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Molecular and Cellular Biology Volume 24, 2004 - Issue 14
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Transcriptional Regulation

Transcriptional Coactivator PC4 Stimulates Promoter Escape and Facilitates Transcriptional Synergy by GAL4-VP16

Aya Fukuda1 Department of Molecular Biology, Saitama Medical School, Moroyama, Iruma-gun, Saitama350-0495, Japan
,
Tomoyoshi Nakadai1 Department of Molecular Biology, Saitama Medical School, Moroyama, Iruma-gun, Saitama350-0495, Japan
,
Miho Shimada1 Department of Molecular Biology, Saitama Medical School, Moroyama, Iruma-gun, Saitama350-0495, Japan
,
Tohru Tsukui1 Department of Molecular Biology, Saitama Medical School, Moroyama, Iruma-gun, Saitama350-0495, Japan
,
Masahito Matsumoto1 Department of Molecular Biology, Saitama Medical School, Moroyama, Iruma-gun, Saitama350-0495, Japan
,
Yasuhisa Nogi1 Department of Molecular Biology, Saitama Medical School, Moroyama, Iruma-gun, Saitama350-0495, Japan
,
Michael Meisterernst2 Gene Expression, Institute of Molecular Immunology, GSF-National Research Center for Environment and Health, Munich, Germany
&
Koji Hisatake1 Department of Molecular Biology, Saitama Medical School, Moroyama, Iruma-gun, Saitama350-0495, JapanCorrespondence[email protected]
 show all
Pages 6525-6535 | Received 24 Dec 2003, Accepted 14 Apr 2004, Published online: 27 Mar 2023

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Archana Anantharaman, I-Ju Lin, Joeva Barrow, Shermi Y. Liang, Jude Masannat, John Strouboulis, Suming Huang & Jörg Bungert. (2011) Role of Helix-Loop-Helix Proteins during Differentiation of Erythroid Cells. Molecular and Cellular Biology 31:7, pages 1332-1343.
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Thomas Pavelitz, Arnold D. Bailey, Christopher P. Elco & Alan M. Weiner. (2008) Human U2 snRNA Genes Exhibit a Persistently Open Transcriptional State and Promoter Disassembly at Metaphase. Molecular and Cellular Biology 28:11, pages 3573-3588.
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Chandrima Das, Kohji Hizume, Kiran Batta, B. R. Prashanth Kumar, Shrikanth S. Gadad, Semanti Ganguly, Stephanie Lorain, Alain Verreault, Parag P. Sadhale, Kunio Takeyasu & Tapas K. Kundu. (2006) Transcriptional Coactivator PC4, a Chromatin-Associated Protein, Induces Chromatin Condensation. Molecular and Cellular Biology 26:22, pages 8303-8315.
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Mary C. Thomas & Cheng-Ming Chiang. (2006) The General Transcription Machinery and General Cofactors. Critical Reviews in Biochemistry and Molecular Biology 41:3, pages 105-178.
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Le Ma, Qiang Gong, Yan Chen, Peng Luo, Jieping Chen & Chunmeng Shi. (2023) Targeting positive cofactor 4 induces autophagic cell death in MYC-expressing diffuse large B-cell lymphoma. Experimental Hematology 119-120, pages 42-57.e4.
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Diego A. Rojas, Fabiola Urbina, Aldo Solari & Edio Maldonado. (2022) The Catalytic Subunit of Schizosaccharomyces pombe CK2 (Cka1) Negatively Regulates RNA Polymerase II Transcription through Phosphorylation of Positive Cofactor 4 (PC4). International Journal of Molecular Sciences 23:16, pages 9499.
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Junhao Zhang, Huan Liao, Xiaogang Xun, Xiujiang Hou, Xinghai Zhu, Qiang Xing, Xiaoting Huang, Jingjie Hu & Zhenmin Bao. (2022) Identification, characterization and expression analyses of PC4 genes in Yesso scallop (Patinopecten yessoensis) reveal functional differentiations in response to ocean acidification. Aquatic Toxicology 244, pages 106099.
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Dengjian Fan, Mingshu Wang, Anchun Cheng, Renyong Jia, Qiao Yang, Ying Wu, Dekang Zhu, Xinxin Zhao, Shun Chen, Mafeng Liu, Shaqiu Zhang, Xumin Ou, Sai Mao, Qun Gao, Di Sun, Xingjian Wen, Yunya Liu, Yanling Yu, Ling Zhang, Bin Tian, Leichang Pan & Xiaoyue Chen. (2020) The Role of VP16 in the Life Cycle of Alphaherpesviruses. Frontiers in Microbiology 11.
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Peng Luo, Chi Zhang, Fengying Liao, Long Chen, Zhenyu Liu, Lei Long, Zhongyong Jiang, Yawei Wang, Ziwen Wang, Zujuan Liu, Hongming Miao & Chunmeng Shi. (2019) Transcriptional positive cofactor 4 promotes breast cancer proliferation and metastasis through c-Myc mediated Warburg effect. Cell Communication and Signaling 17:1.
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Wezley C. Griffin, Jun Gao, Alicia K. Byrd, Shubeena Chib & Kevin D. Raney. (2017) A biochemical and biophysical model of G-quadruplex DNA recognition by positive coactivator of transcription 4. Journal of Biological Chemistry 292:23, pages 9567-9582.
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Antonis Giakountis, Panagiotis Moulos, Michalis E. Sarris, Pantelis Hatzis & Iannis Talianidis. (2017) Smyd3-associated regulatory pathways in cancer. Seminars in Cancer Biology 42, pages 70-80.
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Joachim Griesenbeck, Herbert Tschochner & Dina Grohmann. 2017. Macromolecular Protein Complexes. Macromolecular Protein Complexes 225 270 .
Olga Hernández de la Cruz, Laurence A. Marchat, Nancy Guillén, Christian Weber, Itzel López Rosas, José Díaz-Chávez, Luis Herrera, Arturo Rojo-Domínguez, Esther Orozco & César López-Camarillo. (2016) Multinucleation and Polykaryon Formation is Promoted by the EhPC4 Transcription Factor in Entamoeba histolytica. Scientific Reports 6:1.
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Jin-Man Kim, Kyunghwan Kim, Thomas Schmidt, Vasu Punj, Haley Tucker, Judd C. Rice, Tobias S. Ulmer & Woojin An. (2015) Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells. Nucleic Acids Research 43:18, pages 8868-8883.
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Tomoyoshi Nakadai, Aya Fukuda, Miho Shimada, Ken Nishimura & Koji Hisatake. (2015) The RNA Binding Complexes NF45-NF90 and NF45-NF110 Associate Dynamically with the c-fos Gene and Function as Transcriptional Coactivators. Journal of Biological Chemistry 290:44, pages 26832-26845.
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Yusuke Akimoto, Seiji Yamamoto, Satoshi Iida, Yutaka Hirose, Aki Tanaka, Fumio Hanaoka & Yoshiaki Ohkuma. (2014) Transcription cofactor PC4 plays essential roles in collaboration with the small subunit of general transcription factor TFIIE. Genes to Cells 19:12, pages 879-890.
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Birthe Steigemann, Annina Schulz & Sebastiaan Werten. (2013) Bacteriophage T5 Encodes a Homolog of the Eukaryotic Transcription Coactivator PC4 Implicated in Recombination-Dependent DNA Replication. Journal of Molecular Biology 425:22, pages 4125-4133.
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Aya Fukuda, Miho Shimada, Tomoyoshi Nakadai, Ken Nishimura & Koji Hisatake. (2013) Heterogeneous Nuclear Ribonucleoprotein R Cooperates with Mediator to Facilitate Transcription Reinitiation on the c-Fos Gene. PLoS ONE 8:8, pages e72496.
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Jeanette Blomberg, Ximena Aguilar, Kristoffer Brännström, Linn Rautio, Anders Olofsson, Pernilla Wittung-Stafshede & Stefan Björklund. (2012) Interactions between DNA, transcriptional regulator Dreb2a and the Med25 mediator subunit from Arabidopsis thaliana involve conformational changes. Nucleic Acids Research 40:13, pages 5938-5950.
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Timothy W. Sikorski, Scott B. Ficarro, John Holik, TaeSoo Kim, Oliver J. Rando, Jarrod A. Marto & Stephen Buratowski. (2011) Sub1 and RPA Associate with RNA Polymerase II at Different Stages of Transcription. Molecular Cell 44:3, pages 397-409.
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Shrikanth S. Gadad, Parijat Senapati, Sajad Hussain Syed, Roshan Elizabeth Rajan, Jayasha Shandilya, Venkatesh Swaminathan, Snehajyoti Chatterjee, Emanuela Colombo, Stefan Dimitrov, Pier Giuseppe Pelicci, Udaykumar Ranga & Tapas K. Kundu. (2011) The Multifunctional Protein Nucleophosmin (NPM1) Is a Human Linker Histone H1 Chaperone. Biochemistry 50:14, pages 2780-2789.
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Sébastien Desfarges & Angela Ciuffi. (2010) Retroviral Integration Site Selection. Viruses 2:1, pages 111-130.
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Arounie Tavenet, Audrey Suleau, Géraldine Dubreuil, Roberto Ferrari, Cécile Ducrot, Magali Michaut, Jean-Christophe Aude, Giorgio Dieci, Olivier Lefebvre, Christine Conesa & Joël Acker. (2009) Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription. Proceedings of the National Academy of Sciences 106:34, pages 14265-14270.
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Aya Fukuda, Tomoyoshi Nakadai, Miho Shimada & Koji Hisatake. (2009) Heterogeneous Nuclear Ribonucleoprotein R Enhances Transcription from the Naturally Configured c-fos Promoter in Vitro. Journal of Biological Chemistry 284:35, pages 23472-23480.
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Oliver Mortusewicz, Wera Roth, Na Li, M. Cristina Cardoso, Michael Meisterernst & Heinrich Leonhardt. (2008) Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites. The Journal of Cell Biology 183:5, pages 769-776.
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Juan Contreras-Levicoy, Fabiola Urbina & Edio Maldonado. (2008) Schizosaccharomyces pombe positive cofactor 4 stimulates basal transcription from TATA-containing and TATA-less promoters through Mediator and transcription factor IIA. FEBS Journal 275:11, pages 2873-2883.
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Thomas Uhlmann, Stefan Boeing, Michael Lehmbacher & Michael Meisterernst. (2007) The VP16 Activation Domain Establishes an Active Mediator Lacking CDK8 in Vivo. Journal of Biological Chemistry 282:4, pages 2163-2173.
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Kostya I Panov, J Karsten Friedrich, Jackie Russell & Joost C B M Zomerdijk. (2006) UBF activates RNA polymerase I transcription by stimulating promoter escape. The EMBO Journal 25:14, pages 3310-3322.
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Aaron R Hieb, Sean Baran, James A Goodrich & Jennifer F Kugel. (2006) An 8 nt RNA triggers a rate-limiting shift of RNA polymerase II complexes into elongation. The EMBO Journal 25:13, pages 3100-3109.
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Hendrik R. A. Jonker, Rainer W. Wechselberger, Martijn Pinkse, Robert Kaptein & Gert E. Folkers. (2006) Gradual phosphorylation regulates PC4 coactivator function. FEBS Journal 273:7, pages 1430-1444.
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Sebastiaan Werten & Dino Moras. (2006) A global transcription cofactor bound to juxtaposed strands of unwound DNA. Nature Structural & Molecular Biology 13:2, pages 181-182.
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