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Molecular and Cellular Biology Volume 24, 2004 - Issue 15
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Cell Growth and Development

Drosophila C-Terminal Src Kinase Negatively Regulates Organ Growth and Cell Proliferation through Inhibition of the Src, Jun N-Terminal Kinase, and STAT Pathways

Renee D. Read1 Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri63110
,
Erika A. Bach2 Department of Pharmacology, New York University School of Medicine, New York, New York10012
&
Ross L. Cagan1 Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri63110Correspondence[email protected]
Pages 6676-6689 | Received 20 Oct 2003, Accepted 28 Mar 2004, Published online: 27 Mar 2023

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Tamara Zoranovic, Lydia Grmai & Erika A Bach. (2013) Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway. JAK-STAT 2:3.
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Raghuveera Kumar Goel, Nayoung Kim & Kiven Erique Lukong. (2023) Seeking a better understanding of the non-receptor tyrosine kinase, SRMS. Heliyon 9:6, pages e16421.
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Hiroshi Nishida, Morihiro Okada, Lynna Yang, Tomomi Takano, Sho Tabata, Tomoyoshi Soga, Diana M Ho, Jongkyeong Chung, Yasuhiro Minami & Sa Kan Yoo. (2021) Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila. eLife 10.
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Elina Parri, Heikki Kuusanmäki, Arjan J. van Adrichem, Meri Kaustio & Krister Wennerberg. (2020) Identification of novel regulators of STAT3 activity. PLOS ONE 15:3, pages e0230819.
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Karishma Gangwani, Kirti Snigdha, Mardelle Atkins, Shree Ram Singh & Madhuri Kango-Singh. 2020. Molecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye. Molecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye 259 291 .
Sigrid S. Skånland & Kjetil Taskén. (2019) Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling. The Journal of Immunology 203:4, pages 1055-1063.
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Julia Wittes & Trudi Schüpbach. (2019) A Gene Expression Screen in Drosophila melanogaster Identifies Novel JAK/STAT and EGFR Targets During Oogenesis . G3 Genes|Genomes|Genetics 9:1, pages 47-60.
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Sunny Trivedi & Michelle Starz-Gaiano. (2018) Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis. International Journal of Molecular Sciences 19:12, pages 4056.
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Miranda V. Hunter, Patrick Morley Willoughby, Ashley E.E. Bruce & Rodrigo Fernandez-Gonzalez. (2018) Oxidative Stress Orchestrates Cell Polarity to Promote Embryonic Wound Healing. Developmental Cell 47:3, pages 377-387.e4.
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Carole Poon, Anthony Brumby & Helena Richardson. (2018) Src Cooperates with Oncogenic Ras in Tumourigenesis via the JNK and PI3K Pathways in Drosophila epithelial Tissue. International Journal of Molecular Sciences 19:6, pages 1585.
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Tirtha K Das & Ross L Cagan. (2018) Non-mammalian models of multiple endocrine neoplasia type 2. Endocrine-Related Cancer 25:2, pages T91-T104.
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Shizue Ohsawa, John Vaughen & Tatsushi Igaki. (2018) Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis. Developmental Cell 44:3, pages 284-296.
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Helena E. Richardson & Marta Portela. (2018) Modelling Cooperative Tumorigenesis in Drosophila . BioMed Research International 2018, pages 1-29.
Crossref
Masato Okada. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1210 1214 .
Linda M Parsons, Nicola A Grzeschik, Kasun Amaratunga, Peter Burke, Leonie M Quinn & Helena E Richardson. (2017) A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues . G3 Genes|Genomes|Genetics 7:8, pages 2497-2509.
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M. Sonoshita & R.L. Cagan. 2017. Fly Models of Human Diseases. Fly Models of Human Diseases 287 309 .
Susumu Hirabayashi. (2016) The interplay between obesity and cancer: a fly view. Disease Models & Mechanisms 9:9, pages 917-926.
Crossref
M Buchert, C J Burns & M Ernst. (2015) Targeting JAK kinase in solid tumors: emerging opportunities and challenges. Oncogene 35:8, pages 939-951.
Crossref
Ashlyn M. Spring, Douglas J. Brusich & C. Andrew Frank. (2016) C-terminal Src Kinase Gates Homeostatic Synaptic Plasticity and Regulates Fasciclin II Expression at the Drosophila Neuromuscular Junction. PLOS Genetics 12:2, pages e1005886.
Crossref
Ewa Marcinkowska & Elżbieta Gocek. 2016. Resistance to Tyrosine Kinase Inhibitors. Resistance to Tyrosine Kinase Inhibitors 1 25 .
Nezaket Turkel, Marta Portela, Carole Poon, Jason Li, Anthony M. Brumby & Helena E. Richardson. (2015) Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators in Drosophila epithelial tumorigenesis . Biology Open 4:8, pages 1024-1039.
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Diana M Ho, SK Pallavi & Spyros Artavanis-Tsakonas. (2015) The Notch-mediated hyperplasia circuitry in Drosophila reveals a Src-JNK signaling axis. eLife 4.
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A Kohlmaier, C Fassnacht, Y Jin, H Reuter, J Begum, D Dutta & B A Edgar. (2014) Src kinase function controls progenitor cell pools during regeneration and tumor onset in the Drosophila intestine. Oncogene 34:18, pages 2371-2384.
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Johnna Doherty, Amy E. Sheehan, Rachel Bradshaw, A. Nicole Fox, Tsai-Yi Lu & Marc R. Freeman. (2014) PI3K Signaling and Stat92E Converge to Modulate Glial Responsiveness to Axonal Injury. PLoS Biology 12:11, pages e1001985.
Crossref
B G Fernández, B Jezowska & F Janody. (2013) Drosophila actin-Capping Protein limits JNK activation by the Src proto-oncogene. Oncogene 33:16, pages 2027-2039.
Crossref
Marc Amoyel, Abigail M. Anderson & Erika A. Bach. (2014) JAK/STAT pathway dysregulation in tumors: A Drosophila perspective. Seminars in Cell & Developmental Biology 28, pages 96-103.
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Fei Zhu, Haojie Ding & Binnian Zhu. (2013) Transcriptional profiling of Drosophila S2 cells in early response to Drosophila C virus. Virology Journal 10:1.
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José Carlos Pastor-ParejaTian Xu. (2013) Dissecting Social Cell Biology and Tumors Using Drosophila Genetics . Annual Review of Genetics 47:1, pages 51-74.
Crossref
T K Das, J Sangodkar, N Negre, G Narla & R L Cagan. (2012) Sin3a acts through a multi-gene module to regulate invasion in Drosophila and human tumors. Oncogene 32:26, pages 3184-3197.
Crossref
Sol SotillosMichael KrahnJose Manuel Espinosa-VázquezJames Castelli-Gair Hombría. (2013) Src kinases mediate the interaction of the apical determinant Bazooka/PAR3 with STAT92E and increase signalling efficiency in Drosophila ectodermal cells . Development 140:7, pages 1507-1516.
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Luis Daniel Ríos-Barrera & Juan Rafael Riesgo-Escovar. (2013) Regulating cell morphogenesis: The drosophila jun N-terminal kinase pathway. genesis 51:3, pages 147-162.
Crossref
Theodoulakis Christofi & Yiorgos Apidianakis. 2013. Yellow Biotechnology I. Yellow Biotechnology I 79 110 .
Arvin C. Dar, Tirtha K. Das, Kevan M. Shokat & Ross L. Cagan. (2012) Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature 486:7401, pages 80-84.
Crossref
Yoichiro Tamori & Wu-Min Deng. (2011) Cell competition and its implications for development and cancer. Journal of Genetics and Genomics 38:10, pages 483-495.
Crossref
X. Rebecca ShengErika Matunis. (2011) Live imaging of the Drosophila spermatogonial stem cell niche reveals novel mechanisms regulating germline stem cell output . Development 138:16, pages 3367-3376.
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Stephanie Saja, Haley Buff, Alexis C. Smith, Tiffany S. Williams & Christopher A. Korey. (2010) Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function. Neurobiology of Disease 40:1, pages 135-145.
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Edoardo Fiorillo, Valeria Orrú, Stephanie M. Stanford, Yingge Liu, Mogjiborahman Salek, Novella Rapini, Aaron D. Schenone, Patrizia Saccucci, Lucia G. Delogu, Federica Angelini, Maria Luisa Manca Bitti, Christian Schmedt, Andrew C. Chan, Oreste Acuto & Nunzio Bottini. (2010) Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue. Journal of Biological Chemistry 285:34, pages 26506-26518.
Crossref
Hua Yan, Maryam Jahanshahi, Elizabeth A. Horvath, Hsiu-Yu Liu & Cathie M. Pfleger. (2010) Rabex-5 Ubiquitin Ligase Activity Restricts Ras Signaling to Establish Pathway Homeostasis in Drosophila. Current Biology 20:15, pages 1378-1382.
Crossref
Tirtha DasRoss Cagan. (2010) Drosophila as a Novel Therapeutic Discovery Tool for Thyroid Cancer . Thyroid 20:7, pages 689-695.
Crossref
Marcos Vidal, Lorena Salavaggione, Lourdes Ylagan, Mark Wilkins, Mark Watson, Katherine Weilbaecher & Ross Cagan. (2010) A Role for the Epithelial Microenvironment at Tumor Boundaries. The American Journal of Pathology 176:6, pages 3007-3014.
Crossref
A Sirvent, C Bénistant, J Pannequin, L Veracini, V Simon, J-F Bourgaux, F Hollande, F Cruzalegui & S Roche. (2009) Src family tyrosine kinases-driven colon cancer cell invasion is induced by Csk membrane delocalization. Oncogene 29:9, pages 1303-1315.
Crossref
Paul F. Langton, Julien Colombani, Eunice H.Y. Chan, Alexander Wepf, Matthias Gstaiger & Nicolas Tapon. (2009) The dASPP-dRASSF8 Complex Regulates Cell-Cell Adhesion during Drosophila Retinal Morphogenesis. Current Biology 19:23, pages 1969-1978.
Crossref
X. Rebecca Sheng, Trevor Posenau, Juliann J. Gumulak-Smith, Erika Matunis, Mark Van Doren & Matthew Wawersik. (2009) Jak–STAT regulation of male germline stem cell establishment during Drosophila embryogenesis. Developmental Biology 334:2, pages 335-344.
Crossref
Maria Sol Flaherty, Jiri Zavadil, Laura A. Ekas & Erika A. Bach. (2009) Genome-wide expression profiling in the Drosophila eye reveals unexpected repression of notch signaling by the JAK/STAT pathway . Developmental Dynamics 238:9, pages 2235-2253.
Crossref
Ross Cagan. 2009. 115 135 .
Amparo Garcia-Lopez, Lidon Monferrer, Irma Garcia-Alcover, Marta Vicente-Crespo, M. Carmen Alvarez-Abril & Ruben D. Artero. (2008) Genetic and Chemical Modifiers of a CUG Toxicity Model in Drosophila. PLoS ONE 3:2, pages e1595.
Crossref
Paul F. Langton, Julien Colombani, Birgit L. Aerne & Nicolas Tapon. (2007) Drosophila ASPP Regulates C-Terminal Src Kinase Activity. Developmental Cell 13:6, pages 773-782.
Crossref
Marcos Vidal, Stephen Warner, Renee Read & Ross L. Cagan. (2007) Differing Src Signaling Levels Have Distinct Outcomes in Drosophila . Cancer Research 67:21, pages 10278-10285.
Crossref
Kieran Harvey & Nicolas Tapon. (2007) The Salvador–Warts–Hippo pathway — an emerging tumour-suppressor network. Nature Reviews Cancer 7:3, pages 182-191.
Crossref
Erika A. Bach, Laura A. Ekas, Aidee Ayala-Camargo, Maria Sol Flaherty, Haeryun Lee, Norbert Perrimon & Gyeong-Hun Baeg. (2007) GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. Gene Expression Patterns 7:3, pages 323-331.
Crossref
Iswar K. HariharanDavid Bilder. (2006) Regulation of Imaginal Disc Growth by Tumor-Suppressor Genes in Drosophila . Annual Review of Genetics 40:1, pages 335-361.
Crossref
Alana M. O'ReillyAnna C. BallewByron MiyazawaHugo StockerErnst HafenMichael A. Simon. (2006) Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells . Development 133:14, pages 2627-2638.
Crossref
Natalia I. ArbouzovaMartin P. Zeidler. (2006) JAK/STAT signalling in Drosophila : insights into conserved regulatory and cellular functions . Development 133:14, pages 2605-2616.
Crossref
Feng Zhu, Bu Young Choi, Wei-Ya Ma, Zhongliang Zhao, Yiguo Zhang, Yong Yeon Cho, Hong Seok Choi, Akira Imamoto, Ann M. Bode & Zigang Dong. (2006) COOH-Terminal Src Kinase–Mediated c-Jun Phosphorylation Promotes c-Jun Degradation and Inhibits Cell Transformation. Cancer Research 66:11, pages 5729-5736.
Crossref
Torkel Vang, Trond Methi, André Veillette, Tomas Mustelin & Kjetil Tasken. (2006) Csk. AfCS-Nature Molecule Pages.
Crossref
Frank J. Delfino, Heather Stevenson & Thomas E. Smithgall. (2006) A Growth-suppressive Function for the c-Fes Protein-Tyrosine Kinase in Colorectal Cancer. Journal of Biological Chemistry 281:13, pages 8829-8835.
Crossref
Marcos Vidal & Ross L Cagan. (2006) Drosophila models for cancer research. Current Opinion in Genetics & Development 16:1, pages 10-16.
Crossref
Marcos Vidal, David E. Larson & Ross L. Cagan. (2006) Csk-Deficient Boundary Cells Are Eliminated from Normal Drosophila Epithelia by Exclusion, Migration, and Apoptosis. Developmental Cell 10:1, pages 33-44.
Crossref
Bruce A. Edgar. (2006) From Cell Structure to Transcription: Hippo Forges a New Path. Cell 124:2, pages 267-273.
Crossref
G. Steven Martin. (2006) Fly Src: The Yin and Yang of tumor invasion and tumor suppression. Cancer Cell 9:1, pages 4-6.
Crossref
Sally J Leevers & Helen McNeill. (2005) Controlling the size of organs and organisms. Current Opinion in Cell Biology 17:6, pages 604-609.
Crossref
Renee D Read, Paul J Goodfellow, Elaine R Mardis, Nancy Novak, Jon R Armstrong & Ross L Cagan. (2005) A Drosophila Model of Multiple Endocrine Neoplasia Type 2. Genetics 171:3, pages 1057-1081.
Crossref
Anthony M. Brumby & Helena E. Richardson. (2005) Using Drosophila melanogaster to map human cancer pathways. Nature Reviews Cancer 5:8, pages 626-639.
Crossref
Waheed Sangrar, Ralph A. Zirgnibl, Yan Gao, William J. Muller, Zongchao Jia & Peter A. Greer. (2005) An Identity Crisis for fps/fes : Oncogene or Tumor Suppressor? . Cancer Research 65:9, pages 3518-3522.
Crossref
Tina Mukherjee, James Castelli-Gair Hombría & Martin P Zeidler. (2005) Opposing roles for Drosophila JAK/STAT signalling during cellular proliferation. Oncogene 24:15, pages 2503-2511.
Crossref

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