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Cell Growth and Development

The LRP5 High-Bone-Mass G171V Mutation Disrupts LRP5 Interaction with Mesd

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Pages 4677-4684 | Received 08 Jan 2004, Accepted 24 Feb 2004, Published online: 27 Mar 2023

REFERENCES

  • Babij, P., Zhao W., Small C., Kharode Y., Yaworsky P.J., Bouxsein M. L., Reddy P. S., Bodine P. V., Robinson J. A., Bhat B., Marzolf J., Moran R. A., and Bex F.. 2003. High bone mass in mice expressing a mutant LRP5 gene. J. Bone Miner. Res. 18:960–974.
  • Bafico, A., Liu G., Yaniv A., Gazit A., and Aaronson S. A.. 2001. Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat. Cell Biol. 3:683–686.
  • Bain, G., Muller T., Wang X., and Papkoff J.. 2003. Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction. Biochem. Biophys. Res. Commun. 301:84–91.
  • Boyden, L. M., Mao J., Belsky J., Mitzner L., Farhi A., Mitnick M. A., Wu D., Insogna K., and Lifton R. P.. 2002. High bone density due to a mutation in LDL-receptor-related protein 5. N. Engl. J. Med. 346:1513–1521.
  • Culi, J., and Mann R. S.. 2003. Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila. Cell 112:343–354.
  • Dale, T. C. 1998. Signal transduction by the Wnt family of ligands. Biochem. J. 329:209–223.
  • Glinka, A., Wu W., Delius H., Monaghan A. P., Blumenstock C., and Niehrs C.. 1998. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391:357–362.
  • Gong, Y., Slee R. B., Fukai N., Rawadi G., Roman-Roman S., Reginato A. M., Wang H., Cundy T., Glorieux F. H., Lev D., Zacharin M., Oexle K., Marcelino J., Suwairi W., Heeger S., Sabatakos G., Apte S., Adkins W. N., Allgrove J., Arslan-Kirchner M., Batch J. A., Beighton P., Black G. C., Boles R. G., Boon L. M., Borrone C., Brunner H. G., Carle G. F., Dallapiccola B., De Paepe A., Floege B., Halfhide M. L., Hall B., Hennekam R. C., Hirose T., Jans A., Juppner H., Kim C. A., Keppler-Noreuil K., Kohlschuetter A., LaCombe D., Lambert M., Lemyre E., Letteboer T., Peltonen L., Ramesar R. S., Romanengo M., Somer H., Steichen-Gersdorf E., Steinmann B., Sullivan B., Superti-Furga A., Swoboda W., van den Boogaard M. J., Van Hul W., Vikkula M., Votruba M., Zabel B., Garcia T., Baron R., Olsen B. R., and Warman M. L.. 2001. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107:513–523.
  • Gumbiner, B. M. 1998. Propagation and localization of Wnt signaling. Curr. Opin. Genet. Dev. 8:430–435.
  • Hsieh, J. C., Lee L., Zhang L., Wefer S., Brown K., DeRossi C., Wines M. E., Rosenquist T., and Holdener B. C.. 2003. Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity. Cell 112:355–367.
  • Hsu, S. C., Galceran J., and Grosschedl R.. 1998. Modulation of transcriptional regulation by Lef-1 in response to Wnt-1 signaling and association with beta-catenin. Mol. Cell. Biol. 18:4807–4818.
  • Jeon, H., Meng W., Takagi J., Eck M. J., Springer T. A., and Blacklow S. C.. 2001. Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair. Nat. Struct. Biol. 8:499–504.
  • Kalajzic, I., Kalajzic Z., Kaliterna M., Gronowicz G., Clark S. H., Lichtler A. C., and Rowe D.. 2002. Use of type I collagen green fluorescent protein transgenes to identify subpopulations of cells at different stages of the osteoblast lineage. J. Bone Miner. Res. 17:15–25.
  • Kannus, P., Palvanen M., Niemi S., Parkkari J., and Jarvinen M.. 2000. Epidemiology of osteoporotic pelvic fractures in elderly people in Finland: sharp increase in 1970-1997 and alarming projections for the new millennium. Osteoporos Int. 11:443–448.
  • Kato, M., Patel M. S., Levasseur R., Lobov I., Chang B. H., Glass D. A., Jr., Hartmann C., Li L., Hwang T. H., Brayton C. F., Lang R. A., Karsenty G., and Chan L.. 2002. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J. Cell Biol. 157:303–314.
  • Krupnik, V. E., Sharp J. D., Jiang C., Robison K., Chickering T. W., Amaravadi L., Brown D. E., Guyot D., Mays G., Leiby K., Chang B., Duong T., Goodearl A. D., Gearing D. P., Sokol S. Y., and McCarthy S. A.. 1999. Functional and structural diversity of the human Dickkopf gene family. Gene 238:301–313.
  • Li, L., Mao J., Sun L., Liu W., and Wu D.. 2002. Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J. Biol. Chem. 277:5977–5981.
  • Li, L., Yuan H., Weaver C., Mao J., Farr III G. H., Sussman D. J., Jonkers J., Kimelman D., and Wu D.. 1999. Axin and Frat-1 interact with Dv1 and GSK, bridging Dv1 to GSK in Wnt-mediated regulation of LEF-1. EMBO J. 18:4233–4240.
  • Li, L., Yuan H., Xie W., Mao J., McMahon E., Sussman D., and Wu D.. 1999. Dishevelled proteins lead to two different signaling pathways; regulation of the JNK and β-catenin pathways. J. Biol. Chem. 274:129–134.
  • Lips, P. 1997. Epidemiology and predictors of fractures associated with osteoporosis. Am. J. Med. 103:3S–8S; discussion, 8S-11S.
  • Little, R. D., Carulli J. P., Del Mastro R. G., Dupuis J., Osborne M., Folz C., Manning S. P., Swain P. M., Zhao S. C., Eustace B., Lappe M. M., Spitzer L., Zweier S., Braunschweiger K., Benchekroun Y., Hu X., Adair R., Chee L., FitzGerald M. G., Tulig C., Caruso A., Tzellas N., Bawa A., Franklin B., McGuire S., Nogues X., Gong G., Allen K. M., Anisowicz A., Morales A. J., Lomedico P. T., Recker S. M., Van Eerdewegh P., Recker R. R., and Johnson M. L.. 2002. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am. J. Hum. Genet. 70:11–19.
  • Mao, B., Wu W., Davidson G., Marhold J., Li M., Mechler B. M., Delius H., Hoppe D., Stannek P., Walter C., Glinka A., and Niehrs C.. 2002. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 417:664–667.
  • Mao, B., Wu W., Li Y., Hoppe D., Stannek P., Glinka A., and Niehrs C.. 2001. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411:321–325.
  • Mao, J., Wang J., Liu B., Pan W., Farr G. H., Flynn C., Yuan H., Takada S., Kimelman D., Li L., and Wu D.. 2001. Low-density lipoprotein receptor-related protein-5 binds to axin and regulates the canonical wnt signaling pathway. Mol. Cell 7:801–809.
  • Monaghan, A. P., Kioschis P., Wu W., Zuniga A., Bock D., Poustka A., Delius H., and Niehrs C.. 1999. Dickkopf genes are co-ordinately expressed in mesodermal lineages. Mech. Dev. 87:45–56.
  • NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. 2001. Osteoporosis prevention, diagnosis, and therapy. JAMA 285:785–795.
  • Nusse, R. 2001. Developmental biology. Making head or tail of Dickkopf. Nature 411:255–256.
  • Pandur, P., and Kuhl M.. 2001. An arrow for wingless to take-off. Bioessays 23:207–210.
  • Pfaffl, M. W. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:e45.
  • Pinson, K. I., Brennan J., Monkley S., Avery B. J., and Skarnes W. C.. 2000. An LDL receptor-related protein mediates Wnt singaling in mice. Nature 407:535–538.
  • Schweizer, L., and Varmus H.. 2003. Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors. BMC Cell Biol. 4:4.
  • Semenov, M. V., Tamai K., Brott B. K., Kuhl M., Sokol S., and He X.. 2001. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr. Biol. 11:951–961.
  • Takagi, J., Yang Y., Liu J. H., Wang J. H., and Springer T. A.. 2003. Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface. Nature 424:969–974.
  • Tamai, K., Semenov M., Kato Y., Spokony R., Liu C., Katsuyama Y., Hess F., Saint-Jeannet J. P., and He X.. 2000. LDL-receptor-related proteins in Wnt signal transduction. Nature 407:530–535.
  • Tolwinski, N. S., Wehrli M., Rives A., Erdeniz N., DiNardo S., and Wieschaus E.. 2003. Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity. Dev. Cell. 4:407–418.
  • Van Wesenbeeck, L., Cleiren E., Gram J., Beals R. K., Benichou O., Scopelliti D., Key L., Renton T., Bartels C., Gong Y., Warman M. L., De Vernejoul M. C., Bollerslev J., and Van Hul W.. 2003. Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density. Am. J. Hum. Genet. 72:763–771.
  • Wehrli, M., Dougan S. T., Caldwell K., O'Keefe L., Schwartz S., Vaizel-Ohayon D., Schejter E., Tomlinson A., and DiNardo S.. 2000. arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature 407:527–530.
  • Wodarz, A., and Nusse R.. 1998. Mechanisms of Wnt signaling in development. Annu. Rev. Cell Dev. Biol. 14:59–88.
  • Yuan, H., Mao J., Li L., and Wu D.. 1999. Regulation of GSK and LEF-1 by Wnt, Frat and Akt: suppression of GSK kinase activity is not sufficient for LEF-1 activation. J. Biol. Chem. 274:30419–30423.
  • Zuckerman, J. D. 1996. Hip fracture. N. Engl. J. Med. 334:1519–1525.

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