiaofeng Li, Jufang Shan, Dianqing Wu & Jie J. Zheng. (2008) Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk. Journal of Biological Chemistry 283:34, pages 23364-23370.
Crossref
Crossref
Fei Liu, Sean Kohlmeier & Cun-Yu Wang. (2008) Wnt signaling and skeletal development. Cellular Signalling 20:6, pages 999-1009.
Crossref
Crossref
Wendy Balemans, Elke Piters, Erna Cleiren, Minrong Ai, Liesbeth Van Wesenbeeck, Matthew L. Warman & Wim Van Hul. (2008) The Binding Between Sclerostin and LRP5 is Altered by DKK1 and by High-Bone Mass LRP5 Mutations. Calcified Tissue International 82:6, pages 445-453.
Crossref
Crossref
Elke Piters, Eveline Boudin & Wim Van Hul. (2008) Wnt signaling: A win for bone. Archives of Biochemistry and Biophysics 473:2, pages 112-116.
Crossref
Crossref
Z G Li, J Yang, E S Vazquez, D Rose, F Vakar-Lopez, P Mathew, A Lopez, C J Logothetis, S-H Lin & N M Navone. (2007) Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone. Oncogene 27:5, pages 596-603.
Crossref
Crossref
MARK L. JOHNSON & ROBERT R. RECKER. 2008. Osteoporosis. Osteoporosis
467
490
.
Rutger L. van Bezooijen, Socrates E. Papapoulos, Neveen A.T. Hamdy & Clemens W.G.M. Löwik. 2008. Principles of Bone Biology. Principles of Bone Biology
139
152
.
David J. J. Gorter, Carola Krause, Peter Dijke, Clemens W. G. M. Löwik & Rutger L. Bezooijen. 2008. Bone Morphogenetic Proteins: From Local to Systemic Therapeutics. Bone Morphogenetic Proteins: From Local to Systemic Therapeutics
257
276
.
Weimin Qiu, Tom E Andersen, Jens Bollerslev, Susanne Mandrup, Basem M Abdallah & Moustapha Kassem. (2007) Patients With High Bone Mass Phenotype Exhibit Enhanced Osteoblast Differentiation and Inhibition of Adipogenesis of Human Mesenchymal Stem Cells. Journal of Bone and Mineral Research 22:11, pages 1720-1731.
Crossref
Crossref
Bryan T. MacDonald, Danese M. Joiner, Sivan M. Oyserman, Parul Sharma, Steven A. Goldstein, Xi He & Peter V. Hauschka. (2007) Bone mass is inversely proportional to Dkk1 levels in mice. Bone 41:3, pages 331-339.
Crossref
Crossref
Mone Zaidi. (2007) Skeletal remodeling in health and disease. Nature Medicine 13:7, pages 791-801.
Crossref
Crossref
Wendy Balemans & Wim Van Hul. (2007) The Genetics of Low-Density Lipoprotein Receptor-Related Protein 5 in Bone: A Story of Extremes. Endocrinology 148:6, pages 2622-2629.
Crossref
Crossref
Wendy Balemans, Jean-Pierre Devogelaer, Erna Cleiren, Elke Piters, Emanuelle Caussin & Wim Van Hul. (2007) Novel LRP5 Missense Mutation in a Patient With a High Bone Mass Phenotype Results in Decreased DKK1-Mediated Inhibition of Wnt Signaling*. Journal of Bone and Mineral Research 22:5, pages 708-716.
Crossref
Crossref
Qiou Wei, Chika Yokota, Mikhail V. Semenov, Brad Doble, Jim Woodgett & Xi He. (2007) R-spondin1 Is a High Affinity Ligand for LRP6 and Induces LRP6 Phosphorylation and β-Catenin Signaling. Journal of Biological Chemistry 282:21, pages 15903-15911.
Crossref
Crossref
Sona Kang, Christina N. Bennett, Isabelle Gerin, Lauren A. Rapp, Kurt D. Hankenson & Ormond A. MacDougald. (2007) Wnt Signaling Stimulates Osteoblastogenesis of Mesenchymal Precursors by Suppressing CCAAT/Enhancer-binding Protein α and Peroxisome Proliferator-activated Receptor γ. Journal of Biological Chemistry 282:19, pages 14515-14524.
Crossref
Crossref
Bheem M. Bhat, Kristina M. Allen, Wei Liu, James Graham, Art Morales, Anthony Anisowicz, Ho-Sun Lam, Catherine McCauley, Valerie Coleburn, Michael Cain, Eric Fortier, Ramesh A. Bhat, Frederick J. Bex & Paul J. Yaworsky. (2007) Structure-based mutation analysis shows the importance of LRP5 β-propeller 1 in modulating Dkk1-mediated inhibition of Wnt signaling. Gene 391:1-2, pages 103-112.
Crossref
Crossref
Paul Polakis. (2007) The many ways of Wnt in cancer. Current Opinion in Genetics & Development 17:1, pages 45-51.
Crossref
Crossref
Rutger L van Bezooijen, J Peter Svensson, Daniël Eefting, Annemieke Visser, Geertje van der Horst, Marcel Karperien, Paul HA Quax, Harry Vrieling, Socrates E Papapoulos, Peter ten Dijke & Clemens WGM Löwik. (2006) Wnt but Not BMP Signaling Is Involved in the Inhibitory Action of Sclerostin on BMP-Stimulated Bone Formation. Journal of Bone and Mineral Research 22:1, pages 19-28.
Crossref
Crossref
Yongzhong Wang, Vladimir Volloch, Mariya A. Pindrus, Dominick J. Blasioli, Jingsong Chen & David L. Kaplan. (2007) Murine osteoblasts regulate mesenchymal stem cells via WNT and cadherin pathways: mechanism depends on cell–cell contact mode. Journal of Tissue Engineering and Regenerative Medicine 1:1, pages 39-50.
Crossref
Crossref
Mikhail V. Semenov & Xi He. (2006) LRP5 Mutations Linked to High Bone Mass Diseases Cause Reduced LRP5 Binding and Inhibition by SOST. Journal of Biological Chemistry 281:50, pages 38276-38284.
Crossref
Crossref
Ji Li, Ildiko Sarosi, Russell C. Cattley, James Pretorius, Frank Asuncion, Mario Grisanti, Sean Morony, Stephen Adamu, Zhaopo Geng, Wanrong Qiu, Paul Kostenuik, David L. Lacey, W. Scott Simonet, Brad Bolon, Xueming Qian, Victoria Shalhoub, Michael S. Ominsky, Hua Zhu Ke, Xiaodong Li & William G. Richards. (2006) Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone 39:4, pages 754-766.
Crossref
Crossref
W.M.W. Cheung, L.Y. Jin, D.K. Smith, P.T. Cheung, E.Y.W. Kwan, L. Low & A.W.C. Kung. (2006) A family with osteoporosis pseudoglioma syndrome due to compound heterozygosity of two novel mutations in the LRP5 gene. Bone 39:3, pages 470-476.
Crossref
Crossref
C. Christodoulides, M. Laudes, W. P. Cawthorn, S. Schinner, M. Soos, S. O'Rahilly, J. K. Sethi & A. Vidal-Puig. (2006) The Wnt antagonist Dickkopf-1 and its receptors are coordinately regulated during early human adipogenesis. Journal of Cell Science 119:12, pages 2613-2620.
Crossref
Crossref
Frederic Morvan, Kim Boulukos, Philippe Clément-Lacroix, Sergio Roman Roman, Isabelle Suc-Royer, Béatrice Vayssière, Patrick Ammann, Patrick Martin, Sonia Pinho, Philippe Pognonec, Patrick Mollat, Christof Niehrs, Roland Baron & Georges Rawadi. (2006) Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass. Journal of Bone and Mineral Research 21:6, pages 934-945.
Crossref
Crossref
Christine Hartmann. (2006) A Wnt canon orchestrating osteoblastogenesis. Trends in Cell Biology 16:3, pages 151-158.
Crossref
Crossref
Roland Baron, Georges Rawadi & Sergio Roman‐Roman. 2006.
103
127
.
Donald A. GlassIIII & Gerard Karsenty. 2006.
43
84
.
Rutger L van Bezooijen, Socrates E Papapoulos, Neveen A Hamdy, Peter ten Dijke & Clemens W Löwik. (2005) Control of bone formation by osteocytes? lessons from the rare skeletal disorders sclerosteosis and van Buchem disease. BoneKEy-Osteovision 2:12, pages 33-38.
Crossref
Crossref
Yonghe Li, Jianglei Chen, Wenyan Lu, Lynn M. McCormick, Jianjun Wang & Guojun Bu. (2005) Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding. Journal of Cell Science 118:22, pages 5305-5314.
Crossref
Crossref
Patricia Crabbe, Wendy Balemans, Andy Willaert, Inge Van Pottelbergh, Erna Cleiren, Paul J Coucke, Minrong Ai, Stefan Goemaere, Wim Van Hul, Anne De Paepe & Jean-Marc Kaufman. (2005) Missense Mutations in LRP5 Are Not a Common Cause of Idiopathic Osteoporosis in Adult Men. Journal of Bone and Mineral Research 20:11, pages 1951-1959.
Crossref
Crossref
Kim Henriksen, Jeppe Gram, Pernille Høegh-Andersen, Rune Jemtland, Thor Ueland, Morten H. Dziegiel, Sophie Schaller, Jens Bollerslev & Morten A. Karsdal. (2005) Osteoclasts from Patients with Autosomal Dominant Osteopetrosis Type I Caused by a T253I Mutation in Low-Density Lipoprotein Receptor-Related Protein 5 Are Normal in Vitro, but Have Decreased Resorption Capacity in Vivo. The American Journal of Pathology 167:5, pages 1341-1348.
Crossref
Crossref
Yonghe LiGuojun Bu. (2005) LRP5/6 in Wnt signaling and tumorigenesis. Future Oncology 1:5, pages 673-681.
Crossref
Crossref
Michelle Carter, Xu Chen, Bozena Slowinska, Sharon Minnerath, Sara Glickstein, Lei Shi, Fabien Campagne, Harel Weinstein & M. Elizabeth Ross. (2005)
Crooked tail (
Cd
) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6
. Proceedings of the National Academy of Sciences 102:36, pages 12843-12848.
Crossref
Crossref
Xiaofeng Li, Peng Liu, Wenzhong Liu, Peter Maye, Jianghong Zhang, Yazhou Zhang, Marja Hurley, Caiying Guo, Adele Boskey, Le Sun, Stephen E Harris, David W Rowe, Hua Zhu Ke & Dianqing Wu. (2005) Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nature Genetics 37:9, pages 945-952.
Crossref
Crossref
Mei Lan Kwee, Wendy Balemans, Erna Cleiren, Johan JP Gille, Frits Van Der Blij, Jan M Sepers & Wim Van Hul. (2005) An Autosomal Dominant High Bone Mass Phenotype in Association With Craniosynostosis in an Extended Family Is Caused by an LRP5 Missense Mutation. Journal of Bone and Mineral Research 20:7, pages 1254-1260.
Crossref
Crossref
Mikhail Semënov, Keiko Tamai & Xi He. (2005) SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor. Journal of Biological Chemistry 280:29, pages 26770-26775.
Crossref
Crossref
Yoshifumi Yamaguchi, Satoshi Ogura, Mio Ishida, Mika Karasawa & Shinji Takada. (2005) Gene trap screening as an effective approach for identification of Wnt-responsive genes in the mouse embryo. Developmental Dynamics 233:2, pages 484-495.
Crossref
Crossref
Michael R Rickels, Xiafang Zhang, Steven Mumm & Michael P Whyte. (2004) Oropharyngeal Skeletal Disease Accompanying High Bone Mass and Novel LRP5 Mutation. Journal of Bone and Mineral Research 20:5, pages 878-885.
Crossref
Crossref
Babatunde O Oyajobi, Claire M Shipman & Gregory R Mundy. (2005) Recent insights into myeloma bone disease. BoneKEy-Osteovision 2:5, pages 17-25.
Crossref
Crossref
Xiaofeng Li, Yazhou Zhang, Heeseog Kang, Wenzhong Liu, Peng Liu, Jianghong Zhang, Stephen E. Harris & Dianqing Wu. (2005) Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling. Journal of Biological Chemistry 280:20, pages 19883-19887.
Crossref
Crossref
Serge L Ferrari, Samuel Deutsch & Stylianos E Antonarakis. (2005) Pathogenic mutations and polymorphisms in the lipoprotein receptor-related protein 5 reveal a new biological pathway for the control of bone mass. Current Opinion in Lipidology 16:2, pages 207-214.
Crossref
Crossref
J. Bollerslev, S.G. Wilson, I.M. Dick, F.M.A. Islam, T. Ueland, L. Palmer, A. Devine & R.L. Prince. (2005) LRP5 gene polymorphisms predict bone mass and incident fractures in elderly Australian women. Bone 36:4, pages 599-606.
Crossref
Crossref
Hongliang Hu, Matthew J. Hilton, Xiaolin Tu, Kai Yu, David M. Ornitz & Fanxin Long. (2005) Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development 132:1, pages 49-60.
Crossref
Crossref
Jennifer J. Westendorf, Rachel A. Kahler & Tania M. Schroeder. (2004) Wnt signaling in osteoblasts and bone diseases. Gene 341, pages 19-39.
Crossref
Crossref
Randall T. Moon, Aimee D. Kohn, Giancarlo V. De Ferrari & Ajamete Kaykas. (2004) WNT and β-catenin signalling: diseases and therapies. Nature Reviews Genetics 5:9, pages 691-701.
Crossref
Crossref