152
Views
250
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate

, &
Pages 4943-4954 | Received 05 Nov 2003, Accepted 23 Feb 2004, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Huayin Bao, Wei Wang, Haibo Sun & Jianzhong Chen. (2023) Probing mutation-induced conformational transformation of the GTP/M-RAS complex through Gaussian accelerated molecular dynamics simulations. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
Read now
Ledia Vasjari, Stephanie Bresan, Christoph Biskup, Govind Pai & Ignacio Rubio. (2019) Ras signals principally via Erk in G1 but cooperates with PI3K/Akt for Cyclin D induction and S-phase entry. Cell Cycle 18:2, pages 204-225.
Read now
Ruth Nussinov, Chung-Jung Tsai, Serena Muratcioglu, Hyunbum Jang, Attila Gursoy & Ozlem Keskin. (2015) Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation. Expert Review of Proteomics 12:6, pages 669-682.
Read now
David Romano, Helene Maccario, Carolanne Doherty, Niall P. Quinn, Walter Kolch & David Matallanas. (2013) The Differential Effects of Wild-Type and Mutated K-Ras on MST2 Signaling Are Determined by K-Ras Activation Kinetics. Molecular and Cellular Biology 33:9, pages 1859-1868.
Read now
Jeremy G.T. Wurtzel, Puneet Kumar & Lawrence E. Goldfinger. (2012) Palmitoylation regulates vesicular trafficking of R-Ras to membrane ruffles and effects on ruffling and cell spreading. Small GTPases 3:3, pages 139-153.
Read now
Balbino Alarcón & Nuria Martínez-Martín. (2012) RRas2, RhoG and T-cell phagocytosis. Small GTPases 3:2, pages 97-101.
Read now
Marilyn Gordon & Shairaz Baksh. (2011) RASSF1A. Small GTPases 2:3, pages 148-157.
Read now
Nicholas Underhill-Day, Victoria Hill & Farida Latif. (2011) N-terminal RASSF family. Epigenetics 6:3, pages 284-292.
Read now
Chang Liu, Maho Takahashi, Yanping Li, Shuang Song, Tara J. Dillon, Ujwal Shinde & Philip J. S. Stork. (2008) Ras Is Required for the Cyclic AMP-Dependent Activation of Rap1 via Epac2. Molecular and Cellular Biology 28:23, pages 7109-7125.
Read now
Lowenna J. Holt & Roger J. Daly. (2005) Adapter protein connections: The MRL and Grb7 protein families. Growth Factors 23:3, pages 193-201.
Read now

Articles from other publishers (240)

Daniel A. Bonsor & Dhirendra K. Simanshu. (2023) Structural insights into the role of SHOC2‐MRAS‐PP1C complex in RAF activation . The FEBS Journal.
Crossref
Alejandro M. Hortal, Clara L. Oeste, Claudia Cifuentes, Miguel Alcoceba, Isabel Fernández-Pisonero, Laura Clavaín, Rut Tercero, Pilar Mendoza, Verónica Domínguez, Marta García-Flores, Belén Pintado, David Abia, Carmen García-Macías, Almudena Navarro-Bailón, Xosé R. Bustelo, Marcos González & Balbino Alarcón. (2022) Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia. Molecular Cancer 21:1.
Crossref
Marco Tartaglia, Yoko Aoki & Bruce D. Gelb. (2022) The molecular genetics of RASopathies : An update on novel disease genes and new disorders . American Journal of Medical Genetics Part C: Seminars in Medical Genetics 190:4, pages 425-439.
Crossref
Marilyn Goudreault, Valérie Gagné, Chang Hwa Jo, Swati Singh, Ryan C. Killoran, Anne-Claude Gingras & Matthew J. Smith. (2022) Afadin couples RAS GTPases to the polarity rheostat Scribble. Nature Communications 13:1.
Crossref
Dhirendra K. Simanshu & Deborah K. Morrison. (2022) A Structure is Worth a Thousand Words: New Insights for RAS and RAF Regulation. Cancer Discovery 12:4, pages 899-912.
Crossref
Patrick J. Woida & Karla J. F. Satchell. (2022) Bacterial Toxin and Effector Regulation of Intestinal Immune Signaling. Frontiers in Cell and Developmental Biology 10.
Crossref
Lick Pui Lai, Nicole Fer, William Burgan, Vanessa E. Wall, Bingfang Xu, Daniel Soppet, Dominic Esposito, Dwight V. Nissley & Frank McCormick. (2022) Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors. Proceedings of the National Academy of Sciences 119:5.
Crossref
Frank McCormick. 2022. RAS: Past, Present, and Future. RAS: Past, Present, and Future 1 27 .
Han Yan, Chih-Chieh Yu, Stuart A. Fine, Ayman Lee Youssof, Ye-Ran Yang, Jun Yan, Dillon C. Karg, Edwin C. Cheung, Richard A. Friedman, Haoqiang Ying, Emily I. Chen, Ji Luo, Yi Miao, Wanglong Qiu & Gloria H. Su. (2021) Loss of the wild-type KRAS allele promotes pancreatic cancer progression through functional activation of YAP1. Oncogene 40:50, pages 6759-6771.
Crossref
Geraldine Blanchard-Rohner, Robert J. Ragotte, Anne K. Junker, Mehul Sharma, Kate L. Del Bel, Henry Y. Lu, Stephanie Erdle, Alanna Chomyn, Harinder Gill, Lori B. Tucker, Richard A. Schreiber, Jacob Rozmus, Catherine M. Biggs, Kyla J. Hildebrand, John Wu, Sylvia Stockler-Ipsiroglu & Stuart E. Turvey. (2021) Idiopathic splenomegaly in childhood and the spectrum of RAS-associated lymphoproliferative disease: a case report. BMC Pediatrics 21:1.
Crossref
Biqin Zhang, Cheukyau Luk, Joyce Valadares, Christos Aronis & Lazaros C. Foukas. (2021) Dominant Role of PI3K p110α over p110β in Insulin and β-Adrenergic Receptor Signalling. International Journal of Molecular Sciences 22:23, pages 12813.
Crossref
Antonio Cuevas-Navarro, Richard Van, Alice Cheng, Anatoly Urisman, Pau Castel & Frank McCormick. (2021) The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression. Current Biology 31:17, pages 3915-3924.e9.
Crossref
Shannon M. Weber & Steven L. Carroll. (2021) The Role of R-Ras Proteins in Normal and Pathologic Migration and Morphologic Change. The American Journal of Pathology 191:9, pages 1499-1510.
Crossref
Erica Valencic, Prisca Da Lozzo, Gianluca Tornese, Elena Ghirigato, Francesco Facca, Elisa Piscianz, Flavio Faletra, Andrea Taddio, Alberto Tommasini & Andrea Magnolato. (2021) Clinical and Cytometric Study of Immune Involvement in a Heterogeneous Cohort of Subjects With RASopathies and mTORopathies. Frontiers in Pediatrics 9.
Crossref
Jun Yuan, Qianqian Ju, Jun Zhu, Yun Jiang, Xuechao Yang, Xiaoyu Liu, Jinyu Ma, Cheng Sun & Jiahai Shi. (2021) RASSF9 promotes NSCLC cell proliferation by activating the MEK/ERK axis. Cell Death Discovery 7:1.
Crossref
I. I. Khegay. (2021) Vasopressin Receptors in Blood Vessels and Proliferation of Endotheliocytes. Russian Journal of Bioorganic Chemistry 47:4, pages 815-827.
Crossref
Timothy H. Tran, Albert H. Chan, Lucy C. Young, Lakshman Bindu, Chris Neale, Simon Messing, Srisathiyanarayanan Dharmaiah, Troy Taylor, John-Paul Denson, Dominic Esposito, Dwight V. Nissley, Andrew G. Stephen, Frank McCormick & Dhirendra K. Simanshu. (2021) KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nature Communications 12:1.
Crossref
Byeong Hyeok Choi, Ziyue Kou, Tania Marlyn Colon, Chih-Hong Chen, Yuan Chen & Wei Dai. (2021) Identification of Radil as a Ras binding partner and putative activator. Journal of Biological Chemistry 296, pages 100314.
Crossref
Martin J. Baker & Ignacio Rubio. 2021. Ras Activity and Signaling. Ras Activity and Signaling 117 135 .
Takeshi Endo. (2020) M-Ras is Muscle-Ras, Moderate-Ras, Mineral-Ras, Migration-Ras, and Many More-Ras. Experimental Cell Research 397:1, pages 112342.
Crossref
Renata Tisi, Vadim Gaponenko, Marco Vanoni & Elena Sacco. (2020) Natural Products Attenuating Biosynthesis, Processing, and Activity of Ras Oncoproteins: State of the Art and Future Perspectives. Biomolecules 10:11, pages 1535.
Crossref
Hyuk-Joon Jeon & Jeong Su Oh. (2020) RASSF1A Regulates Spindle Organization by Modulating Tubulin Acetylation via SIRT2 and HDAC6 in Mouse Oocytes. Frontiers in Cell and Developmental Biology 8.
Crossref
Chandu Sadasivan, Pavel Zhabyeyev, Dina Labib, James A. White, D. Ian Paterson & Gavin Y. Oudit. (2020) Cardiovascular toxicity of PI3Kα inhibitors. Clinical Science 134:19, pages 2595-2622.
Crossref
To Van Ta, Quang Ngoc Nguyen, Ha Hoang Chu, Van-Long Truong & Linh Dieu Vuong. (2020) RAS/RAF mutations and their associations with epigenetic alterations for distinct pathways in Vietnamese colorectal cancer. Pathology - Research and Practice 216:4, pages 152898.
Crossref
Yi‐Tzu Lin, Michael D. Deel & Corinne M. Linardic. (2019) RASSF4 is required for skeletal muscle differentiation. Cell Biology International 44:2, pages 381-390.
Crossref
Qing Yang, Chuandong Lang, Zhengquan Wu, Yuhu Dai, Shaofu He, Wei Guo, Shuai Huang, Hong Du, Dong Ren & Xinsheng Peng. (2019) MAZ promotes prostate cancer bone metastasis through transcriptionally activating the KRas-dependent RalGEFs pathway. Journal of Experimental & Clinical Cancer Research 38:1.
Crossref
Ryan C. Killoran & Matthew J. Smith. (2019) Conformational resolution of nucleotide cycling and effector interactions for multiple small GTPases determined in parallel. Journal of Biological Chemistry 294:25, pages 9937-9948.
Crossref
Liang Qu, Chao Pan, Shi-Ming He, Bing Lang, Guo-Dong Gao, Xue-Lian Wang & Yuan Wang. (2019) The Ras Superfamily of Small GTPases in Non-neoplastic Cerebral Diseases. Frontiers in Molecular Neuroscience 12.
Crossref
Pau Castel, Alice ChengAntonio Cuevas-Navarro, David B. EvermanAlex G. PapageorgeDhirendra K. Simanshu, Alexandra Tankka, Jacqueline GaleasAnatoly Urisman & Frank McCormick. (2019) RIT1 oncoproteins escape LZTR1-mediated proteolysis. Science 363:6432, pages 1226-1230.
Crossref
Iikki Donner, Riku Katainen, Eevi Kaasinen, Mervi Aavikko, Lauri J. Sipilä, Eero Pukkala & Lauri A. Aaltonen. (2018) Candidate susceptibility variants in angioimmunoblastic T-cell lymphoma. Familial Cancer 18:1, pages 113-119.
Crossref
Zhiliang Xu, Fengsen Duan, Huiai Lu, Maytham Abdulkadhim Dragh, Yanzhi Xia, Huageng Liang & Ling Hong. (2018) UBIAD1 suppresses the proliferation of bladder carcinoma cells by regulating H-Ras intracellular trafficking via interaction with the C-terminal domain of H-Ras. Cell Death & Disease 9:12.
Crossref
Lucy C. Young & Pablo Rodriguez-Viciana. (2018) MRAS: A Close but Understudied Member of the RAS Family. Cold Spring Harbor Perspectives in Medicine 8:12, pages a033621.
Crossref
Lucy C. YoungNicole HartigIsabel Boned del RíoSibel SariBenjamin Ringham-Terry, Joshua R. WainwrightGreg G. JonesFrank McCormick & Pablo Rodriguez-Viciana. (2018) SHOC2–MRAS–PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis. Proceedings of the National Academy of Sciences 115:45.
Crossref
Ruth Nussinov, Mingzhen Zhang, Chung-Jung Tsai, Tsung-Jen Liao, David Fushman & Hyunbum Jang. (2018) Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a comprehensive review underscoring the challenges in pharmacological intervention. Biophysical Reviews 10:5, pages 1263-1282.
Crossref
Hema Adhikari & Christopher M. Counter. (2018) Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability. Nature Communications 9:1.
Crossref
Devanand T, Prasanna Venkatraman & Satyavani Vemparala. (2018) Phosphorylation promotes binding affinity of Rap-Raf complex by allosteric modulation of switch loop dynamics. Scientific Reports 8:1.
Crossref
Wang Peng, Zhi-Yin Sun, Qi Zhang, Sui-Qi Cheng, Shi-Ke Wang, Xiao-Na Wang, Guo-Tao Kuang, Xiao-Xuan Su, Jia-Heng Tan, Zhi-Shu Huang & Tian-Miao Ou. (2018) Design, Synthesis, and Evaluation of Novel p -(Methylthio)styryl Substituted Quindoline Derivatives as Neuroblastoma RAS (NRAS) Repressors via Specific Stabilizing the RNA G-Quadruplex . Journal of Medicinal Chemistry 61:15, pages 6629-6646.
Crossref
Madhura B. de Silva & Tewin Tencomnao. (2018) The protective effect of some Thai plants and their bioactive compounds in UV light-induced skin carcinogenesis. Journal of Photochemistry and Photobiology B: Biology 185, pages 80-89.
Crossref
Daiki Ohama, Takahiko Matsuda & Izumi Oinuma. (2018) Differential regional and subcellular localization patterns of afadin splice variants in the mouse central nervous system. Brain Research 1692, pages 74-86.
Crossref
Agata Adelajda Krygowska & Esther Castellano. (2018) PI3K: A Crucial Piece in the RAS Signaling Puzzle. Cold Spring Harbor Perspectives in Medicine 8:6, pages a031450.
Crossref
Pilar Mendoza, Nuria Martínez-Martín, Elena R. BovolentaDiana Reyes-Garau, Pablo Hernansanz-AgustínPilar Delgado, Manuel D. Diaz-Muñoz, Clara L. Oeste, Isabel Fernández-Pisonero, Ester CastellanoAntonio Martínez-Ruiz, Diego Alonso-Lopez, Eugenio Santos, Xosé R. Bustelo, Tomohiro Kurosaki & Balbino Alarcón. (2018) R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes. Science Signaling 11:532.
Crossref
Xuefeng Zhang, Shufen Cao, Guillermo Barila, Martin M. Edreira, Mamta Wankhede, Nyla Naim, Matthias Buck & Daniel L. Altschuler. (2018) Cyclase-associated protein 1 (CAP1) is a prenyl-binding partner of Rap1 GTPase. Journal of Biological Chemistry 293:20, pages 7659-7673.
Crossref
Joanna Podkalicka, Agnieszka Biernatowska, Paulina Olszewska, Sabina Tabaczar & Aleksander F. Sikorski. (2018) The microdomain-organizing protein MPP1 is required for insulin-stimulated activation of H-Ras. Oncotarget 9:26, pages 18410-18421.
Crossref
Laura Aragoneses-Fenoll, Gloria Ojeda, María Montes-Casado, Yeny Acosta-Ampudia, Umberto Dianzani, Pilar Portolés & José M. Rojo. (2018) T-Cell-Specific Loss of the PI-3-Kinase p110α Catalytic Subunit Results in Enhanced Cytokine Production and Antitumor Response. Frontiers in Immunology 9.
Crossref
Aaron S. Mansfield, Grace K. Dy, Mjung-Ju Ahn & Alex A. Adjei. 2018. IASLC Thoracic Oncology. IASLC Thoracic Oncology 479 489.e6 .
M. Kulesz-Martin, X. Ouyang, A. Barling, J.R. Gallegos, Y. Liu & T. Medler. 2018. Comprehensive Toxicology. Comprehensive Toxicology 11 35 .
John Colicelli, Pamela Y. Ting & Christine Janson. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 4740 4744 .
Leanne Bradley, Delia Koennig, Maria Laura Tognoli, Jelte van der Vaart & Eric O’Neill. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 4501 4523 .
Giulia Miglietta, Susanna Cogoi, Jessica Marinello, Giovanni Capranico, Alexander S. Tikhomirov, Andrey Shchekotikhin & Luigi E. Xodo. (2017) RNA G-Quadruplexes in Kirsten Ras ( KRAS ) Oncogene as Targets for Small Molecules Inhibiting Translation . Journal of Medicinal Chemistry 60:23, pages 9448-9461.
Crossref
Cristian Bodo, Cathy Fernandes & Matthias Krause. (2017) Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice. Scientific Reports 7:1.
Crossref
Braden D. Siempelkamp, Manoj K. Rathinaswamy, Meredith L. Jenkins & John E. Burke. (2017) Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas. Journal of Biological Chemistry 292:29, pages 12256-12266.
Crossref
Dhirendra K. Simanshu, Dwight V. Nissley & Frank McCormick. (2017) RAS Proteins and Their Regulators in Human Disease. Cell 170:1, pages 17-33.
Crossref
Xiaoyu Zhang, Nicole A Spiegelman, Ornella D Nelson, Hui Jing & Hening Lin. (2017) SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation. eLife 6.
Crossref
Chih-Chieh Yu, Wanglong Qiu, Caroline S. Juang, Mahesh M. Mansukhani, Balazs Halmos & Gloria H. Su. (2017) Mutant allele specific imbalance in oncogenes with copy number alterations: Occurrence, mechanisms, and potential clinical implications. Cancer Letters 384, pages 86-93.
Crossref
Leanne Bradley, Delia Koennig, Maria Laura Tognoli, Jelte van der Vaart & Eric O’Neill. 2017. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 23 .
Hossein Nakhaeizadeh, Ehsan Amin, Saeideh Nakhaei-Rad, Radovan Dvorsky & Mohammad Reza Ahmadian. (2016) The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions. PLOS ONE 11:12, pages e0167145.
Crossref
Eliana Amato, Stefano Barbi, Matteo Fassan, Claudio Luchini, Caterina Vicentini, Matteo Brunelli, Giuseppe Malleo, Aldo Scarpa & Giorgio Malpeli. (2016) RASSF1 tumor suppressor gene in pancreatic ductal adenocarcinoma: correlation of expression, chromosomal status and epigenetic changes. BMC Cancer 16:1.
Crossref
Mohammed K. Hankir, Michael A. Cowley & Wiebke K. Fenske. (2016) A BAT-Centric Approach to the Treatment of Diabetes: Turn on the Brain. Cell Metabolism 24:1, pages 31-40.
Crossref
Anca Margineanu, Jia Jia Chan, Douglas J. Kelly, Sean C. Warren, Delphine Flatters, Sunil Kumar, Matilda Katan, Christopher W. Dunsby & Paul M. W. French. (2016) Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM). Scientific Reports 6:1.
Crossref
J V Michael, J G T Wurtzel & L E Goldfinger. (2016) Regulation of H-Ras-driven MAPK signaling, transformation and tumorigenesis, but not PI3K signaling and tumor progression, by plasma membrane microdomains. Oncogenesis 5:5, pages e228-e228.
Crossref
Hyeran Sung, Krishna L. Kanchi, Xue Wang, Kristen S. Hill, Jane L. Messina, Ji-Hyun Lee, Youngchul Kim, Nathan D. Dees, Li Ding, Jamie K. Teer, Shengyu Yang, Amod A. Sarnaik, Vernon K. Sondak, James J. Mulé, Richard K. Wilson, Jeffrey S. Weber & Minjung Kim. (2016) Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation. Oncotarget 7:17, pages 23885-23896.
Crossref
Sook In Chung, Hyuk Moon, Hye-Lim Ju, Dae Yeong Kim, Kyung Joo Cho, Silvia Ribback, Frank Dombrowski, Diego F. Calvisi & Simon Weonsang Ro. (2016) Comparison of liver oncogenic potential among human RAS isoforms. Oncotarget 7:6, pages 7354-7366.
Crossref
Anjum Riaz, Ying Huang & Staffan Johansson. (2016) G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling. International Journal of Molecular Sciences 17:2, pages 215.
Crossref
Zhaoxia Li, Jun Yao, Yangjie Xie, Xin Geng & Zhanjiang Liu. (2016) Phosphoinositide 3-kinase family in channel catfish and their regulated expression after bacterial infection. Fish & Shellfish Immunology 49, pages 364-373.
Crossref
Sukhamoy Gorai, Debasish Paul, Nandan Haloi, Rituparna Borah, Manas Kumar Santra & Debasis Manna. (2016) Mechanistic insights into the phosphatidylinositol binding properties of the pleckstrin homology domain of lamellipodin. Molecular BioSystems 12:3, pages 747-757.
Crossref
Ruth Nussinov, Serena Muratcioglu, Chung-Jung Tsai, Hyunbum Jang, Attila Gursoy & Ozlem Keskin. (2015) The Key Role of Calmodulin in KRAS -Driven Adenocarcinomas . Molecular Cancer Research 13:9, pages 1265-1273.
Crossref
Hongzhao Li & Aaron J. Marshall. (2015) Phosphatidylinositol (3,4) bisphosphate-specific phosphatases and effector proteins: A distinct branch of PI3K signaling. Cellular Signalling 27:9, pages 1789-1798.
Crossref
Hugo Lavoie & Marc Therrien. (2015) Regulation of RAF protein kinases in ERK signalling. Nature Reviews Molecular Cell Biology 16:5, pages 281-298.
Crossref
Stergios J. Moschos & Ramya Pinnamaneni. (2015) Targeted Therapies in Melanoma. Surgical Oncology Clinics of North America 24:2, pages 347-358.
Crossref
John E. Burke & Roger L. Williams. (2015) Synergy in activating class I PI3Ks. Trends in Biochemical Sciences 40:2, pages 88-100.
Crossref
Joshua G. Pemberton, James L. Stafford & John P. Chang. (2015) Ligand-Selective Signal Transduction by Two Endogenous GnRH Isoforms Involves Biased Activation of the Class I PI3K Catalytic Subunits p110β, p110γ, and p110δ in Pituitary Gonadotropes and Somatotropes. Endocrinology 156:1, pages 218-230.
Crossref
Lauren M. Thorpe, Haluk Yuzugullu & Jean J. Zhao. (2014) PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting. Nature Reviews Cancer 15:1, pages 7-24.
Crossref
Rebecca Newman & Martin Turner. 2015. Crossroads Between Innate and Adaptive Immunity V. Crossroads Between Innate and Adaptive Immunity V 119 135 .
Leanna R. Gentry, Timothy D. Martin, David J. Reiner & Channing J. Der. (2014) Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:12, pages 2976-2988.
Crossref
Matthias Krause & Alexis Gautreau. (2014) Steering cell migration: lamellipodium dynamics and the regulation of directional persistence. Nature Reviews Molecular Cell Biology 15:9, pages 577-590.
Crossref
Enrico Ravera, Azzurra Carlon & Giacomo Parigi. (2014) Pairwise binding competition experiments for sorting hub-protein/effector interaction hierarchy and simultaneous equilibria. Journal of Biomolecular NMR 60:1, pages 29-36.
Crossref
Lee Silver, James V. Michael, Lawrence E. Goldfinger & Gianluca Gallo. (2014) Activation of PI3K and R-ras signaling promotes the extension of sensory axons on inhibitory chondroitin sulfate proteoglycans. Developmental Neurobiology 74:9, pages 918-933.
Crossref
Natalia Volodko, Marilyn Gordon, Mohamed Salla, Haya Abu Ghazaleh & Shairaz Baksh. (2014) RASSF tumor suppressor gene family: Biological functions and regulation. FEBS Letters 588:16, pages 2671-2684.
Crossref
David A. Hottman & Ling Li. (2014) Protein Prenylation and Synaptic Plasticity: Implications for Alzheimer’s Disease. Molecular Neurobiology 50:1, pages 177-185.
Crossref
Hao Zhang, Yu-Chung Chang, Mark L. Brennan & Jinhua Wu. (2014) The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism. Journal of Molecular Cell Biology 6:2, pages 128-139.
Crossref
Matthew J Smith & Mitsuhiko Ikura. (2014) Integrated RAS signaling defined by parallel NMR detection of effectors and regulators. Nature Chemical Biology 10:3, pages 223-230.
Crossref
Andrew G. Stephen, Dominic Esposito, Rachel K. Bagni & Frank McCormick. (2014) Dragging Ras Back in the Ring. Cancer Cell 25:3, pages 272-281.
Crossref
David A. Fruman & Christian Rommel. (2014) PI3K and cancer: lessons, challenges and opportunities. Nature Reviews Drug Discovery 13:2, pages 140-156.
Crossref
Guillaume Vandal, Benjamin Geiling & David Dankort. (2014) Ras Effector Mutant Expression Suggest a Negative Regulator Inhibits Lung Tumor Formation. PLoS ONE 9:1, pages e84745.
Crossref
Lisa E.S. Crose, Kathleen A. Galindo, Julie Grondin Kephart, Candy Chen, Julien Fitamant, Nabeel Bardeesy, Rex C. Bentley, Rene L. Galindo, Jen-Tsan Ashley Chi & Corinne M. Linardic. (2013) Alveolar rhabdomyosarcoma–associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression. Journal of Clinical Investigation 124:1, pages 285-296.
Crossref
Tikvah K. Hayes & Channing J. Der. 2014. Ras Superfamily Small G Proteins: Biology and Mechanisms 1. Ras Superfamily Small G Proteins: Biology and Mechanisms 1 135 156 .
Sylvia Gutierrez-Erlandsson, Pedro Herrero-Vidal, Marcos Fernandez-Alfara, Susana Hernandez-Garcia, Sandra Gonzalo-Flores, Alberto Mudarra-Rubio, Manuel Fresno & Beatriz Cubelos. (2013) R-RAS2 overexpression in tumors of the human central nervous system. Molecular Cancer 12:1.
Crossref
Chenyang Duan, Mengying Liu, Jiqiang Zhang & Ruiyan Ma. (2013) RASSF1A: A potential novel therapeutic target against cardiac hypertrophy. Progress in Biophysics and Molecular Biology 113:2, pages 284-288.
Crossref
Tina L. Yuan & Frank McCormick. (2013) Killing Tumors by Keeping Ras and PI3′ Kinase Apart. Cancer Cell 24:5, pages 562-563.
Crossref
Veronique Juvin, Mouhannad Malek, Karen E. Anderson, Carine Dion, Tamara Chessa, Charlotte Lecureuil, G. John Ferguson, Sabina Cosulich, Phillip T. Hawkins & Len R. Stephens. (2013) Signaling via Class IA Phosphoinositide 3-Kinases (PI3K) in Human, Breast-Derived Cell Lines. PLoS ONE 8:10, pages e75045.
Crossref
Jia Jia Chan & Matilda Katan. (2013) PLCɛ and the RASSF family in tumour suppression and other functions. Advances in Biological Regulation 53:3, pages 258-279.
Crossref
Hualin Li & Alemayehu A. Gorfe. (2013) Aggregation of Lipid-Anchored Full-Length H-Ras in Lipid Bilayers: Simulations with the MARTINI Force Field. PLoS ONE 8:7, pages e71018.
Crossref
Rachel Schnur Salamon & Jonathan M. Backer. (2013) Phosphatidylinositol-3,4,5-trisphosphate: Tool of choice for class I PI 3-kinases. BioEssays 35:7, pages 602-611.
Crossref
Carolyn BentleyStefanie S. JurinkaNoelyn M. KljavinSteffan VartanianSree R. RamaniLino C. GonzalezKebing YuZora ModrusanPan DuRichard BourgonRichard M. NeveDavid Stokoe. (2013) A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation. Biochemical Journal 452:2, pages 313-320.
Crossref
Jia Jia Chan, Delphine Flatters, Fernando Rodrigues-Lima, Jun Yan, Konstantinos Thalassinos & Matilda Katan. (2013) Comparative analysis of interactions of RASSF1-10. Advances in Biological Regulation 53:2, pages 190-201.
Crossref
Ralph Fritsch, Inge de Krijger, Kornelia Fritsch, Roger George, Beth Reason, Madhu S. Kumar, Markus Diefenbacher, Gordon Stamp & Julian Downward. (2013) RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms. Cell 153:5, pages 1050-1063.
Crossref
Klaus Okkenhaug. (2013) Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells. Annual Review of Immunology 31:1, pages 675-704.
Crossref
Matthew J. Smith, Benjamin G. Neel & Mitsuhiko Ikura. (2013) NMR-based functional profiling of RASopathies and oncogenic RAS mutations. Proceedings of the National Academy of Sciences 110:12, pages 4574-4579.
Crossref
Yu-Chung Chang, Hao Zhang, Mark L. Brennan & Jinhua Wu. (2013) Crystal structure of Lamellipodin implicates diverse functions in actin polymerization and Ras signaling. Protein & Cell 4:3, pages 211-219.
Crossref
Sarah L. Rowland, Kathryn Tuttle, Raul M. Torres & Roberta Pelanda. (2012) Antigen and cytokine receptor signals guide the development of the naïve mature B cell repertoire. Immunologic Research 55:1-3, pages 231-240.
Crossref
Willem-Jan Pannekoek, Jelena R. Linnemann, Patricia M. Brouwer, Johannes L. Bos & Holger Rehmann. (2013) Rap1 and Rap2 Antagonistically Control Endothelial Barrier Resistance. PLoS ONE 8:2, pages e57903.
Crossref
Maria Sofia Fernandes, Fátima Carneiro, Carla Oliveira & Raquel Seruca. (2013) Colorectal cancer and RASSF family-A special emphasis on RASSF1A. International Journal of Cancer 132:2, pages 251-258.
Crossref
Julie Baussand & Jens Kleinjung. (2012) Specific Conformational States of Ras GTPase upon Effector Binding. Journal of Chemical Theory and Computation 9:1, pages 738-749.
Crossref
Oliver Hoeller, Parvin Bolourani, Jonathan Clark, Len R. Stephens, Phillip T. Hawkins, Orion D. Weiner, Gerald Weeks & Robert R. Kay. (2013) Two distinct functions for PI3-kinases in macropinocytosis. Journal of Cell Science.
Crossref
Amy Young, David Lou & Frank McCormick. (2013) Oncogenic and Wild-type Ras Play Divergent Roles in the Regulation of Mitogen-Activated Protein Kinase Signaling. Cancer Discovery 3:1, pages 112-123.
Crossref
Benjamin L. Lampson, Nicole L.K. Pershing, Joseph A. Prinz, Joshua R. Lacsina, William F. Marzluff, Christopher V. Nicchitta, David M. MacAlpine & Christopher M. Counter. (2013) Rare Codons Regulate KRas Oncogenesis. Current Biology 23:1, pages 70-75.
Crossref
Bernard Desbuquois, Nadège Carré & Anne-Françoise Burnol. (2012) Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins. FEBS Journal, pages n/a-n/a.
Crossref
Georgina P. Coló, Esther M. Lafuente & Joaquin Teixidó. (2012) The MRL proteins: Adapting cell adhesion, migration and growth. European Journal of Cell Biology 91:11-12, pages 861-868.
Crossref
Noah Rodriguez, Junzheng Yang, Kathleen Hasselblatt, Shubai Liu, Yilan Zhou, Jose A. Rauh‐Hain, Shu‐Kay Ng, Pui‐Wah Choi, Wing‐Ping Fong, Nathalie Y. R. Agar, William R. Welch, Ross S. Berkowitz & Shu‐Wing Ng. (2012) Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells. EMBO Molecular Medicine 4:9, pages 952-963.
Crossref
Nariaki Iwasawa, Manabu Negishi & Izumi Oinuma. (2012) R-Ras controls axon branching through afadin in cortical neurons. Molecular Biology of the Cell 23:14, pages 2793-2804.
Crossref
Hee Won Yang, Min-Gyoung Shin, Sangkyu Lee, Jeong-Rae Kim, Wei Sun Park, Kwang-Hyun Cho, Tobias Meyer & Won Do Heo. (2012) Cooperative Activation of PI3K by Ras and Rho Family Small GTPases. Molecular Cell 47:2, pages 281-290.
Crossref
Navid Sadeghi & David E Gerber. (2012) Targeting the PI3K pathway for cancer therapy. Future Medicinal Chemistry 4:9, pages 1153-1169.
Crossref
Annett Mueller, Erika Bachmann, Monika Linnig, Katrin Khillimberger, Carl Christoph Schimanski, Peter R. Galle & Markus Moehler. (2012) Selective PI3K inhibition by BKM120 and BEZ235 alone or in combination with chemotherapy in wild-type and mutated human gastrointestinal cancer cell lines. Cancer Chemotherapy and Pharmacology 69:6, pages 1601-1615.
Crossref
Dominic P. Del Re & Junichi Sadoshima. (2012) RASSF1A Signaling in the Heart: Novel Functions beyond Tumor Suppression. Molecular Biology International 2012, pages 1-6.
Crossref
Ting Jin, Qiurong Ding, Heng Huang, Daqian Xu, Yuhui Jiang, Ben Zhou, Zhenghu Li, Xiaomeng Jiang, Jing He, Weizhong Liu, Yixuan Zhang, Yi Pan, Zhenzhen Wang, Walter G Thomas & Yan Chen. (2011) PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus. Cell Research 22:4, pages 661-676.
Crossref
Ian A. Prior & John F. Hancock. (2012) Ras trafficking, localization and compartmentalized signalling. Seminars in Cell & Developmental Biology 23:2, pages 145-153.
Crossref
Ariel F. Castro, Tania Campos, Justin T. Babcock, Marisol E. Armijo, Alfonso Martínez-Conde, Roxana Pincheira & Lawrence A. Quilliam. (2012) M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast cancer cells. Journal of Cellular Biochemistry 113:4, pages 1253-1264.
Crossref
Ana Maria Rojas, Gloria Fuentes, Antonio Rausell & Alfonso Valencia. (2012) The Ras protein superfamily: Evolutionary tree and role of conserved amino acids. Journal of Cell Biology 196:2, pages 189-201.
Crossref
Matthias Wymann. 2012. Phosphoinositides I: Enzymes of Synthesis and Degradation. Phosphoinositides I: Enzymes of Synthesis and Degradation 111 181 .
Massimo Micaroni. 2012. Calcium Signaling. Calcium Signaling 439 460 .
Volker Endris, Lydia Haussmann, Elena Buss, Claire Bacon, Dusan Bartsch & Gudrun Rappold. (2011) SrGAP3 interacts with lamellipodin at the cell membrane and regulates Rac-dependent cellular protrusions. Journal of Cell Science 124:23, pages 3941-3955.
Crossref
Michelle L. Janas & Martin Turner. (2011) Interaction of Ras with P110γ Is Required for Thymic β-Selection in the Mouse. The Journal of Immunology 187:9, pages 4667-4675.
Crossref
Oscar Vadas, John E. Burke, Xuxiao ZhangAlex Berndt & Roger L. Williams. (2011) Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases. Science Signaling 4:195.
Crossref
Weikang Cai, Jennifer L. Rudolph, Susan M. W. Harrison, Ling Jin, Aubrey L. Frantz, Douglas A. Harrison & Douglas A. Andres. (2011) An evolutionarily conserved Rit GTPase–p38 MAPK signaling pathway mediates oxidative stress resistance. Molecular Biology of the Cell 22:17, pages 3231-3241.
Crossref
Yenny Y. Acosta, Maria Paz Zafra, Gloria Ojeda, Ilaria Seren Bernardone, Umberto Dianzani, Pilar Portolés & Jose M. Rojo. (2010) Biased binding of class IA phosphatidyl inositol 3-kinase subunits to inducible costimulator (CD278). Cellular and Molecular Life Sciences 68:18, pages 3065-3079.
Crossref
Nuria Martínez-Martín, Elena Fernández-Arenas, Saso Cemerski, Pilar Delgado, Martin Turner, John Heuser, Darrell J. Irvine, Bonnie Huang, Xosé R. Bustelo, Andrey Shaw & Balbino Alarcón. (2011) T Cell Receptor Internalization from the Immunological Synapse Is Mediated by TC21 and RhoG GTPase-Dependent Phagocytosis. Immunity 35:2, pages 208-222.
Crossref
Nam Joo Kang, Sung Keun Jung, Ki Won Lee & Hyong Joo Lee. (2011) Myricetin is a potent chemopreventive phytochemical in skin carcinogenesis. Annals of the New York Academy of Sciences 1229:1, pages 124-132.
Crossref
Salvador IborraManuel SotoLuiz Stark-AroeiraEsther Castellano, Balbino AlarcónCarlos AlonsoEugenio Santos & Edgar Fernández-Malavé. (2011) H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity. Blood 117:19, pages 5102-5111.
Crossref
Kousuke Matsumoto, Fumi Shima, Shin Muraoka, Mitsugu Araki, Lizhi Hu, Yuichi Ijiri, Rina Hirai, Jingling Liao, Takashi Yoshioka, Takashi Kumasaka, Masaki Yamamoto, Atsuo Tamura & Tohru Kataoka. (2011) Critical Roles of Interactions among Switch I-preceding Residues and between Switch II and Its Neighboring α-Helix in Conformational Dynamics of the GTP-bound Ras Family Small GTPases. Journal of Biological Chemistry 286:17, pages 15403-15412.
Crossref
Chiou-Mei Lee, Polung Yang, Lih-Chyang Chen, Chia-Chun Chen, Shinn-Chih Wu, Hsiao-Yun Cheng & Yu-Sun Chang. (2011) A Novel Role of RASSF9 in Maintaining Epidermal Homeostasis. PLoS ONE 6:3, pages e17867.
Crossref
Yihao Tian, Yu Hou, Xiang Zhou, Hanhua Cheng & Rongjia Zhou. (2011) Tumor Suppressor RASSF1A Promoter: p53 Binding and Methylation. PLoS ONE 6:2, pages e17017.
Crossref
V K Hill, N Underhill-Day, D Krex, K Robel, C B Sangan, H R Summersgill, M Morris, D Gentle, A D Chalmers, E R Maher & F Latif. (2010) Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis. Oncogene 30:8, pages 978-989.
Crossref
Frank Gertler & John Condeelis. (2011) Metastasis: tumor cells becoming MENAcing. Trends in Cell Biology 21:2, pages 81-90.
Crossref
Tanya P. Zand, David J. Reiner & Channing J. Der. (2011) Ras Effector Switching Promotes Divergent Cell Fates in C. elegans Vulval Patterning. Developmental Cell 20:1, pages 84-96.
Crossref
Len Stephens & Phill Hawkins. (2011) Signalling via class IA PI3Ks. Advances in Enzyme Regulation 51:1, pages 27-36.
Crossref
Uyen T. T. Nguyen, Andrew Goodall, Kirill Alexandrov & Daniel Abankwa. 2011. Post-Translational Modifications in Health and Disease. Post-Translational Modifications in Health and Disease 1 37 .
Elisa Ferro & Lorenza Trabalzini. (2010) RalGDS family members couple Ras to Ral signalling and that's not all. Cellular Signalling 22:12, pages 1804-1810.
Crossref
Dominico Vigil, Timothy D. Martin, Falina Williams, Jen Jen Yeh, Sharon L. Campbell & Channing J. Der. (2010) Aberrant Overexpression of the Rgl2 Ral Small GTPase-specific Guanine Nucleotide Exchange Factor Promotes Pancreatic Cancer Growth through Ral-dependent and Ral-independent Mechanisms. Journal of Biological Chemistry 285:45, pages 34729-34740.
Crossref
Markus Werner, Elias Hobeika & Hassan Jumaa. (2010) Role of PI3K in the generation and survival of B cells. Immunological Reviews 237:1, pages 55-71.
Crossref
Pei-Yu Chu, Tsai-Kun Li, Shih-Torng Ding, I-Rue Lai & Tang-Long Shen. (2010) EGF-induced Grb7 Recruits and Promotes Ras Activity Essential for the Tumorigenicity of Sk-Br3 Breast Cancer Cells. Journal of Biological Chemistry 285:38, pages 29279-29285.
Crossref
F E Lock, N Underhill-Day, T Dunwell, D Matallanas, W Cooper, L Hesson, A Recino, A Ward, T Pavlova, E Zabarovsky, M M Grant, E R Maher, A D Chalmers, W Kolch & F Latif. (2010) The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-κB signaling pathways. Oncogene 29:30, pages 4307-4316.
Crossref
Xinnong Jiang, Sen Chen, John M. Asara & Steven P. Balk. (2010) Phosphoinositide 3-Kinase Pathway Activation in Phosphate and Tensin Homolog (PTEN)-deficient Prostate Cancer Cells Is Independent of Receptor Tyrosine Kinases and Mediated by the p110β and p110δ Catalytic Subunits. Journal of Biological Chemistry 285:20, pages 14980-14989.
Crossref
Bart Vanhaesebroeck, Julie Guillermet-Guibert, Mariona Graupera & Benoit Bilanges. (2010) The emerging mechanisms of isoform-specific PI3K signalling. Nature Reviews Molecular Cell Biology 11:5, pages 329-341.
Crossref
Y. Nadler, A.M. González, R.L. Camp, D.L. Rimm, H.M. Kluger & Y. Kluger. (2010) Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer. Annals of Oncology 21:3, pages 466-473.
Crossref
Haruko Watanabe-Takano, Kazunori Takano, Etsuko Keduka & Takeshi Endo. (2010) M-Ras is activated by bone morphogenetic protein-2 and participates in osteoblastic determination, differentiation, and transdifferentiation. Experimental Cell Research 316:3, pages 477-490.
Crossref
Daniel Abankwa, Alemayehu A. Gorfe, Kerry Inder & John F. Hancock. (2010) Ras membrane orientation and nanodomain localization generate isoform diversity. Proceedings of the National Academy of Sciences 107:3, pages 1130-1135.
Crossref
Victoria SherwoodAsha RecinoAlex JeffriesAndrew WardAndrew D. Chalmers. (2009) The N-terminal RASSF family: a new group of Ras-association-domaincontaining proteins, with emerging links to cancer formation. Biochemical Journal 425:2, pages 303-311.
Crossref
Wenjiao Song, Zhipeng Yu, Michael M. Madden & Qing Lin. (2010) A bioorthogonal chemistry strategy for probing protein lipidation in live cells. Molecular BioSystems 6:9, pages 1576.
Crossref
Gretchen A. Repasky, Adrienne D. Cox, Ariella B. Hanker, Natalia Mitin & Channing J. Der. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 1753 1762 .
M. Kulesz-Martin, J.R. Gallegos & Y. Liu. 2010. Comprehensive Toxicology. Comprehensive Toxicology 11 33 .
Esther Castellano & Julian Downward. 2011. Phosphoinositide 3-kinase in Health and Disease. Phosphoinositide 3-kinase in Health and Disease 143 169 .
David A. Fruman. 2011. Phosphoinositide 3-kinase in Health and Disease. Phosphoinositide 3-kinase in Health and Disease 225 244 .
Tao Wang, Hongli Liu, Yeshan Chen, Wei Liu, Jing Yu & Gang Wu. (2009) Methylation associated inactivation of RASSF1A and its synergistic effect with activated K-Ras in nasopharyngeal carcinoma. Journal of Experimental & Clinical Cancer Research 28:1.
Crossref
Barbara KurigAliaksei ShymanetsThomas Bohnacker PrajwalCarsten Brock, Mohammad Reza AhmadianMichael Schaefer, Antje GohlaChristian HarteneckMatthias P. WymannElisabeth JeanclosBernd Nürnberg. (2009) Ras is an indispensable coregulator of the class I B phosphoinositide 3-kinase p87/p110γ . Proceedings of the National Academy of Sciences 106:48, pages 20312-20317.
Crossref
Ho Y. Poon & James C. Stone. (2009) Functional links between diacylglycerol and phosphatidylinositol signaling systems in human leukocyte-derived cell lines. Biochemical and Biophysical Research Communications 390:4, pages 1395-1401.
Crossref
Antje M. Richter, Gerd P. Pfeifer & Reinhard H. Dammann. (2009) The RASSF proteins in cancer; from epigenetic silencing to functional characterization. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1796:2, pages 114-128.
Crossref
Kathryn Balmanno, Simon D. Chell, Annette S. Gillings, Shaista Hayat & Simon J. Cook. (2009) Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines. International Journal of Cancer 125:10, pages 2332-2341.
Crossref
Gloria Fuentes & Alfonso Valencia. (2009) Ras classical effectors: new tales from in silico complexes. Trends in Biochemical Sciences 34:11, pages 533-539.
Crossref
Delvac Oceandy, Elizabeth J. Cartwright & Ludwig Neyses. (2009) Ras-Association Domain Family Member 1A (RASSF1A)—Where the Heart and Cancer Meet. Trends in Cardiovascular Medicine 19:8, pages 262-267.
Crossref
Delvac OceandyAdam PickardSukhpal PreharMin ZiTamer M.A. MohamedPeter J. StanleyFlorence Baudoin-StanleyRaja NadifStella TommasiGerd P. PfeiferAngel L. ArmesillaElizabeth J. CartwrightLudwig Neyses. (2009) Tumor Suppressor Ras-Association Domain Family 1 Isoform A Is a Novel Regulator of Cardiac Hypertrophy. Circulation 120:7, pages 607-616.
Crossref
Sherwin J. Abraham, Ryan P. Nolet, Richard J. Calvert, Lucy M. Anderson & Vadim Gaponenko. (2009) The Hypervariable Region of K-Ras4B Is Responsible for Its Specific Interactions with Calmodulin. Biochemistry 48:32, pages 7575-7583.
Crossref
Elif Yaman, Raphael Gasper, Carolin Koerner, Alfred Wittinghofer & Uygar H. Tazebay. (2009) RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange. FEBS Journal 276:16, pages 4607-4616.
Crossref
Rafael S Depetris, Jinhua Wu & Stevan R Hubbard. (2009) Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14. Nature Structural & Molecular Biology 16:8, pages 833-839.
Crossref
Pilar Delgado, Beatriz Cubelos, Enrique Calleja, Nuria Martínez-Martín, Angel Ciprés, Isabel Mérida, Carmen Bellas, Xosé R Bustelo & Balbino Alarcón. (2009) Essential function for the GTPase TC21 in homeostatic antigen receptor signaling. Nature Immunology 10:8, pages 880-888.
Crossref
Philip J. Tofilon & Kevin Camphausen. (2009) Molecular Targets for Tumor Radiosensitization. Chemical Reviews 109:7, pages 2974-2988.
Crossref
Pei-Yu Chu, Ling-Ya Huang, Chun-Hua Hsu, Chun-Chi Liang, Jun-Lin Guan, Ting-Hsuan Hung & Tang-Long Shen. (2009) Tyrosine Phosphorylation of Growth Factor Receptor-bound Protein-7 by Focal Adhesion Kinase in the Regulation of Cell Migration, Proliferation, and Tumorigenesis. Journal of Biological Chemistry 284:30, pages 20215-20226.
Crossref
Anna Gates, Simon Hohenester, M. Sawkat Anwer & Cynthia R. L. Webster. (2009) cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 β/α in rat hepatocytes. American Journal of Physiology-Gastrointestinal and Liver Physiology 296:4, pages G764-G774.
Crossref
Judith H. Raaijmakers & Johannes L. Bos. (2009) Specificity in Ras and Rap Signaling. Journal of Biological Chemistry 284:17, pages 10995-10999.
Crossref
Francis S. Willard, Melinda D. Willard, Adam J. Kimple, Meera Soundararajan, Emily A. Oestreich, Xiaoyan Li, Nathaniel A. Sowa, Randall J. Kimple, Declan A. Doyle, Channing J. Der, Mark J. Zylka, William D. Snider & David P. Siderovski. (2009) Regulator of G-Protein Signaling 14 (RGS14) Is a Selective H-Ras Effector. PLoS ONE 4:3, pages e4884.
Crossref
André Bernards & Jeffrey Settleman. (2009) Loss of the Ras Regulator RASAL1: Another Route to Ras Activation in Colorectal Cancer. Gastroenterology 136:1, pages 46-48.
Crossref
Amy Young, Jesse Lyons, Abigail L. Miller, Vernon T. Phan, Irma Rangel Alarcón & Frank McCormick. 2009. 1 17 .
David Stokoe & Frank B. Furnari. 2009. CNS Cancer. CNS Cancer 315 357 .
Evangelia A. Papakonstanti, Olivier Zwaenepoel, Antonio Bilancio, Emily Burns, Gemma E. Nock, Benjamin Houseman, Kevan Shokat, Anne J. Ridley & Bart Vanhaesebroeck. (2008) Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages. Journal of Cell Science 121:24, pages 4124-4133.
Crossref
Michael D Oberst, Stacey J Beberman, Liu Zhao, Juan Juan Yin, Yvona Ward & Kathleen Kelly. (2008) TDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation. BMC Cancer 8:1.
Crossref
Ekaterina Lyulcheva, Eleanor Taylor, Magdalene Michael, Anne Vehlow, Shengjiang Tan, Adam Fletcher, Matthias Krause & Daimark Bennett. (2008) Drosophila Pico and Its Mammalian Ortholog Lamellipodin Activate Serum Response Factor and Promote Cell Proliferation. Developmental Cell 15:5, pages 680-690.
Crossref
Violeta Serra, Ben Markman, Maurizio Scaltriti, Pieter J.A. Eichhorn, Vanesa Valero, Marta Guzman, Maria Luisa Botero, Elisabeth Llonch, Francesco Atzori, Serena Di Cosimo, Michel Maira, Carlos Garcia-Echeverria, Josep Lluis Parra, Joaquin Arribas & José Baselga. (2008) NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations. Cancer Research 68:19, pages 8022-8030.
Crossref
John Colicelli. (2008) Rin1. AfCS-Nature Molecule Pages.
Crossref
Emilio Hirsch, Elisa Ciraolo, Alessandra Ghigo & Carlotta Costa. (2008) Taming the PI3K team to hold inflammation and cancer at bay. Pharmacology & Therapeutics 118:2, pages 192-205.
Crossref
Jingling Liao, Fumi Shima, Mitsugu Araki, Min Ye, Shin Muraoka, Takeshi Sugimoto, Mei Kawamura, Naoki Yamamoto, Atsuo Tamura & Tohru Kataoka. (2008) Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics. Biochemical and Biophysical Research Communications 369:2, pages 327-332.
Crossref
Parvin Bolourani, George B. Spiegelman & Gerald Weeks. (2008) Rap1 Activation in Response to cAMP Occurs Downstream of Ras Activation during Dictyostelium Aggregation. Journal of Biological Chemistry 283:16, pages 10232-10240.
Crossref
Fabien GarçonDaniel T. PattonJuliet L. EmeryEmilio HirschRobert RottapelTakehiko Sasaki & Klaus Okkenhaug. (2008) CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood 111:3, pages 1464-1471.
Crossref
Lawrence E. Goldfinger. (2008) Choose your own path: specificity in Ras GTPase signaling. Molecular BioSystems 4:4, pages 293.
Crossref
Sharon Eisenberg & Yoav I. Henis. (2008) Interactions of Ras proteins with the plasma membrane and their roles in signaling. Cellular Signalling 20:1, pages 31-39.
Crossref
Adam Denley, Marco Gymnopoulos, Jonathan R. Hart, Hao Jiang, Li Zhao & Peter K. Vogt. 2008. Small GTPases in Disease, Part A. Small GTPases in Disease, Part A 291 305 .
Tony Pawson & Claus Jorgensen. 2008. The Molecular Basis of Cancer. The Molecular Basis of Cancer 155 168 .
G. Pula & M. Krause. 2008. Protein-Protein Interactions as New Drug Targets. Protein-Protein Interactions as New Drug Targets 39 65 .
Michele Sallese. 2008. The Golgi Apparatus. The Golgi Apparatus 247 269 .
Daniel Kalderon. 2008. Principles of Molecular Oncology. Principles of Molecular Oncology 153 188 .
Haley L. Bennett, Tilman Brummer, Paul Timpson, Kate I. Patterson & Roger J. Daly. 2008. EGFR Signaling Networks in Cancer Therapy. EGFR Signaling Networks in Cancer Therapy 224 244 .
Jennifer L. Rudolph, Geng-Xian Shi, Eda Erdogan, Alan P. Fields & Douglas A. Andres. (2007) Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773:12, pages 1793-1800.
Crossref

Displaying 200 of 250 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.